Metabolomics: Publications

  • Entwistle, LJ; Pelly, VS; Coomes, SM; Kannan, Y; Perez-Lloret, J; Czieso, S; Silva dos Santos, M; MacRae, JI; Collinson, L; Sesay, A; Nikolov, N; Metidji, A; Helmby, H; Hui, DY and Wilson, MS (2017)
    Epithelial-cell-derived phospholipase A2 group 1B is an endogenous anthelmintic.
    Cell Host & Microbe 22, 484-493.e485 PubMed abstract
  • Gehrig, S; Macpherson, JA; Driscoll, PC; Symon, A; Martin, SR; MacRae, JI; Kleinjung, J; Fraternali, F and Anastasiou, D (2017)
    An engineered photoswitchable mammalian pyruvate kinase.
    FEBS Journal 284, 2955-2980 PubMed abstract
  • Méndez-Lucas, A; Li, X; Hu, J; Che, L; Song, X; Jia, J; Wang, J; Xie, C; Driscoll, PC; Tschaharganeh, DF; Calvisi, DF; Yuneva, M and Chen, X (2017)
    Glucose catabolism in liver tumors induced by c-MYC can be sustained by various PKM1/PKM2 ratios and pyruvate kinase activities.
    Cancer Research 77, 4355-4364 PubMed abstract
  • Messner, CB; Driscoll, PC; Piedrafita, G; De Volder, MFL and Ralser, M (2017)
    Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice.
    Proceedings of the National Academy of Sciences of the United States of America 114, 7403-7407 PubMed abstract
  • Pasricha, S; MacRae, JI; Chua, HH; Chambers, J; Boyce, KJ; McConville, MJ and Andrianopoulos, A (2017)
    Extensive metabolic remodeling differentiates non-pathogenic and pathogenic growth forms of the dimorphic pathogen Talaromyces marneffei.
    Frontiers in Cellular and Infection Microbiology 7, 368 PubMed abstract
  • Shears, MJ; MacRae, JI; Mollard, V; Goodman, CD; Sturm, A; Orchard, LM; Llinás, M; McConville, MJ; Botté, CY and McFadden, GI (2017)
    Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.
    Cellular Microbiology 19, e12633 PubMed abstract
  • Amiar, S; MacRae, JI; Callahan, DL; Dubois, D; van Dooren, GG; Shears, MJ; Cesbron-Delauw, M-F; Maréchal, E; McConville, MJ; McFadden, GI; Yamaryo-Botté, Y and Botté, CY (2016)
    Apicoplast-localized lysophosphatidic acid precursor assembly is required for bulk phospholipid synthesis in Toxoplasma gondii and relies on an algal/plant-like glycerol 3-phosphate acyltransferase.
    PLOS Pathogens 12, e1005765 PubMed abstract
  • Blassberg, R; MacRae, JI; Briscoe, J and Jacob, J (2016)
    Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz Syndrome.
    Human Molecular Genetics 25, 693-705 PubMed abstract
  • Creek, DJ; Chua, HH; Cobbold, SA; Nijagal, B; Macrae, JI; Dickerman, BK; Gilson, PR; Ralph, SA and McConville, MJ (2016)
    Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action.
    Antimicrobial Agents and Chemotherapy 60, 6650-6663 PubMed abstract
  • Jacot, D; Waller, RF; Soldati-Favre, D; MacPherson, DA and MacRae, JI (2016)
    Apicomplexan energy metabolism: carbon source promiscuity and the quiescence hyperbole.
    Trends in Parasitology 32, 56-70 PubMed abstract
  • Pericleous, C; Ferreira, I; Borghi, O; Pregnolato, F; McDonnell, T; Garza-Garcia, A; Driscoll, P; Pierangeli, S; Isenberg, D; Ioannou, Y; Giles, I; Meroni, PL and Rahman, A (2016)
    Measuring IgA anti-β2-glycoprotein I and IgG/IgA anti-domain I antibodies adds value to current serological assays for the antiphospholipid syndrome.
    PLOS ONE 11, e0156407 PubMed abstract
  • Srivastava, A; Philip, N; Hughes, KR; Georgiou, K; MacRae, JI; Barrett, MP; Creek, DJ; McConville, MJ and Waters, AP (2016)
    Stage-specific changes in Plasmodium metabolism required for differentiation and adaptation to different host and vector environments.
    PLOS Pathogens 12, e1006094 PubMed abstract
  • Allen, SM; Lim, EE; Jortzik, E; Preuss, J; Chua, HH; MacRae, JI; Rahlfs, S; Haeussler, K; Downton, MT; McConville, MJ; Becker, K and Ralph, SA (2015)
    Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target.
    FEBS Journal 282, 3808-3823 PubMed abstract
  • Bailey, AP; Koster, G; Guillermier, C; Hirst, EMA; MacRae, JI; Lechene, CP; Postle, AD and Gould, AP (2015)
    Antioxidant role for lipid droplets in a stem cell niche of Drosophila.
    Cell 163, 340-353 PubMed abstract
  • Gornik, SG; Febrimarsa; Cassin, AM; MacRae, JI; Ramaprasad, A; Rchiad, Z; McConville, MJ; Bacic, A; McFadden, GI; Pain, A and Waller, RF (2015)
    Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate.
    Proceedings of the National Academy of Sciences of the United States of America 112, 5767-5772 PubMed abstract
  • Macrae, JI and McConville, MJ (2015)
    A gas chromatography-mass spectrometry-based two stage assay for measurement of in vitro myo-inositol 3-phosphate synthase (INO1) activity.
    Bio-Protocol 5, e1418
  • Ramakrishnan, S; Docampo, MD; MacRae, JI; Ralton, JE; Rupasinghe, T; McConville, MJ and Striepen, B (2015)
    The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell.
    Molecular Microbiology 97, 64-76 PubMed abstract
  • MacRae, JI; Lopaticki, S; Maier, AG; Rupasinghe, T; Nahid, A; Cowman, AF and McConville, MJ (2014)
    Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity.
    Molecular Microbiology 91, 762-776 PubMed abstract
  • Oppenheim, RD; Creek, DJ; Macrae, JI; Modrzynska, KK; Pino, P; Limenitakis, J; Polonais, V; Seeber, F; Barrett, MP; Billker, O; McConville, MJ and Soldati-Favre, D (2014)
    BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei.
    PLOS Pathogens 10, e1004263 PubMed abstract
  • Villaseñor, A; Ramamoorthy, A; Silva dos Santos, M; Lorenzo, MP; Laje, G; Zarate, C, Jr.; Barbas, C and Wainer, IW (2014)
    A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks.
    British Journal of Pharmacology 171, 2230-2242 PubMed abstract
  • Botté, CY; Yamaryo-Botté, Y; Rupasinghe, TWT; Mullin, KA; MacRae, JI; Spurck, TP; Kalanon, M; Shears, MJ; Coppel, RL; Crellin, PK; Maréchal, E; McConville, MJ and McFadden, GI (2013)
    Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites.
    Proceedings of the National Academy of Sciences of the United States of America 110, 7506-7511 PubMed abstract
  • Danne, JC; Gornik, SG; MacRae, JI; McConville, MJ and Waller, RF (2013)
    Alveolate mitochondrial metabolic evolution: dinoflagellates force reassessment of the role of parasitism as a driver of change in apicomplexans.
    Molecular Biology and Evolution 30, 123-139 PubMed abstract
  • MacRae, JI; Dixon, MWA; Dearnley, MK; Chua, HH; Chambers, JM; Kenny, S; Bottova, I; Tilley, L and McConville, MJ (2013)
    Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum.
    BMC Biology 11, 67 PubMed abstract
  • Ragan, TJ; Bailey, AP; Gould, AP and Driscoll, PC (2013)
    Volume determination with two standards allows absolute quantification and improved chemometric analysis of metabolites by NMR from submicroliter samples.
    Analytical Chemistry 85, 12046-12054 PubMed abstract
  • MacRae, JI; Marechal, E; Biot, C and Botte, CY (2012)
    The apicoplast: a key target to cure malaria.
    Current Pharmaceutical Design 18, 3490-3504 PubMed abstract
  • MacRae, JI; Sheiner, L; Nahid, A; Tonkin, C; Striepen, B and McConville, MJ (2012)
    Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii.
    Cell Host & Microbe 12, 682-692 PubMed abstract
  • Ramakrishnan, S; Docampo, MD; MacRae, JI; Pujol, FM; Brooks, CF; van Dooren, GG; Hiltunen, JK; Kastaniotis, AJ; McConville, MJ and Striepen, B (2012)
    Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii.
    Journal of Biological Chemistry 287, 4957-4971 PubMed abstract
  • Saunders, EC; MacRae, JI; Naderer, T; Ng, M; McConville, MJ and Likić, VA (2012)
    LeishCyc: a guide to building a metabolic pathway database and visualization of metabolomic data.
    Methods in Molecular Biology 881, 505-529 PubMed abstract
  • Cheng, LY; Bailey, AP; Leevers, SJ; Ragan, TJ; Driscoll, PC and Gould, AP (2011)
    Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila.
    Cell 146, 435-447 PubMed abstract
  • Saunders, EC; De Souza, DP; MacRae, JI; Likić, VA and McConville, MJ (2011)
    Metabolomic analysis of protozoan parasites.
    Microbiology Australia 32, 144-147
  • Saunders, EC; De Souza, DP; Naderer, T; Sernee, MF; Ralton, JE; Doyle, MA; MacRae, JI; Chambers, JL; Heng, J; Nahid, A; Likic, VA and McConville, MJ (2010)
    Central carbon metabolism of Leishmania parasites.
    Parasitology 137, 1303-1313 PubMed abstract

[Page last updated 1 Nov 2017]

James MacRae 

james.macrae@crick.ac.uk
+44 (0) 20 8816 2071