Structural Biology: Publications

  • Alfano, C; Sanfelice, D; Martin, SR; Pastore, A and Temussi, PA (2017)
    An optimized strategy to measure protein stability highlights differences between cold and hot unfolded states.
    Nature Communications 8, 15428 PubMed abstract
  • Benton, DJ; Wharton, SA; Martin, SR and McCauley, JW (2017)
    Role of neuraminidase in influenza A(H7N9) receptor binding.
    Journal of Virology 91, e02293-02216 PubMed abstract
  • Chao, WCH; Wade, BO; Bouchoux, C; Jones, AW; Purkiss, AG; Federico, S; O'Reilly, N; Snijders, AP; Uhlmann, F and Singleton, MR (2017)
    Structural basis of Eco1-mediated cohesin acetylation.
    Scientific Reports 7, 44313 PubMed abstract
  • Collins, KM; Kainov, YA; Christodolou, E; Ray, D; Morris, Q; Hughes, T; Taylor, IA; Makeyev, EV and Ramos, A (2017)
    An RRM-ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion.
    Nucleic Acids Research 45, 6761-6774 PubMed abstract
  • Gehrig, S; Macpherson, JA; Driscoll, PC; Symon, A; Martin, SR; MacRae, JI; Kleinjung, J; Fraternali, F and Anastasiou, D (2017)
    An engineered photoswitchable mammalian pyruvate kinase.
    FEBS Journal 284, 2955-2980 PubMed abstract
  • Green, JL; Wall, RJ; Vahokoski, J; Yusuf, NA; Ridzuan, MAM; Stanway, RR; Stock, J; Knuepfer, E; Brady, D; Martin, SR; Howell, SA; Pires, IP; Moon, RW; Molloy, JE; Kursula, I; Tewari, R and Holder, AA (2017)
    Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.
    Journal of Biological Chemistry [Epub ahead of print] PubMed abstract
  • Kliza, K; Taumer, C; Pinzuti, I; Franz-Wachtel, M; Kunzelmann, S; Stieglitz, B; Macek, B and Husnjak, K (2017)
    Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry.
    Nature Methods 14, 504-512 PubMed abstract
  • Nicastro, G; Candel, AM; Uhl, M; Oregioni, A; Hollingworth, D; Backofen, R; Martin, SR and Ramos, A (2017)
    Mechanism of β-actin mRNA recognition by ZBP1.
    Cell Reports 18, 1187-1199 PubMed abstract
  • Ordonez, P; Kunzelmann, S; Groom, HCT; Yap, MW; Weising, S; Meier, C; Bishop, KN; Taylor, IA and Stoye, JP (2017)
    SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.
    Scientific Reports 7, 42824 PubMed abstract
  • Peacock, TP; Benton, DJ; James, J; Sadeyen, J-R; Chang, P; Sealy, JE; Bryant, JE; Martin, SR; Shelton, H; Barclay, WS and Iqbal, M (2017)
    Immune escape variants of H9N2 influenza viruses containing deletions at the hemagglutinin receptor binding site retain fitness in vivo and display enhanced zoonotic characteristics.
    Journal of Virology 91, e00218-00217 PubMed abstract
  • Peacock, TP; Benton, DJ; Sadeyen, J-R; Chang, P; Sealy, JE; Bryant, JE; Martin, SR; Shelton, H; McCauley, JW; Barclay, WS and Iqbal, M (2017)
    Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion.
    Emerging Microbes & Infections 6, e11 PubMed abstract
  • Pisco, JP; de Chiara, C; Pacholarz, KJ; Garza-Garcia, A; Ogrodowicz, RW; Walker, PA; Barran, PE; Smerdon, SJ and de Carvalho, LPS (2017)
    Uncoupling conformational states from activity in an allosteric enzyme.
    Nature Communications 8, 203 PubMed abstract
  • Sanjuan Nandin, I; Fong, C; Deantonio, C; Torreno-Pina, JA; Pecetta, S; Maldonado, P; Gasparrini, F; Ordovas-Montanes, J; Kazer, SW; Kjaer, S; Borley, DW; Nair, U; Coleman, JA; Lingwood, D; Shalek, AK; Meffre, E; Poignard, P; Burton, DR and Batista, FD (2017)
    Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.
