MRC Biomedical NMR Centre

The Medical Research Council (MRC) Biomedical NMR Centre is a multi-user national facility for biomolecular liquid-state nuclear magnetic resonance (NMR). The Centre was set up by the MRC in 1980 to provide advanced and well-supported facilities for use by scientists at the National Institute for Medical Research (now part of the Francis Crick Institute) and other UK academic research establishments.

NMR studies of the type carried out at the Centre provide a wide range of information, ranging from the atomic-level (e.g. determining the pKa of individual histidine groups in proteins), through to full determination of the structure and dynamics of proteins in solution. An important area of application is the identification of interaction surfaces between the components of macromolecular complexes.

The Centre's facilities consist of four spectrometers with 1H operating frequencies ranging from 600 MHz to 950 MHz, all configured for studies of biological macromolecules in solution. The Centre's 950 MHz spectrometer resulted from substantial investment by the MRC and is only the second such instrument in the UK.

All of the instruments have cryogenically cooled probes and two are equipped with high-capacity automatic sample-changers. The facilities are currently used by research groups from 14 different universities and institutes from around the UK.

Spectrometer

Magnet of the Centre's 950 MHz spectrometer.

More information about the MRC Biomedical NMR Centre is available here.