Robert J Wilkinson: Publications

  • Bell, L; Peyper, JM; Garnett, S; Tadokera, R; Wilkinson, R; Meintjes, G and Blackburn, JM (2017)
    TB-IRIS: Proteomic analysis of in vitro PBMC responses to Mycobacterium tuberculosis and response modulation by dexamethasone.
    Experimental and Molecular Pathology 102, 237-246 PubMed abstract
  • Brilha, S; Sathyamoorthy, T; Stuttaford, LH; Walker, NF; Wilkinson, RJ; Singh, S; Moores, RC; Elkington, PT and Friedland, JS (2017)
    Early secretory antigenic target-6 drives matrix metalloproteinase-10 gene expression and secretion in tuberculosis.
    American Journal of Respiratory Cell and Molecular Biology 56, 223-232 PubMed abstract
  • Bunjun, R; Riou, C; Soares, AP; Thawer, N; Müller, TL; Kiravu, A; Ginbot, Z; Oni, T; Goliath, R; Kalsdorf, B; von Groote-Bidlingmaier, F; Hanekom, W; Walzl, G; Wilkinson, RJ and Burgers, WA (2017)
    Effect of HIV on the frequency and number of Mycobacterium tuberculosis-specific CD4+ T cells in blood and the airways in latent tuberculosis infection.
    Journal of Infectious Diseases [Epub ahead of print] PubMed abstract
  • Esmail, H and Wilkinson, RJ (2017)
    Minimizing tuberculosis risk in patients receiving anti-TNF therapy.
    Annals of the American Thoracic Society 14, 621-623 PubMed abstract
  • Janssen, S; Schutz, C; Ward, A; Nemes, E; Wilkinson, KA; Scriven, J; Huson, MA; Aben, N; Maartens, G; Burton, R; Wilkinson, RJ; Grobusch, MP; Van der Poll, T and Meintjes, G (2017)
    Mortality in severe human immunodeficiency virus-tuberculosis associates with innate immune activation and dysfunction of monocytes.
    Clinical Infectious Diseases 65, 73-82 PubMed abstract
  • Janssen, S; Schutz, C; Ward, AM; Huson, MAM; Wilkinson, RJ; Burton, R; Maartens, G; Wilkinson, KA; Meijers, JCM; Lutter, R; Grobusch, MP; Meintjes, G and van der Poll, T (2017)
    Hemostatic changes associated with increased mortality rates in hospitalized patients with HIV-associated tuberculosis: a prospective cohort study.
    Journal of Infectious Diseases 215, 247-258 PubMed abstract
  • Koch, AS; Brites, D; Stucki, D; Evans, JC; Seldon, R; Heekes, A; Mulder, N; Nicol, M; Oni, T; Warner, DF; Mizrahi, V; Parkhill, J; Gagneux, S; Martin, DP and Wilkinson, RJ (2017)
    The influence of HIV on the evolution of Mycobacterium tuberculosis.
    Molecular Biology and Evolution 34, 1654-1668 PubMed abstract
  • Marais, BJ; Heemskerk, AD; Marais, SS; van Crevel, R; Rohlwink, U; Caws, M; Meintjes, G; Misra, UK; Mai, NTH; Ruslami, R; Seddon, JA; Solomons, R; Toorn, Rv; Figaji, A; McIlleron, H; Aarnoutse, R; Schoeman, JF; Wilkinson, RJ; Thwaites, GE and Tuberculous Meningitis International Research Consortium (2017)
    Standardized methods for enhanced quality and comparability of tuberculous meningitis studies.
    Clinical Infectious Diseases 64, 501-509 PubMed abstract
  • Oni, T; Berkowitz, N; Kubjane, M; Goliath, R; Levitt, NS and Wilkinson, RJ (2017)
    Trilateral overlap of tuberculosis, diabetes and HIV-1 in a high-burden African setting: implications for TB control.
    European Respiratory Journal 50, 1700004 PubMed abstract
  • Prosser, G; Julius, B; Reiling, N; Barry, CE, 3rd; Wilkinson, RJ and Wilkinson, KA (2017)
    The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition.
    Microbes and Infection 19, 177-192 PubMed abstract
  • Riou, C; Berkowitz, N; Goliath, R; Burgers, WA and Wilkinson, RJ (2017)
    Analysis of the phenotype of Mycobacterium tuberculosis-specific CD4+T cells to discriminate latent from active tuberculosis in HIV-uninfected and HIV-infected individuals.
    Frontiers in Immunology 8, 968 PubMed abstract
  • Rockwood, N; Costa, DL; Amaral, EP; Du Bruyn, E; Kubler, A; Gil-Santana, L; Fukutani, KF; Scanga, CA; Flynn, JL; Jackson, SH; Wilkinson, KA; Bishai, WR; Sher, A; Wilkinson, RJ and Andrade, BB (2017)
    Mycobacterium tuberculosis induction of heme oxygenase-1 expression is dependent on oxidative stress and reflects treatment outcomes.
    Frontiers in Immunology 8, 542 PubMed abstract
  • Rockwood, N; Pasipanodya, JG; Denti, P; Sirgel, F; Lesosky, M; Gumbo, T; Meintjes, G; McIlleron, H and Wilkinson, RJ (2017)
    Concentration-dependent antagonism and culture conversion in pulmonary tuberculosis.
    Clinical Infectious Diseases 64, 1350-1359 PubMed abstract
  • Rockwood, N; Sirgel, F; Streicher, E; Warren, R; Meintjes, G and Wilkinson, RJ (2017)
    Low frequency of acquired isoniazid and rifampicin resistance in rifampicin-susceptible pulmonary tuberculosis in a setting of high HIV-1 infection and tuberculosis coprevalence.
    Journal of Infectious Diseases 216, 632-640 PubMed abstract
  • Rockwood, N; Wojno, J; Ghebrekristos, Y; Nicol, MP; Meintjes, G and Wilkinson, RJ (2017)
    Utility of second-generation line probe assay (Hain MTBDRplus) directly on 2-month sputum specimens for monitoring tuberculosis treatment response.
    Journal of Clinical Microbiology 55, 1508-1515 PubMed abstract
  • Rohlwink, UK; Mauff, K; Wilkinson, KA; Enslin, N; Wegoye, E; Wilkinson, RJ and Figaji, AA (2017)
    Biomarkers of cerebral injury and inflammation in pediatric tuberculous meningitis.
    Clinical Infectious Diseases 65, 1298-1307 PubMed abstract
  • Schnettger, L; Rodgers, A; Repnik, U; Lai, RP; Pei, G; Verdoes, M; Wilkinson, RJ; Young, DB and Gutierrez, MG (2017)
    A Rab20-dependent membrane trafficking pathway controls M. tuberculosis replication by regulating phagosome spaciousness and integrity.
    Cell Host & Microbe 21, 619-628.e615 PubMed abstract
  • Scriven, JE; Graham, LM; Schutz, C; Scriba, TJ; Wilkinson, KA; Wilkinson, RJ; Boulware, DR; Urban, BC; Meintjes, G and Lalloo, DG (2017)
    The CSF immune response in HIV-1-associated cryptococcal meningitis: macrophage activation, correlates of disease severity and effect of antiretroviral therapy.
    Journal of Acquired Immune Deficiency Syndromes 75, 299-307 PubMed abstract
  • Strickland, N; Müller, TL; Berkowitz, N; Goliath, R; Carrington, MN; Wilkinson, RJ; Burgers, WA and Riou, C (2017)
    Characterization of Mycobacterium tuberculosis-specific cells using MHC class II tetramers reveals phenotypic differences related to HIV infection and tuberculosis disease.