    Journal of Experimental Medicine 214, 2471-2490 PubMed abstract
  • Skytte Rasmussen, M; Mouilleron, S; Kumar Shrestha, B; Wirth, M; Lee, R; Bowitz Larsen, K; Abudu Princely, Y; O'Reilly, N; Sjøttem, E; Tooze, SA; Lamark, T and Johansen, T (2017)
    ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.
    Autophagy 13, 834-853 PubMed abstract
  • Vancraenenbroeck, R; Kunzelmann, S and Webb, MR (2017)
    Development of a range of fluorescent reagentless biosensors for ATP, based on malonyl-coenzyme A synthetase.
    PLOS ONE 12, e0179547 PubMed abstract
  • Willows, R; Sanders, MJ; Xiao, B; Patel, BR; Martin, SR; Read, J; Wilson, JR; Hubbard, J; Gamblin, SJ and Carling, D (2017)
    Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells.
    Biochemical Journal 474, 3059-3073 PubMed abstract
  • Wyatt, HDM; Laister, RC; Martin, SR; Arrowsmith, CH and West, SC (2017)
    The SMX DNA repair tri-nuclease.
    Molecular Cell 65, 848-860 e811 PubMed abstract
  • Abella, JVG; Galloni, C; Pernier, J; Barry, DJ; Kjær, S; Carlier, M-F and Way, M (2016)
    Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
    Nature Cell Biology 18, 76-86 PubMed abstract
  • Diaz, SA; Martin, SR; Howell, SA; Grainger, M; Moon, RW; Green, JL and Holder, AA (2016)
    The binding of Plasmodium falciparum adhesins and erythrocyte invasion proteins to aldolase is enhanced by phosphorylation.
    PLOS ONE 11, e0161850 PubMed abstract
  • Hanč, P; Schulz, O; Fischbach, H; Martin, SR; Kjær, S and Reis e Sousa, C (2016)
    A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells.
    EMBO Journal 35, 2484-2497 PubMed abstract
  • Justin, N; Zhang, Y; Tarricone, C; Martin, SR; Chen, S; Underwood, E; De Marco, V; Haire, LF; Walker, PA; Reinberg, D; Wilson, JR and Gamblin, SJ (2016)
    Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
    Nature Communications 7, 11316 PubMed abstract
  • Kallewaard, NL; Corti, D; Collins, PJ; Neu, U; McAuliffe, JM; Benjamin, E; Wachter-Rosati, L; Palmer-Hill, FJ; Yuan, AQ; Walker, PA; Vorlaender, MK; Bianchi, S; Guarino, B; De Marco, A; Vanzetta, F; Agatic, G; Foglierini, M; Pinna, D; Fernandez-Rodriguez, B; Fruehwirth, A; Silacci, C; Ogrodowicz, RW; Martin, SR; Sallusto, F; Suzich, JA; Lanzavecchia, A; Zhu, Q; Gamblin, SJ and Skehel, JJ (2016)
    Structure and function analysis of an antibody recognizing all influenza A subtypes.
    Cell 166, 596-608 PubMed abstract
  • Kaplan, E; Guichou, J-F; Chaloin, L; Kunzelmann, S; Leban, N; Serpersu, EH and Lionne, C (2016)
    Aminoglycoside binding and catalysis specificity of aminoglycoside 2''-phosphotransferase IVa: a thermodynamic, structural and kinetic study.
    Biochimica et Biophysica Acta 1860, 802-813 PubMed abstract
  • Koliopoulos, MG; Esposito, D; Christodoulou, E; Taylor, IA and Rittinger, K (2016)
    Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
    EMBO Journal 35, 1204-1218 PubMed abstract
  • Kyrieleis, OJP; McIntosh, PB; Webb, SR; Calder, LJ; Lloyd, J; Patel, NA; Martin, SR; Robinson, CV; Rosenthal, PB and Smerdon, SJ (2016)
    Three-dimensional architecture of the human BRCA1-A histone deubiquitinase core complex.
    Cell Reports 17, 3099-3106 PubMed abstract
  • Martino, L; Holland, L; Christodoulou, E; Kunzelmann, S; Esposito, D and Rittinger, K (2016)
    The biophysical characterisation and SAXS analysis of human NLRP1 uncover a new level of complexity of NLR proteins.
