Structural Biology: Publications

  • Claus, J; Patel, G; Autore, F; Colomba, A; Weitsman, G; Soliman, TN; Roberts, S; Zanetti-Domingues, LC; Hirsch, M; Collu, F; George, R; Ortiz-Zapater, E; Barber, PR; Vojnovic, B; Yarden, Y; Martin-Fernandez, ML; Cameron, A; Fraternali, F; Ng, T and Parker, PJ (2018)
    Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface.
    eLife 7, e32271 PubMed abstract
  • Craggs, PD; Mouilleron, S; Rejzek, M; de Chiara, C; Young, RJ; Field, RA; Argyrou, A and de Carvalho, LPS (2018)
    On the catalytic mechanism of acetyl transfer catalysed by Mycobacterium tuberculosis GlmU.
    Biochemistry [Epub ahead of print] PubMed abstract
  • Gentsch, GE; Spruce, T; Monteiro, RS; Owens, NDL; Martin, SR and Smith, JC (2018)
    Innate immune response and off-target mis-splicing are common morpholino-induced side effects in Xenopus.
    Developmental Cell 44, 597-610.e510 PubMed abstract
  • Hobor, F; Dallmann, A; Ball, NJ; Cicchini, C; Battistelli, C; Ogrodowicz, RW; Christodoulou, E; Martin, SR; Castello, A; Tripodi, M; Taylor, IA and Ramos, A (2018)
    A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets.
    Nature Communications 9, 831 PubMed abstract
  • Koliopoulos, MG; Lethier, M; van der Veen, AG; Haubrich, K; Hennig, J; Kowalinski, E; Stevens, RV; Martin, SR; Reis e Sousa, C; Cusack, S and Rittinger, K (2018)
    Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
    Nature Communications 9, 1820 PubMed abstract
  • Kümper, S; Gantke, T; Chen, C-S; Soneji, Y; Pattison, MJ; Chakravarty, P; Kjær, S; Thomas, D; Haslam, C; Leavens, BJ; House, D; Powell, DJ and Ley, SC (2018)
    Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate.
    Biochemical Journal 475, 329-340 PubMed abstract
  • Mittal, A; Hobor, F; Zhang, Y; Martin, SR; Gamblin, SJ; Ramos, A and Wilson, JR (2018)
    The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites.
    Nucleic Acids Research 46, 3802-3812
  • Morini, MF; Giampietro, C; Corada, M; Pisati, F; Lavarone, E; Cunha, SI; Conze, LL; O'Reilly, N; Joshi, D; Kjaer, S; George, R; Nye, E; Ma, A; Jin, J; Mitter, R; Lupia, M; Cavallaro, U; Pasini, D; Calado, DP; Dejana, E and Taddei, A (2018)
    VE-cadherin-mediated epigenetic regulation of endothelial gene expression.
    Circulation Research 122, 231-245 PubMed abstract
  • Suen, KM; Lin, CC; Seiler, C; George, R; Poncet-Montange, G; Biter, AB; Ahmed, Z; Arold, ST and Ladbury, JE (2018)
    Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.
    International Journal of Biochemistry and Cell Biology 94, 89-97 PubMed abstract
  • van der Veen, AG; Maillard, PV; Schmidt, JM; Lee, SA; Deddouche-Grass, S; Borg, A; Kjær, S; Snijders, AP and Reis e Sousa, C (2018)
    The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells.
    EMBO Journal 37, e97479 PubMed abstract
  • Alfano, C; Sanfelice, D; Martin, SR; Pastore, A and Temussi, PA (2017)
    An optimized strategy to measure protein stability highlights differences between cold and hot unfolded states.
    Nature Communications 8, 15428 PubMed abstract
  • Benton, DJ; Wharton, SA; Martin, SR and McCauley, JW (2017)
    Role of neuraminidase in influenza A(H7N9) receptor binding.
    Journal of Virology 91, e02293-02216 PubMed abstract
  • Chao, WCH; Wade, BO; Bouchoux, C; Jones, AW; Purkiss, AG; Federico, S; O'Reilly, N; Snijders, AP; Uhlmann, F and Singleton, MR (2017)
    Structural basis of Eco1-mediated cohesin acetylation.
    Scientific Reports 7, 44313 PubMed abstract
  • Collins, KM; Kainov, YA; Christodolou, E; Ray, D; Morris, Q; Hughes, T; Taylor, IA; Makeyev, EV and Ramos, A (2017)
    An RRM-ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion.
    Nucleic Acids Research 45, 6761-6774 PubMed abstract
  • Gehrig, S; Macpherson, JA; Driscoll, PC; Symon, A; Martin, SR; MacRae, JI; Kleinjung, J; Fraternali, F and Anastasiou, D (2017)
    An engineered photoswitchable mammalian pyruvate kinase.
