Mass Spectroscopy: Publications

  • Chao, WCH; Murayama, Y; Muñoz, S; Jones, AW; Wade, BO; Purkiss, AG; Hu, X-W; Borg, A; Snijders, AP; Uhlmann, F and Singleton, MR (2017)
    Structure of the cohesin loader Scc2.
    Nature Communications 8, 13952 PubMed abstract
  • Chao, WCH; Wade, BO; Bouchoux, C; Jones, AW; Purkiss, AG; Federico, S; O'Reilly, N; Snijders, AP; Uhlmann, F and Singleton, MR (2017)
    Structural basis of Eco1-mediated cohesin acetylation.
    Scientific Reports 7, 44313 PubMed abstract
  • Crockford, A; Zalmas, LP; Grönroos, E; Dewhurst, SM; McGranahan, N; Cuomo, ME; Encheva, V; Snijders, AP; Begum, J; Purewal, S; Cerveira, J; Patel, H; Renshaw, MJ and Swanton, C (2017)
    Cyclin D mediates tolerance of genome-doubling in cancers with functional p53.
    Annals of Oncology 28, 149-156 PubMed abstract
  • Godfrey, M; Touati, SA; Kataria, M; Jones, A; Snijders, AP and Uhlmann, F (2017)
    PP2ACdc55 phosphatase imposes ordered cell-cycle phosphorylation by opposing threonine phosphorylation.
    Molecular Cell 65, 393-402 e393 PubMed abstract
  • Green, JL; Wall, RJ; Vahokoski, J; Yusuf, NA; Ridzuan, MAM; Stanway, RR; Stock, J; Knuepfer, E; Brady, D; Martin, SR; Howell, SA; Pires, IP; Moon, RW; Molloy, JE; Kursula, I; Tewari, R and Holder, AA (2017)
    Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.
    Journal of Biological Chemistry [Epub ahead of print] PubMed abstract
  • Joachim, J; Razi, M; Judith, D; Wirth, M; Calamita, E; Encheva, V; Dynlacht, BD; Snijders, AP; O'Reilly, N; Jefferies, HBJ and Tooze, SA (2017)
    Centriolar satellites control GABARAP ubiquitination and GABARAP-mediated autophagy.
    Current Biology 27, 2123-2136.e2127 PubMed abstract
  • Kume, K; Cantwell, H; Neumann, FR; Jones, AW; Snijders, AP and Nurse, P (2017)
    A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.
    PLOS Genetics 13, e1006767 PubMed abstract
  • Novellasdemunt, L; Foglizzo, V; Cuadrado, L; Antas, P; Kucharska, A; Encheva, V; Snijders, AP and Li, VSW (2017)
    USP7 is a tumor-specific WNT activator for APC-mutated colorectal cancer by mediating β-catenin deubiquitination.
    Cell Reports 21, 612-627
  • Rapisarda, V; Borghesan, M; Miguela, V; Encheva, V; Snijders, AP; Lujambio, A and O'Loghlen, A (2017)
    Integrin beta 3 regulates cellular senescence by activating the TGF-β pathway.
    Cell Reports 18, 2480-2493 PubMed abstract
  • Swuec, P; Renault, L; Borg, A; Shah, F; Murphy, VJ; van Twest, S; Snijders, AP; Deans, AJ and Costa, A (2017)
    The FA core complex contains a homo-dimeric catalytic module for the symmetric mono-ubiquitination of FANCI-FANCD2.
    Cell Reports 18, 611-623 PubMed abstract
  • Boeing, S; Williamson, L; Encheva, V; Gori, I; Saunders, RE; Instrell, R; Aygün, O; Rodriguez-Martinez, M; Weems, JC; Kelly, GP; Conaway, JW; Conaway, RC; Stewart, A; Howell, M; Snijders, AP and Svejstrup, JQ (2016)
    Multiomic analysis of the UV-induced DNA damage response.
    Cell Reports 15, 1597-1610 PubMed abstract
  • Debaisieux, S; Encheva, V; Chakravarty, P; Snijders, AP and Schiavo, G (2016)
    Analysis of signaling endosome composition and dynamics using SILAC in embryonic stem cell-derived neurons.
    Molecular & Cellular Proteomics 15, 542-557 PubMed abstract
  • Diaz, SA; Martin, SR; Howell, SA; Grainger, M; Moon, RW; Green, JL and Holder, AA (2016)
    The binding of Plasmodium falciparum adhesins and erythrocyte invasion proteins to aldolase is enhanced by phosphorylation.