    Journal of Immunology 199, 2440-2450 PubMed abstract
  • Tientcheu, LD; Koch, A; Ndengane, M; Andoseh, G; Kampmann, B and Wilkinson, RJ (2017)
    Immunological consequences of strain variation within the Mycobacterium tuberculosis complex.
    European Journal of Immunology 47, 432-445 PubMed abstract
  • Walker, NF; Wilkinson, KA; Meintjes, G; Tezera, LB; Goliath, R; Peyper, JM; Tadokera, R; Opondo, C; Coussens, AK; Wilkinson, RJ; Friedland, JS and Elkington, PT (2017)
    Matrix degradation in human immunodeficiency virus type 1-associated tuberculosis and tuberculosis immune reconstitution inflammatory syndrome: a prospective observational study.
    Clinical Infectious Diseases 65, 121-132 PubMed abstract
  • Wilkinson, RJ; Rohlwink, U; Misra, UK; van Crevel, R; Mai, NTH; Dooley, KE; Caws, M; Figaji, A; Savic, R; Solomons, R; Thwaites, GE and Tuberculous Meningitis International Research Consortium (2017)
    Tuberculous meningitis.
    Nature Reviews Neurology 13, 581-598 PubMed abstract
  • Bahr, NC; Marais, S; Caws, M; van Crevel, R; Wilkinson, RJ; Tyagi, JS; Thwaites, GE; Boulware, DR and Tuberculous Meningitis International Research Consortium (2016)
    GeneXpert MTB/Rif to diagnose tuberculous meningitis: Perhaps the first test but not the last.
    Clinical Infectious Diseases 62, 1133-1135 PubMed abstract
  • Bana, TM; Lesosky, M; Pepper, DJ; van der Plas, H; Schutz, C; Goliath, R; Morroni, C; Mendelson, M; Maartens, G; Wilkinson, RJ and Meintjes, G (2016)
    Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors.
    BMC Infectious Diseases 16, 518 PubMed abstract
  • Bangani, N; Nakiwala, J; Martineau, AR; Wilkinson, RJ; Wilkinson, KA and Lowe, DM (2016)
    HIV-1 infection impairs CD16 and CD35 mediated opsonophagocytosis of Mycobacterium tuberculosis by human neutrophils.
    Journal of Acquired Immune Deficiency Syndromes 73, 263-267 PubMed abstract
  • Diedrich, CR; O'Hern, J; Gutierrez, MG; Allie, N; Papier, P; Meintjes, G; Coussens, AK; Wainwright, H and Wilkinson, RJ (2016)
    Relationship between HIV coinfection, interleukin 10 production, and Mycobacterium tuberculosis in human lymph node granulomas.
    Journal of Infectious Diseases 214, 1309-1318 PubMed abstract
  • Diedrich, CR; O'Hern, J and Wilkinson, RJ (2016)
    HIV-1 and the Mycobacterium tuberculosis granuloma: A systematic review and meta-analysis.
    Tuberculosis 98, 62-76 PubMed abstract
  • Du Bruyn, E and Wilkinson, RJ (2016)
    The immune interaction between HIV-1 infection and Mycobacterium tuberculosis.
    Microbiology Spectrum 4, TBTB2-0012-2016 PubMed abstract
  • Esmail, H; Lai, RP; Lesosky, M; Wilkinson, KA; Graham, CM; Coussens, AK; Oni, T; Warwick, JM; Said-Hartley, Q; Koegelenberg, CF; Walzl, G; Flynn, JL; Young, DB; Barry III, CE; O'Garra, A and Wilkinson, RJ (2016)
    Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-ᴅ glucose positron emission and computed tomography.
    Nature Medicine 22, 1090-1093 PubMed abstract
  • Esmail, H; Oni, T; Thienemann, F; Omar-Davies, N; Wilkinson, RJ and Ntsekhe, M (2016)
    Cardio-thoracic ratio is stable, reproducible and has potential as a screening tool for HIV-1 related cardiac disorders in resource poor settings.
    PLOS ONE 11, e0163490 PubMed abstract
  • Esmail, H; Thienemann, F; Oni, T; Goliath, R; Wilkinson, KA and Wilkinson, RJ (2016)
    QuantiFERON conversion following tuberculin administration is common in HIV infection and relates to baseline response.
    BMC Infectious Diseases 16, 545 PubMed abstract
  • Horvati, K; Bősze, S; Gideon, HP; Bacsa, B; Szabó, TG; Goliath, R; Rangaka, MX; Hudecz, F; Wilkinson, RJ and Wilkinson, KA (2016)
    Population tailored modification of tuberculosis specific interferon-gamma release assay.
    Journal of Infection 72, 179-188 PubMed abstract
  • Jacobs, AJ; Mongkolsapaya, J; Screaton, GR; McShane, H and Wilkinson, RJ (2016)
    Antibodies and tuberculosis.
    Tuberculosis 101, 102-113 PubMed abstract
  • Lerner, TR; de Souza Carvalho-Wodarz, C; Repnik, U; Russell, MRG; Borel, S; Diedrich, CR; Rohde, M; Wainwright, H; Collinson, LM; Wilkinson, RJ; Griffiths, G and Gutierrez, MG (2016)
    Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis.
    Journal of Clinical Investigation 126, 1093-1108 PubMed abstract
  • Marais, S; Lai, RPJ; Wilkinson, KA; Meintjes, G; O'Garra, A and Wilkinson, RJ (2016)
    Inflammasome activation underlies central nervous system deterioration in HIV-associated tuberculosis.
    Journal of Infectious Diseases 215, 677-686 PubMed abstract
  • Marais, S; Meintjes, G; Lesosky, M; Wilkinson, KA and Wilkinson, RJ (2016)
    Interleukin-17 mediated differences in the pathogenesis of HIV-1-associated tuberculous and cryptococcal meningitis.
    AIDS 30, 395-404 PubMed abstract
  • Norval, M; Coussens, AK; Wilkinson, RJ; Bornman, L; Lucas, RM and Wright, CY (2016)
    Vitamin D status and its consequences for health in South Africa.
    International Journal of Environmental Research and Public Health 13, 1019 PubMed abstract
  • Riou, C; Bunjun, R; Müller, TL; Kiravu, A; Ginbot, Z; Oni, T; Goliath, R; Wilkinson, RJ and Burgers, WA (2016)
    Selective reduction of IFN-γ single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection.
    Tuberculosis 101, 25-30 PubMed abstract
  • Riou, C; Strickland, N; Soares, AP; Corleis, B; Kwon, DS; Wherry, EJ; Wilkinson, RJ and Burgers, WA (2016)
    HIV skews the lineage-defining transcriptional profile of Mycobacterium tuberculosis-specific CD4+ T cells.
    Journal of Immunology 196, 3006-3018 PubMed abstract
  • Rockwood, N; du Bruyn, E; Morris, T and Wilkinson, RJ (2016)
    Assessment of treatment response in tuberculosis.
    Expert Review of Respiratory Medicine 10, 643-654 PubMed abstract
  • Rockwood, N; Meintjes, G; Chirehwa, M; Wiesner, L; McIlleron, H; Wilkinson, RJ and Denti, P (2016)
    HIV-1 coinfection does not reduce exposure to rifampicin, isoniazid, and pyrazinamide in South African tuberculosis outpatients.
    Antimicrobial Agents and Chemotherapy 60, 6050-6059 PubMed abstract
  • Scriven, JE; Graham, LM; Schutz, C; Scriba, TJ; Wilkinson, KA; Wilkinson, RJ; Boulware, DR; Urban, BC; Lalloo, DG and Meintjes, G (2016)
    A glucuronoxylomannan-associated immune signature, characterized by monocyte deactivation and an increased interleukin 10 level, is a predictor of death in cryptococcal meningitis.