    FEBS Journal 284, 2955-2980 PubMed abstract
  • Green, JL; Wall, RJ; Vahokoski, J; Yusuf, NA; Ridzuan, MAM; Stanway, RR; Stock, J; Knuepfer, E; Brady, D; Martin, SR; Howell, SA; Pires, IP; Moon, RW; Molloy, JE; Kursula, I; Tewari, R and Holder, AA (2017)
    Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.
    Journal of Biological Chemistry 292, 17857-17875 PubMed abstract
  • Kliza, K; Taumer, C; Pinzuti, I; Franz-Wachtel, M; Kunzelmann, S; Stieglitz, B; Macek, B and Husnjak, K (2017)
    Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry.
    Nature Methods 14, 504-512 PubMed abstract
  • Nicastro, G; Candel, AM; Uhl, M; Oregioni, A; Hollingworth, D; Backofen, R; Martin, SR and Ramos, A (2017)
    Mechanism of β-actin mRNA recognition by ZBP1.
    Cell Reports 18, 1187-1199 PubMed abstract
  • Ordonez, P; Kunzelmann, S; Groom, HCT; Yap, MW; Weising, S; Meier, C; Bishop, KN; Taylor, IA and Stoye, JP (2017)
    SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.
    Scientific Reports 7, 42824 PubMed abstract
  • Peacock, TP; Benton, DJ; James, J; Sadeyen, J-R; Chang, P; Sealy, JE; Bryant, JE; Martin, SR; Shelton, H; Barclay, WS and Iqbal, M (2017)
    Immune escape variants of H9N2 influenza viruses containing deletions at the hemagglutinin receptor binding site retain fitness in vivo and display enhanced zoonotic characteristics.
    Journal of Virology 91, e00218-00217 PubMed abstract
  • Peacock, TP; Benton, DJ; Sadeyen, J-R; Chang, P; Sealy, JE; Bryant, JE; Martin, SR; Shelton, H; McCauley, JW; Barclay, WS and Iqbal, M (2017)
    Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion.
    Emerging Microbes & Infections 6, e11 PubMed abstract
  • Pisco, JP; de Chiara, C; Pacholarz, KJ; Garza-Garcia, A; Ogrodowicz, RW; Walker, PA; Barran, PE; Smerdon, SJ and de Carvalho, LPS (2017)
    Uncoupling conformational states from activity in an allosteric enzyme.
    Nature Communications 8, 203 PubMed abstract
  • Sanjuan Nandin, I; Fong, C; Deantonio, C; Torreno-Pina, JA; Pecetta, S; Maldonado, P; Gasparrini, F; Ordovas-Montanes, J; Kazer, SW; Kjaer, S; Borley, DW; Nair, U; Coleman, JA; Lingwood, D; Shalek, AK; Meffre, E; Poignard, P; Burton, DR and Batista, FD (2017)
    Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.
    Journal of Experimental Medicine 214, 2471-2490 PubMed abstract
  • Skytte Rasmussen, M; Mouilleron, S; Kumar Shrestha, B; Wirth, M; Lee, R; Bowitz Larsen, K; Abudu Princely, Y; O'Reilly, N; Sjøttem, E; Tooze, SA; Lamark, T and Johansen, T (2017)
    ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.
    Autophagy 13, 834-853 PubMed abstract
  • Vancraenenbroeck, R; Kunzelmann, S and Webb, MR (2017)
    Development of a range of fluorescent reagentless biosensors for ATP, based on malonyl-coenzyme A synthetase.
    PLOS ONE 12, e0179547 PubMed abstract
  • Willows, R; Sanders, MJ; Xiao, B; Patel, BR; Martin, SR; Read, J; Wilson, JR; Hubbard, J; Gamblin, SJ and Carling, D (2017)
    Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells.
    Biochemical Journal 474, 3059-3073 PubMed abstract
  • Wyatt, HDM; Laister, RC; Martin, SR; Arrowsmith, CH and West, SC (2017)
    The SMX DNA repair tri-nuclease.
    Molecular Cell 65, 848-860 e811 PubMed abstract
  • Abella, JVG; Galloni, C; Pernier, J; Barry, DJ; Kjær, S; Carlier, M-F and Way, M (2016)
    Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
    Nature Cell Biology 18, 76-86 PubMed abstract
  • Diaz, SA; Martin, SR; Howell, SA; Grainger, M; Moon, RW; Green, JL and Holder, AA (2016)
    The binding of Plasmodium falciparum adhesins and erythrocyte invasion proteins to aldolase is enhanced by phosphorylation.
    PLOS ONE 11, e0161850 PubMed abstract
  • Hanč, P; Schulz, O; Fischbach, H; Martin, SR; Kjær, S and Reis e Sousa, C (2016)
    A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells.