    PLOS ONE 11, e0161850 PubMed abstract
  • Green, JL; Moon, RW; Whalley, D; Bowyer, PW; Wallace, C; Rochani, A; Nageshan, RK; Howell, SA; Grainger, M; Jones, HM; Ansell, KH; Chapman, TM; Taylor, DL; Osborne, SA; Baker, DA; Tatu, U and Holder, AA (2016)
    Imidazopyridazine inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 also target cyclic GMP-dependent protein kinase and heat shock protein 90 to kill the parasite at different stages of intracellular development.
    Antimicrobial Agents and Chemotherapy 60, 1464-1475 PubMed abstract
  • Guven, M; Barnouin, K; Snijders, AP and Karran, P (2016)
    Photosensitized UVA-induced cross-linking between human DNA repair and replication proteins and DNA revealed by proteomic analysis.
    Journal of Proteome Research 15, 4612-4623 PubMed abstract
  • Hori, A; Barnouin, K; Snijders, AP and Toda, T (2016)
    A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation.
    EMBO Reports 17, 326-337 PubMed abstract
  • Lamb, CA; Nühlen, S; Judith, D; Frith, D; Snijders, AP; Behrends, C and Tooze, SA (2016)
    TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic.
    EMBO Journal 35, 281-301 PubMed abstract
  • Nadarajan, S; Mohideen, F; Tzur, YB; Ferrandiz, N; Crawley, O; Montoya, A; Faull, P; Snijders, AP; Cutillas, PR; Jambhekar, A; Blower, MD; Martinez-Perez, E; Harper, JW and Colaiacovo, MP (2016)
    The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis.
    eLife 5, e12039 PubMed abstract
  • Panayiotou, R; Miralles, F; Pawlowski, R; Diring, J; Flynn, HR; Skehel, M and Treisman, R (2016)
    Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity.
    eLife 5, e15460 PubMed abstract
  • Pattison, MJ; Mitchell, O; Flynn, HR; Chen, C-S; Yang, H-T; Ben-Addi, H; Boeing, S; Snijders, AP and Ley, SC (2016)
    TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.
    Biochemical Journal 473, 2845-2861 PubMed abstract
  • Plaza-Menacho, I; Barnouin, K; Barry, R; Borg, A; Orme, M; Chauhan, R; Mouilleron, S; Martínez-Torres, RJ; Meier, P and McDonald, NQ (2016)
    RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements.
    Cell Reports 17, 3319-3332 PubMed abstract
  • Prosser, GA; Rodenburg, A; Khoury, H; de Chiara, C; Howell, S; Snijders, AP and de Carvalho, LPS (2016)
    Glutamate racemase is the primary target of β-chloro-ᴅ-alanine in Mycobacterium tuberculosis.
    Antimicrobial Agents and Chemotherapy 60, 6091-6099 PubMed abstract
  • Ranes, M; Boeing, S; Wang, Y; Wienholz, F; Menoni, H; Walker, J; Encheva, V; Chakravarty, P; Mari, P-O; Stewart, A; Giglia-Mari, G; Snijders, AP; Vermeulen, W and Svejstrup, JQ (2016)
    A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.
    Nucleic Acids Research 44, 5246-5255 PubMed abstract
  • Soriano, EV; Ivanova, ME; Fletcher, G; Riou, P; Knowles, PP; Barnouin, K; Purkiss, A; Kostelecky, B; Saiu, P; Linch, M; Elbediwy, A; Kjær, S; O'Reilly, N; Snijders, AP; Parker, PJ; Thompson, BJ and McDonald, NQ (2016)
    aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization.
    Developmental Cell 38, 384-398 PubMed abstract
  • Swaffer, MP; Jones, AW; Flynn, HR; Snijders, AP and Nurse, P (2016)
    CDK substrate phosphorylation and ordering the cell cycle.
    Cell 167, 1750-1761.e1716 PubMed abstract
  • Arnold, LH; Groom, HCT; Kunzelmann, S; Schwefel, D; Caswell, SJ; Ordonez, P; Mann, MC; Rueschenbaum, S; Goldstone, DC; Pennell, S; Howell, SA; Stoye, JP; Webb, M; Taylor, IA and Bishop, KN (2015)
    Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction.
    PLOS Pathogens 11, e1005194 PubMed abstract
  • Hori, A; Morand, A; Ikebe, C; Frith, D; Snijders, AP and Toda, T (2015)
    The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation.
    Biochemical and Biophysical Research Communications 468, 39-45 PubMed abstract
  • Joachim, J; Jefferies, HBJ; Razi, M; Frith, D; Snijders, AP; Chakravarty, P; Judith, D and Tooze, SA (2015)
    Activation of ULK kinase and autophagy by GABARAP trafficking from the centrosome is regulated by WAC and GM130.