    PLOS ONE 11, e0164662 PubMed abstract
  • Newton, R; Bowler, KA; Burns, EM; Chapman, PJ; Fairweather, EE; Fritzl, SJR; Goldberg, KM; Hamilton, NM; Holt, SV; Hopkins, GV; Jones, SD; Jordan, AM; Lyons, AJ; March, HN; McDonald, NQ; Maguire, LA; Mould, DP; Purkiss, AG; Small, HF; Stowell, AIJ; Thomson, GJ; Waddell, ID; Waszkowycz, B; Watson, AJ and Ogilvie, DJ (2016)
    The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
    European Journal of Medicinal Chemistry 112, 20-32 PubMed abstract
  • Parker, L; Wharton, SA; Martin, SR; Cross, K; Lin, Y; Liu, Y; Feizi, T; Daniels, RS and McCauley, JW (2016)
    Effects of egg-adaptation on receptor-binding and antigenic properties of recent Influenza A (H3N2) vaccine viruses.
    Journal of General Virology 97, 1333-1344 PubMed abstract
  • Pike, T; Brownlow, N; Kjaer, S; Carlton, J and Parker, PJ (2016)
    PKCε switches Aurora B specificity to exit the abscission checkpoint.
    Nature Communications 7, 13853 PubMed abstract
  • Plaza-Menacho, I; Barnouin, K; Barry, R; Borg, A; Orme, M; Chauhan, R; Mouilleron, S; Martínez-Torres, RJ; Meier, P and McDonald, NQ (2016)
    RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements.
    Cell Reports 17, 3319-3332 PubMed abstract
  • Soriano, EV; Ivanova, ME; Fletcher, G; Riou, P; Knowles, PP; Barnouin, K; Purkiss, A; Kostelecky, B; Saiu, P; Linch, M; Elbediwy, A; Kjær, S; O'Reilly, N; Snijders, AP; Parker, PJ; Thompson, BJ and McDonald, NQ (2016)
    aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization.
    Developmental Cell 38, 384-398 PubMed abstract
  • Arnold, LH; Groom, HCT; Kunzelmann, S; Schwefel, D; Caswell, SJ; Ordonez, P; Mann, MC; Rueschenbaum, S; Goldstone, DC; Pennell, S; Howell, SA; Stoye, JP; Webb, M; Taylor, IA and Bishop, KN (2015)
    Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction.
    PLOS Pathogens 11, e1005194 PubMed abstract
  • Arnold, LH; Kunzelmann, S; Webb, MR and Taylor, IA (2015)
    A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1.
    Antimicrobial Agents and Chemotherapy 59, 186-192 PubMed abstract
  • Benton, DJ; Martin, SR; Wharton, SA and McCauley, JW (2015)
    Biophysical measurement of the balance of influenza A hemagglutinin and neuraminidase activities.
    Journal of Biological Chemistry 290, 6516-6521 PubMed abstract
  • Das, S; Hertrich, N; Perrin, AJ; Withers-Martinez, C; Collins, CR; Jones, ML; Watermeyer, JM; Fobes, ET; Martin, SR; Saibil, HR; Wright, GJ; Treeck, M; Epp, C and Blackman, MJ (2015)
    Processing of Plasmodium falciparum merozoite surface protein MSP1 activates a spectrin-binding function enabling parasite egress from RBCs.
    Cell Host & Microbe 18, 433-444 PubMed abstract
  • Ehrensberger, AH; Franchini, D-M; East, P; George, R; Matthews, N; Maslen, SL and Svejstrup, JQ (2015)
    Retention of the native epigenome in purified mammalian chromatin.
    PLOS ONE 10, e0133246 PubMed abstract
  • Hanč, P; Fujii, T; Iborra, S; Yamada, Y; Huotari, J; Schulz, O; Ahrens, S; Kjær, S; Way, M; Sancho, D; Namba, K and Reis e Sousa, C (2015)
    Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens.
    Immunity 42, 839-849 PubMed abstract
  • Ivanova, ME; Fletcher, GC; O'Reilly, N; Purkiss, AG; Thompson, BJ and McDonald, NQ (2015)
    Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove.
    Acta Crystallographica. Section D, Biological Crystallography 71, 555-564 PubMed abstract
  • Schwefel, D; Boucherit, VC; Christodoulou, E; Walker, PA; Stoye, JP; Bishop, KN and Taylor, IA (2015)
    Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.