    EMBO Journal 35, 2484-2497 PubMed abstract
  • Justin, N; Zhang, Y; Tarricone, C; Martin, SR; Chen, S; Underwood, E; De Marco, V; Haire, LF; Walker, PA; Reinberg, D; Wilson, JR and Gamblin, SJ (2016)
    Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
    Nature Communications 7, 11316 PubMed abstract
  • Kallewaard, NL; Corti, D; Collins, PJ; Neu, U; McAuliffe, JM; Benjamin, E; Wachter-Rosati, L; Palmer-Hill, FJ; Yuan, AQ; Walker, PA; Vorlaender, MK; Bianchi, S; Guarino, B; De Marco, A; Vanzetta, F; Agatic, G; Foglierini, M; Pinna, D; Fernandez-Rodriguez, B; Fruehwirth, A; Silacci, C; Ogrodowicz, RW; Martin, SR; Sallusto, F; Suzich, JA; Lanzavecchia, A; Zhu, Q; Gamblin, SJ and Skehel, JJ (2016)
    Structure and function analysis of an antibody recognizing all influenza A subtypes.
    Cell 166, 596-608 PubMed abstract
  • Kaplan, E; Guichou, J-F; Chaloin, L; Kunzelmann, S; Leban, N; Serpersu, EH and Lionne, C (2016)
    Aminoglycoside binding and catalysis specificity of aminoglycoside 2''-phosphotransferase IVa: a thermodynamic, structural and kinetic study.
    Biochimica et Biophysica Acta 1860, 802-813 PubMed abstract
  • Koliopoulos, MG; Esposito, D; Christodoulou, E; Taylor, IA and Rittinger, K (2016)
    Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
    EMBO Journal 35, 1204-1218 PubMed abstract
  • Kyrieleis, OJP; McIntosh, PB; Webb, SR; Calder, LJ; Lloyd, J; Patel, NA; Martin, SR; Robinson, CV; Rosenthal, PB and Smerdon, SJ (2016)
    Three-dimensional architecture of the human BRCA1-A histone deubiquitinase core complex.
    Cell Reports 17, 3099-3106 PubMed abstract
  • Martino, L; Holland, L; Christodoulou, E; Kunzelmann, S; Esposito, D and Rittinger, K (2016)
    The biophysical characterisation and SAXS analysis of human NLRP1 uncover a new level of complexity of NLR proteins.
    PLOS ONE 11, e0164662 PubMed abstract
  • Newton, R; Bowler, KA; Burns, EM; Chapman, PJ; Fairweather, EE; Fritzl, SJR; Goldberg, KM; Hamilton, NM; Holt, SV; Hopkins, GV; Jones, SD; Jordan, AM; Lyons, AJ; March, HN; McDonald, NQ; Maguire, LA; Mould, DP; Purkiss, AG; Small, HF; Stowell, AIJ; Thomson, GJ; Waddell, ID; Waszkowycz, B; Watson, AJ and Ogilvie, DJ (2016)
    The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
    European Journal of Medicinal Chemistry 112, 20-32 PubMed abstract
  • Parker, L; Wharton, SA; Martin, SR; Cross, K; Lin, Y; Liu, Y; Feizi, T; Daniels, RS and McCauley, JW (2016)
    Effects of egg-adaptation on receptor-binding and antigenic properties of recent Influenza A (H3N2) vaccine viruses.
    Journal of General Virology 97, 1333-1344 PubMed abstract
  • Pike, T; Brownlow, N; Kjaer, S; Carlton, J and Parker, PJ (2016)
    PKCε switches Aurora B specificity to exit the abscission checkpoint.
    Nature Communications 7, 13853 PubMed abstract
  • Plaza-Menacho, I; Barnouin, K; Barry, R; Borg, A; Orme, M; Chauhan, R; Mouilleron, S; Martínez-Torres, RJ; Meier, P and McDonald, NQ (2016)
    RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements.
    Cell Reports 17, 3319-3332 PubMed abstract
  • Soriano, EV; Ivanova, ME; Fletcher, G; Riou, P; Knowles, PP; Barnouin, K; Purkiss, A; Kostelecky, B; Saiu, P; Linch, M; Elbediwy, A; Kjær, S; O'Reilly, N; Snijders, AP; Parker, PJ; Thompson, BJ and McDonald, NQ (2016)
    aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization.
    Developmental Cell 38, 384-398 PubMed abstract
  • Arnold, LH; Groom, HCT; Kunzelmann, S; Schwefel, D; Caswell, SJ; Ordonez, P; Mann, MC; Rueschenbaum, S; Goldstone, DC; Pennell, S; Howell, SA; Stoye, JP; Webb, M; Taylor, IA and Bishop, KN (2015)
    Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction.
