Experimental Histopathology: Publications

  • Egawa, N; Wang, Q; Griffin, HM; Murakami, I; Jackson, D; Mahmood, R and Doorbar, J (2017)
    HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions.
    PLOS Pathogens 13, e1006282 PubMed abstract
  • Ferreira, RMM; Sancho, R; Messal, HA; Nye, E; Spencer-Dene, B; Stone, RK; Stamp, G; Rosewell, I; Quaglia, A and Behrens, A (2017)
    Duct- and acinar-derived pancreatic ductal adenocarcinomas show distinct tumor progression and marker expression.
    Cell Reports 21, 966-978 PubMed abstract
  • Khan, S; Stott, S; Chabrat, A; Truckenbrodt, AM; Spencer-Dene, B; Nave, K-A; Guillemot, F; Levesque, M and Ang, S-L (2017)
    Survival of a novel subset of midbrain dopaminergic neurons projecting to the lateral septum is dependent on NeuroD proteins.
    Journal of Neuroscience 37, 2305-2316 PubMed abstract
  • Koch, P-S; Olsavszky, V; Ulbrich, F; Sticht, C; Demory, A; Leibing, T; Henzler, T; Meyer, M; Zierow, J; Schneider, S; Breitkopf-Heinlein, K; Gaitantzi, H; Spencer-Dene, B; Arnold, B; Klapproth, K; Schledzewski, K; Goerdt, S and Géraud, C (2017)
    Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis.
    Blood 129, 415-419 PubMed abstract
  • Lin, J-W; Sodenkamp, J; Cunningham, D; Deroost, K; Tshitenge, TC; McLaughlin, S; Lamb, TJ; Spencer-Dene, B; Hosking, C; Ramesar, J; Janse, CJ; Graham, C; O'Garra, A and Langhorne, J (2017)
    Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria.
    Scientific Reports 7, 41722 PubMed abstract
  • López-Garcia, C; Sansregret, L; Domingo, E; McGranahan, N; Hobor, S; Birkbak, NJ; Horswell, S; Grönroos, E; Favero, F; Rowan, AJ; Matthews, N; Begum, S; Phillimore, B; Burrell, R; Oukrif, D; Spencer-Dene, B; Kovac, M; Stamp, G; Stewart, A; Danielsen, H; Novelli, M; Tomlinson, I and Swanton, C (2017)
    BCL9L dysfunction impairs caspase-2 expression permitting aneuploidy tolerance in colorectal cancer.
    Cancer Cell 31, 79-93 PubMed abstract
  • Williamson, L; Saponaro, M; Boeing, S; East, P; Mitter, R; Kantidakis, T; Kelly, GP; Lobley, A; Walker, J; Spencer-Dene, B; Howell, M; Stewart, A and Svejstrup, JQ (2017)
    UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene.
    Cell 168, 843-855 PubMed abstract
  • Yu-Wai-Man, C; Spencer-Dene, B; Lee, RMH; Hutchings, K; Lisabeth, EM; Treisman, R; Bailly, M; Larsen, SD; Neubig, RR and Khaw, PT (2017)
    Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis.
    Scientific Reports 7, 518 PubMed abstract
  • Blaas, L; Pucci, F; Messal, HA; Andersson, AB; Ruiz, EJ; Gerling, M; Douagi, I; Spencer-Dene, B; Musch, A; Mitter, R; Bhaw, L; Stone, R; Bornhorst, D; Sesay, AK; Jonkers, J; Stamp, G; Malanchi, I; Toftgård, R and Behrens, A (2016)
    Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.
    Nature Cell Biology 18, 1346-1356 PubMed abstract
  • Di Marco Barros, R; Roberts, NA; Dart, RJ; Vantourout, P; Jandke, A; Nussbaumer, O; Deban, L; Cipolat, S; Hart, R; Iannitto, ML; Laing, A; Spencer-Dene, B; East, P; Gibbons, D; Irving, PM; Pereira, P; Steinhoff, U and Hayday, A (2016)
    Epithelia use butyrophilin-like molecules to shape organ-specific γδ T cell compartments.