    Journal of Infectious Diseases 213, 1725-1734 PubMed abstract
  • Scriven, JE; Graham, LM; Schutz, C; Scriba, TJ; Wilkinson, RJ; Boulware, DR; Meintjes, G; Lalloo, DG and Urban, BC (2016)
    Flow cytometry to assess cerebrospinal fluid fungal burden in cryptococcal meningitis.
    Journal of Clinical Microbiology 54, 802-804 PubMed abstract
  • Stek, C; Schutz, C; Blumenthal, L; Thienemann, F; Buyze, J; Nöstlinger, C; Ravinetto, R; Wouters, E; Colebunders, R; Maartens, G; Wilkinson, RJ; Lynen, L and Meintjes, G (2016)
    Preventing paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in high-risk patients: protocol of a randomized placebo-controlled trial of prednisone (predART trial).
    JMIR Research Protocols 5, e173 PubMed abstract
  • Stucki, D; Brites, D; Jeljeli, L; Coscolla, M; Liu, Q; Trauner, A; Fenner, L; Rutaihwa, L; Borrell, S; Luo, T; Gao, Q; Kato-Maeda, M; Ballif, M; Egger, M; Macedo, R; Mardassi, H; Moreno, M; Vilanova, GT; Fyfe, J; Globan, M; Thomas, J; Jamieson, F; Guthrie, JL; Asante-Poku, A; Yeboah-Manu, D; Wampande, E; Ssengooba, W; Joloba, M; Boom, WH; Basu, I; Bower, J; Saraiva, M; Vasconcellos, SEG; Suffys, P; Koch, A; Wilkinson, R; Gail-Bekker, L; Malla, B; Ley, SD; Beck, H-P; de Jong, BC; Toit, K; Sanchez-Padilla, E; Bonnet, M; Gil-Brusola, A; Frank, M; Penlap Beng, VN; Eisenach, K; Alani, I; Ndung'u, PW; Revathi, G; Gehre, F; Akter, S; Ntoumi, F; Stewart-Isherwood, L; Ntinginya, NE; Rachow, A; Hoelscher, M; Cirillo, DM; Skenders, G; Hoffner, S; Bakonyte, D; Stakenas, P; Diel, R; Crudu, V; Moldovan, O; Al-Hajoj, S; Otero, L; Barletta, F; Carter, EJ; Diero, L; Supply, P; Comas, I; Niemann, S and Gagneux, S (2016)
    Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.
    Nature Genetics 48, 1535-1543 PubMed abstract
  • Sumner, T; Houben, RMGJ; Rangaka, MX; Maartens, G; Boulle, A; Wilkinson, RJ and White, RG (2016)
    Post-treatment effect of isoniazid preventive therapy on tuberculosis incidence in HIV-infected individuals on antiretroviral therapy.
    AIDS 30, 1279-1286 PubMed abstract
  • Wilkinson, KA; Oni, T; Gideon, HP; Goliath, R; Wilkinson, RJ and Riou, C (2016)
    Activation profile of Mycobacterium tuberculosis-specific CD4+ T cells reflects disease activity irrespective of HIV status.
    American Journal of Respiratory and Critical Care Medicine 193, 1307-1310 PubMed abstract
  • Wilkinson, KA and Walker, N (2016)
    Biomarkers for identifying risk of immune reconstitution inflammatory syndrome.
    EBioMedicine 4, 9-10 PubMed abstract
  • Coussens, AK; Naude, CE; Goliath, R; Chaplin, G; Wilkinson, RJ and Jablonski, NG (2015)
    High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans.
    Proceedings of the National Academy of Sciences of the United States of America 112, 8052-8057 PubMed abstract
  • Coussens, AK; Wilkinson, RJ and Martineau, AR (2015)
    Phenylbutyrate is bacteriostatic against Mycobacterium tuberculosis and regulates the macrophage response to infection, synergistically with 25-hydroxy-vitamin D3.
    PLOS Pathogens 11, e1005007 PubMed abstract
  • Deffur, A; Wilkinson, RJ and Coussens, AK (2015)
    Tricks to translating TB transcriptomics.
    Annals of Translational Medicine 3, S43 PubMed abstract
  • Getahun, H; Matteelli, A; Abubakar, I; Aziz, MA; Baddeley, A; Barreira, D; Den Boon, S; Borroto Gutierrez, SM; Bruchfeld, J; Burhan, E; Cavalcante, S; Cedillos, R; Chaisson, R; Chee, CB-E; Chesire, L; Corbett, E; Dara, M; Denholm, J; de Vries, G; Falzon, D; Ford, N; Gale-Rowe, M; Gilpin, C; Girardi, E; Go, U-Y; Govindasamy, D; Grant, AD; Grzemska, M; Harris, R; Horsburgh, CR, Jr.; Ismayilov, A; Jaramillo, E; Kik, S; Kranzer, K; Lienhardt, C; LoBue, P; Lönnroth, K; Marks, G; Menzies, D; Migliori, GB; Mosca, D; Mukadi, YD; Mwinga, A; Nelson, L; Nishikiori, N; Oordt-Speets, A; Rangaka, MX; Reis, A; Rotz, L; Sandgren, A; Sañé Schepisi, M; Schünemann, HJ; Sharma, SK; Sotgiu, G; Stagg, HR; Sterling, TR; Tayeb, T; Uplekar, M; van der Werf, MJ; Vandevelde, W; van Kessel, F; Van't Hoog, A; Varma, JK; Vezhnina, N; Voniatis, C; Vonk Noordegraaf-Schouten, M; Weil, D; Weyer, K; Wilkinson, RJ; Yoshiyama, T; Zellweger, JP and Raviglione, M (2015)
    Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries.
    European Respiratory Journal 46, 1563-1576 PubMed abstract
  • Jacobs, A and Wilkinson, RJ (2015)
    Humoral immunity in tuberculosis.
    European Journal of Immunology 45, 647-649 PubMed abstract
  • Jones, CE; Hesseling, AC; Tena-Coki, NG; Scriba, TJ; Chegou, NN; Kidd, M; Wilkinson, RJ and Kampmann, B (2015)
    The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination.
    AIDS 29, 155-165 PubMed abstract
  • Lai, RPJ; Meintjes, G; Wilkinson, KA; Graham, CM; Marais, S; Van der Plas, H; Deffur, A; Schutz, C; Bloom, C; Munagala, I; Anguiano, E; Goliath, R; Maartens, G; Banchereau, J; Chaussabel, D; O'Garra, A and Wilkinson, RJ (2015)
    HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling.
    Nature Communications 6, 8451 PubMed abstract
  • Lai, RPJ; Meintjes, G and Wilkinson, RJ (2015)
    HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome.
    Seminars in Immunopathology 38, 185-198 PubMed abstract
  • Lawn, SD and Wilkinson, RJ (2015)
    ART and prevention of HIV-associated tuberculosis.
    Lancet HIV 2, e221-e222 PubMed abstract
  • Marais, S and Wilkinson, RJ (2015)
    Are the present doses of anti tubercular drugs adequate for severe disease?
    EBioMedicine 2, 1572-1573 PubMed abstract
  • Matthews, K; Deffur, A; Ntsekhe, M; Syed, F; Russell, JBW; Tibazarwa, K; Wolske, J; Brink, J; Mayosi, BM; Wilkinson, RJ and Wilkinson, KA (2015)
    A compartmentalized profibrotic immune response characterizes pericardial tuberculosis, irrespective of HIV-1 infection.
