Stephen West: Publications

  • Chan, YW; Fugger, K and West, SC (2018)
    Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations.
    Nature Cell Biology 20, 92-103 PubMed abstract
  • Chan, YW and West, SC (2018)
    GEN1 endonuclease: Purification and nuclease assays.
    Methods in Enzymology 600, 527-542 PubMed abstract
  • Shah Punatar, R and West, SC (2018)
    Preparation and resolution of Holliday junction DNA recombination intermediates.
    Methods in Enzymology 600, 569-590 PubMed abstract
  • West, SC and Chan, YW (2018)
    Genome instability as a consequence of defects in the resolution of recombination intermediates.
    Cold Spring Harbor Symposia on Quantitative Biology 82, [Epub ahead of print] PubMed abstract
  • Matos, J and West, SC (2017)
    Analysis of structure-selective endonuclease activities from yeast and human extracts.
    Methods in Enzymology 591, 271-286 PubMed abstract
  • Shah Punatar, R; Martin, MJ; Wyatt, HDM; Chan, YW and West, SC (2017)
    Resolution of single and double Holliday junction recombination intermediates by GEN1.
    Proceedings of the National Academy of Sciences of the United States of America 114, 443-450 PubMed abstract
  • Wyatt, HDM; Laister, RC; Martin, SR; Arrowsmith, CH and West, SC (2017)
    The SMX DNA repair tri-nuclease.
    Molecular Cell 65, 848-860 e811 PubMed abstract
  • Fugger, K and West, SC (2016)
    Keeping homologous recombination in check.
    Cell Research 26, 397-398 PubMed abstract
  • Kotýnková, K; Su, K-C; West, SC and Petronczki, M (2016)
    Plasma membrane association but not midzone recruitment of RhoGEF ECT2 is essential for cytokinesis.
    Cell Reports 17, 2672-2686 PubMed abstract
  • Chan, YW and West, S (2015)
    GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism.
    Nucleic Acids Research 43, 10882-10892 PubMed abstract
  • Gaur, V; Wyatt, HDM; Komorowska, W; Szczepanowski, RH; de Sanctis, D; Gorecka, KM; West, SC and Nowotny, M (2015)
    Structural and mechanistic analysis of the Slx1-Slx4 endonuclease.
    Cell Reports 10, 1467-1476 PubMed abstract
  • West, SC; Blanco, MG; Chan, YW; Matos, J; Sarbajna, S and Wyatt, HDM (2015)
    Resolution of recombination intermediates: mechanisms and regulation.
    Cold Spring Harbor Symposia on Quantitative Biology 80, 103-109 PubMed abstract
  • Blanco, MG; Matos, J and West, SC (2014)
    Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.
    Molecular Cell 54, 94-106 PubMed abstract
  • Chan, YW and West, SC (2014)
    Spatial control of the GEN1 Holliday junction resolvase ensures genome stability.
    Nature Communications 5, 4844 PubMed abstract
  • Matos, J and West, SC (2014)
    Holliday junction resolution: regulation in space and time.
    DNA Repair 19, 176-181 PubMed abstract
  • Pepe, A and West, SC (2014)
    MUS81-EME2 promotes replication fork restart.
    Cell Reports 7, 1048-1055 PubMed abstract
  • Pepe, A and West, SC (2014)
    Substrate specificity of the MUS81-EME2 structure selective endonuclease.
    Nucleic Acids Research 42, 3833-3845 PubMed abstract
  • Sarbajna, S; Davies, D and West, SC (2014)
    Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.
    Genes & Development 28, 1124-1136 PubMed abstract
  • Sarbajna, S and West, SC (2014)
    Holliday junction processing enzymes as guardians of genome stability.
    Trends in Biochemical Sciences 39, 409-419 PubMed abstract
  • Shahid, T; Soroka, J; Kong, EH; Malivert, L; McIlwraith, MJ; Pape, T; West, SC and Zhang, X (2014)
    Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor.
    Nature Structural & Molecular Biology 21, 962-968 PubMed abstract
  • Wyatt, HDM and West, SC (2014)
    Holliday junction resolvases.
    Cold Spring Harbor Perspectives in Biology 6, a023192 PubMed abstract