    Cell 167, 203-218 e217 PubMed abstract
  • Elbediwy, A; Vincent-Mistiaen, ZI; Spencer-Dene, B; Stone, RK; Boeing, S; Wculek, SK; Cordero, J; Tan, EH; Ridgway, R; Brunton, VG; Sahai, E; Gerhardt, H; Behrens, A; Malanchi, I; Sansom, OJ and Thompson, BJ (2016)
    Integrin signalling regulates YAP and TAZ to control skin homeostasis.
    Development 143, 1674-1687 PubMed abstract
  • Gruber, R; Panayiotou, R; Nye, E; Spencer-Dene, B; Stamp, G and Behrens, A (2016)
    YAP1 and TAZ control pancreatic cancer initiation in mice by direct up-regulation of JAK-STAT3 signaling.
    Gastroenterology 151, 526-539 PubMed abstract
  • Kannan, Y; Perez-Lloret, J; Li, Y; Entwistle, LJ; Khoury, H; Papoutsopoulou, S; Mahmood, R; Mansour, NR; Ching-Cheng Huang, S; Pearce, EJ; de Carvalho, LPS; Ley, SC and Wilson, MS (2016)
    TPL-2 regulates macrophage lipid metabolism and M2 differentiation to control TH2-mediated immunopathology.
    PLOS Pathogens 12, e1005783 PubMed abstract
  • Kümper, S; Mardakheh, FK; McCarthy, A; Yeo, M; Stamp, GW; Paul, A; Worboys, J; Sadok, A; Jørgensen, C; Guichard, S and Marshall, CJ (2016)
    Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
    eLife 5, e12203 PubMed abstract
  • Lorenzi, F; Babaei-Jadidi, R; Sheard, J; Spencer-Dene, B and Nateri, AS (2016)
    Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture.
    Molecular Therapy. Methods & Clinical Development 3, 16024 PubMed abstract
  • Morales Torres, C; Biran, A; Burney, MJ; Patel, H; Henser-Brownhill, T; Cohen, A-HS; Li, Y; Ben-Hamo, R; Nye, E; Spencer-Dene, B; Chakravarty, P; Efroni, S; Matthews, N; Misteli, T; Meshorer, E and Scaffidi, P (2016)
    The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.
    Science 353, aaf1644 PubMed abstract
  • Peck, B; Schug, ZT; Zhang, Q; Dankworth, B; Jones, DT; Smethurst, E; Patel, R; Mason, S; Jiang, M; Saunders, R; Howell, M; Mitter, R; Spencer-Dene, B; Stamp, G; McGarry, L; James, D; Shanks, E; Aboagye, EO; Critchlow, SE; Leung, HY; Harris, AL; Wakelam, MJO; Gottlieb, E and Schulze, A (2016)
    Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.
    Cancer & Metabolism 4, 6 PubMed abstract
  • Quétier, I; Marshall, JJT; Spencer-Dene, B; Lachmann, S; Casamassima, A; Franco, C; Escuin, S; Worrall, JT; Baskaran, P; Rajeeve, V; Howell, M; Copp, AJ; Stamp, G; Rosewell, I; Cutillas, P; Gerhardt, H; Parker, PJ and Cameron, AJM (2016)
    Knockout of the PKN family of Rho effector kinases reveals a non-redundant role for PKN2 in developmental mesoderm expansion.
    Cell Reports 14, 440-448 PubMed abstract
  • Smith, SJ; Towers, N; Saldanha, JW; Shang, CA; Mahmood, SR; Taylor, WR and Mohun, TJ (2016)
    The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly.
    Developmental Biology 416, 373-388 PubMed abstract
  • Baenke, F; Dubuis, S; Brault, C; Weigelt, B; Dankworth, B; Griffiths, B; Jiang, M; Mackay, A; Saunders, B; Spencer-Dene, B; Ros, S; Stamp, G; Reis-Filho, JS; Howell, M; Zamboni, N and Schulze, A (2015)
    Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival.