    American Journal of Respiratory and Critical Care Medicine 192, 1518-1521 PubMed abstract
  • Mzinza, DT; Sloan, DJ; Jambo, KC; Shani, D; Kamdolozi, M; Wilkinson, KA; Wilkinson, RJ; Davies, GR; Heyderman, RS and Mwandumba, HC (2015)
    Kinetics of Mycobacterium tuberculosis-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis.
    Tuberculosis 95, 463-469 PubMed abstract
  • Namale, PE; Abdullahi, LH; Fine, S; Kamkuemah, M; Wilkinson, RJ and Meintjes, G (2015)
    Paradoxical TB-IRIS in HIV-infected adults: a systematic review and meta-analysis.
    Future Microbiology 10, 1077-1099 PubMed abstract
  • Ndiaye, BP; Thienemann, F; Ota, M; Landry, BS; Camara, M; Dièye, S; Dieye, TN; Esmail, H; Goliath, R; Huygen, K; January, V; Ndiaye, I; Oni, T; Raine, M; Romano, M; Satti, I; Sutton, S; Thiam, A; Wilkinson, KA; Mboup, S; Wilkinson, RJ and McShane, H (2015)
    Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial.
    Lancet Respiratory Medicine 3, 190-200 PubMed abstract
  • Offerman, K; Deffur, A; Carulei, O; Wilkinson, R; Douglass, N and Williamson, A-L (2015)
    Six host-range restricted poxviruses from three genera induce distinct gene expression profiles in an in vivo mouse model.
    BMC Genomics 16, 510 PubMed abstract
  • Oni, T; Youngblood, E; Boulle, A; McGrath, N; Wilkinson, RJ and Levitt, NS (2015)
    Patterns of HIV, TB, and non-communicable disease multi-morbidity in peri-urban South Africa- a cross sectional study.
    BMC Infectious Diseases 15, 20 PubMed abstract
  • Pepper, DJ; Schomaker, M; Wilkinson, RJ; de Azevedo, V and Maartens, G (2015)
    Independent predictors of tuberculosis mortality in a high HIV prevalence setting: a retrospective cohort study.
    AIDS Research and Therapy 12, 35 PubMed abstract
  • Rockwood, N; Abdullahi, LH; Wilkinson, RJ and Meintjes, G (2015)
    Risk factors for acquired rifamycin and isoniazid resistance: a systematic review and meta-analysis.
    PLOS ONE 10, e0139017 PubMed abstract
  • Rockwood, N and Wilkinson, RJ (2015)
    Understanding and intervening in HIV-associated tuberculosis.
    Clinical Medicine 15 , s43-s49 PubMed abstract
  • Sathyamoorthy, T; Tezera, LB; Walker, NF; Brilha, S; Saraiva, L; Mauri, FA; Wilkinson, RJ; Friedland, JS and Elkington, PT (2015)
    Membrane type 1 matrix metalloproteinase regulates monocyte migration and collagen destruction in tuberculosis.
    Journal of Immunology 195, 882-891 PubMed abstract
  • Subbarao, S; Wilkinson, KA; van Halsema, CL; Rao, SS; Boyles, T; Utay, NS; Wilkinson, RJ and Meintjes, G (2015)
    Raised venous lactate and markers of intestinal translocation are associated with mortality among in-patients with HIV-associated TB in rural South Africa.
    Journal of Acquired Immune Deficiency Syndromes 70, 406-413 PubMed abstract
  • Torrado, E; Fountain, JJ; Liao, M; Tighe, M; Reiley, WW; Lai, RP; Meintjes, G; Pearl, JE; Chen, X; Zak, DE; Thompson, EG; Aderem, A; Ghilardi, N; Solache, A; McKinstry, KK; Strutt, TM; Wilkinson, RJ; Swain, SL and Cooper, AM (2015)
    Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection.
    Journal of Experimental Medicine 212, 1449-1463 PubMed abstract
  • Torres, M; García-García, L; Cruz-Hervert, P; Guio, H; Carranza, C; Ferreyra-Reyes, L; Canizales, S; Molina, S; Ferreira-Guerrero, E; Téllez, N; Montero-Campos, R; Delgado-Sánchez, G; Mongua-Rodriguez, N; Sifuentes-Osornio, J; Ponce-de Leon, A; Sada, E; Young, DB and Wilkinson, RJ (2015)
    Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis.
    European Respiratory Journal 45, 473-482 PubMed abstract
  • Walker, NF; Scriven, J; Meintjes, G and Wilkinson, RJ (2015)
    Immune reconstitution inflammatory syndrome in HIV-infected patients.
    HIV/AIDS - Research and Palliative Care 7, 49-64 PubMed abstract
  • Wilkinson, KA; Walker, NF; Meintjes, G; Deffur, A; Nicol, MP; Skolimowska, KH; Matthews, K; Tadokera, R; Seldon, R; Maartens, G; Rangaka, MX; Besra, GS and Wilkinson, RJ (2015)
    Cytotoxic mediators in paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.
    Journal of Immunology 194, 1748-1754 PubMed abstract
  • Zumla, A; Chakaya, J; Hoelscher, M; Ntoumi, F; Rustomjee, R; Vilaplana, C; Yeboah-Manu, D; Rasolof, V; Munderi, P; Singh, N; Aklillu, E; Padayatchi, N; Macete, E; Kapata, N; Mulenga, M; Kibiki, G; Mfinanga, S; Nyirenda, T; Maboko, L; Garcia-Basteiro, A; Rakotosamimanana, N; Bates, M; Mwaba, P; Reither, K; Gagneux, S; Edwards, S; Mfinanga, E; Abdulla, S; Cardona, P-J; Russell, JBW; Gant, V; Noursadeghi, M; Elkington, P; Bonnet, M; Menendez, C; Dieye, TN; Diarra, B; Maiga, A; Aseffa, A; Parida, S; Wejse, C; Petersen, E; Kaleebu, P; Oliver, M; Craig, G; Corrah, T; Tientcheu, L; Antonio, M; Rao, M; McHugh, TD; Sheikh, A; Ippolito, G; Ramjee, G; Kaufmann, SHE; Churchyard, G; Steyn, A; Grobusch, M; Sanne, I; Martinson, N; Madansein, R; Wilkinson, RJ; Mayosi, B; Schito, M; Wallis, RS and Maeurer, M (2015)
    Towards host-directed therapies for tuberculosis.
    Nature Reviews Drug Discovery 14, 511-512 PubMed abstract
  • Andrade, BB; Singh, A; Narendran, G; Schechter, ME; Nayak, K; Subramanian, S; Anbalagan, S; Jensen, SMR; Porter, BO; Antonelli, LR; Wilkinson, KA; Wilkinson, RJ; Meintjes, G; van der Plas, H; Follmann, D; Barber, DL; Swaminathan, S; Sher, A and Sereti, I (2014)
    Mycobacterial antigen driven activation of CD14++CD16- monocytes is a predictor of tuberculosis-associated immune reconstitution inflammatory syndrome.
    PLOS Pathogens 10, e1004433 PubMed abstract
  • Coussens, AK; Martineau, AR and Wilkinson, RJ (2014)
    Anti-inflammatory and antimicrobial actions of vitamin D in combating TB/HIV.
    Scientifica 2014, 903680 PubMed abstract
  • Esmail, H; Barry, CE; Young, DB and Wilkinson, RJ (2014)
    The ongoing challenge of latent tuberculosis.
    Philosophical Transactions of the Royal Society B: Biological Sciences 369, 20130437 PubMed abstract
  • Koch, A and Wilkinson, RJ (2014)
    The road to drug resistance in Mycobacterium tuberculosis.