    PLOS Pathogens 11, e1005194 PubMed abstract
  • Arnold, LH; Kunzelmann, S; Webb, MR and Taylor, IA (2015)
    A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1.
    Antimicrobial Agents and Chemotherapy 59, 186-192 PubMed abstract
  • Benton, DJ; Martin, SR; Wharton, SA and McCauley, JW (2015)
    Biophysical measurement of the balance of influenza A hemagglutinin and neuraminidase activities.
    Journal of Biological Chemistry 290, 6516-6521 PubMed abstract
  • Das, S; Hertrich, N; Perrin, AJ; Withers-Martinez, C; Collins, CR; Jones, ML; Watermeyer, JM; Fobes, ET; Martin, SR; Saibil, HR; Wright, GJ; Treeck, M; Epp, C and Blackman, MJ (2015)
    Processing of Plasmodium falciparum merozoite surface protein MSP1 activates a spectrin-binding function enabling parasite egress from RBCs.
    Cell Host & Microbe 18, 433-444 PubMed abstract
  • Ehrensberger, AH; Franchini, D-M; East, P; George, R; Matthews, N; Maslen, SL and Svejstrup, JQ (2015)
    Retention of the native epigenome in purified mammalian chromatin.
    PLOS ONE 10, e0133246 PubMed abstract
  • Hanč, P; Fujii, T; Iborra, S; Yamada, Y; Huotari, J; Schulz, O; Ahrens, S; Kjær, S; Way, M; Sancho, D; Namba, K and Reis e Sousa, C (2015)
    Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens.
    Immunity 42, 839-849 PubMed abstract
  • Ivanova, ME; Fletcher, GC; O'Reilly, N; Purkiss, AG; Thompson, BJ and McDonald, NQ (2015)
    Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove.
    Acta Crystallographica. Section D, Biological Crystallography 71, 555-564 PubMed abstract
  • Schwefel, D; Boucherit, VC; Christodoulou, E; Walker, PA; Stoye, JP; Bishop, KN and Taylor, IA (2015)
    Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.
    Cell Host & Microbe 17, 489-499 PubMed abstract
  • Solscheid, C; Kunzelmann, S; Davis, CT; Hunter, JL; Nofer, A and Webb, MR (2015)
    Development of a reagentless biosensor for inorganic phosphate, applicable over a wide concentration range.
    Biochemistry 54, 5054-5062 PubMed abstract
  • Xiong, X; Corti, D; Liu, J; Pinna, D; Foglierini, M; Calder, LJ; Martin, SR; Lin, YP; Walker, PA; Collins, PJ; Monne, I; Suguitan, AL, Jr.; Santos, C; Temperton, NJ; Subbarao, K; Lanzavecchia, A; Gamblin, SJ and Skehel, JJ (2015)
    Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody.
    Proceedings of the National Academy of Sciences of the United States of America 112, 9430-9435 PubMed abstract
  • Yusuf, NA; Green, JL; Wall, RJ; Knuepfer, E; Moon, RW; Schulte-Huxel, C; Stanway, RR; Martin, SR; Howell, SA; Douse, CH; Cota, E; Tate, EW; Tewari, R and Holder, AA (2015)
    The Plasmodium class XIV myosin, MyoB has a distinct subcellular location in invasive and motile stages of the malaria parasite, and an unusual light chain.
    Journal of Biological Chemistry 290, 12147-12164 PubMed abstract
  • Ben-Addi, A; Mambole-Dema, A; Brender, C; Martin, SR; Janzen, J; Kjaer, S; Smerdon, SJ and Ley, SC (2014)
    IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
    Proceedings of the National Academy of Sciences of the United States of America 111, E2394-E2403 PubMed abstract
  • Collins, PJ; Vachieri, SG; Haire, LF; Ogrodowicz, RW; Martin, SR; Walker, PA; Xiong, X; Gamblin, SJ and Skehel, JJ (2014)
    Recent evolution of equine influenza and the origin of canine influenza.
    Proceedings of the National Academy of Sciences of the United States of America 111, 11175-11180 PubMed abstract
  • Deddouche, S; Goubau, D; Rehwinkel, J; Chakravarty, P; Begum, S; Maillard, PV; Borg, A; Matthews, N; Feng, Q; van Kuppeveld, FJM and Reis e Sousa, C (2014)
    Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
    eLife 3, e01535 PubMed abstract
  • Diaz, SA; Martin, SR; Grainger, M; Howell, SA; Green, JL and Holder, AA (2014)
    Plasmodium falciparum aldolase and the C-terminal cytoplasmic domain of certain apical organellar proteins promote actin polymerization.