    Journal of Pathology 237, 152-165 PubMed abstract
  • Coda, S; Siersema, PD; Stamp, GWH and Thillainayagam, AV (2015)
    Biophotonic endoscopy: a review of clinical research techniques for optical imaging and sensing of early gastrointestinal cancer.
    Endoscopy International Open 3, E380-E392 PubMed abstract
  • del Pozo Martin, Y; Park, D; Ramachandran, A; Ombrato, L; Calvo, F; Chakravarty, P; Spencer-Dene, B; Derzsi, S; Hill, CS; Sahai, E and Malanchi, I (2015)
    Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization.
    Cell Reports 13, 2456-2469 PubMed abstract
  • Favero, F; McGranahan, N; Salm, M; Birkbak, NJ; Sanborn, JZ; Benz, SC; Becq, J; Peden, JF; Kingsbury, Z; Grocok, RJ; Humphray, S; Bentley, D; Spencer-Dene, B; Gutteridge, A; Brada, M; Roger, S; Dietrich, P-Y; Forshew, T; Gerlinger, M; Rowan, A; Stamp, G; Eklund, AC; Szallasi, Z and Swanton, C (2015)
    Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.
    Annals of Oncology 26, 880-887 PubMed abstract
  • Hirata, E; Girotti, MR; Viros, A; Hooper, S; Spencer-Dene, B; Matsuda, M; Larkin, J; Marais, R and Sahai, E (2015)
    Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling.
    Cancer Cell 27, 574-588 PubMed abstract
  • Kovac, M; Navas, C; Horswell, S; Salm, M; Bardella, C; Rowan, A; Stares, M; Castro-Giner, F; Fisher, R; de Bruin, EC; Kovacova, M; Gorman, M; Makino, S; Williams, J; Jaeger, E; Jones, A; Howarth, K; Larkin, J; Pickering, L; Gore, M; Nicol, DL; Hazell, S; Stamp, G; O'Brien, T; Challacombe, B; Matthews, N; Phillimore, B; Begum, S; Rabinowitz, A; Varela, I; Chandra, A; Horsfield, C; Polson, A; Tran, M; Bhatt, R; Terracciano, L; Eppenberger-Castori, S; Protheroe, A; Maher, E; El Bahrawy, M; Fleming, S; Ratcliffe, P; Heinimann, K; Swanton, C and Tomlinson, I (2015)
    Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution.
    Nature Communications 6, 6336 PubMed abstract
  • Schug, ZT; Peck, B; Jones, DT; Zhang, Q; Grosskurth, S; Alam, IS; Goodwin, LM; Smethurst, E; Mason, S; Blyth, K; McGarry, L; James, D; Shanks, E; Kalna, G; Saunders, RE; Jiang, M; Howell, M; Lassailly, F; Thin, MZ; Spencer-Dene, B; Stamp, G; van den Broek, NJF; Mackay, G; Bulusu, V; Kamphorst, JJ; Tardito, S; Strachan, D; Harris, AL; Aboagye, EO; Critchlow, SE; Wakelam, MJO; Schulze, A and Gottlieb, E (2015)
    Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.
    Cancer Cell 27, 57-71 PubMed abstract
  • van Boxtel, AL; Chesebro, JE; Heliot, C; Ramel, M-C; Stone, RK and Hill, CS (2015)
    A temporal window for signal activation dictates the dimensions of a nodal signaling domain.
    Developmental Cell 35, 175-185 PubMed abstract
  • Acton, SE; Farrugia, AJ; Astarita, JL; Mourão-Sá, D; Jenkins, RP; Nye, E; Hooper, S; van Blijswijk, J; Rogers, NC; Snelgrove, KJ; Rosewell, I; Moita, LF; Stamp, G; Turley, SJ; Sahai, E and Reis e Sousa, C (2014)
    Dendritic cells control fibroblastic reticular network tension and lymph node expansion.