    Genome Biology 15, 520 PubMed abstract
  • Marais, S; Wilkinson, KA; Lesosky, M; Coussens, AK; Deffur, A; Pepper, DJ; Schutz, C; Ismail, Z; Meintjes, G and Wilkinson, RJ (2014)
    Neutrophil-associated central nervous system inflammation in tuberculous meningitis immune reconstitution inflammatory syndrome.
    Clinical Infectious Diseases 59, 1638-1647 PubMed abstract
  • Marais, S and Wilkinson, RJ (2014)
    The diagnosis and medical management of tuberculous meningitis in adults.
    South African Medical Journal 104, 895
  • Rangaka, MX; Wilkinson, RJ; Boulle, A; Glynn, JR; Fielding, K; van Cutsem, G; Wilkinson, KA; Goliath, R; Mathee, S; Goemaere, E and Maartens, G (2014)
    Isoniazid plus antiretroviral therapy to prevent tuberculosis: a randomised double-blind, placebo-controlled trial.
    Lancet 384, 682-690 PubMed abstract
  • Tadokera, R; Meintjes, GA; Wilkinson, KA; Skolimowska, KH; Walker, N; Friedland, JS; Maartens, G; Elkington, PTG and Wilkinson, RJ (2014)
    Matrix metalloproteinases and tissue damage in HIV-tuberculosis immune reconstitution inflammatory syndrome.
    European Journal of Immunology 44, 127-136 PubMed abstract
  • van der Watt, JJ; Wilkinson, KA; Wilkinson, RJ and Heckmann, JM (2014)
    Plasma cytokine profiles in HIV-1 infected patients developing neuropathic symptoms shortly after commencing antiretroviral therapy: a case-control study.
    BMC Infectious Diseases 14, 71 PubMed abstract
  • Wilkinson, RJ (2014)
    Host-directed therapies against tuberculosis.
    Lancet Respiratory Medicine 2, 85-87 PubMed abstract
  • Bahr, N; Boulware, DR; Marais, S; Scriven, J; Wilkinson, RJ and Meintjes, G (2013)
    Central nervous system immune reconstitution inflammatory syndrome.
    Current Infectious Disease Reports 15, 583-593 PubMed abstract
  • Bloom, CI; Graham, CM; Berry, MPR; Rozakeas, F; Redford, PS; Wang, Y; Xu, Z; Wilkinson, KA; Wilkinson, RJ; Kendrick, Y; Devouassoux, G; Ferry, T; Miyara, M; Bouvry, D; Valeyre, D; Gorochov, G; Blankenship, D; Saadatian, M; Vanhems, P; Beynon, H; Vancheeswaran, R; Wickremasinghe, M; Chaussabel, D; Banchereau, J; Pascual, V; Ho, L-P; Lipman, M and O'Garra, A (2013)
    Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers.
    PLOS ONE 8, e70630 PubMed abstract
  • Coussens, AK; Wilkinson, RJ; Nikolayevskyy, V; Elkington, PT; Hanifa, Y; Islam, K; Timms, PM; Bothamley, GH; Claxton, AP; Packe, GE; Darmalingam, M; Davidson, RN; Milburn, HJ; Baker, LV; Barker, RD; Drobniewski, FA; Mein, CA; Bhaw-Rosun, L; Nuamah, RA; Griffiths, CJ and Martineau, AR (2013)
    Ethnic variation in inflammatory profile in tuberculosis.
    PLOS Pathogens 9, e1003468 PubMed abstract
  • Decloedt, EH; Mwansa-Kambafwile, J; van der Walt, JS; McIlleron, H; Denti, P; Smith, P; Wiesner, L; Rangaka, M; Wilkinson, RJ and Maartens, G (2013)
    The pharmacokinetics of nevirapine when given with isoniazid in South African HIV-infected individuals.
    International Journal of Tuberculosis and Lung Disease 17, 333-335 PubMed abstract
  • Deffur, A; Mulder, NJ and Wilkinson, RJ (2013)
    Co-infection with Mycobacterium tuberculosis and human immunodeficiency virus: an overview and motivation for systems approaches.
    Pathogens and Disease 69, 101-113 PubMed abstract
  • Dodd, LE and Wilkinson, RJ (2013)
    Diagnosis of paediatric tuberculosis: the culture conundrum.
    Lancet Infectious Diseases 13, 36-42 PubMed abstract
  • Gideon, HP; Hamilton, MS; Wood, K; Pepper, D; Oni, T; Seldon, R; Banwell, C; Langford, PR; Wilkinson, RJ and Wilkinson, KA (2013)
    Impairment of IFN-gamma response to synthetic peptides of Mycobacterium tuberculosis in a 7-day whole blood assay.
    PLOS ONE 8, e71351 PubMed abstract
  • Kaforou, M; Wright, VJ; Oni, T; French, N; Anderson, ST; Bangani, N; Banwell, CM; Brent, AJ; Crampin, AC; Dockrell, HM; Eley, B; Heyderman, RS; Hibberd, ML; Kern, F; Langford, PR; Ling, L; Mendelson, M; Ottenhoff, TH; Zgambo, F; Wilkinson, RJ; Coin, LJ and Levin, M (2013)
    Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study.
    PLOS Medicine 10, e1001538 PubMed abstract
  • Kalsdorf, B; Skolimowska, KH; Scriba, TJ; Dawson, R; Dheda, K; Wood, K; Hofmeister, J; Hanekom, WA; Lange, C and Wilkinson, RJ (2013)
    Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis.
    European Journal of Immunology 43, 540-549 PubMed abstract
  • Lai, RPJ; Nakiwala, JK; Meintjes, G and Wilkinson, RJ (2013)
    The immunopathogenesis of the HIV tuberculosis immune reconstitution inflammatory syndrome.
    European Journal of Immunology 43, 1995-2002 PubMed abstract
  • Liang, F; Bond, E; Sandgren, KJ; Smed-Sörensen, A; Rangaka, MX; Lange, C; Koup, RA; McComsey, GA; Lederman, MM; Wilkinson, RJ; Andersson, J and Loré, K (2013)
    Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T cell infiltration.
    AIDS 27, 1071-1080 PubMed abstract
  • Lowe, DM; Bandara, AK; Packe, GE; Barker, RD; Wilkinson, RJ; Griffiths, CJ and Martineau, AR (2013)
    Neutrophilia independently predicts death in tuberculosis.
    European Respiratory Journal 42, 1752-1757 PubMed abstract
  • Marais, S; Meintjes, G; Pepper, DJ; Dodd, LE; Schutz, C; Ismail, Z; Wilkinson, KA and Wilkinson, RJ (2013)
    Frequency, severity and prediction of tuberculous meningitis immune reconstitution inflammatory syndrome.
    Clinical Infectious Diseases 56, 450-460 PubMed abstract
  • Ntsekhe, M; Matthews, K; Syed, FF; Deffur, A; Badri, M; Commerford, PJ; Gersh, BJ; Wilkinson, KA; Wilkinson, RJ and Mayosi, BM (2013)
    Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion.
    PLOS ONE 8, e77532 PubMed abstract
  • O'Garra, A; Redford, PS; McNab, FW; Bloom, CI; Wilkinson, RJ and Berry, MPR (2013)
    The immune response in tuberculosis.
    Annual Review of Immunology 31, 475-527 PubMed abstract
  • Oni, T; Stoever, K and Wilkinson, RJ (2013)
    Tuberculosis, HIV, and type 2 diabetes mellitus: a neglected priority.
    Lancet Respiratory Medicine 1, 356-358 PubMed abstract
  • Rangaka, MX and Wilkinson, RJ (2013)
    Isoniazid prevention of HIV-associated tuberculosis.
