Focus: Cancer

'Open for Dicovery', our current exhibition, features the work of Crick scientists Ilaria Malanchi, Adrian Hayday, Charles Swanton and Erik Sahai. Scroll down for detailed information about their current research, related news stories and events, and recommended reading.

Science in conversation: Cancer complexity and the Crick

 

Featured scientist: Ilaria Malanchi

Ilaria Malanchi in the Tumour-Host Interaction Laboratory

Ilaria Malanchi in the Tumour-Host Interaction Laboratory (Click to view larger image)
© Thomas Farnetti / 2017 / Wellcome

Ilaria Malanchi is Group Leader of the Tumour-Host Interaction Laboratory. The lab studies the strategies adopted by cancer cells to establish crucial interactions with their microenvironment (local tissue cells or inflammatory cells) during the process of tumour initiation as well as metastatic spreading.

Read more about the research of the Tumour-Host Interaction Laboratory.

Featured scientist: Adrian Hayday

Adrian Hayday with members of the Immunosurveillance Laboratory

Adrian Hayday with members of the Immunosurveillance Laboratory (Click to view larger image)
© Ben Gilbert / 2017 / Wellcome

Adrian Hayday is Group Leader of the Immunosurveillance Laboratory which focuses on understanding how lymphocytes function within epithelial tissues.

Read more about the research of the Immunosurveillance Laboratory.

Featured scientist: Charles Swanton

Charles Swanton in the Translational Cancer Therapeutics Laboratory

Charles Swanton in the Translational Cancer Therapeutics Laboratory (Click to view larger image)
© Thomas Farnetti / 2017 / Wellcome

Charles Swanton is Group Leader of the Translational Cancer Therapeutics Laboratory, which focuses on mechanisms generating cancer genetic diversity and its consequences on clinical outcome.

This group and others, through next generation sequencing studies, have demonstrated that the principles of Darwinian evolution apply to the growth and adaptation of human tumours.

Read more about the research of the Translational Cancer Therapeutics Laboratory.

Featured scientist: Erik Sahai

Erik Sahai in the Tumour Cell Biology Laboratory

Erik Sahai in the Tumour Cell Biology Laboratory (Click to view larger image)
© Thomas Farnetti / 2017 / Wellcome

Erik Sahai works in the Tumour Cell Biology Laboratory focusing on the spread of cancer through the body and how the tumour microenvironment affects this process.

Read more about the research of the Tumour Cell Biology Laboratory.

Find out more

Upcoming Events

The Francis Crick Institute Flagship lectures are open to scientists from other institutes and universities in and around London.

The upcoming lectures related to this topic are:

  • 27 July 2017 - Lewis Cantley, Cornell University, New York
  • 15 November 2017 - Harold Varmus, Weil Cornell Medicine, New York

More information about the Flagship lectures.

Recent news stories

Discover more about cancer research at the Crick.

Further reading suggestions

Books

Mukherjee, S. (2011) The Emperor of All Maladies: A Biography of Cancer, London: HarperCollins.

Skloot, R. (2011) The Immortal Life of Henrietta Lacks, London: Pan Books.

Hesketh, R. (2012) Betrayed by Nature: The War on Cancer. New York: Palgrave Macmillan.

Papers

Malanchi, I (2013)
Tumour cells coerce host tissue to cancer spread. BoneKEy reports 2, 371

Vantourout, P and Hayday, A (2013)
Six-of-the-best: unique contributions of γδ T cells to immunology. Nature Reviews Immunology 13, 88-100

Swanton, C; McGranahan, N; Starrett, GJ and Harris, RS (2015)
APOBEC enzymes: Mutagenic fuel for cancer evolution and heterogeneity. Cancer Discovery 5, 704-712

Walther, V; Hiley, CT; Shibata, D; Swanton, C; Turner, PE and Maley, CC (2015)
Can oncology recapitulate paleontology? Lessons from species extinctions. Nature Reviews Clinical Oncology 12, 273-285

Jamal-Hanjani, M; Quezada, SA; Larkin, J and Swanton, C (2015)
Translational implications of tumor heterogeneity. Clinical Cancer Research 21, 1258-1266

Hiley, C; de Bruin, EC; McGranahan, N and Swanton, C (2014)
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine. Genome Biology 15, 453

de Bruin, EC; Taylor, TB and Swanton, C (2013)
Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications. Genome Medicine 5, 101

Fisher, R; Pusztai, L and Swanton, C (2013)
Cancer heterogeneity: implications for targeted therapeutics. British Journal of Cancer 108, 479-485

Jamal-Hanjani, M; Thanopoulou, E; Peggs, KS; Quezada, SA and Swanton, C (2013)
Tumour heterogeneity and immune-modulation. Current Opinion in Pharmacology 13, 497-503 

Thompson, BJ and Sahai, E (2015)
MST kinases in development and disease. Journal of Cell Biology 210, 871-882

Di Marco Barros, R., et al. (2016)
Epithelia Use Butyrophilin-like Molecules to Shape Organ-specific γδ T Cell Compartments, Cell, 167, pp203-218.

Gerlinger, M., et al. (2012)
Intratumour Heterogenity and Branched Evolution Revealed by Multiregion Sequencing, NEJM, March 8, 366: 10, pp883-92.

Sahai, E. (2007)
Illuminating the Metastatic Process, Nature Reviews: Cancer, 7, October, pp737-49.

Swanton, C. (2014)
Cancer Evolution: The Final Frontier of Precision Medicine? Editorial, Annals of Oncology, 25, pp549-51.

Wculek, S.K. and Malanchi, I. (2015)
Neutrophils Support Lung Colonization of Metastasis-Initiating Breast Cancer Cells, Nature, 17 December, 528, pp413-17.

Other

Webb, M (2005)
A lottery ticket and a packet of cigarettes, please. Mill Hill Essays (2005)

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