    Nature 514, 498-502 PubMed abstract
  • de Bruin, EC; McGranahan, N; Mitter, R; Salm, M; Wedge, DC; Yates, L; Jamal-Hanjani, M; Shafi, S; Murugaesu, N; Rowan, AJ; Grönroos, E; Muhammad, MA; Horswell, S; Gerlinger, M; Varela, I; Jones, D; Marshall, J; Voet, T; Van Loo, P; Rassl, DM; Rintoul, RC; Janes, SM; Lee, S-M; Forster, M; Ahmad, T; Lawrence, D; Falzon, M; Capitanio, A; Harkins, TT; Lee, CC; Tom, W; Teefe, E; Chen, S-C; Begum, S; Rabinowitz, A; Phillimore, B; Spencer-Dene, B; Stamp, G; Szallasi, Z; Matthews, N; Stewart, A; Campbell, P and Swanton, C (2014)
    Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.
    Science 346, 251-256 PubMed abstract
  • Diefenbacher, ME; Popov, N; Blake, SM; Schülein-Völk, C; Nye, E; Spencer-Dene, B; Jaenicke, LA; Eilers, M and Behrens, A (2014)
    The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.
    Journal of Clinical Investigation 124, 3407-3418 PubMed abstract
  • Fisher, R; Horswell, S; Rowan, A; Salm, MP; de Bruin, EC; Gulati, S; McGranahan, N; Stares, M; Gerlinger, M; Varela, I; Crockford, A; Favero, F; Quidville, V; André, F; Navas, C; Grönroos, E; Nicol, D; Hazell, S; Hrouda, D; O'Brien, T; Matthews, N; Phillimore, B; Begum, S; Rabinowitz, A; Biggs, J; Bates, PA; McDonald, NQ; Stamp, G; Spencer-Dene, B; Hsieh, JJ; Xu, J; Pickering, L; Gore, M; Larkin, J and Swanton, C (2014)
    Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution.
    Genome Biology 15, 433 PubMed abstract
  • Gerlinger, M; Horswell, S; Larkin, J; Rowan, AJ; Salm, MP; Varela, I; Fisher, R; McGranahan, N; Matthews, N; Santos, CR; Martinez, P; Phillimore, B; Begum, S; Rabinowitz, A; Spencer-Dene, B; Gulati, S; Bates, PA; Stamp, G; Pickering, L; Gore, M; Nicol, DL; Hazell, S; Futreal, PA; Stewart, A and Swanton, C (2014)
    Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.
    Nature Genetics 46, 225-233 PubMed abstract
  • Murillo, MM; Zelenay, S; Nye, E; Castellano, E; Lassailly, F; Stamp, G and Downward, J (2014)
    RAS interaction with PI3K p110α is required for tumor-induced angiogenesis.
    Journal of Clinical Investigation 124, 3601-3611 PubMed abstract
  • Terenzio, M; Golding, M; Russell, MRG; Wicher, KB; Rosewell, I; Spencer-Dene, B; Ish-Horowicz, D and Schiavo, G (2014)
    Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors.
    EMBO Journal 33, 1582-1598 PubMed abstract
  • Veeriah, S; Leboucher, P; de Naurois, J; Jethwa, N; Nye, E; Bunting, T; Stone, R; Stamp, G; Calleja, V; Jeffrey, SS; Parker, PJ and Larijani, B (2014)
    High-throughput time-resolved FRET reveals Akt/PKB activation as a poor prognostic marker in breast cancer.
    Cancer Research 74, 4983-4995 PubMed abstract
  • Adelman, CA; Lolo, RL; Birkbak, NJ; Murina, O; Matsuzaki, K; Horejsi, Z; Parmar, K; Borel, V; Skehel, JM; Stamp, G; D'Andrea, A; Sartori, AA; Swanton, C and Boulton, SJ (2013)
    HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
    Nature 502, 381-384 PubMed abstract
  • Castellano, E; Sheridan, C; Thin, MZ; Nye, E; Spencer-Dene, B; Diefenbacher, ME; Moore, C; Kumar, MS; Murillo, MM; Grönroos, E; Lassailly, F; Stamp, G and Downward, J (2013)
    Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance.
