Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Breadcrumb Proteomics Proteomics : Publications Lab contentLab contentIn this section Overview Publications Members The Mass Spectrometry Proteomics STP. Toggle to view hero caption Publications Displaying 1 - 10 of 237Last updated : 25 April 2024 03:16 Spatial architecture of myeloid and T cells orchestrates immune evasion and clinical outcome in lung cancer Authors (35)Katey Enfield Emma Colliver Claudia Lee Alastair Magness David A Moore Monica Sivakumar[...]Crispin HileyJulian DownwardErik SahaiCharles SwantonMihaela Angelova Cancer Discovery Published 6 April 2024 Crick labs/ facilitiesCharles SwantonErik SahaiJulian DownwardFlow CytometryExperimental HistopathologyScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details CDK activity at the centrosome regulates the cell cycle Authors (6)Emma RobertsJessica GreenwoodNitin Kapadia Tania AuchynnikavaSaz BasuPaul Nurse Cell Reports Published 23 April 2024 Crick labs/ facilitiesPaul NurseProteomicsLight MicroscopyFlow CytometryFull details Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders Authors (11) Jianzhi Jiang Brent Wilkinson Ilse Flores Nicolas HartelSimeon Mihaylov Veronica A Clementel Helen R Flynn Fowsan S AlkurayaSila Ultanir Nicholas A Graham Marcelo P Coba Frontiers in Molecular Neuroscience Published 4 April 2024 Crick labs/ facilitiesSila UltanirProteomicsFull details ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication Authors (6)Guy PearsonHarriet MearsMalgorzata BroncelBram SnijdersDavid LV BauerJeremy Carlton Science advances Published 3 April 2024 Crick labs/ facilitiesJeremy CarltonDavid LV BauerProteomicsLight MicroscopyFull details FOXL2 interaction with different binding partners regulates the dynamics of ovarian development Authors (7)Roberta MigaleMichelle Neumann Richard MitterMahmoud-Reza Rafiee Sophie WoodJessica OlsenRobin Lovell-Badge Science advances Published 22 March 2024 Crick labs/ facilitiesJernej UleRobin Lovell-BadgeGenetic Modification ServiceBioinformatics and BiostatisticsProteomicsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Decoding chromatin states by proteomic profiling of nucleosome readers Authors (20) Saulius Lukauskas Andrey Tvardovskiy Nhuong V Nguyen Mara StadlerPeter Faull Tina Ravnsborg[...] Christian L Müller Peter A DiMaggio Ole N Jensen Robert Schneider Till Bartke Nature Published 21 March 2024 Crick labs/ facilitiesProteomicsFull details Exploring the ATG9A interactome uncovers interaction with VPS13A Authors (7)Alexander Van VlietHarold JefferiesPeter Faull Jessica Chadwick Fairouz IbrahimMark SkehelSharon Tooze Journal of Cell Science Published 15 February 2024 Crick labs/ facilitiesSharon ToozeProteomicsFull details Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat AoidiMiriam Llorian SopenaDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability Authors (10)Marisol Sampedro CastanedaLucas BaltussenAndre Teixeira Lopes Yichen Qiu Liina SirvioSimeon MihaylovSuzanne Claxton Jill C Richardson Gabriele LignaniSila Ultanir Nature Communications Published 11 December 2023 Crick labs/ facilitiesSila UltanirProteomicsGenetic Modification ServiceBiological Research FacilityFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Spatial architecture of myeloid and T cells orchestrates immune evasion and clinical outcome in lung cancer Authors (35)Katey Enfield Emma Colliver Claudia Lee Alastair Magness David A Moore Monica Sivakumar[...]Crispin HileyJulian DownwardErik SahaiCharles SwantonMihaela Angelova Cancer Discovery Published 6 April 2024 Crick labs/ facilitiesCharles SwantonErik SahaiJulian DownwardFlow CytometryExperimental HistopathologyScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
CDK activity at the centrosome regulates the cell cycle Authors (6)Emma RobertsJessica GreenwoodNitin Kapadia Tania AuchynnikavaSaz BasuPaul Nurse Cell Reports Published 23 April 2024 Crick labs/ facilitiesPaul NurseProteomicsLight MicroscopyFlow CytometryFull details
Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders Authors (11) Jianzhi Jiang Brent Wilkinson Ilse Flores Nicolas HartelSimeon Mihaylov Veronica A Clementel Helen R Flynn Fowsan S AlkurayaSila Ultanir Nicholas A Graham Marcelo P Coba Frontiers in Molecular Neuroscience Published 4 April 2024 Crick labs/ facilitiesSila UltanirProteomicsFull details
ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication Authors (6)Guy PearsonHarriet MearsMalgorzata BroncelBram SnijdersDavid LV BauerJeremy Carlton Science advances Published 3 April 2024 Crick labs/ facilitiesJeremy CarltonDavid LV BauerProteomicsLight MicroscopyFull details
FOXL2 interaction with different binding partners regulates the dynamics of ovarian development Authors (7)Roberta MigaleMichelle Neumann Richard MitterMahmoud-Reza Rafiee Sophie WoodJessica OlsenRobin Lovell-Badge Science advances Published 22 March 2024 Crick labs/ facilitiesJernej UleRobin Lovell-BadgeGenetic Modification ServiceBioinformatics and BiostatisticsProteomicsLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Decoding chromatin states by proteomic profiling of nucleosome readers Authors (20) Saulius Lukauskas Andrey Tvardovskiy Nhuong V Nguyen Mara StadlerPeter Faull Tina Ravnsborg[...] Christian L Müller Peter A DiMaggio Ole N Jensen Robert Schneider Till Bartke Nature Published 21 March 2024 Crick labs/ facilitiesProteomicsFull details
Exploring the ATG9A interactome uncovers interaction with VPS13A Authors (7)Alexander Van VlietHarold JefferiesPeter Faull Jessica Chadwick Fairouz IbrahimMark SkehelSharon Tooze Journal of Cell Science Published 15 February 2024 Crick labs/ facilitiesSharon ToozeProteomicsFull details
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat AoidiMiriam Llorian SopenaDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation Authors (16) Cory A Ocasio Marc P Baggelaar James Sipthorp Ana Losada de la Lastra Manuel Tavares Jana Volarić[...]Goran TomicCharlotte CarrJulian Downward Ulrike S Eggert Edward W Tate Nature Biotechnology Published 8 January 2024 Crick labs/ facilitiesEd TateJulian DownwardMetabolomicsFlow CytometryChemical BiologyProteomicsLight MicroscopyCell ServicesAdvanced SequencingFull details
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability Authors (10)Marisol Sampedro CastanedaLucas BaltussenAndre Teixeira Lopes Yichen Qiu Liina SirvioSimeon MihaylovSuzanne Claxton Jill C Richardson Gabriele LignaniSila Ultanir Nature Communications Published 11 December 2023 Crick labs/ facilitiesSila UltanirProteomicsGenetic Modification ServiceBiological Research FacilityFull details