    Cell Host & Microbe 17, 489-499 PubMed abstract
  • Solscheid, C; Kunzelmann, S; Davis, CT; Hunter, JL; Nofer, A and Webb, MR (2015)
    Development of a reagentless biosensor for inorganic phosphate, applicable over a wide concentration range.
    Biochemistry 54, 5054-5062 PubMed abstract
  • Xiong, X; Corti, D; Liu, J; Pinna, D; Foglierini, M; Calder, LJ; Martin, SR; Lin, YP; Walker, PA; Collins, PJ; Monne, I; Suguitan, AL, Jr.; Santos, C; Temperton, NJ; Subbarao, K; Lanzavecchia, A; Gamblin, SJ and Skehel, JJ (2015)
    Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody.
    Proceedings of the National Academy of Sciences of the United States of America 112, 9430-9435 PubMed abstract
  • Yusuf, NA; Green, JL; Wall, RJ; Knuepfer, E; Moon, RW; Schulte-Huxel, C; Stanway, RR; Martin, SR; Howell, SA; Douse, CH; Cota, E; Tate, EW; Tewari, R and Holder, AA (2015)
    The Plasmodium class XIV myosin, MyoB has a distinct subcellular location in invasive and motile stages of the malaria parasite, and an unusual light chain.
    Journal of Biological Chemistry 290, 12147-12164 PubMed abstract
  • Ben-Addi, A; Mambole-Dema, A; Brender, C; Martin, SR; Janzen, J; Kjaer, S; Smerdon, SJ and Ley, SC (2014)
    IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
    Proceedings of the National Academy of Sciences of the United States of America 111, E2394-E2403 PubMed abstract
  • Collins, PJ; Vachieri, SG; Haire, LF; Ogrodowicz, RW; Martin, SR; Walker, PA; Xiong, X; Gamblin, SJ and Skehel, JJ (2014)
    Recent evolution of equine influenza and the origin of canine influenza.
    Proceedings of the National Academy of Sciences of the United States of America 111, 11175-11180 PubMed abstract
  • Deddouche, S; Goubau, D; Rehwinkel, J; Chakravarty, P; Begum, S; Maillard, PV; Borg, A; Matthews, N; Feng, Q; van Kuppeveld, FJM and Reis e Sousa, C (2014)
    Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
    eLife 3, e01535 PubMed abstract
  • Diaz, SA; Martin, SR; Grainger, M; Howell, SA; Green, JL and Holder, AA (2014)
    Plasmodium falciparum aldolase and the C-terminal cytoplasmic domain of certain apical organellar proteins promote actin polymerization.
    Molecular and Biochemical Parasitology 197, 9-14 PubMed abstract
  • Goldstone, DC; Walker, PA; Calder, LJ; Coombs, PJ; Kirkpatrick, J; Ball, NJ; Hilditch, L; Yap, MW; Rosenthal, PB; Stoye, JP and Taylor, IA (2014)
    Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.
    Proceedings of the National Academy of Sciences of the United States of America 111, 9609-9614 PubMed abstract
  • Goodman, KM; Kjær, S; Beuron, F; Knowles, PP; Nawrotek, A; Burns, EM; Purkiss, AG; George, R; Santoro, M; Morris, EP and McDonald, NQ (2014)
    RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association.
    Cell Reports 8, 1894-1904 PubMed abstract
  • Hořejší, Z; Stach, L; Flower, TG; Joshi, D; Flynn, H; Skehel, JM; O'Reilly, NJ; Ogrodowicz, RW; Smerdon, SJ and Boulton, SJ (2014)
    Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.
    Cell Reports 7, 19-26 PubMed abstract
  • Kunzelmann, S; Solscheid, C and Webb, MR (2014)
    Fluorescent biosensors: design and application to motor proteins.
    In: Fluorescent Methods for Molecular Motors. Edited by Toseland, CP and Fili, N.
    Basel, Springer, 2014. 25-47. (Experientia Supplementum, 105).
  • Moody, P; Chudasama, V; Nathani, RI; Maruani, A; Martin, S; Smith, MEB and Caddick, S (2014)
    A rapid, site-selective and efficient route to the dual modification of DARPins.
    Chemical Communications 50, 4898-4900 PubMed abstract
  • Plaza-Menacho, I; Barnouin, K; Goodman, K; Martínez-Torres, RJ; Borg, A; Murray-Rust, J; Mouilleron, S; Knowles, P and McDonald, NQ (2014)
    Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
    Molecular Cell 53, 738-751 PubMed abstract
  • Sanfelice, D; Puglisi, R; Martin, SR; Di Bari, L; Pastore, A and Temussi, PA (2014)
    Yeast frataxin is stabilized by low salt concentrations: cold denaturation disentangles ionic strength effects from specific interactions.