    Cancer Cell 24, 617-630 PubMed abstract
  • Chaudhry, SI; Hooper, S; Nye, E; Williamson, P; Harrington, K and Sahai, E (2013)
    Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts.
    Oncogene 32, 747-758 PubMed abstract
  • De Filippo, K; Dudeck, A; Hasenberg, M; Nye, E; van Rooijen, N; Hartmann, K; Gunzer, M; Roers, A and Hogg, N (2013)
    Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation.
    Blood 121, 4930-4937 PubMed abstract
  • Fritsch, R; de Krijger, I; Fritsch, K; George, R; Reason, B; Kumar, MS; Diefenbacher, M; Stamp, G and Downward, J (2013)
    RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
    Cell 153, 1050-1063 PubMed abstract
  • Humphries, A; Cereser, B; Gay, LJ; Miller, DSJ; Das, B; Gutteridge, A; Elia, G; Nye, E; Jeffery, R; Poulsom, R; Novelli, MR; Rodriguez-Justo, M; McDonald, SAC; Wright, NA and Graham, TA (2013)
    Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.
    Proceedings of the National Academy of Sciences of the United States of America 110, E2490-E2499 PubMed abstract
  • Teixeira, VH; Nadarajan, P; Graham, TA; Pipinikas, CP; Brown, JM; Falzon, M; Nye, E; Poulsom, R; Lawrence, D; Wright, NA; McDonald, S; Giangreco, A; Simons, BD and Janes, SM (2013)
    Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors.
    eLife 2, e00966 PubMed abstract
  • Cesca, F; Yabe, A; Spencer-Dene, B; Scholz-Starke, J; Medrihan, L; Maden, CH; Gerhardt, H; Orriss, IR; Baldelli, P; Al-Qatari, M; Koltzenburg, M; Adams, RH; Benfenati, F and Schiavo, G (2012)
    Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems.
    Cell Death and Differentiation 19, 194-208 PubMed abstract
  • Ferone, G; Thomason, HA; Antonini, D; De Rosa, L; Hu, B; Gemei, M; Zhou, H; Ambrosio, R; Rice, DP; Acampora, D; van Bokhoven, H; Del Vecchio, L; Koster, MI; Tadini, G; Spencer-Dene, B; Dixon, M; Dixon, J and Missero, C (2012)
    Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome.
    EMBO Molecular Medicine 4, 192-205 PubMed abstract
  • Fontana, X; Hristova, M; Da Costa, C; Patodia, S; Thei, L; Makwana, M; Spencer-Dene, B; Latouche, M; Mirsky, R; Jessen, KR; Klein, R; Raivich, G and Behrens, A (2012)
    c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling.
    Journal of Cell Biology 198, 127-141 PubMed abstract
  • Gerlinger, M; Rowan, AJ; Horswell, S; Larkin, J; Endesfelder, D; Gronroos, E; Martinez, P; Matthews, N; Stewart, A; Tarpey, P; Varela, I; Phillimore, B; Begum, S; McDonald, NQ; Butler, A; Jones, D; Raine, K; Latimer, C; Santos, CR; Nohadani, M; Eklund, AC; Spencer-Dene, B; Clark, G; Pickering, L; Stamp, G; Gore, M; Szallasi, Z; Downward, J; Futreal, PA and Swanton, C (2012)
    Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
    New England Journal of Medicine 366, 883-892 PubMed abstract
  • Gerlinger, M; Santos, CR; Spencer-Dene, B; Martinez, P; Endesfelder, D; Burrell, RA; Vetter, M; Jiang, M; Saunders, RE; Kelly, G; Dykema, K; Rioux-Leclercq, N; Stamp, G; Patard, JJ; Larkin, J; Howell, M and Swanton, C (2012)
    Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.
    Journal of Pathology 227, 146-156 PubMed abstract
  • Ibrahim, EE; Babaei-Jadidi, R; Saadeddin, A; Spencer-Dene, B; Hossaini, S; Abuzinadah, M; Li, N; Fadhil, W; Ilyas, M; Bonnet, D and Nateri, AS (2012)
    Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms.
