Focus: DNA

'Open for Dicovery', our current exhibition, features the work of Crick scientists John Diffley and Stephen West. Scroll down for detailed information about their current research, related news stories and events, and recommended reading.

Science in conversation: Open research


Featured scientist: John Diffley

John Diffley in the Chromosome Replication Laboratory

John Diffley in the Chromosome Replication Laboratory (Click to view larger image)
© Ben Gilbert / 2017 / Wellcome

John Diffley is an Associate Research Director at the Francis Crick Institute and Group Leader of the Chromosome Replication Laboratory. 

Read more about the research of the Chromosome Replication Laboratory.

Featured scientist: Stephen West

Stephen West with members of the DNA Recombination and Repair Laboratory

Stephen West with members of the DNA Recombination and Repair Laboratory (Click to view larger image)
© Ben Gilbert / 2017 / Wellcome

Stephen is Group Leader of the DNA Recombination and Repair Laboratory. His work centres on mechanisms of genetic recombination and DNA strand break repair.

In particular, he has defined relationships between defective DNA repair processes and human diseases such as inheritable breast cancer and neurological disorders.

The laboratory's current projects include research into the breast cancer tumour suppressor BRCA2 and genome instability disorders linked to defects in the resolution of recombination intermediates.

Read more about the research of the DNA Recombination and Repair Laboratory.

Find out more

Upcoming events

The Francis Crick Institute Flagship lectures are open to scientists from other institutes and universities in and around London. The upcoming lectures related to this topic are:

  • 20 April 2017 - KJ Patel, MRC-LMB, Cambridge (DNA)
  • 15 June 2017 - Adrian Bird, University of Edinburgh
  • 7 September 2017 - Patrick Cramer, Max Planck Biophysical Chemistry, Gottingen 

Get more information about the Flagship lectures.

Recent news stories

Read more about the Crick's work on DNA.

Further suggested reading

Books

Weston, KM (2014) Blue Skies and Bench Space, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

Papers

Hills, SA and Diffley, JFX (2014)
DNA replication and oncogene-induced replicative stress. Current Biology 24, R435-R444

Siddiqui, K; On, KF and Diffley, JFX (2013)
Regulating DNA replication in Eukarya. Cold Spring Harbor Perspectives in Biology 5, a012930

Wyatt, HDM and West, SC (2014)
Holliday junction resolvases. Cold Spring Harbor Perspectives in Biology 6, a023192

Matos, J and West, SC (2014)
Holliday junction resolution: regulation in space and time. DNA Repair 19, 176-181

Diffley, J.F.X. (2016)
On the Road to Replication, EMBO Mol Med, 8, pp77-79.

Ip, S.C.Y., et al. (2008)
Identification of Holliday Junction Resolvases from Humans and Yeast , Nature, 20 November, 456, pp357-61.

Lindahl, T. (1993)
Instability and Decay of the Primary Structure of DNA, Nature, 22 April, pp709-15.

West, S.C. (2009)
The Search for a Human Holliday Junction Resolvase, Biochem Soc Trans, June, 37, pp519-26.

Yeeles, J.T.P., et al. (2015)
Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins, Nature, 26 March, 519, pp431-35.

Read the Francis Crick Institute's Use of Animals in Research Policy 

Explore the full list of Crick research topics.

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