    Molecular and Biochemical Parasitology 197, 9-14 PubMed abstract
  • Goldstone, DC; Walker, PA; Calder, LJ; Coombs, PJ; Kirkpatrick, J; Ball, NJ; Hilditch, L; Yap, MW; Rosenthal, PB; Stoye, JP and Taylor, IA (2014)
    Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.
    Proceedings of the National Academy of Sciences of the United States of America 111, 9609-9614 PubMed abstract
  • Goodman, KM; Kjær, S; Beuron, F; Knowles, PP; Nawrotek, A; Burns, EM; Purkiss, AG; George, R; Santoro, M; Morris, EP and McDonald, NQ (2014)
    RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association.
    Cell Reports 8, 1894-1904 PubMed abstract
  • Hořejší, Z; Stach, L; Flower, TG; Joshi, D; Flynn, H; Skehel, JM; O'Reilly, NJ; Ogrodowicz, RW; Smerdon, SJ and Boulton, SJ (2014)
    Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.
    Cell Reports 7, 19-26 PubMed abstract
  • Kunzelmann, S; Solscheid, C and Webb, MR (2014)
    Fluorescent biosensors: design and application to motor proteins.
    In: Fluorescent Methods for Molecular Motors. Edited by Toseland, CP and Fili, N.
    Basel, Springer, 2014. 25-47. (Experientia Supplementum, 105).
  • Moody, P; Chudasama, V; Nathani, RI; Maruani, A; Martin, S; Smith, MEB and Caddick, S (2014)
    A rapid, site-selective and efficient route to the dual modification of DARPins.
    Chemical Communications 50, 4898-4900 PubMed abstract
  • Plaza-Menacho, I; Barnouin, K; Goodman, K; Martínez-Torres, RJ; Borg, A; Murray-Rust, J; Mouilleron, S; Knowles, P and McDonald, NQ (2014)
    Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
    Molecular Cell 53, 738-751 PubMed abstract
  • Sanfelice, D; Puglisi, R; Martin, SR; Di Bari, L; Pastore, A and Temussi, PA (2014)
    Yeast frataxin is stabilized by low salt concentrations: cold denaturation disentangles ionic strength effects from specific interactions.
    PLOS ONE 9, e95801 PubMed abstract
  • Schwefel, D; Groom, HCT; Boucherit, VC; Christodoulou, E; Walker, PA; Stoye, JP; Bishop, KN and Taylor, IA (2014)
    Structural basis of lentiviral subversion of a cellular protein degradation pathway.
    Nature 505, 234-238 PubMed abstract
  • Simon, AC; Zhou, JC; Perera, RL; van Deursen, F; Evrin, C; Ivanova, ME; Kilkenny, ML; Renault, L; Kjaer, S; Matak-Vinković, D; Labib, K; Costa, A and Pellegrini, L (2014)
    A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome.
    Nature 510, 293-297 PubMed abstract
  • Streicher, H; Martin, SR; Coombs, PJ; McCauley, J; Neill-Hall, D and Stanley, M (2014)
    A phospha-oseltamivir-biotin conjugate as a strong and selective adhesive for the influenza virus.
    Bioorganic & Medicinal Chemistry Letters 24, 1805-1807 PubMed abstract
  • Vachieri, SG; Xiong, X; Collins, PJ; Walker, PA; Martin, SR; Haire, LF; Zhang, Y; McCauley, JW; Gamblin, SJ and Skehel, JJ (2014)
    Receptor binding by H10 influenza viruses.
    Nature 511, 475-477 PubMed abstract
  • Withers-Martinez, C; Strath, M; Hackett, F; Haire, LF; Howell, SA; Walker, PA; Christodoulou, E; Dodson, GG and Blackman, MJ (2014)
    The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
    Nature Communications 5, 3726 PubMed abstract
  • Xiong, X; Xiao, H; Martin, SR; Coombs, PJ; Liu, J; Collins, PJ; Vachieri, SG; Walker, PA; Lin, YP; McCauley, JW; Gamblin, SJ and Skehel, JJ (2014)
    Enhanced human receptor binding by H5 haemagglutinins.
    Virology 456-457, 179-187 PubMed abstract
  • Crusat, M; Liu, J; Palma, AS; Childs, RA; Liu, Y; Wharton, SA; Lin, YP; Coombs, PJ; Martin, SR; Matrosovich, M; Chen, Z; Stevens, DJ; Hien, VM; Thanh, TT; Nhu, LNT; Nguyet, LA; Ha, DQ; van Doorn, HR; Hien, TT; Conradt, HS; Kiso, M; Gamblin, SJ; Chai, W; Skehel, JJ; Hay, AJ; Farrar, J; de Jong, MD and Feizi, T (2013)
    Changes in the hemagglutinin of H5N1 viruses during human infection - influence on receptor binding.