    Molecular Cell 60, 899-913 PubMed abstract
  • Kakugawa, S; Langton, PF; Zebisch, M; Howell, SA; Chang, T-H; Liu, Y; Feizi, T; Bineva, G; O'Reilly, N; Snijders, AP; Jones, EY and Vincent, J-P (2015)
    Notum deacylates Wnt proteins to suppress signalling activity.
    Nature 519, 187-192 PubMed abstract
  • Koyano, T; Barnouin, K; Snijders, AP; Kume, K; Hirata, D and Toda, T (2015)
    Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.
    Genes to Cells 20, 1046-1058 PubMed abstract
  • Snijders, AP; Hautbergue, GM; Bloom, A; Williamson, JC; Minshull, TC; Phillips, HL; Mihaylov, SR; Gjerde, DT; Hornby, DP; Wilson, SA; Hurd, PJ and Dickman, MJ (2015)
    Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA.
    RNA 21, 347-359 PubMed abstract
  • Stallmach, R; Kavishwar, M; Withers-Martinez, C; Hackett, F; Collins, CR; Howell, SA; Yeoh, S; Knuepfer, E; Atid, AJ; Holder, AA and Blackman, MJ (2015)
    Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.
    Molecular Microbiology 96, 368-387 PubMed abstract
  • Yusuf, NA; Green, JL; Wall, RJ; Knuepfer, E; Moon, RW; Schulte-Huxel, C; Stanway, RR; Martin, SR; Howell, SA; Douse, CH; Cota, E; Tate, EW; Tewari, R and Holder, AA (2015)
    The Plasmodium class XIV myosin, MyoB has a distinct subcellular location in invasive and motile stages of the malaria parasite, and an unusual light chain.
    Journal of Biological Chemistry 290, 12147-12164 PubMed abstract
  • Blombach, F; Launay, H; Snijders, APL; Zorraquino, V; Wu, H; de Koning, B; Brouns, SJJ; Ettema, TJG; Camilloni, C; Cavalli, A; Vendruscolo, M; Dickman, MJ; Cabrita, LD; La Teana, A; Benelli, D; Londei, P; Christodoulou, J and van der Oost, J (2014)
    Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain.
    Biochemical Journal 462, 373-384 PubMed abstract
  • Diaz, SA; Martin, SR; Grainger, M; Howell, SA; Green, JL and Holder, AA (2014)
    Plasmodium falciparum aldolase and the C-terminal cytoplasmic domain of certain apical organellar proteins promote actin polymerization.
    Molecular and Biochemical Parasitology 197, 9-14 PubMed abstract
  • Hořejší, Z; Stach, L; Flower, TG; Joshi, D; Flynn, H; Skehel, JM; O'Reilly, NJ; Ogrodowicz, RW; Smerdon, SJ and Boulton, SJ (2014)
    Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.
    Cell Reports 7, 19-26 PubMed abstract
  • Luxton, HJ; Barnouin, K; Kelly, G; Hanrahan, S; Totty, N; Neal, DE and Whitaker, HC (2014)
    Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491.
    Molecular Oncology 8, 633-641 PubMed abstract
  • Maertens, GN; Cook, NJ; Wang, W; Hare, S; Gupta, SS; Öztop, I; Lee, K; Pye, VE; Cosnefroy, O; Snijders, AP; KewalRamani, VN; Fassati, A; Engelman, A and Cherepanov, P (2014)
    Structural basis for nuclear import of splicing factors by human Transportin 3.
    Proceedings of the National Academy of Sciences of the United States of America 111, 2728-2733 PubMed abstract
  • On, KF; Beuron, F; Frith, D; Snijders, AP; Morris, EP and Diffley, JFX (2014)
    Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication.
    EMBO Journal 33, 605-620 PubMed abstract
  • Pitcher, DS; de Mattos-Shipley, K; Wang, Z; Tzortzis, K; Goudevenou, K; Flynn, H; Bohn, G; Rahemtulla, A; Roberts, I; Snijders, AP; Karadimitris, A and Kleijnen, MF (2014)
    Nuclear proteasomes carry a constitutive posttranslational modification which derails SDS-PAGE (but not CTAB-PAGE).
    Biochimica et Biophysica Acta 1844, 2222-2228 PubMed abstract
  • Plaza-Menacho, I; Barnouin, K; Goodman, K; Martínez-Torres, RJ; Borg, A; Murray-Rust, J; Mouilleron, S; Knowles, P and McDonald, NQ (2014)
    Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.