  • Coulthard, R; Deans, AJ; Swuec, P; Bowles, M; Costa, A; West, SC and McDonald, NQ (2013)
    Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.
    Structure 21, 1648-1658 PubMed abstract
  • Matos, J; Blanco, MG and West, SC (2013)
    Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation.
    Cell Reports 4, 76-86 PubMed abstract
  • Wyatt, HDM; Sarbajna, S; Matos, J and West, SC (2013)
    Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells.
    Molecular Cell 52, 234-247 PubMed abstract
  • Yüce, Ö and West, SC (2013)
    Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
    Molecular and Cellular Biology 33, 406-417 PubMed abstract
  • Zilio, N; Williamson, CT; Eustermann, S; Shah, R; West, SC; Neuhaus, D and Ulrich, HD (2013)
    DNA-dependent SUMO modification of PARP-1.
    DNA Repair 12, 761-773 PubMed abstract
  • Blackford, AN; Schwab, RA; Nieminuszczy, J; Deans, AJ; West, SC and Niedzwiedz, W (2012)
    The DNA translocase activity of FANCM protects stalled replication forks.
    Human Molecular Genetics 21, 2005-2016 PubMed abstract
  • Muñoz-Galván, S; Tous, C; Blanco, MG; Schwartz, EK; Ehmsen, KT; West, SC; Heyer, W-D and Aguilera, A (2012)
    Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange.
    Molecular and Cellular Biology 32, 1592-1603 PubMed abstract
  • Deans, AJ and West, SC (2011)
    DNA interstrand crosslink repair and cancer.
    Nature Reviews Cancer 11, 467-480 PubMed abstract
  • Matos, J; Blanco, MG; Maslen, S; Skehel, JM and West, SC (2011)
    Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis.
    Cell 147, 158-172 PubMed abstract
  • Wechsler, T; Newman, S and West, SC (2011)
    Aberrant chromosome morphology in human cells defective for Holliday junction resolution.
    Nature 471, 642-646 PubMed abstract
  • Blanco, MG; Matos, J; Rass, U; Ip, SCY and West, SC (2010)
    Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae.
    DNA Repair 9, 394-402 PubMed abstract
  • Eustermann, S; Brockmann, C; Mehrotra, PV; Yang, J-C; Loakes, D; West, SC; Ahel, I and Neuhaus, D (2010)
    Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
    Nature Structural & Molecular Biology 17, 241-243 PubMed abstract
  • Lorenz, A; West, SC and Whitby, MC (2010)
    The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.
    Nucleic Acids Research 38, 1866-1873 PubMed abstract
  • MacKay, C; Déclais, A-C; Lundin, C; Agostinho, A; Deans, AJ; MacArtney, TJ; Hofmann, K; Gartner, A; West, SC; Helleday, T; Lilley, DMJ and Rouse, J (2010)
    Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
    Cell 142, 65-76 PubMed abstract
  • Rass, U; Compton, SA; Matos, J; Singleton, MR; Ip, SCY; Blanco, MG; Griffith, JD and West, SC (2010)
    Mechanism of Holliday junction resolution by the human GEN1 protein.
    Genes & Development 24, 1559-1569 PubMed abstract
  • Thorslund, T; McIlwraith, MJ; Compton, SA; Lekomtsev, S; Petronczki, M; Griffith, JD and West, SC (2010)
    The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.
    Nature Structural & Molecular Biology 17, 1263-1265 PubMed abstract
  • Wyatt, HDM; West, SC and Beattie, TL (2010)
    InTERTpreting telomerase structure and function.
    Nucleic Acids Research 38, 5609-5622 PubMed abstract
  • Youds, JL; Mets, DG; McIlwraith, MJ; Martin, JS; Ward, JD; ONeil, NJ; Rose, AM; West, SC; Meyer, BJ and Boulton, SJ (2010)
    RTEL-1 enforces meiotic crossover interference and homeostasis.
    Science 327, 1254-1258 PubMed abstract

[Page last updated 1 Jun 2018]

Stephen West
+44 (0)20 379 62071

  • Qualifications and History
  • 1977 PhD in Biochemistry, Newcastle University, UK
  • 1978 Research Associate, Department of Therapeutic Radiology, Yale University, USA
  • 1985 Established lab at the Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2015 Group Leader, the Francis Crick Institute, London, UK