    Virology 447, 326-337 PubMed abstract
  • de Chiara, C; Rees, M; Menon, RP; Pauwels, K; Lawrence, C; Konarev, PV; Svergun, DI; Martin, SR; Chen, YW and Pastore, A (2013)
    Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold.
    Biophysical Journal 104, 1304-1313 PubMed abstract
  • Fritsch, R; de Krijger, I; Fritsch, K; George, R; Reason, B; Kumar, MS; Diefenbacher, M; Stamp, G and Downward, J (2013)
    RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
    Cell 153, 1050-1063 PubMed abstract
  • Gentsch, GE; Owens, NDL; Martin, SR; Piccinelli, P; Faial, T; Trotter, MWB; Gilchrist, MJ and Smith, JC (2013)
    In vivo T-box transcription factor profiling reveals joint regulation of embryonic neuromesodermal bipotency.
    Cell Reports 4, 1185-1196 PubMed abstract
  • Goldstone, DC; Flower, TG; Ball, NJ; Sanz-Ramos, M; Yap, MW; Ogrodowicz, RW; Stanke, N; Reh, J; Lindemann, D; Stoye, JP and Taylor, IA (2013)
    A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid.
    PLOS Pathogens 9, e1003376 PubMed abstract
  • Kjær, S; Linch, M; Purkiss, A; Kostelecky, B; Knowles, PP; Rosse, C; Riou, P; Soudy, C; Kaye, S; Patel, B; Soriano, E; Murray-Rust, J; Barton, C; Dillon, C; Roffey, J; Parker, PJ and McDonald, NQ (2013)
    Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes.
    Biochemical Journal 451, 329-342 PubMed abstract
  • Linch, M; Sanz-Garcia, M; Soriano, E; Zhang, Y; Riou, P; Rosse, C; Cameron, A; Knowles, P; Purkiss, A; Kjaer, S; McDonald, NQ and Parker, PJ (2013)
    A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif.
    Science Signaling 6, ra82 PubMed abstract
  • Marín, MJ; Rashid, A; Rejzek, M; Fairhurst, SA; Wharton, SA; Martin, SR; McCauley, JW; Wileman, T; Field, RA and Russell, DA (2013)
    Glyconanoparticles for the plasmonic detection and discrimination between human and avian influenza virus.
    Organic & Biomolecular Chemistry 11, 7101-7107 PubMed abstract
  • Moody, P; Burlina, F; Martin, SR; Morgan, RE; Offer, J; Smith, MEB; Molloy, JE and Caddick, S (2013)
    Evaluating the use of Apo-neocarzinostatin as a cell penetrating protein.
    Protein Engineering Design and Selection 26, 277-281 PubMed abstract
  • Riou, P; Kjær, S; Garg, R; Purkiss, A; George, R; Cain, RJ; Bineva, G; Reymond, N; McColl, B; Thompson, AJ; O'Reilly, N; McDonald, NQ; Parker, PJ and Ridley, AJ (2013)
    14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
    Cell 153, 640-653 PubMed abstract
  • Rock, JM; Lim, D; Stach, L; Ogrodowicz, RW; Keck, JM; Jones, MH; Wong, CCL; Yates, JR; Winey, M; Smerdon, SJ; Yaffe, MB and Amon, A (2013)
    Activation of the yeast hippo pathway by phosphorylation-dependent assembly of signaling complexes.
    Science 340, 871-875 PubMed abstract
  • Sanfelice, D; Politou, A; Martin, SR; De Los Rios, P; Temussi, P and Pastore, A (2013)
    The effect of crowding and confinement: a comparison of Yfh1 stability in different environments.
    Physical Biology 10, 045002 PubMed abstract
  • Stieglitz, B; Rana, RR; Koliopoulos, MG; Morris-Davies, AC; Schaeffer, V; Christodoulou, E; Howell, S; Brown, NR; Dikic, I and Rittinger, K (2013)
    Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
    Nature 503, 422-426 PubMed abstract
  • Xiao, B; Sanders, MJ; Carmena, D; Bright, NJ; Haire, LF; Underwood, E; Patel, BR; Heath, RB; Walker, PA; Hallen, S; Giordanetto, F; Martin, SR; Carling, D and Gamblin, SJ (2013)
    Structural basis of AMPK regulation by small molecule activators.
    Nature Communications 4, 3017 PubMed abstract
  • Xiong, X; Coombs, PJ; Martin, SR; Liu, J; Xiao, H; McCauley, JW; Locher, K; Walker, PA; Collins, PJ; Kawaoka, Y; Skehel, JJ and Gamblin, SJ (2013)
    Receptor binding by a ferret-transmissible H5 avian influenza virus.