    PLOS ONE 9, e95801 PubMed abstract
  • Schwefel, D; Groom, HCT; Boucherit, VC; Christodoulou, E; Walker, PA; Stoye, JP; Bishop, KN and Taylor, IA (2014)
    Structural basis of lentiviral subversion of a cellular protein degradation pathway.
    Nature 505, 234-238 PubMed abstract
  • Simon, AC; Zhou, JC; Perera, RL; van Deursen, F; Evrin, C; Ivanova, ME; Kilkenny, ML; Renault, L; Kjaer, S; Matak-Vinković, D; Labib, K; Costa, A and Pellegrini, L (2014)
    A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome.
    Nature 510, 293-297 PubMed abstract
  • Streicher, H; Martin, SR; Coombs, PJ; McCauley, J; Neill-Hall, D and Stanley, M (2014)
    A phospha-oseltamivir-biotin conjugate as a strong and selective adhesive for the influenza virus.
    Bioorganic & Medicinal Chemistry Letters 24, 1805-1807 PubMed abstract
  • Vachieri, SG; Xiong, X; Collins, PJ; Walker, PA; Martin, SR; Haire, LF; Zhang, Y; McCauley, JW; Gamblin, SJ and Skehel, JJ (2014)
    Receptor binding by H10 influenza viruses.
    Nature 511, 475-477 PubMed abstract
  • Withers-Martinez, C; Strath, M; Hackett, F; Haire, LF; Howell, SA; Walker, PA; Christodoulou, E; Dodson, GG and Blackman, MJ (2014)
    The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
    Nature Communications 5, 3726 PubMed abstract
  • Xiong, X; Xiao, H; Martin, SR; Coombs, PJ; Liu, J; Collins, PJ; Vachieri, SG; Walker, PA; Lin, YP; McCauley, JW; Gamblin, SJ and Skehel, JJ (2014)
    Enhanced human receptor binding by H5 haemagglutinins.
    Virology 456-457, 179-187 PubMed abstract
  • Crusat, M; Liu, J; Palma, AS; Childs, RA; Liu, Y; Wharton, SA; Lin, YP; Coombs, PJ; Martin, SR; Matrosovich, M; Chen, Z; Stevens, DJ; Hien, VM; Thanh, TT; Nhu, LNT; Nguyet, LA; Ha, DQ; van Doorn, HR; Hien, TT; Conradt, HS; Kiso, M; Gamblin, SJ; Chai, W; Skehel, JJ; Hay, AJ; Farrar, J; de Jong, MD and Feizi, T (2013)
    Changes in the hemagglutinin of H5N1 viruses during human infection - influence on receptor binding.
    Virology 447, 326-337 PubMed abstract
  • de Chiara, C; Rees, M; Menon, RP; Pauwels, K; Lawrence, C; Konarev, PV; Svergun, DI; Martin, SR; Chen, YW and Pastore, A (2013)
    Self-assembly and conformational heterogeneity of the AXH domain of ataxin-1: an unusual example of a chameleon fold.
    Biophysical Journal 104, 1304-1313 PubMed abstract
  • Fritsch, R; de Krijger, I; Fritsch, K; George, R; Reason, B; Kumar, MS; Diefenbacher, M; Stamp, G and Downward, J (2013)
    RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
    Cell 153, 1050-1063 PubMed abstract
  • Gentsch, GE; Owens, NDL; Martin, SR; Piccinelli, P; Faial, T; Trotter, MWB; Gilchrist, MJ and Smith, JC (2013)
    In vivo T-box transcription factor profiling reveals joint regulation of embryonic neuromesodermal bipotency.
    Cell Reports 4, 1185-1196 PubMed abstract
  • Goldstone, DC; Flower, TG; Ball, NJ; Sanz-Ramos, M; Yap, MW; Ogrodowicz, RW; Stanke, N; Reh, J; Lindemann, D; Stoye, JP and Taylor, IA (2013)
    A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid.