    Lancet Infectious Diseases 13, 825-827 PubMed abstract
  • Seddon, J; Kasprowicz, V; Walker, NF; Yuen, HM; Sunpath, H; Tezera, L; Meintjes, G; Wilkinson, RJ; Bishai, WR; Friedland, JS and Elkington, PT (2013)
    Procollagen III N-terminal propeptide and desmosine are released by matrix destruction in pulmonary tuberculosis.
    Journal of Infectious Diseases 208, 1571-1579 PubMed abstract
  • Tadokera, R; Wilkinson, KA; Meintjes, GA; Skolimowska, KH; Matthews, K; Seldon, R; Rangaka, MX; Maartens, G and Wilkinson, RJ (2013)
    Role of the interleukin 10 family of cytokines in patients with immune reconstitution inflammatory syndrome associated with HIV infection and tuberculosis .
    Journal of Infectious Diseases 207, 1148-1156 PubMed abstract
  • van der Plas, H; Meintjes, G; Schutz, C; Goliath, R; Myer, L; Baatjie, D; Wilkinson, RJ; Maartens, G and Mendelson, M (2013)
    Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis.
    PLOS ONE 8, e54145 PubMed abstract
  • Walker, NF; Meintjes, G and Wilkinson, RJ (2013)
    HIV-1 and the immune response to TB.
    Future Virology 8, 57-80 PubMed abstract
  • Bloom, CI; Graham, CM; Berry, MPR; Wilkinson, KA; Oni, T; Rozakeas, F; Xu, Z; Rossello-Urgell, J; Chaussabel, D; Banchereau, J; Pascual, V; Lipman, M; Wilkinson, RJ and O'Garra, A (2012)
    Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy.
    PLOS ONE 7, e46191 PubMed abstract
  • Bond, E; Liang, F; Sandgren, KJ; Smed-Sörensen, A; Bergman, P; Brighenti, S; Adams, WC; Betemariam, SA; Rangaka, MX; Lange, C; Wilkinson, RJ; Andersson, J and Loré, K (2012)
    Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurations.
    Journal of Investigative Dermatology 132, 114-123 PubMed abstract
  • Conesa-Botella, A; Meintjes, G; Coussens, AK; van der Plas, H; Goliath, R; Schutz, C; Moreno-Reyes, R; Mehta, M; Martineau, AR; Wilkinson, RJ; Colebunders, R and Wilkinson, KA (2012)
    Corticosteroid therapy, vitamin D status, and inflammatory cytokine profile in the HIV-TB immune reconstitution inflammatory syndrome (TB-IRIS).
    Clinical Infectious Diseases 55, 1004-1011 PubMed abstract
  • Coussens, AK; Wilkinson, RJ; Hanifa, Y; Nikolayevskyy, V; Elkington, PT; Islam, K; Timms, PM; Venton, TR; Bothamley, GH; Packe, GE; Darmalingam, M; Davidson, RN; Milburn, HJ; Baker, LV; Barker, RD; Mein, CA; Bhaw-Rosun, L; Nuamah, R; Young, DB; Drobniewski, FA; Griffiths, CJ and Martineau, AR (2012)
    Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment.
    Proceedings of the National Academy of Sciences of the United States of America 109, 15449-15454 PubMed abstract
  • Gideon, HP; Wilkinson, KA; Rustad, TR; Oni, T; Guio, H; Sherman, DR; Vordermeier, HM; Robertson, BD; Young, DB and Wilkinson, RJ (2012)
    Bioinformatic and empirical analysis of novel hypoxia-inducible targets of the human antituberculosis T cell response.
    Journal of Immunology 189, 5867-5876 PubMed abstract
  • Klassen, K; Martineau, AR; Wilkinson, RJ; Cooke, G; Courtney, AP and Hickson, M (2012)
    The effect of tenofovir on vitamin D metabolism in HIV-infected adults is dependent on sex and ethnicity.
    PLOS ONE 7, e44845 PubMed abstract
  • Lowe, DM; Bangani, N; Mehta, MR; Lang, DM; Rossi, AG; Wilkinson, KA; Wilkinson, RJ and Martineau, AR (2012)
    A novel assay of antimycobacterial activity and phagocytosis by human neutrophils.
    Tuberculosis 93, 167-178 PubMed abstract
  • Lowe, DM; Redford, PS; Wilkinson, RJ; O'Garra, A and Martineau, AR (2012)
    Neutrophils in tuberculosis: friend or foe?
    Trends in Immunology 33, 14-25 PubMed abstract
  • Meintjes, G; Skolimowska, KH; Wilkinson, KA; Matthews, K; Tadokera, R; Conesa-Botella, A; Seldon, R; Rangaka, MX; Rebe, K; Pepper, DJ; Morroni, C; Colebunders, R; Maartens, G and Wilkinson, RJ (2012)
    Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome.
    American Journal of Respiratory and Critical Care Medicine 186, 369-377 PubMed abstract
  • Ntsekhe, M; Matthews, K; Wolske, J; Badri, M; Wilkinson, KA; Wilkinson, RJ; Sturrock, ED and Mayosi, BM (2012)
    Scientific letter: Ac-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline) and Galectin-3 levels in tuberculous pericardial effusion: implications for pathogenesis and prevention of pericardial constriction.
    Heart 98, 1326-1328 PubMed abstract
  • Oni, T; Gideon, HP; Bangani, N; Tsekela, R; Seldon, R; Wood, K; Wilkinson, KA; Goliath, RT; Ottenhoff, TH and Wilkinson, RJ (2012)
    Risk factors associated with indeterminate interferon gamma responses in the assessment of latent tuberculosis infection in a high incidence environment.
    Clinical and Vaccine Immunology 19, 1243-1247 PubMed abstract
  • Oni, T; Gideon, HP; Bangani, N; Tsekela, R; Seldon, R; Wood, K; Wilkinson, KA; Goliath, RT; Ottenhoff, THM and Wilkinson, RJ (2012)
    Smoking, BCG and employment and the risk of tuberculosis infection in HIV-infected persons in South Africa.
    PLOS ONE 7, e47072 PubMed abstract
  • Oni, T; Tsekela, R; Kwaza, B; Manjezi, L; Bangani, N; Wilkinson, KA; Coetzee, D and Wilkinson, RJ (2012)
    A recent HIV diagnosis is associated with non-completion of isoniazid preventive therapy in an HIV-infected cohort in Cape Town.
    PLOS ONE 7, e52489 PubMed abstract
  • Pepper, DJ; Marais, S; Bhaijee, F; Wilkinson, RJ; De Azevedo, V and Meintjes, G (2012)
    Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients.
    PLOS ONE 7, e37634 PubMed abstract
  • Rangaka, MX; Gideon, HP; Wilkinson, KA; Pai, M; Mwansa-Kambafwile, J; Maartens, G; Glynn, JR; Boulle, A; Fielding, K; Goliath, R; Titus, R; Mathee, S and Wilkinson, RJ (2012)
    Interferon release does not add discriminatory value to smear-negative HIV-tuberculosis algorithms.
    European Respiratory Journal 39, 163-171 PubMed abstract
  • Rangaka, MX; Wilkinson, KA; Glynn, JR; Ling, D; Menzies, D; Mwansa-Kambafwile, J; Fielding, K; Wilkinson, RJ and Pai, M (2012)
    Predictive value of interferon-γ release assays for incident active tuberculosis: a systematic review and meta-analysis.
    Lancet Infectious Diseases 12, 45-55 PubMed abstract
  • Rangaka, MX; Wilkinson, RJ; Glynn, JR; Boulle, A; van Cutsem, G; Goliath, R; Mathee, S and Maartens, G (2012)
    Effect of antiretroviral therapy on the diagnostic accuracy of symptom screening for intensified tuberculosis case finding in a South African HIV clinic.