    Nature 497, 392-396 PubMed abstract
  • Xiong, X; Martin, SR; Haire, LF; Wharton, SA; Daniels, RS; Bennett, MS; McCauley, JW; Collins, PJ; Walker, PA; Skehel, JJ and Gamblin, SJ (2013)
    Receptor binding by an H7N9 influenza virus from humans.
    Nature 499, 496-499 PubMed abstract
  • Xiong, X; Tuzikov, A; Coombs, PJ; Martin, S; Walker, PA; Gamblin, SJ; Bovin, N and Skehel, JJ (2013)
    Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus.
    Virus Research 178, 12-14 PubMed abstract
  • Yan, R; Adinolfi, S; Iannuzzi, C; Kelly, G; Oregioni, A; Martin, S and Pastore, A (2013)
    Cluster and fold stability of E. coli ISC-type ferredoxin.
    PLOS ONE 8, e78948 PubMed abstract
  • Yan, R; Konarev, PV; Iannuzzi, C; Adinolfi, S; Roche, B; Kelly, G; Simon, L; Martin, SR; Py, B; Barras, F; Svergun, DI and Pastore, A (2013)
    Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS.
    Journal of Biological Chemistry 288, 24777-24787 PubMed abstract
  • Adrover, M; Martorell, G; Martin, SR; Urosev, D; Konarev, PV; Svergun, DI; Daura, X; Temussi, P and Pastore, A (2012)
    The role of hydration in protein stability: comparison of the cold and heat unfolded states of Yfh1.
    Journal of Molecular Biology 417, 413-424 PubMed abstract
  • Ahrens, S; Zelenay, S; Sancho, D; Hanč, P; Kjær, S; Feest, C; Fletcher, G; Durkin, C; Postigo, A; Skehel, M; Batista, F; Thompson, B; Way, M; Reis e Sousa, C and Schulz, O (2012)
    F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells.
    Immunity 36, 635-645 PubMed abstract
  • Bowles, M; Lally, J; Fadden, AJ; Mouilleron, S; Hammonds, T and McDonald, NQ (2012)
    Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition.
    Nucleic Acids Research 40, e101 PubMed abstract
  • Lallemand, P; Leban, N; Kunzelmann, S; Chaloin, L; Serpersu, EH; Webb, MR; Barman, T and Lionne, C (2012)
    Transient kinetics of aminoglycoside phosphotransferase(3')-IIIa reveals a potential drug target in the antibiotic resistance mechanism.
    FEBS Letters 586, 4223-4227 PubMed abstract
  • Lin, YP; Xiong, X; Wharton, SA; Martin, SR; Coombs, PJ; Vachieri, SG; Christodoulou, E; Walker, PA; Liu, J; Skehel, JJ; Gamblin, SJ; Hay, AJ; Daniels, RS and McCauley, JW (2012)
    Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin.
    Proceedings of the National Academy of Sciences of the United States of America 109, 21474-21479 PubMed abstract
  • Mouilleron, S; Wiezlak, M; O'Reilly, N; Treisman, R and McDonald, NQ (2012)
    Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity.
    Structure 20, 1960-1970 PubMed abstract
  • Stieglitz, B; Morris-Davies, AC; Koliopoulos, MG; Christodoulou, E and Rittinger, K (2012)
    LUBAC synthesizes linear ubiquitin chains via a thioester intermediate.
    EMBO Reports 13, 840-846 PubMed abstract
  • van den Boom, J; Heider, D; Martin, SR; Pastore, A and Mueller, JW (2012)
    3'-Phospho-adenosine-5'-phosphosulphate (PAPS) synthases - naturally fragile enzymes specifically stabilised by nucleotide binding.
    Journal of Biological Chemistry 287, 17645-17655
  • van der Vries, E; Collins, PJ; Vachieri, SG; Xiong, X; Liu, J; Walker, PA; Haire, LF; Hay, AJ; Schutten, M; Osterhaus, ADME; Martin, SR; Boucher, CAB; Skehel, JJ and Gamblin, SJ (2012)
    H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis.
    PLOS Pathogens 8, e1002914 PubMed abstract
  • Wiezlak, M; Diring, J; Abella, J; Mouilleron, S; Way, M; McDonald, NQ and Treisman, R (2012)
    G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly.
    Journal of Cell Science 125, 5860-5872 PubMed abstract
  • Deas, E; Plun-Favreau, H; Gandhi, S; Desmond, H; Kjaer, S; Loh, SHY; Renton, AEM; Harvey, RJ; Whitworth, AJ; Martins, LM; Abramov, AY and Wood, NW (2011)
    PINK1 cleavage at position A103 by the mitochondrial protease PARL.