    Stem Cells 30, 2076-2087 PubMed abstract
  • Kumar, MS; Hancock, DC; Molina-Arcas, M; Steckel, M; East, P; Diefenbacher, M; Armenteros-Monterroso, E; Lassailly, F; Matthews, N; Nye, E; Stamp, G; Behrens, A and Downward, J (2012)
    The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.
    Cell 149, 642-655 PubMed abstract
  • Lewis, A; Davis, H; Deheragoda, M; Pollard, P; Nye, E; Jeffery, R; Segditsas, S; East, P; Poulsom, R; Stamp, G; Wright, N and Tomlinson, I (2012)
    The C-terminus of Apc does not influence intestinal adenoma development or progression.
    Journal of Pathology 226, 73-83 PubMed abstract
  • Valorani, MG; Montelatici, E; Germani, A; Biddle, A; D'Alessandro, D; Strollo, R; Patrizi, MP; Lazzari, L; Nye, E; Otto, WR; Pozzilli, P and Alison, MR (2012)
    Pre-culturing human adipose tissue mesenchymal stem cells under hypoxia increases their adipogenic and osteogenic differentiation potentials.
    Cell Proliferation 45, 225-238 PubMed abstract
  • Adam, J; Hatipoglu, E; O'Flaherty, L; Ternette, N; Sahgal, N; Lockstone, H; Baban, D; Nye, E; Stamp, GW; Wolhuter, K; Stevens, M; Fischer, R; Carmeliet, P; Maxwell, PH; Pugh, CW; Frizzell, N; Soga, T; Kessler, BM; El-Bahrawy, M; Ratcliffe, PJ and Pollard, PJ (2011)
    Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
    Cancer Cell 20, 524-537 PubMed abstract
  • Babaei-Jadidi, R; Li, N; Saadeddin, A; Spencer-Dene, B; Jandke, A; Muhammad, B; Ibrahim, EE; Muraleedharan, R; Abuzinadah, M; Davis, H; Lewis, A; Watson, S; Behrens, A; Tomlinson, I and Nateri, AS (2011)
    FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
    Journal of Experimental Medicine 208, 295-312 PubMed abstract
  • Baker, JR; Jeffery, R; May, RD; Mathies, M; Spencer-Dene, B; Poulsom, R and Hogg, N (2011)
    Distinct roles for S100a8 in early embryo development and in the maternal deciduum.
    Developmental Dynamics 240, 2194-2203 PubMed abstract
  • Cesca, F; Yabe, A; Spencer-Dene, B; Arrigoni, A; Al-Qatari, M; Henderson, D; Phillips, H; Koltzenburg, M; Benfenati, F and Schiavo, G (2011)
    Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development.
    Cell Death & Disease 2, e226 PubMed abstract
  • Davis, H; Lewis, A; Spencer-Dene, B; Tateossian, H; Stamp, G; Behrens, A and Tomlinson, I (2011)
    FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development.
    Journal of Pathology 224, 180-189 PubMed abstract
  • Giangreco, A; Lu, L; Mazzatti, DJ; Spencer-Dene, B; Nye, E; Teixeira, VH and Janes, SM (2011)
    Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance.
    Journal of Pathology 224, 190-202 PubMed abstract
  • Hunziker, L; Benitah, SA; Braun, KM; Jensen, K; McNulty, K; Butler, C; Potton, E; Nye, E; Boyd, R; Laurent, G; Glogauer, M; Wright, NA; Watt, FM and Janes, SM (2011)
    Rac1 deletion causes thymic atrophy.
    PLOS ONE 6, e19292 PubMed abstract
  • Jandke, A; Da Costa, C; Sancho, R; Nye, E; Spencer-Dene, B and Behrens, A (2011)
    The F-box protein Fbw7 is required for cerebellar development.
    Developmental Biology 358, 201-212 PubMed abstract
  • Köhler, A; De Filippo, K; Hasenberg, M; van den Brandt, C; Nye, E; Hosking, MP; Lane, TE; Männ, L; Ransohoff, RM; Hauser, AE; Winter, O; Schraven, B; Geiger, H; Hogg, N and Gunzer, M (2011)
    G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.