    PLOS Pathogens 9, e1003376 PubMed abstract
  • Kjær, S; Linch, M; Purkiss, A; Kostelecky, B; Knowles, PP; Rosse, C; Riou, P; Soudy, C; Kaye, S; Patel, B; Soriano, E; Murray-Rust, J; Barton, C; Dillon, C; Roffey, J; Parker, PJ and McDonald, NQ (2013)
    Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes.
    Biochemical Journal 451, 329-342 PubMed abstract
  • Linch, M; Sanz-Garcia, M; Soriano, E; Zhang, Y; Riou, P; Rosse, C; Cameron, A; Knowles, P; Purkiss, A; Kjaer, S; McDonald, NQ and Parker, PJ (2013)
    A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif.
    Science Signaling 6, ra82 PubMed abstract
  • Marín, MJ; Rashid, A; Rejzek, M; Fairhurst, SA; Wharton, SA; Martin, SR; McCauley, JW; Wileman, T; Field, RA and Russell, DA (2013)
    Glyconanoparticles for the plasmonic detection and discrimination between human and avian influenza virus.
    Organic & Biomolecular Chemistry 11, 7101-7107 PubMed abstract
  • Moody, P; Burlina, F; Martin, SR; Morgan, RE; Offer, J; Smith, MEB; Molloy, JE and Caddick, S (2013)
    Evaluating the use of Apo-neocarzinostatin as a cell penetrating protein.
    Protein Engineering Design and Selection 26, 277-281 PubMed abstract
  • Riou, P; Kjær, S; Garg, R; Purkiss, A; George, R; Cain, RJ; Bineva, G; Reymond, N; McColl, B; Thompson, AJ; O'Reilly, N; McDonald, NQ; Parker, PJ and Ridley, AJ (2013)
    14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
    Cell 153, 640-653 PubMed abstract
  • Rock, JM; Lim, D; Stach, L; Ogrodowicz, RW; Keck, JM; Jones, MH; Wong, CCL; Yates, JR; Winey, M; Smerdon, SJ; Yaffe, MB and Amon, A (2013)
    Activation of the yeast hippo pathway by phosphorylation-dependent assembly of signaling complexes.
    Science 340, 871-875 PubMed abstract
  • Sanfelice, D; Politou, A; Martin, SR; De Los Rios, P; Temussi, P and Pastore, A (2013)
    The effect of crowding and confinement: a comparison of Yfh1 stability in different environments.
    Physical Biology 10, 045002 PubMed abstract
  • Stieglitz, B; Rana, RR; Koliopoulos, MG; Morris-Davies, AC; Schaeffer, V; Christodoulou, E; Howell, S; Brown, NR; Dikic, I and Rittinger, K (2013)
    Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
    Nature 503, 422-426 PubMed abstract
  • Xiao, B; Sanders, MJ; Carmena, D; Bright, NJ; Haire, LF; Underwood, E; Patel, BR; Heath, RB; Walker, PA; Hallen, S; Giordanetto, F; Martin, SR; Carling, D and Gamblin, SJ (2013)
    Structural basis of AMPK regulation by small molecule activators.
    Nature Communications 4, 3017 PubMed abstract
  • Xiong, X; Coombs, PJ; Martin, SR; Liu, J; Xiao, H; McCauley, JW; Locher, K; Walker, PA; Collins, PJ; Kawaoka, Y; Skehel, JJ and Gamblin, SJ (2013)
    Receptor binding by a ferret-transmissible H5 avian influenza virus.
    Nature 497, 392-396 PubMed abstract
  • Xiong, X; Martin, SR; Haire, LF; Wharton, SA; Daniels, RS; Bennett, MS; McCauley, JW; Collins, PJ; Walker, PA; Skehel, JJ and Gamblin, SJ (2013)
    Receptor binding by an H7N9 influenza virus from humans.
    Nature 499, 496-499 PubMed abstract
  • Xiong, X; Tuzikov, A; Coombs, PJ; Martin, S; Walker, PA; Gamblin, SJ; Bovin, N and Skehel, JJ (2013)
    Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus.
    Virus Research 178, 12-14 PubMed abstract
  • Yan, R; Adinolfi, S; Iannuzzi, C; Kelly, G; Oregioni, A; Martin, S and Pastore, A (2013)
    Cluster and fold stability of E. coli ISC-type ferredoxin.