    Human Molecular Genetics 20, 867-879 PubMed abstract
  • East, DA; Sousa, D; Martin, SR; Edwards, TA; Lehman, W and Mulvihill, DP (2011)
    Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin.
    Biochemical Journal 438, 265-273 PubMed abstract
  • Goldstone, DC; Ennis-Adeniran, V; Hedden, JJ; Groom, HCT; Rice, GI; Christodoulou, E; Walker, PA; Kelly, G; Haire, LF; Yap, MW; de Carvalho, LP; Stoye, JP; Crow, YJ; Taylor, IA and Webb, M (2011)
    HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.
    Nature 480, 379-382 PubMed abstract
  • Jama, AM; Gabriel, J; Al-Nagar, AJ; Martin, S; Baig, SZ; Soleymani, H; Chowdhury, Z; Beesley, P and Török, K (2011)
    Lobe-specific functions of Ca2+•calmodulin in αCa2+ •calmodulin-dependent protein kinase II activation.
    Journal of Biological Chemistry 286, 12308-12316 PubMed abstract
  • Kunzelmann, S and Webb, MR (2011)
    Fluorescent detection of GDP in real time with the reagentless biosensor, rhodamine-ParM.
    Biochemical Journal 440, 43-49 PubMed abstract
  • Martin, SR; Schilstra, MJ and Siligardi, G (2011)
    Circular Dichroism.
    In: Biophysical approaches determining ligand binding to biomolecular targets: detection, measurement and modelling. Edited by Podjarny, A; Dejaegere, AP and Kieffer, B.
    RSC Publishing, 2011. 226-246. (RSC Biomolecular Sciences, 22).
  • Masino, L; Nicastro, G; De Simone, A; Calder, L; Molloy, J and Pastore, A (2011)
    The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
    Biophysical Journal 100, 2033-2042 PubMed abstract
  • Mayer, FV; Heath, R; Underwood, E; Sanders, MJ; Carmena, D; McCartney, RR; Leiper, FC; Xiao, B; Jing, C; Walker, PA; Haire, LF; Ogrodowicz, R; Martin, SR; Schmidt, MC; Gamblin, SJ and Carling, D (2011)
    ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.
    Cell Metabolism 14, 707-714 PubMed abstract
  • Mouilleron, S; Langer, CA; Guettler, S; McDonald, NQ and Treisman, R (2011)
    Structure of a pentavalent G-actin•MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
    Science Signaling 4, ra40 PubMed abstract
  • Xiao, B; Sanders, MJ; Underwood, E; Heath, R; Mayer, FV; Carmena, D; Jing, C; Walker, PA; Eccleston, JF; Haire, LF; Saiu, P; Howell, SA; Aasland, R; Martin, SR; Carling, D and Gamblin, SJ (2011)
    Structure of mammalian AMPK and its regulation by ADP.
    Nature 472, 230-233 PubMed abstract
  • Zhou, R; Kunzelmann, S; Webb, MR and Ha, T (2011)
    Detecting intramolecular conformational dynamics of single molecules in short distance range with subnanometer sensitivity.
    Nano letters 11, 5482-5488 PubMed abstract
  • Cukier, CD; Hollingworth, D; Martin, SR; Kelly, G; Díaz-Moreno, I and Ramos, A (2010)
    Molecular basis of FIR-mediated c-myc transcriptional control.
    Nature Structural & Molecular Biology 17, 1058-1064 PubMed abstract
  • Kjær, S; Hanrahan, S; Totty, N and McDonald, NQ (2010)
    Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations.
    Nature Structural & Molecular Biology 17, 726-731 PubMed abstract
  • Kunzelmann, S; Morris, C; Chavda, AP; Eccleston, JF and Webb, MR (2010)
    Mechanism of interaction between single-stranded DNA binding protein and DNA.
    Biochemistry 49, 843-852 PubMed abstract
  • Kunzelmann, S and Webb, MR (2010)
    A fluorescent, reagentless biosensor for ADP based on tetramethylrhodamine-labeled ParM.
    ACS Chemical Biology 5, 415-425 PubMed abstract
  • Mologni, L; Rostagno, R; Brussolo, S; Knowles, PP; Kjaer, S; Murray-Rust, J; Rosso, E; Zambon, A; Scapozza, L; McDonald, NQ; Lucchini, V and Gambacorti-Passerini, C (2010)
    Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.
    Bioorganic & Medicinal Chemistry 18, 1482-1496 PubMed abstract
  • Thomas, JC; Green, JL; Howson, RI; Simpson, P; Moss, DK; Martin, SR; Holder, AA; Cota, E and Tate, EW (2010)
    Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.
    Molecular BioSystems 6, 494-498 PubMed abstract

[Page last updated 1 Jun 2018]

Philip Walker Structural Biology lead portrait

Phil Walker (Head)
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