    Blood 117, 4349-4357 PubMed abstract
  • Lee, MY; Racine, V; Jagadpramana, P; Sun, L; Yu, W; Du, T; Spencer-Dene, B; Rubin, N; Le, L; Ndiaye, D; Bellusci, S; Kratochwil, K and Veltmaat, JM (2011)
    Ectodermal influx and cell hypertrophy provide early growth for all murine mammary rudiments, and are differentially regulated among them by Gli3.
    PLOS ONE 6, e26242 PubMed abstract
  • Lubbe, SJ; Pittman, AM; Matijssen, C; Twiss, P; Olver, B; Lloyd, A; Qureshi, M; Brown, N; Nye, E; Stamp, G; Blagg, J and Houlston, RS (2011)
    Evaluation of germline BMP4 mutation as a cause of colorectal cancer.
    Human Mutation 32, E1928-E1938 PubMed abstract
  • Stamataki, D; Holder, M; Hodgetts, C; Jeffery, R; Nye, E; Spencer-Dene, B; Winton, DJ and Lewis, J (2011)
    Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.
    PLOS ONE 6, e24484
  • Ashrafian, H; O'Flaherty, L; Adam, J; Steeples, V; Chung, Y-L; East, P; Vanharanta, S; Lehtonen, H; Nye, E; Hatipoglu, E; Miranda, M; Howarth, K; Shukla, D; Troy, H; Griffiths, J; Spencer-Dene, B; Yusuf, M; Volpi, E; Maxwell, PH; Stamp, G; Poulsom, R; Pugh, CW; Costa, B; Bardella, C; Di Renzo, MF; Kotlikoff, MI; Launonen, V; Aaltonen, L; El-Bahrawy, M; Tomlinson, I and Pollard, PJ (2010)
    Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.
    Cancer Research 70, 9153-9165 PubMed abstract
  • Hoeck, JD; Jandke, A; Blake, SM; Nye, E; Spencer-Dene, B; Brandner, S and Behrens, A (2010)
    Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.
    Nature Neuroscience 13, 1365-1372 PubMed abstract
  • Kyriazi, S; Nye, E; Stamp, G; Collins, DJ; Kaye, SB and deSouza, NM (2010)
    Value of diffusion-weighted imaging for assessing site-specific response of advanced ovarian cancer to neoadjuvant chemotherapy: correlation of apparent diffusion coefficients with epithelial and stromal densities on histology.
    Cancer Biomarkers 7, 201-210 PubMed abstract
  • Lewis, A; Segditsas, S; Deheragoda, M; Pollard, P; Jeffery, R; Nye, E; Lockstone, H; Davis, H; Clark, S; Stamp, G; Poulsom, R; Wright, N and Tomlinson, I (2010)
    Severe polyposis in Apc1322T mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.
    Gut 59, 1680-1686 PubMed abstract
  • Poulin, LF; Salio, M; Griessinger, E; Anjos-Afonso, F; Craciun, L; Chen, J-L; Keller, AM; Joffre, O; Zelenay, S; Nye, E; Le Moine, A; Faure, F; Donckier, V; Sancho, D; Cerundolo, V; Bonnet, D and Reis e Sousa, C (2010)
    Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells.
    Journal of Experimental Medicine 207, 1261-1271 PubMed abstract
  • Swanton, C; Larkin, JM; Gerlinger, M; Eklund, AC; Howell, M; Stamp, G; Downward, J; Gore, M; Futreal, PA; Escudier, B; Andre, F; Albiges, L; Beuselinck, B; Oudard, S; Hoffmann, J; Gyorffy, B; Torrance, CJ; Boehme, KA; Volkmer, H; Toschi, L; Nicke, B; Beck, M and Szallasi, Z (2010)
    Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets.
    Genome Medicine 2, 53 PubMed abstract

[Page last updated 1 Nov 2017]

Emma Nye (Lead) 

emma.nye@crick.ac.uk
+44 (0) 20 7269 3621