    PLOS ONE 8, e78948 PubMed abstract
  • Yan, R; Konarev, PV; Iannuzzi, C; Adinolfi, S; Roche, B; Kelly, G; Simon, L; Martin, SR; Py, B; Barras, F; Svergun, DI and Pastore, A (2013)
    Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS.
    Journal of Biological Chemistry 288, 24777-24787 PubMed abstract
  • Adrover, M; Martorell, G; Martin, SR; Urosev, D; Konarev, PV; Svergun, DI; Daura, X; Temussi, P and Pastore, A (2012)
    The role of hydration in protein stability: comparison of the cold and heat unfolded states of Yfh1.
    Journal of Molecular Biology 417, 413-424 PubMed abstract
  • Ahrens, S; Zelenay, S; Sancho, D; Hanč, P; Kjær, S; Feest, C; Fletcher, G; Durkin, C; Postigo, A; Skehel, M; Batista, F; Thompson, B; Way, M; Reis e Sousa, C and Schulz, O (2012)
    F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells.
    Immunity 36, 635-645 PubMed abstract
  • Bowles, M; Lally, J; Fadden, AJ; Mouilleron, S; Hammonds, T and McDonald, NQ (2012)
    Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition.
    Nucleic Acids Research 40, e101 PubMed abstract
  • Lallemand, P; Leban, N; Kunzelmann, S; Chaloin, L; Serpersu, EH; Webb, MR; Barman, T and Lionne, C (2012)
    Transient kinetics of aminoglycoside phosphotransferase(3')-IIIa reveals a potential drug target in the antibiotic resistance mechanism.
    FEBS Letters 586, 4223-4227 PubMed abstract
  • Lin, YP; Xiong, X; Wharton, SA; Martin, SR; Coombs, PJ; Vachieri, SG; Christodoulou, E; Walker, PA; Liu, J; Skehel, JJ; Gamblin, SJ; Hay, AJ; Daniels, RS and McCauley, JW (2012)
    Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin.
    Proceedings of the National Academy of Sciences of the United States of America 109, 21474-21479 PubMed abstract
  • Mouilleron, S; Wiezlak, M; O'Reilly, N; Treisman, R and McDonald, NQ (2012)
    Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity.
    Structure 20, 1960-1970 PubMed abstract
  • Stieglitz, B; Morris-Davies, AC; Koliopoulos, MG; Christodoulou, E and Rittinger, K (2012)
    LUBAC synthesizes linear ubiquitin chains via a thioester intermediate.
    EMBO Reports 13, 840-846 PubMed abstract
  • van den Boom, J; Heider, D; Martin, SR; Pastore, A and Mueller, JW (2012)
    3'-Phospho-adenosine-5'-phosphosulphate (PAPS) synthases - naturally fragile enzymes specifically stabilised by nucleotide binding.
    Journal of Biological Chemistry 287, 17645-17655
  • van der Vries, E; Collins, PJ; Vachieri, SG; Xiong, X; Liu, J; Walker, PA; Haire, LF; Hay, AJ; Schutten, M; Osterhaus, ADME; Martin, SR; Boucher, CAB; Skehel, JJ and Gamblin, SJ (2012)
    H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis.
    PLOS Pathogens 8, e1002914 PubMed abstract
  • Wiezlak, M; Diring, J; Abella, J; Mouilleron, S; Way, M; McDonald, NQ and Treisman, R (2012)
    G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly.
    Journal of Cell Science 125, 5860-5872 PubMed abstract
  • Deas, E; Plun-Favreau, H; Gandhi, S; Desmond, H; Kjaer, S; Loh, SHY; Renton, AEM; Harvey, RJ; Whitworth, AJ; Martins, LM; Abramov, AY and Wood, NW (2011)
    PINK1 cleavage at position A103 by the mitochondrial protease PARL.
    Human Molecular Genetics 20, 867-879 PubMed abstract
  • East, DA; Sousa, D; Martin, SR; Edwards, TA; Lehman, W and Mulvihill, DP (2011)
    Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin.
    Biochemical Journal 438, 265-273 PubMed abstract
  • Goldstone, DC; Ennis-Adeniran, V; Hedden, JJ; Groom, HCT; Rice, GI; Christodoulou, E; Walker, PA; Kelly, G; Haire, LF; Yap, MW; de Carvalho, LP; Stoye, JP; Crow, YJ; Taylor, IA and Webb, M (2011)
    HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.