    Clinical Infectious Diseases 55, 1698-1706 PubMed abstract
  • Robertson, BD; Altmann, D; Barry, C; Bishai, B; Cole, S; Dick, T; Duncan, K; Dye, C; Ehrt, S; Esmail, H; Flynn, J; Hafner, R; Handley, G; Hanekom, W; van Helden, P; Kaplan, G; Kaufmann, SHE; Kim, P; Lienhardt, C; Mizrahi, V; Rubin, E; Schnappinger, D; Sherman, D; Thole, J; Vandal, O; Walzl, G; Warner, D; Wilkinson, R and Young, D (2012)
    Detection and treatment of subclinical tuberculosis.
    Tuberculosis 92, 447-452 PubMed abstract
  • Sarkar, R; Lenders, L; Wilkinson, KA; Wilkinson, RJ and Nicol, MP (2012)
    Modern lineages of Mycobacterium tuberculosis exhibit lineage-specific patterns of growth and cytokine induction in human monocyte-derived macrophages.
    PLOS ONE 7, e43170 PubMed abstract
  • Schutz, C; Ismail, Z; Proxenos, CJ; Marais, S; Burton, R; Kenyon, C; Maartens, G; Wilkinson, RJ and Meintjes, G (2012)
    Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa.
    South African Medical Journal 102, 506-511 PubMed abstract
  • Skolimowska, KH; Rangaka, MX; Meintjes, G; Pepper, DJ; Seldon, R; Matthews, K; Wilkinson, RJ and Wilkinson, KA (2012)
    Altered ratio of IFN-γ/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV- tuberculosis Immune Reconstitution Inflammatory Syndrome.
    PLOS ONE 7, e46481 PubMed abstract
  • Vordermeier, HM; Hewinson, RG; Wilkinson, RJ; Wilkinson, KA; Gideon, HP; Young, DB and Sampson, SL (2012)
    Conserved immune recognition hierarchy of mycobacterial PE/PPE proteins during infection in natural hosts.
    PLOS ONE 7, e40890 PubMed abstract
  • Walker, NF; Clark, SO; Oni, T; Andreu, N; Tezera, L; Singh, S; Saraiva, L; Pedersen, B; Kelly, DL; Tree, JA; D'Armiento, JM; Meintjes, G; Mauri, FA; Williams, A; Wilkinson, RJ; Friedland, JS and Elkington, PT (2012)
    Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases.
    American Journal of Respiratory and Critical Care Medicine 185, 989-997 PubMed abstract
  • Wilkinson, KA; Meintjes, G; Seldon, R; Goliath, R and Wilkinson, RJ (2012)
    Immunological characterisation of an unmasking TB-IRIS case.
    South African Medical Journal 102, 512-517 PubMed abstract
  • Wilkinson, KA; Torok, ME; Schwander, S and Meintjes, G (2012)
    HIV-associated tuberculosis 2012.
    Clinical and Developmental Immunology 2012, 950964 PubMed abstract
  • Wilkinson, RJ (2012)
    Human genetic susceptibility to tuberculosis: time for a bottom-up approach?
    Journal of Infectious Diseases 205, 525-527
  • Dodd, LE and Wilkinson, RJ (2011)
    Isoniazid preventive therapy in HIV infection.
    Lancet 377, 1548-1550 PubMed abstract
  • Esmail, H; Barry, CE, 3rd and Wilkinson, RJ (2011)
    Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies.
    Drug Discovery Today 17, 514-521 PubMed abstract
  • Jones, GJ; Pirson, C; Gideon, HP; Wilkinson, KA; Sherman, DR; Wilkinson, RJ; Hewinson, RG and Vordermeier, HM (2011)
    Immune responses to the Enduring Hypoxic Response antigen Rv0188 are preferentially detected in Mycobacterium bovis infected cattle with low pathology.
    PLOS ONE 6, e21371 PubMed abstract
  • Marais, S; Pepper, DJ; Schutz, C; Wilkinson, RJ and Meintjes, G (2011)
    Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting.
    PLOS ONE 6, e20077 PubMed abstract
  • Martineau, AR; Nhamoyebonde, S; Oni, T; Rangaka, MX; Marais, S; Bangani, N; Tsekela, R; Bashe, L; de Azevedo, V; Caldwell, J; Venton, TR; Timms, PM; Wilkinson, KA and Wilkinson, RJ (2011)
    Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa.
    Proceedings of the National Academy of Sciences of the United States of America 108, 19013-19017 PubMed abstract
  • Martineau, AR; Timms, PM; Bothamley, GH; Hanifa, Y; Islam, K; Claxton, AP; Packe, GE; Moore-Gillon, JC; Darmalingam, M; Davidson, RN; Milburn, HJ; Baker, LV; Barker, RD; Woodward, NJ; Venton, TR; Barnes, KE; Mullett, CJ; Coussens, AK; Rutterford, CM; Mein, CA; Davies, GR; Wilkinson, RJ; Nikolayevskyy, V; Drobniewski, FA; Eldridge, SM and Griffiths, CJ (2011)
    High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial.
    Lancet 377, 242-250 PubMed abstract
  • Matthews, K; Ntsekhe, M; Syed, F; Scriba, T; Russell, J; Tibazarwa, K; Deffur, A; Hanekom, W; Mayosi, BM; Wilkinson, RJ and Wilkinson, KA (2011)
    HIV-1 infection alters CD4+ memory T cell phenotype at the site of disease in extrapulmonary tuberculosis.
    European Journal of Immunology 42, 147-157 PubMed abstract
  • Matthews, K; Wilkinson, KA; Kalsdorf, B; Roberts, T; Diacon, A; Walzl, G; Wolske, J; Ntsekhe, M; Syed, F; Russell, J; Mayosi, BM; Dawson, R; Dheda, K; Wilkinson, RJ; Hanekom, WA and Scriba, TJ (2011)
    Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis.
    Tuberculosis 91, 587-593 PubMed abstract
  • McNab, FW; Berry, MPR; Graham, CM; Bloch, SAA; Oni, T; Wilkinson, KA; Wilkinson, RJ; Kon, OM; Banchereau, J; Chaussabel, D and O'Garra, A (2011)
    Programmed Death Ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis.
    European Journal of Immunology 41, 1941-1947 PubMed abstract
  • Oni, T; Burke, R; Tsekela, R; Bangani, N; Seldon, R; Gideon, HP; Wood, K; Wilkinson, KA; Ottenhoff, THM and Wilkinson, RJ (2011)
    High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB screening.
    Thorax 66, 669-673 PubMed abstract
  • Pepper, DJ; Marais, S; Wilkinson, RJ; Bhaijee, F; De Azevedo, V and Meintjes, G (2011)
    Barriers to initiation of antiretrovirals during antituberculosis therapy in Africa.
    PLOS ONE 6, e1984 PubMed abstract
  • Tadokera, R; Meintjes, G; Skolimowska, KH; Wilkinson, KA; Matthews, K; Seldon, R; Chegou, NN; Maartens, G; Rangaka, MX; Rebe, K; Walzl, G and Wilkinson, RJ (2011)
    Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome.
    European Respiratory Journal 37, 1248-1259 PubMed abstract
  • Asselman, V; Thienemann, F; Pepper, DJ; Boulle, A; Wilkinson, RJ; Meintjes, G and Marais, S (2010)
    Central nervous system disorders after starting antiretroviral therapy in South Africa.