    Molecular Cell 53, 738-751 PubMed abstract
  • Ribeiro, P; Holder, M; Frith, D; Snijders, AP and Tapon, N (2014)
    Crumbs promotes expanded recognition and degradation by the SCFSlimb/β-TrCP ubiquitin ligase.
    Proceedings of the National Academy of Sciences of the United States of America 111, E1980-E1989 PubMed abstract
  • Silva, N; Ferrandiz, N; Barroso, C; Tognetti, S; Lightfoot, J; Telecan, O; Encheva, V; Faull, P; Hanni, S; Furger, A; Snijders, AP; Speck, C and Martinez-Perez, E (2014)
    The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression.
    Developmental Cell 31, 503-511 PubMed abstract
  • Swarts, DC; Jore, MM; Westra, ER; Zhu, Y; Janssen, JH; Snijders, AP; Wang, Y; Patel, DJ; Berenguer, J; Brouns, SJJ and van der Oost, J (2014)
    DNA-guided DNA interference by a prokaryotic Argonaute.
    Nature 507, 258-261 PubMed abstract
  • van Breevoort, D; Snijders, AP; Hellen, N; Weckhuysen, S; van Hooren, KWEM; Eikenboom, J; Valentijn, K; Fernandez-Borja, M; Ceulemans, B; De Jonghe, P; Voorberg, J; Hannah, M; Carter, T and Bierings, R (2014)
    STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a.
    Blood 123, 3185-3194 PubMed abstract
  • Withers-Martinez, C; Strath, M; Hackett, F; Haire, LF; Howell, SA; Walker, PA; Christodoulou, E; Dodson, GG and Blackman, MJ (2014)
    The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
    Nature Communications 5, 3726 PubMed abstract
  • Zhang, T; Cronshaw, J; Kanu, N; Snijders, AP and Behrens, A (2014)
    UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.
    Proceedings of the National Academy of Sciences of the United States of America 111, 12091-12096 PubMed abstract
  • Acosta, JC; Banito, A; Wuestefeld, T; Georgilis, A; Janich, P; Morton, JP; Athineos, D; Kang, T-W; Lasitschka, F; Andrulis, M; Pascual, G; Morris, KJ; Khan, S; Jin, H; Dharmalingam, G; Snijders, AP; Carroll, T; Capper, D; Pritchard, C; Inman, GJ; Longerich, T; Sansom, OJ; Benitah, SA; Zender, L and Gil, J (2013)
    A complex secretory program orchestrated by the inflammasome controls paracrine senescence.
    Nature Cell Biology 15, 978-990 PubMed abstract
  • Acosta, JC; Snijders, AP and Gil, J (2013)
    Unbiased characterization of the senescence-associated secretome using SILAC-based quantitative proteomics.
    Methods in Molecular Biology 965, 175-184 PubMed abstract
  • Gantke, T; Boussouf, S; Janzen, J; Morrice, NA; Howell, S; Mühlberger, E and Ley, SC (2013)
    Ebola virus VP35 induces high-level production of recombinant TPL-2—ABIN-2—NF-κB1 p105 complex in co-transfected HEK-293 cells.
    Biochemical Journal 452, 359-365 PubMed abstract
  • Martin, N; Popov, N; Aguilo, F; O'Loghlen, A; Raguz, S; Snijders, AP; Dharmalingam, G; Li, S; Thymiakou, E; Carroll, T; Zeisig, BB; So, CWE; Peters, G; Episkopou, V; Walsh, MJ and Gil, J (2013)
    Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK4a regulation.
    EMBO Journal 32, 982-995 PubMed abstract
  • Stieglitz, B; Rana, RR; Koliopoulos, MG; Morris-Davies, AC; Schaeffer, V; Christodoulou, E; Howell, S; Brown, NR; Dikic, I and Rittinger, K (2013)
    Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
    Nature 503, 422-426 PubMed abstract
  • Thomas, ERA; Atanur, SS; Norsworthy, PJ; Encheva, V; Snijders, AP; Game, L; Vandrovcova, J; Siddiq, A; Seed, M; Soutar, AK and Aitman, TJ (2013)
    Identification and biochemical analysis of a novel APOB mutation that causes autosomal dominant hypercholesterolemia.
    Molecular genetics & genomic medicine 1, 155-161 PubMed abstract
  • Gari, K; León Ortiz, AM; Borel, V; Flynn, H; Skehel, JM and Boulton, SJ (2012)
    MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
    Science 337, 243-245 PubMed abstract
  • Hughes, S; Elustondo, F; Di Fonzo, A; Leroux, FG; Wong, AC; Snijders, AP; Matthews, SJ and Cherepanov, P (2012)
    Crystal structure of human CDC7 kinase in complex with its activator DBF4.