    Nature 480, 379-382 PubMed abstract
  • Jama, AM; Gabriel, J; Al-Nagar, AJ; Martin, S; Baig, SZ; Soleymani, H; Chowdhury, Z; Beesley, P and Török, K (2011)
    Lobe-specific functions of Ca2+•calmodulin in αCa2+ •calmodulin-dependent protein kinase II activation.
    Journal of Biological Chemistry 286, 12308-12316 PubMed abstract
  • Kunzelmann, S and Webb, MR (2011)
    Fluorescent detection of GDP in real time with the reagentless biosensor, rhodamine-ParM.
    Biochemical Journal 440, 43-49 PubMed abstract
  • Martin, SR; Schilstra, MJ and Siligardi, G (2011)
    Circular Dichroism.
    In: Biophysical approaches determining ligand binding to biomolecular targets: detection, measurement and modelling. Edited by Podjarny, A; Dejaegere, AP and Kieffer, B.
    RSC Publishing, 2011. 226-246. (RSC Biomolecular Sciences, 22).
  • Masino, L; Nicastro, G; De Simone, A; Calder, L; Molloy, J and Pastore, A (2011)
    The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
    Biophysical Journal 100, 2033-2042 PubMed abstract
  • Mayer, FV; Heath, R; Underwood, E; Sanders, MJ; Carmena, D; McCartney, RR; Leiper, FC; Xiao, B; Jing, C; Walker, PA; Haire, LF; Ogrodowicz, R; Martin, SR; Schmidt, MC; Gamblin, SJ and Carling, D (2011)
    ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.
    Cell Metabolism 14, 707-714 PubMed abstract
  • Mouilleron, S; Langer, CA; Guettler, S; McDonald, NQ and Treisman, R (2011)
    Structure of a pentavalent G-actin•MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
    Science Signaling 4, ra40 PubMed abstract
  • Xiao, B; Sanders, MJ; Underwood, E; Heath, R; Mayer, FV; Carmena, D; Jing, C; Walker, PA; Eccleston, JF; Haire, LF; Saiu, P; Howell, SA; Aasland, R; Martin, SR; Carling, D and Gamblin, SJ (2011)
    Structure of mammalian AMPK and its regulation by ADP.
    Nature 472, 230-233 PubMed abstract
  • Zhou, R; Kunzelmann, S; Webb, MR and Ha, T (2011)
    Detecting intramolecular conformational dynamics of single molecules in short distance range with subnanometer sensitivity.
    Nano letters 11, 5482-5488 PubMed abstract
  • Cukier, CD; Hollingworth, D; Martin, SR; Kelly, G; Díaz-Moreno, I and Ramos, A (2010)
    Molecular basis of FIR-mediated c-myc transcriptional control.
    Nature Structural & Molecular Biology 17, 1058-1064 PubMed abstract
  • Kjær, S; Hanrahan, S; Totty, N and McDonald, NQ (2010)
    Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations.
    Nature Structural & Molecular Biology 17, 726-731 PubMed abstract
  • Kunzelmann, S; Morris, C; Chavda, AP; Eccleston, JF and Webb, MR (2010)
    Mechanism of interaction between single-stranded DNA binding protein and DNA.
    Biochemistry 49, 843-852 PubMed abstract
  • Kunzelmann, S and Webb, MR (2010)
    A fluorescent, reagentless biosensor for ADP based on tetramethylrhodamine-labeled ParM.
    ACS Chemical Biology 5, 415-425 PubMed abstract
  • Mologni, L; Rostagno, R; Brussolo, S; Knowles, PP; Kjaer, S; Murray-Rust, J; Rosso, E; Zambon, A; Scapozza, L; McDonald, NQ; Lucchini, V and Gambacorti-Passerini, C (2010)
    Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.
    Bioorganic & Medicinal Chemistry 18, 1482-1496 PubMed abstract
  • Thomas, JC; Green, JL; Howson, RI; Simpson, P; Moss, DK; Martin, SR; Holder, AA; Cota, E and Tate, EW (2010)
    Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.
    Molecular BioSystems 6, 494-498 PubMed abstract

[Page last updated 1 Nov 2017]

Philip Walker Structural Biology lead portrait

Phil Walker (Head) 

philip.walker@crick.ac.uk
+44 (0)20 379 61670

Svend Kjaer (Deputy Head) 

svend.kjaer@crick.ac.uk
+44 (0)20 379 61699