    AIDS 24, 2871-2876 PubMed abstract
  • Barry, CE, 3rd; Boshoff, HI; Dartois, V; Dick, T; Ehrt, S; Flynn, J; Schnappinger, D; Wilkinson, RJ and Young, D (2010)
    Spectrum of latent tuberculosis - existing tests cannot resolve the underlying phenotypes: authors' reply.
    Nature Reviews Microbiology 8, 242 PubMed abstract
  • Berry, MPR; Graham, CM; McNab, FW; Xu, Z; Bloch, SAA; Oni, T; Wilkinson, KA; Banchereau, R; Skinner, J; Wilkinson, RJ; Quinn, C; Blankenship, D; Dhawan, R; Cush, JJ; Mejias, A; Ramilo, O; Kon, OM; Pascual, V; Banchereau, J; Chaussabel, D and O'Garra, A (2010)
    An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.
    Nature 466, 973-977 PubMed abstract
  • Bhaijee, F; Wainwright, H; Meintjes, G; Wilkinson, RJ; Todd, G; de Vries, E and Pepper, DJ (2010)
    Warfarin-induced skin necrosis in HIV-1-infected patients with tuberculosis and venous thrombosis.
    South African Medical Journal 100, 372-377 PubMed abstract
  • Chatterjee, A; D'Souza, D; Vira, T; Bamne, A; Ambe, GT; Nicol, MP; Wilkinson, RJ and Mistry, N (2010)
    Strains of Mycobacterium tuberculosis from Western Maharashtra, India exhibit a high degree of diversity and strain-specific associations with drug resistance, cavitary disease and treatment failure.
    Journal of Clinical Microbiology 48, 3593-3599 PubMed abstract
  • Chun, RF; Lauridsen, AL; Suon, L; Zella, LA; Pike, JW; Modlin, RL; Martineau, AR; Wilkinson, RJ; Adams, J and Hewison, M (2010)
    Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D.
    Journal of Clinical Endocrinology and Metabolism 95, 3368-3376 PubMed abstract
  • Connell, TG; Davies, MA; Johannisen, C; Wood, K; Pienaar, S; Wilkinson, KA; Wilkinson, RJ; Zar, HJ; Beatty, D; Nicol, MP; Curtis, N and Eley, B (2010)
    Reversion and conversion of Mycobacterium tuberculosis IFN-γ ELISpot results during anti-tuberculous treatment in HIV-infected children.
    BMC Infectious Diseases 10, 138 PubMed abstract
  • Gideon, HP; Wilkinson, KA; Rustad, TR; Oni, T; Guio, H; Kozak, RA; Sherman, DR; Meintjes, G; Behr, MA; Vordermeier, HM; Young, DB and Wilkinson, RJ (2010)
    Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines.
    PLOS Pathogens 6, e1001237 PubMed abstract
  • Lange, C and Wilkinson, RJ (2010)
    Vitamin D and active tuberculosis: a futile quest?
    American Journal of Respiratory and Critical Care Medicine 181, 95
  • Lawn, SD and Wilkinson, RJ (2010)
    Primate model to study reactivation of TB associated with retroviral infection.
    Future Virology 5, 391-395
  • Lawn, SD; Wood, R and Wilkinson, RJ (2010)
    Changing concepts of "latent tuberculosis infection" in patients living with HIV infection.
    Clinical & Developmental Immunology 2011, 980594 PubMed abstract
  • Marais, S; Scholtz, P; Pepper, DJ; Meintjes, G; Wilkinson, RJ and Candy, S (2010)
    Neuroradiological features of the tuberculosis-associated immune reconstitution inflammatory syndrome.
    International Journal of Tuberculosis and Lung Disease 14, 188-196 PubMed abstract
  • Marais, S; Thwaites, G; Schoeman, JF; Török, ME; Misra, UK; Prasad, K; Donald, PR; Wilkinson, RJ and Marais, BJ (2010)
    Tuberculous meningitis: a uniform case definition for use in clinical research.
    Lancet Infectious Diseases 10, 803-812 PubMed abstract
  • Martineau, AR; Leandro, ACCS; Anderson, ST; Newton, SM; Wilkinson, KA; Nicol, MP; Pienaar, SM; Skolimowska, KH; Rocha, MA; Rolla, VC; Levin, M; Davidson, RN; Bremner, SA; Griffiths, CJ; Eley, BS; Bonecini-Almeida, MG and Wilkinson, RJ (2010)
    Association between Gc genotype and susceptibility to TB is dependent on vitamin D status.
    European Respiratory Journal 35, 1106-1112 PubMed abstract
  • Meintjes, G and Wilkinson, RJ (2010)
    Optimum timing of antiretroviral therapy for HIV-infected patients with concurrent serious opportunistic infections.
    Clinical Infectious Diseases 50, 1539-1541 PubMed abstract
  • Meintjes, G and Wilkinson, RJ (2010)
    Undiagnosed active tuberculosis in HIV-infected patients commencing antiretroviral therapy.
    Clinical Infectious Diseases 51, 830-832 PubMed abstract
  • Meintjes, G; Wilkinson, RJ; Morroni, C; Pepper, DJ; Rebe, K; Rangaka, MX; Oni, T and Maartens, G (2010)
    Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome.
    AIDS 24, 2381-2390 PubMed abstract
  • Oni, T; Patel, J; Gideon, HP; Seldon, R; Wood, K; Hlombe, Y; Wilkinson, KA; Rangaka, MX; Mendelson, M and Wilkinson, RJ (2010)
    Enhanced diagnosis of HIV-1 associated tuberculosis by relating T-SPOT.TB and CD4 counts.
    European Respiratory Journal 36, 594-600 PubMed abstract
  • Pepper, DJ; Marais, S; Wilkinson, RJ; Bhaijee, F; Maartens, G; McIlleron, H; De Azevedo, V; Cox, H; McDermid, C; Sokhela, S; Patel, J and Meintjes, G (2010)
    Clinical deterioration during anti-tuberculosis treatment in Africa: Incidence, causes and risk factors.
    BMC Infectious Diseases 10, 83 PubMed abstract
  • Schutz, C; Meintjes, G; Almajid, F; Wilkinson, RJ and Pozniak, A (2010)
    Clinical management of tuberculosis and HIV-1 co-infection.
    European Respiratory Journal 36, 1460-1481 PubMed abstract
  • Tena-Coki, NG; Scriba, TJ; Peteni, N; Eley, B; Wilkinson, RJ; Andersen, P; Hanekom, WA and Kampmann, B (2010)
    CD4 and CD8 T cell responses to mycobacterial antigens in African children.
    American Journal of Respiratory and Critical Care Medicine 182 , 120-129 PubMed abstract
  • Wilkinson, KA and Wilkinson, RJ (2010)
    Polyfunctional T cells in human tuberculosis.
    European Journal of Immunology 40, 2139-2142 PubMed abstract
  • Wood, R; Liang, H; Wu, H; Middelkoop, K; Oni, T; Rangaka, MX; Wilkinson, RJ; Bekker, L-G and Lawn, SD (2010)
    Changing prevalence of tuberculosis infection with increasing age in high-burden townships in South Africa.
    International Journal of Tuberculosis and Lung Disease 14, 406-412 PubMed abstract

[Page last updated 1 Nov 2017]

Robert Wilkinson

Robert Wilkinson

robert.wilkinson@crick.ac.uk
+27 21 406 6084

  • Qualifications and history
  • 1988 MA (Natural Sciences) University of Cambridge, UK
  • 1987 BM BCh University of Oxford, UK
  • 1989 DTM&H Royal College of Physicians of London, UK
  • 1997 PhD Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
  • 2003 FRCP Royal College of Physicians of London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK