Publications

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

Authors (8)

Nature Communications

Published 26 October 2023

Crick labs/ facilities

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Method to generate Holliday junction recombination intermediates via RecA-mediated four-strand exchange

Authors (2)

Analytical Biochemistry

Published 1 December 2023

Crick labs

Stephen West

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Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein

Authors (11)

Molecular Cell

Published 17 August 2023

Crick labs

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Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor

Authors (10)

Nature

Published 20 July 2023

Crick labs/ facilities

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Human endonuclease ANKLE1 localizes at the midbody and processes chromatin bridges to prevent DNA damage and cGAS-STING activation

Authors (5)

Huadong Jiang
Nannan Kong
Zeyuan Liu
Stephen West
Ying Wai Chan

Advanced Science

Published 26 April 2023

Crick labs

Stephen West

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GEN1 promotes common fragile site expression

Authors (7)

Cell Reports

Published 28 February 2023

Crick labs/ facilities

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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

Authors (16)

Ondrej Belan
Marie Sebald
Marek Adamowicz
Roopesh Anand
Aleksandra Vancevska
Joana Neves
[...]
Geoff S Higgins
Graeme CM Smith
Stephen West
David S Rueda
Simon Boulton

Molecular Cell

Published 15 December 2022

Crick labs

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Generation of double Holliday junction DNAs and their dissolution/resolution within a chromatin context

Authors (2)

Proceedings of the National Academy of Sciences of USA

Published 3 May 2022

Crick labs/ facilities

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Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation

Authors (17)

Madison Caballero
Tiffany Ge
Ana Rita Rebelo
Seungmae Seo
Sean Kim
Kayla Brooks
[...]
Nissim Benvenisty
Stephen West
Dieter Egli
Emily M Mace
Amnon Koren

Human Molecular Genetics

Published 1 September 2022

Crick labs

Stephen West

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Integrated genome and transcriptome analyses reveal the mechanism of genome instability in ataxia with oculomotor apraxia 2

Authors (13)

Radhakrishnan Kanagaraj
Richard Mitter
Theodoros Kantidakis
Matthew M Edwards
Anaid Benitez
Probir Chakravarty
[...]
Fengtang Yang
Martin F Lavin
Amnon Koren
Aengus Stewart
Stephen West

Proceedings of the National Academy of Sciences of USA

Published 25 January 2022

Crick labs/ facilities

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Tackling PARP inhibitor resistance

Authors (4)

Trends in Cancer

Published 1 December 2021

Crick labs

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Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability

Authors (2)

Critical Reviews in Biochemistry and Molecular Biology

Published 17 February 2021

Crick labs

Stephen West

Full details

Charles M. Radding: A love of science and art

Authors (2)

Stephen West
Stephen C Kowalczykowski

Proceedings of the National Academy of Sciences of USA

Published 9 February 2021

Crick labs

Stephen West

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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Authors (27)

Graeme Hewitt
Valerie Borel
Sandra Segura-Bayona
Tohru Takaki
Phil Ruis
Roberto Bellelli
[...]
Ivan Ahel
Dragana Ahel
J Ross Chapman
Sebastian Deindl
Simon Boulton

Molecular Cell

Published 18 February 2021

Crick labs/ facilities

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MutSβ stimulates Holliday junction resolution by the SMX complex

Authors (8)

Cell Reports

Published 20 October 2020

Crick labs/ facilities

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Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Authors (33)

Niek van Wietmarschen
Sriram Sridharan
William J Nathan
Anthony Tubbs
Edmond M Chan
Elsa Callen
[...]
Stephen West
Peter J McHugh
Paul S Meltzer
Adam J Bass
André Nussenzweig

Nature

Published 8 October 2020

Crick labs

Stephen West

Full details

A new class of ultrafine anaphase bridges generated by homologous recombination

Authors (2)

Cell Cycle

Published 25 September 2018

Crick labs

Stephen West

Full details

GEN1 endonuclease: Purification and nuclease assays

Authors (2)

Methods in Enzymology

Published 9 January 2018

Crick labs

Stephen West

Full details

Preparation and resolution of Holliday junction DNA recombination intermediates

Authors (2)

Methods in Enzymology

Published 9 January 2018

Crick labs

Stephen West

Full details

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Postdoctoral clinical fellows

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: Publications

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Publications

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Journal

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1

Method to generate Holliday junction recombination intermediates via RecA-mediated four-strand exchange

Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein

Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor

Human endonuclease ANKLE1 localizes at the midbody and processes chromatin bridges to prevent DNA damage and cGAS-STING activation

GEN1 promotes common fragile site expression

POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

Generation of double Holliday junction DNAs and their dissolution/resolution within a chromatin context

Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation

Integrated genome and transcriptome analyses reveal the mechanism of genome instability in ataxia with oculomotor apraxia 2

Tackling PARP inhibitor resistance

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability

Charles M. Radding: A love of science and art

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

MutSβ stimulates Holliday junction resolution by the SMX complex

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

A new class of ultrafine anaphase bridges generated by homologous recombination

GEN1 endonuclease: Purification and nuclease assays

Preparation and resolution of Holliday junction DNA recombination intermediates

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Postdoctoral clinical fellows

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Research topics

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