    Nature Structural & Molecular Biology 19, 1101-1107 PubMed abstract
  • O'Loghlen, A; Muñoz-Cabello, AM; Gaspar-Maia, A; Wu, H-A; Banito, A; Kunowska, N; Racek, T; Pemberton, HN; Beolchi, P; Lavial, F; Masui, O; Vermeulen, M; Carroll, T; Graumann, J; Heard, E; Dillon, N; Azuara, V; Snijders, AP; Peters, G; Bernstein, E and Gil, J (2012)
    MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation.
    Cell Stem Cell 10, 33-46 PubMed abstract
  • Rosse, C; Boeckeler, K; Linch, M; Radtke, S; Frith, D; Barnouin, K; Morsi, AS; Hafezparast, M; Howell, M and Parker, PJ (2012)
    Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration.
    Journal of Cell Science 125, 3733-3738 PubMed abstract
  • Jore, MM; Lundgren, M; van Duijn, E; Bultema, JB; Westra, ER; Waghmare, SP; Wiedenheft, B; Pul, Ü; Wurm, R; Wagner, R; Beijer, MR; Barendregt, A; Zhou, K; Snijders, APL; Dickman, MJ; Doudna, JA; Boekema, EJ; Heck, AJR; van der Oost, J and Brouns, SJJ (2011)
    Structural basis for CRISPR RNA-guided DNA recognition by Cascade.
    Nature Structural & Molecular Biology 18, 529-536 PubMed abstract
  • Ogun, SA; Tewari, R; Otto, TD; Howell, SA; Knuepfer, E; Cunningham, DA; Xu, Z; Pain, A and Holder, AA (2011)
    Targeted disruption of py235ebp-1: Invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein.
    PLOS Pathogens 7, e1001288 PubMed abstract
  • Xiao, B; Sanders, MJ; Underwood, E; Heath, R; Mayer, FV; Carmena, D; Jing, C; Walker, PA; Eccleston, JF; Haire, LF; Saiu, P; Howell, SA; Aasland, R; Martin, SR; Carling, D and Gamblin, SJ (2011)
    Structure of mammalian AMPK and its regulation by ADP.
    Nature 472, 230-233 PubMed abstract
  • Chakraborty, S; Snijders, AP; Chakravorty, R; Ahmed, M; Tarek, AM and Hossain, MA (2010)
    Comparative network clustering of direct repeats (DRs) and cas genes confirms the possibility of the horizontal transfer of CRISPR locus among bacteria.
    Molecular Phylogenetics and Evolution 56, 878-887 PubMed abstract
  • Hung, M-L; Hautbergue, GM; Snijders, APL; Dickman, MJ and Wilson, SA (2010)
    Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.
    Nucleic Acids Research 38, 3351-3361 PubMed abstract
  • Kadekoppala, M; Ogun, SA; Howell, S; Gunaratne, RS and Holder, AA (2010)
    Systematic genetic analysis of the Plasmodium falciparum MSP7-like family reveals differences in protein expression, location and importance in asexual growth of the blood stage parasite.
    Eukaryotic Cell 9, 1064-1074 PubMed abstract
  • Phillips, HL; Williamson, JC; van Elburg, KA; Snijders, APL; Wright, PC and Dickman, MJ (2010)
    Shotgun proteome analysis utilising mixed mode (reversed phase-anion exchange chromatography) in conjunction with reversed phase liquid chromatography mass spectrometry analysis.
    Proteomics 10, 2950-2960 PubMed abstract
  • Snijders, APL; Hung, M-L; Wilson, SA and Dickman, MJ (2010)
    Analysis of arginine and lysine methylation utilizing peptide separations at neutral pH and electron transfer dissociation mass spectrometry.
    Journal of the American Society for Mass Spectrometry 21, 88-96 PubMed abstract
  • Wu, H; Sun, L; Blombach, F; Brouns, SJJ; Snijders, APL; Lorenzen, K; van den Heuvel, RHH; Heck, AJR; Fu, S; Li, X; Zhang, XC; Rao, Z and van der Oost, J (2010)
    Structure of the ribosome associating GTPase HflX.
    Proteins 78, 705-713 PubMed abstract

[Page last updated 1 Nov 2017]

Bram Snijders - Proteomics Lead 

bram.snijders@crick.ac.uk
+44 (0) 1707 625716