Peter Van Loo: Publications

  • Abbosh, C; Birkbak, NJ; Wilson, GA; Jamal-Hanjani, M; Constantin, T; Salari, R; Quesne, JL; Moore, DA; Veeriah, S; Rosenthal, R; Marafioti, T; Kirkizlar, E; Watkins, TBK; McGranahan, N; Ward, S; Martinson, L; Riley, J; Fraioli, F; Bakir, MA; Grönroos, E; Zambrana, F; Endozo, R; Bi, WL; Fennessy, FM; Sponer, N; Johnson, D; Laycock, J; Shafi, S; Czyzewska-Khan, J; Rowan, A; Chambers, T; Matthews, N; Turajlic, S; Hiley, C; Lee, SM; Forster, MD; Ahmad, T; Falzon, M; Borg, E; Lawrence, D; Hayward, M; Kolvekar, S; Panagiotopoulos, N; Janes, SM; Thakrar, R; Ahmed, A; Blackhall, F; Summers, Y; Hafez, D; Naik, A; Ganguly, A; Kareht, S; Shah, R; Joseph, L; Quinn, AM; Crosbie, P; Naidu, B; Middleton, G; Langman, G; Trotter, S; Nicolson, M; Remmen, H; Kerr, K; Chetty, M; Gomersall, L; Fennell, DA; Nakas, A; Rathinam, S; Anand, G; Khan, S; Russell, P; Ezhil, V; Ismail, B; Irvin-sellers, M; Prakash, V; Lester, JF; Kornaszewska, M; Attanoos, R; Adams, H; Davies, H; Oukrif, D; Akarca, AU; Hartley, JA; Lowe, HL; Lock, S; Iles, N; Bell, H; Ngai, Y; Elgar, G; Szallasi, Z; Schwarz, RF; Herrero, J; Stewart, A; Quezada, SA; Van Loo, P; Dive, C; Lin, CJ; Rabinowitz, M; Aerts, HJWL; Hackshaw, A; Shaw, JA; Zimmermann, BG; The TRACERx Consortium; The PEACE Consortium and Swanton, C (2017)
    Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.
    Nature 545, 446-451 PubMed abstract
  • Behjati, S; Tarpey, PS; Haase, K; Ye, H; Young, MD; Alexandrov, LB; Farndon, SJ; Collord, G; Wedge, DC; Martincorena, I; Cooke, SL; Davies, H; Mifsud, W; Lidgren, M; Martin, S; Latimer, C; Maddison, M; Butler, AP; Teague, JW; Pillay, N; Shlien, A; McDermott, U; Futreal, PA; Baumhoer, D; Zaikova, O; Bjerkehagen, B; Myklebost, O; Amary, MF; Tirabosco, R; Van Loo, P; Stratton, MR; Flanagan, AM and Campbell, PJ (2017)
    Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.
    Nature Communications 8, 15936 PubMed abstract
  • Camacho, N; Van Loo, P; Edwards, S; Kay, JD; Matthews, L; Haase, K; Clark, J; Dennis, N; Thomas, S; Kremeyer, B; Zamora, J; Butler, AP; Gundem, G; Merson, S; Luxton, H; Hawkins, S; Ghori, M; Marsden, L; Lambert, A; Karaszi, K; Pelvender, G; Massie, CE; Kote-Jarai, Z; Raine, K; Jones, D; Howat, WJ; Hazell, S; Livni, N; Fisher, C; Ogden, C; Kumar, P; Thompson, A; Nicol, D; Mayer, E; Dudderidge, T; Yu, Y; Zhang, H; Shah, NC; Gnanapragasam, VJ; The CRUK-ICGC Prostate Group; Isaacs, W; Visakorpi, T; Hamdy, F; Berney, D; Verrill, C; Warren, AY; Wedge, DC; Lynch, AG; Foster, CS; Lu, YJ; Bova, GS; Whitaker, HC; McDermott, U; Neal, DE; Eeles, R; Cooper, CS and Brewer, DS (2017)
    Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data.
    PLOS Genetics 13, e1007001 PubMed abstract
  • Cheng, J; Demeulemeester, J; Wedge, DC; Vollan, HKM; Pitt, JJ; Russnes, HG; Pandey, BP; Nilsen, G; Nord, S; Bignell, GR; White, KP; Børresen-Dale, A-L; Campbell, PJ; Kristensen, VN; Stratton, MR; Lingjærde, OC; Moreau, Y and Loo, PV (2017)
    Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.
    Nature Communications 8, 1221
  • Dentro, SC; Wedge, DC and Van Loo, P (2017)
    Principles of reconstructing the subclonal architecture of cancers.
    Cold Spring Harbor Perspectives in Medicine 7, a026625 PubMed abstract
  • Jamal-Hanjani, M; Wilson, GA; McGranahan, N; Birkbak, NJ; Watkins, TBK; Veeriah, S; Shafi, S; Johnson, DH; Mitter, R; Rosenthal, R; Salm, M; Horswell, S; Escudero, M; Matthews, N; Rowan, A; Chambers, T; Moore, DA; Turajlic, S; Xu, H; Lee, S-M; Forster, MD; Ahmad, T; Hiley, CT; Abbosh, C; Falzon, M; Borg, E; Marafioti, T; Lawrence, D; Hayward, M; Kolvekar, S; Panagiotopoulos, N; Janes, SM; Thakrar, R; Ahmed, A; Blackhall, F; Summers, Y; Shah, R; Joseph, L; Quinn, AM; Crosbie, PA; Naidu, B; Middleton, G; Langman, G; Trotter, S; Nicolson, M; Remmen, H; Kerr, K; Chetty, M; Gomersall, L; Fennell, DA; Nakas, A; Rathinam, S; Anand, G; Khan, S; Russell, P; Ezhil, V; Ismail, B; Irvin-Sellers, M; Prakash, V; Lester, JF; Kornaszewska, M; Attanoos, R; Adams, H; Davies, H; Dentro, S; Taniere, P; O'Sullivan, B; Lowe, HL; Hartley, JA; Iles, N; Bell, H; Ngai, Y; Shaw, JA; Herrero, J; Szallasi, Z; Schwarz, RF; Stewart, A; Quezada, SA; Le Quesne, J; Van Loo, P; Dive, C; Hackshaw, A; Swanton, C and The TRACERx Consortium (2017)
    Tracking the evolution of non-small-cell lung cancer.
    New England Journal of Medicine 376, 2109-2121 PubMed abstract
  • Linch, M; Goh, G; Hiley, C; Shanmugabavan, Y; McGranahan, N; Rowan, A; Wong, YNS; King, H; Furness, A; Freeman, A; Linares, J; Akarca, A; Herrero, J; Rosenthal, R; Harder, N; Schmidt, G; Wilson, GA; Birkbak, NJ; Mitter, R; Dentro, S; Cathcart, P; Arya, M; Johnston, E; Scott, R; Hung, M; Emberton, M; Attard, G; Szallasi, Z; Punwani, S; Quezada, SA; Marafioti, T; Gerlinger, M; Ahmed, HU and Swanton, C (2017)
    Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters.
    Annals of Oncology 28, 2472-2480 PubMed abstract
  • Macintyre, G; Van Loo, P; Corcoran, NM; Wedge, DC; Markowetz, F and Hovens, CM (2017)
    How subclonal modeling is changing the metastatic paradigm.
    Clinical Cancer Research 23, 630-635 PubMed abstract
  • Martincorena, I; Raine, KM; Gerstung, M; Dawson, KJ; Haase, K; Van Loo, P; Davies, H; Stratton, MR and Campbell, PJ (2017)
    Universal patterns of selection in cancer and somatic tissues.
    Cell 171, [Epub ahead of print] PubMed abstract
  • Yates, LR; Knappskog, S; Wedge, D; Farmery, JHR; Gonzalez, S; Martincorena, I; Alexandrov, LB; Van Loo, P; Haugland, HK; Lilleng, PK; Gundem, G; Gerstung, M; Pappaemmanuil, E; Gazinska, P; Bhosle, SG; Jones, D; Raine, K; Mudie, L; Latimer, C; Sawyer, E; Desmedt, C; Sotiriou, C; Stratton, MR; Sieuwerts, AM; Lynch, AG; Martens, JW; Richardson, AL; Tutt, A; Lønning, PE and Campbell, PJ (2017)
    Genomic evolution of breast cancer metastasis and relapse.
    Cancer Cell 32, 169-184 e167 PubMed abstract
  • Alexandrov, LB; Ju, YS; Haase, K; Van Loo, P; Martincorena, I; Nik-Zainal, S; Totoki, Y; Fujimoto, A; Nakagawa, H; Shibata, T; Campbell, PJ; Vineis, P; Phillips, DH and Stratton, MR (2016)
    Mutational signatures associated with tobacco smoking in human cancer.
    Science 354, 618-622 PubMed abstract
  • Behjati, S; Gundem, G; Wedge, DC; Roberts, ND; Tarpey, PS; Cooke, SL; Van Loo, P; Alexandrov, LB; Ramakrishna, M; Davies, H; Nik-Zainal, S; Hardy, C; Latimer, C; Raine, KM; Stebbings, L; Menzies, A; Jones, D; Shepherd, R; Butler, AP; Teague, JW; Jorgensen, M; Khatri, B; Pillay, N; Shlien, A; Futreal, PA; Badie, C; Group, IP; McDermott, U; Bova, GS; Richardson, AL; Flanagan, AM; Stratton, MR and Campbell, PJ (2016)
    Mutational signatures of ionizing radiation in second malignancies.
    Nature Communications 7, 12605 PubMed abstract
  • Demeulemeester, J; Kumar, P; Møller, EK; Nord, S; Wedge, DC; Peterson, A; Mathiesen, RR; Fjelldal, R; Zamani Esteki, M; Theunis, K; Fernandez Gallardo, E; Grundstad, AJ; Borgen, E; Baumbusch, LO; Børresen-Dale, A-L; White, KP; Kristensen, VN; Van Loo, P; Voet, T and Naume, B (2016)
    Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing.
    Genome Biology 17, 250 PubMed abstract
  • Desmedt, C; Zoppoli, G; Gundem, G; Pruneri, G; Larsimont, D; Fornili, M; Fumagalli, D; Brown, D; Rothé, F; Vincent, D; Kheddoumi, N; Rouas, G; Majjaj, S; Brohée, S; Van Loo, P; Maisonneuve, P; Salgado, R; Van Brussel, T; Lambrechts, D; Bose, R; Metzger, O; Galant, C; Bertucci, F; Piccart-Gebhart, M; Viale, G; Biganzoli, E; Campbell, PJ and Sotiriou, C (2016)
    Genomic characterization of primary invasive lobular breast cancer.
    Journal of Clinical Oncology 34, 1872-1881 PubMed abstract
  • Grove, CS; Bolli, N; Manes, N; Varela, I; Van't Veer, M; Bench, A; Eldaly, H; Wedge, D; Van Loo, P and Vassiliou, GS (2016)
    Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution.
    British Journal of Haematology 176, 825-829 PubMed abstract
  • Nik-Zainal, S; Davies, H; Staaf, J; Ramakrishna, M; Glodzik, D; Zou, X; Martincorena, I; Alexandrov, LB; Martin, S; Wedge, DC; Van Loo, P; Ju, YS; Smid, M; Brinkman, AB; Morganella, S; Aure, MR; Lingjærde, OC; Langerød, A; Ringnér, M; Ahn, S-M; Boyault, S; Brock, JE; Broeks, A; Butler, A; Desmedt, C; Dirix, L; Dronov, S; Fatima, A; Foekens, JA; Gerstung, M; Hooijer, GKJ; Jang, SJ; Jones, DR; Kim, H-Y; King, TA; Krishnamurthy, S; Lee, HJ; Lee, J-Y; Li, Y; McLaren, S; Menzies, A; Mustonen, V; O'Meara, S; Pauporté, I; Pivot, X; Purdie, CA; Raine, K; Ramakrishnan, K; Rodríguez-González, FG; Romieu, G; Sieuwerts, AM; Simpson, PT; Shepherd, R; Stebbings, L; Stefansson, OA; Teague, J; Tommasi, S; Treilleux, I; Van den Eynden, GG; Vermeulen, P; Vincent-Salomon, A; Yates, L; Caldas, C; Veer, Lvt; Tutt, A; Knappskog, S; Tan, BKT; Jonkers, J; Borg, Å; Ueno, NT; Sotiriou, C; Viari, A; Futreal, PA; Campbell, PJ; Span, PN; Van Laere, S; Lakhani, SR; Eyfjord, JE; Thompson, AM; Birney, E; Stunnenberg, HG; van de Vijver, MJ; Martens, JWM; Børresen-Dale, A-L; Richardson, AL; Kong, G; Thomas, G and Stratton, MR (2016)
    Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
    Nature 534, 47-54 PubMed abstract
  • Papaemmanuil, E; Gerstung, M; Bullinger, L; Gaidzik, VI; Paschka, P; Roberts, ND; Potter, NE; Heuser, M; Thol, F; Bolli, N; Gundem, G; Van Loo, P; Martincorena, I; Ganly, P; Mudie, L; McLaren, S; O'Meara, S; Raine, K; Jones, DR; Teague, JW; Butler, AP; Greaves, MF; Ganser, A; Döhner, K; Schlenk, RF; Döhner, H and Campbell, PJ (2016)
    Genomic classification and prognosis in acute myeloid leukemia.
    New England Journal of Medicine 374, 2209-2221 PubMed abstract
  • Raine, KM; Van Loo, P; Wedge, DC; Jones, D; Menzies, A; Butler, AP; Teague, JW; Tarpey, P; Nik-Zainal, S and Campbell, PJ (2016)
    ascatNgs: identifying somatically acquired copy-number alterations from whole-genome sequencing data.
    Current Protocols in Bioinformatics 56, 15.19.11-15.19.17 PubMed abstract
  • Sandhu, V; Wedge, DC; Bowitz Lothe, IM; Labori, KJ; Dentro, SC; Buanes, T; Skrede, ML; Dalsgaard, AM; Munthe, E; Myklebost, O; Lingjærde, OC; Børressen-Dale, A-L; Ikdahl, T; Van Loo, P; Nord, S and Kure, EH (2016)
    The genomic landscape of pancreatic and periampullary adenocarcinoma.
    Cancer Research 76, 5092-5102 PubMed abstract
  • Shlien, A; Raine, K; Fuligni, F; Arnold, R; Nik-Zainal, S; Dronov, S; Mamanova, L; Rosic, A; Ju, YS; Cooke, SL; Ramakrishna, M; Papaemmanuil, E; Davies, HR; Tarpey, PS; Van Loo, P; Wedge, DC; Jones, DR; Martin, S; Marshall, J; Anderson, E; Hardy, C; ICGC Breast Cancer Working Group; Oslo Breast Cancer Research Consortium; Barbashina, V; Aparicio, SAJR; Sauer, T; Garred, Ø; Vincent-Salomon, A; Mariani, O; Boyault, S; Fatima, A; Langerød, A; Borg, Å; Thomas, G; Richardson, AL; Børresen-Dale, A-L; Polyak, K; Stratton, MR and Campbell, PJ (2016)
    Direct transcriptional consequences of somatic mutation in breast cancer.
    Cell Reports 16, 2032-2046 PubMed abstract
  • Borge, KS; Nord, S; Van Loo, P; Lingjærde, OC; Gunnes, G; Alnæs, GIG; Solvang, HK; Lüders, T; Kristensen, VN; Børresen-Dale, A-L and Lingaas, F (2015)
    Canine mammary tumours are affected by frequent copy number aberrations, including amplification of MYC and loss of PTEN.
    PLOS ONE 10, e0126371 PubMed abstract
  • Cooper, CS; Eeles, R; Wedge, DC; Van Loo, P; Gundem, G; Alexandrov, LB; Kremeyer, B; Butler, A; Lynch, AG; Camacho, N; Massie, CE; Kay, J; Luxton, HJ; Edwards, S; Kote-Jarai, Z; Dennis, N; Merson, S; Leongamornlert, D; Zamora, J; Corbishley, C; Thomas, S; Nik-Zainal, S; Ramakrishna, M; O'Meara, S; Matthews, L; Clark, J; Hurst, R; Mithen, R; Bristow, RG; Boutros, PC; Fraser, M; Cooke, S; Raine, K; Jones, D; Menzies, A; Stebbings, L; Hinton, J; Teague, J; McLaren, S; Mudie, L; Hardy, C; Anderson, E; Joseph, O; Goody, V; Robinson, B; Maddison, M; Gamble, S; Greenman, C; Berney, D; Hazell, S; Livni, N; The ICGC Prostate Group; Fisher, C; Ogden, C; Kumar, P; Thompson, A; Woodhouse, C; Nicol, D; Mayer, E; Dudderidge, T; Shah, NC; Gnanapragasam, V; Voet, T; Campbell, P; Futreal, A; Easton, D; Warren, AY; Foster, CS; Stratton, MR; Whitaker, HC; McDermott, U; Brewer, DS and Neal, DE (2015)
    Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.
    Nature Genetics 47, 367-372 PubMed abstract
  • Frigerio, CS; Lau, P; Troakes, C; Deramecourt, V; Gele, P; Van Loo, P; Voet, T and De Strooper, B (2015)
    On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients.
    Alzheimer's & Dementia 11, 1265-1276 PubMed abstract
  • Gundem, G; Van Loo, P; Kremeyer, B; Alexandrov, LB; Tubio, JMC; Papaemmanuil, E; Brewer, DS; Kallio, HML; Högnäs, G; Annala, M; Kivinummi, K; Goody, V; Latimer, C; O'Meara, S; Dawson, KJ; Isaacs, W; Emmert-Buck, MR; Nykter, M; Foster, C; Kote-Jarai, Z; Easton, D; Whitaker, HC; ICGC Prostate UK Group; Neal, DE; Cooper, CS; Eeles, RA; Visakorpi, T; Campbell, PJ; McDermott, U; Wedge, DC and Bova, GS (2015)
    The evolutionary history of lethal metastatic prostate cancer.
    Nature 520, 353-357 PubMed abstract
  • Hong, MKH; Macintyre, G; Wedge, DC; Van Loo, P; Patel, K; Lunke, S; Alexandrov, LB; Sloggett, C; Cmero, M; Marass, F; Tsui, D; Mangiola, S; Lonie, A; Naeem, H; Sapre, N; Phal, PM; Kurganovs, N; Chin, X; Kerger, M; Warren, AY; Neal, D; Gnanapragasam, V; Rosenfeld, N; Pedersen, JS; Ryan, A; Haviv, I; Costello, AJ; Corcoran, NM and Hovens, CM (2015)
    Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.
    Nature Communications 6, 6605 PubMed abstract
  • Martincorena, I; Roshan, A; Gerstung, M; Ellis, P; Van Loo, P; McLaren, S; Wedge, DC; Fullam, A; Alexandrov, LB; Tubio, JM; Stebbings, L; Menzies, A; Widaa, S; Stratton, MR; Jones, PH and Campbell, PJ (2015)
    High burden and pervasive positive selection of somatic mutations in normal human skin.
    Science 348, 880-886 PubMed abstract
  • Møller, E; Kumar, P; Nordi, S; Wedge, D; van Loo, P; Peterson, A; Mathiesen, RR; Fjelldal, R; Esteki, MZ; Grundstad, JA; Borgen, E; Baumbusch, LO; Børresen-Dale, AL; White, KP; Voet, T; Naume, B and Kristensen, VN (2015)
    Tumor heterogeneity and dissemination in breast cancer: Deep sequencing of single disseminated cells from bone marrow compared to primary tumor and lymph node metastases.
    Cancer Research 75, Abstract LB-051
  • Nielsen, HM; How-Kit, A; Guerin, C; Castinetti, F; Moen Vollan, HK; De Micco, C; Daunay, A; Taieb, D; Van Loo, P; Besse, C; Kristensen, VN; Hansen, LL; Barlier, A; Sebag, F and Tost, J (2015)
    Copy number variations alter methylation and parallel IGF2 overexpression in adrenal tumors.
    Endocrine-Related Cancer 22, 953-967 PubMed abstract
  • Shlien, A; Campbell, BB; de Borja, R; Alexandrov, LB; Merico, D; Wedge, D; Van Loo, P; Tarpey, PS; Coupland, P; Behjati, S; Pollett, A; Lipman, T; Heidari, A; Deshmukh, S; Avitzur, Na; Meier, B; Gerstung, M; Hong, Y; Merino, DM; Ramakrishna, M; Remke, M; Arnold, R; Panigrahi, GB; Thakkar, NP; Hodel, KP; Henninger, EE; Göksenin, AY; Bakry, D; Charames, GS; Druker, H; Lerner-Ellis, J; Mistry, M; Dvir, R; Grant, R; Elhasid, R; Farah, R; Taylor, GP; Nathan, PC; Alexander, S; Ben-Shachar, S; Ling, SC; Gallinger, S; Constantini, S; Dirks, P; Huang, A; Scherer, SW; Grundy, RG; Durno, C; Aronson, M; Gartner, A; Meyn, MS; Taylor, MD; Pursell, ZF; Pearson, CE; Malkin, D; Futreal, PA; Stratton, MR; Bouffet, E; Hawkins, C; Campbell, PJ and Tabori, U (2015)
    Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.
    Nature Genetics 47, 257-262 PubMed abstract
  • Voet, T and Van Loo, P (2015)
    SNES makes sense? Single-cell exome sequencing evolves.
    Genome Biology 16, 86 PubMed abstract
  • Behjati, S; Tarpey, PS; Sheldon, H; Martincorena, I; Van Loo, P; Gundem, G; Wedge, DC; Ramakrishna, M; Cooke, SL; Pillay, N; Vollan, HKM; Papaemmanuil, E; Koss, H; Bunney, TD; Hardy, C; Joseph, OR; Martin, S; Mudie, L; Butler, A; Teague, JW; Patil, M; Steers, G; Cao, Y; Gumbs, C; Ingram, D; Lazar, AJ; Little, L; Mahadeshwar, H; Protopopov, A; Al Sannaa, GA; Seth, S; Song, X; Tang, J; Zhang, J; Ravi, V; Torres, KE; Khatri, B; Halai, D; Roxanis, I; Baumhoer, D; Tirabosco, R; Amary, MF; Boshoff, C; McDermott, U; Katan, M; Stratton, MR; Futreal, PA; Flanagan, AM; Harris, A and Campbell, PJ (2014)
    Recurrent PTPRB and PLCG1 mutations in angiosarcoma.
    Nature Genetics 46, 376-379 PubMed abstract
  • Bolli, N; Avet-Loiseau, H; Wedge, DC; Van Loo, P; Alexandrov, LB; Martincorena, I; Dawson, KJ; Iorio, F; Nik-Zainal, S; Bignell, GR; Hinton, JW; Li, Y; Tubio, JMC; McLaren, S; O' Meara, S; Butler, AP; Teague, JW; Mudie, L; Anderson, E; Rashid, N; Tai, Y-T; Shammas, MA; Sperling, AS; Fulciniti, M; Richardson, PG; Parmigiani, G; Magrangeas, F; Minvielle, S; Moreau, P; Attal, M; Facon, T; Futreal, PA; Anderson, KC; Campbell, PJ and Munshi, NC (2014)
    Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.
    Nature Communications 5, 2997 PubMed abstract
  • de Bruin, EC; McGranahan, N; Mitter, R; Salm, M; Wedge, DC; Yates, L; Jamal-Hanjani, M; Shafi, S; Murugaesu, N; Rowan, AJ; Grönroos, E; Muhammad, MA; Horswell, S; Gerlinger, M; Varela, I; Jones, D; Marshall, J; Voet, T; Van Loo, P; Rassl, DM; Rintoul, RC; Janes, SM; Lee, S-M; Forster, M; Ahmad, T; Lawrence, D; Falzon, M; Capitanio, A; Harkins, TT; Lee, CC; Tom, W; Teefe, E; Chen, S-C; Begum, S; Rabinowitz, A; Phillimore, B; Spencer-Dene, B; Stamp, G; Szallasi, Z; Matthews, N; Stewart, A; Campbell, P and Swanton, C (2014)
    Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.
    Science 346, 251-256 PubMed abstract
  • Li, Y; Schwab, C; Ryan, SL; Papaemmanuil, E; Robinson, HM; Jacobs, P; Moorman, AV; Dyer, S; Borrow, J; Griffiths, M; Heerema, NA; Carroll, AJ; Talley, P; Bown, N; Telford, N; Ross, FM; Gaunt, L; McNally, RJQ; Young, BD; Sinclair, P; Rand, V; Teixeira, MR; Joseph, O; Robinson, B; Maddison, M; Dastugue, N; Vandenberghe, P; Haferlach, C; Stephens, PJ; Cheng, J; Van Loo, P; Stratton, MR; Campbell, PJ and Harrison, CJ (2014)
    Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia.
    Nature 508, 98-102 PubMed abstract
  • Papaemmanuil, E; Rapado, I; Li, Y; Potter, NE; Wedge, DC; Tubio, J; Alexandrov, LB; Van Loo, P; Cooke, SL; Marshall, J; Martincorena, I; Hinton, J; Gundem, G; van Delft, FW; Nik-Zainal, S; Jones, DR; Ramakrishna, M; Titley, I; Stebbings, L; Leroy, C; Menzies, A; Gamble, J; Robinson, B; Mudie, L; Raine, K; O'Meara, S; Teague, JW; Butler, AP; Cazzaniga, G; Biondi, A; Zuna, J; Kempski, H; Muschen, M; Ford, AM; Stratton, MR; Greaves, M and Campbell, PJ (2014)
    RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.
    Nature Genetics 46, 116-125 PubMed abstract
  • Quigley, DA; Fiorito, E; Nord, S; Van Loo, P; Alnæs, GG; Fleischer, T; Tost, J; Moen Vollan, HK; Tramm, T; Overgaard, J; Bukholm, IR; Hurtado, A; Balmain, A; Børresen-Dale, A-L and Kristensen, V (2014)
    The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.
    Molecular Oncology 8, 273-284 PubMed abstract
  • Rashid, NU; Sperling, AS; Bolli, N; Wedge, DC; Van Loo, P; Tai, Y-T; Shammas, MA; Fulciniti, M; Samur, MK; Richardson, PG; Magrangeas, F; Minvielle, S; Futreal, PA; Anderson, KC; Avet-Loiseau, H; Campbell, PJ; Parmigiani, G and Munshi, NC (2014)
    Differential and limited expression of mutant alleles in multiple myeloma.
    Blood 124, 3110-3117 PubMed abstract
  • Tubio, JMC; Li, Y; Ju, YS; Martincorena, I; Cooke, SL; Tojo, M; Gundem, G; Pipinikas, CP; Zamora, J; Raine, K; Menzies, A; Roman-Garcia, P; Fullam, A; Gerstung, M; Shlien, A; Tarpey, PS; Papaemmanuil, E; Knappskog, S; Van Loo, P; Ramakrishna, M; Davies, HR; Marshall, J; Wedge, DC; Teague, JW; Butler, AP; Nik-Zainal, S; Alexandrov, L; Behjati, S; Yates, LR; Bolli, N; Mudie, L; Hardy, C; Martin, S; McLaren, S; O'Meara, S; Anderson, E; Maddison, M; Gamble, S; ICGC Breast Cancer Group; ICGC Bone Canccer Group; ICGC Prostate Cancer Group; Foster, C; Warren, AY; Whitaker, H; Brewer, D; Eeles, R; Cooper, C; Neal, D; Lynch, AG; Visakorpi, T; Isaacs, WB; van't Veer, L; Caldas, C; Desmedt, C; Sotiriou, C; Aparicio, S; Foekens, JA; Eyfjörd, JE; Lakhani, SR; Thomas, G; Myklebost, O; Span, PN; Børresen-Dale, A-L; Richardson, AL; Van de Vijver, M; Vincent-Salomon, A; Van den Eynden, GG; Flanagan, AM; Futreal, PA; Janes, SM; Bova, GS; Stratton, MR; McDermott, U and Campbell, PJ (2014)
    Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.
    Science 345, 1251343 PubMed abstract
  • Van Loo, P and Voet, T (2014)
    Single cell analysis of cancer genomes.
    Current Opinion in Genetics & Development 24, 82-91 PubMed abstract
  • Behjati, S; Tarpey, PS; Presneau, N; Scheipl, S; Pillay, N; Van Loo, P; Wedge, DC; Cooke, SL; Gundem, G; Davies, H; Nik-Zainal, S; Martin, S; McLaren, S; Goody, V; Robinson, B; Butler, A; Teague, JW; Halai, D; Khatri, B; Myklebost, O; Baumhoer, D; Jundt, G; Hamoudi, R; Tirabosco, R; Amary, MF; Futreal, PA; Stratton, MR; Campbell, PJ and Flanagan, AM (2013)
    Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.
    Nature Genetics 45, 1479-1482 PubMed abstract
  • Møller, EK; Kumar, P; Voet, T; Peterson, A; Van Loo, P; Mathiesen, RR; Fjelldal, R; Grundstad, J; Borgen, E; Baumbusch, LO; Naume, B; Børresen-Dale, A-L; White, KP; Nord, S and Kristensen, VN (2013)
    Next-generation sequencing of disseminated tumor cells.
    Frontiers in Oncology 3, 320 PubMed abstract
  • Morscio, J; Dierickx, D; Ferreiro, JF; Herreman, A; Van Loo, P; Bittoun, E; Verhoef, G; Matthys, P; Cools, J; Wlodarska, I; De Wolf-Peeters, C; Sagaert, X and Tousseyn, T (2013)
    Gene expression profiling reveals clear differences between EBV-positive and EBV-negative posttransplant lymphoproliferative disorders.
    American Journal of Transplantation 13, 1305-1316 PubMed abstract
  • Nangalia, J; Massie, CE; Baxter, EJ; Nice, FL; Gundem, G; Wedge, DC; Avezov, E; Li, J; Kollmann, K; Kent, DG; Aziz, A; Godfrey, AL; Hinton, J; Martincorena, I; Van Loo, P; Jones, AV; Guglielmelli, P; Tarpey, P; Harding, HP; Fitzpatrick, JD; Goudie, CT; Ortmann, CA; Loughran, SJ; Raine, K; Jones, DR; Butler, AP; Teague, JW; O'Meara, S; McLaren, S; Bianchi, M; Silber, Y; Dimitropoulou, D; Bloxham, D; Mudie, L; Maddison, M; Robinson, B; Keohane, C; Maclean, C; Hill, K; Orchard, K; Tauro, S; Du, MQ; Greaves, M; Bowen, D; Huntly, BJP; Harrison, CN; Cross, NCP; Ron, D; Vannucchi, AM; Papaemmanuil, E; Campbell, PJ and Green, AR (2013)
    Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
    New England Journal of Medicine 369, 2391-2405 PubMed abstract
  • Papaemmanuil, E; Gerstung, M; Malcovati, L; Tauro, S; Gundem, G; Van Loo, P; Yoon, CJ; Ellis, P; Wedge, DC; Pellagatti, A; Shlien, A; Groves, MJ; Forbes, SA; Raine, K; Hinton, J; Mudie, LJ; McLaren, S; Hardy, C; Latimer, C; Della Porta, MG; O'Meara, S; Ambaglio, I; Galli, A; Butler, AP; Walldin, G; Teague, JW; Quek, L; Sternberg, A; Gambacorti-Passerini, C; Cross, NCP; Green, AR; Boultwood, J; Vyas, P; Hellstrom-Lindberg, E; Bowen, D; Cazzola, M; Stratton, MR and Campbell, PJ (2013)
    Clinical and biological implications of driver mutations in myelodysplastic syndromes.
    Blood 122, 3616-3627; quiz 3699 PubMed abstract
  • Stephens, PJ; Davies, HR; Mitani, Y; Van Loo, P; Shlien, A; Tarpey, PS; Papaemmanuil, E; Cheverton, A; Bignell, GR; Butler, AP; Gamble, J; Gamble, S; Hardy, C; Hinton, J; Jia, M; Jayakumar, A; Jones, D; Latimer, C; McLaren, S; McBride, DJ; Menzies, A; Mudie, L; Maddison, M; Raine, K; Nik-Zainal, S; O'Meara, S; Teague, JW; Varela, I; Wedge, DC; Whitmore, I; Lippman, SM; McDermott, U; Stratton, MR; Campbell, PJ; El-Naggar, AK and Futreal, PA (2013)
    Whole exome sequencing of adenoid cystic carcinoma.
    Journal of Clinical Investigation 123, 2965-2968 PubMed abstract
  • Tarpey, PS; Behjati, S; Cooke, SL; Van Loo, P; Wedge, DC; Pillay, N; Marshall, J; O'Meara, S; Davies, H; Nik-Zainal, S; Beare, D; Butler, A; Gamble, J; Hardy, C; Hinton, J; Jia, MM; Jayakumar, A; Jones, D; Latimer, C; Maddison, M; Martin, S; McLaren, S; Menzies, A; Mudie, L; Raine, K; Teague, JW; Tubio, JMC; Halai, D; Tirabosco, R; Amary, F; Campbell, PJ; Stratton, MR; Flanagan, AM and Futreal, PA (2013)
    Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma.
    Nature Genetics 45, 923-926 PubMed abstract
  • Voet, T; Kumar, P; Van Loo, P; Cooke, SL; Marshall, J; Lin, M-L; Zamani Esteki, M; Van der Aa, N; Mateiu, L; McBride, DJ; Bignell, GR; McLaren, S; Teague, J; Butler, A; Raine, K; Stebbings, LA; Quail, MA; D'Hooghe, T; Moreau, Y; Futreal, PA; Stratton, MR; Vermeesch, JR and Campbell, PJ (2013)
    Single-cell paired-end genome sequencing reveals structural variation per cell cycle.
    Nucleic Acids Research 41, 6119-6138 PubMed abstract
  • Yen, J; White, RM; Wedge, DC; Van Loo, P; de Ridder, J; Capper, A; Richardson, J; Jones, D; Raine, K; Watson, IR; Wu, C-J; Cheng, J; Martincorena, I; Nik-Zainal, S; Mudie, L; Moreau, Y; Marshall, J; Ramakrishna, M; Tarpey, P; Shlien, A; Whitmore, I; Gamble, S; Latimer, C; Langdon, E; Kaufman, C; Dovey, M; Taylor, A; Menzies, A; McLaren, S; O'Meara, S; Butler, A; Teague, J; Lister, J; Chin, L; Campbell, P; Adams, DJ; Zon, LI; Patton, EE; Stemple, DL and Futreal, PA (2013)
    The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.
    Genome Biology 14, R113 PubMed abstract
  • Cowin, PA; George, J; Fereday, S; Loehrer, E; Van Loo, P; Cullinane, C; Etemadmoghadam, D; Ftouni, S; Galletta, L; Anglesio, MS; Hendley, J; Bowes, L; Sheppard, KE; Christie, EL; Australian Overaian Cancer Study; Pearson, RB; Harnett, PR; Heinzelmann-Schwarz, V; Friedlander, M; McNally, O; Quinn, M; Campbell, P; deFazio, A and Bowtell, DDL (2012)
    LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin.
    Cancer Research 72, 4060-4073 PubMed abstract
  • Kristensen, VN; Vaske, CJ; Ursini-Siegel, J; Van Loo, P; Nordgard, SH; Sachidanandam, R; Sørlie, T; Wärnberg, F; Haakensen, VD; Helland, Å; Naume, B; Perou, CM; Haussler, D; Troyanskaya, OG and Børresen-Dale, A-L (2012)
    Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling.
    Proceedings of the National Academy of Sciences of the United States of America 109, 2802-2807 PubMed abstract
  • Nik-Zainal, S; Alexandrov, LB; Wedge, DC; Van Loo, P; Greenman, CD; Raine, K; Jones, D; Hinton, J; Marshall, J; Stebbings, LA; Menzies, A; Martin, S; Leung, K; Chen, L; Leroy, C; Ramakrishna, M; Rance, R; Lau, KW; Mudie, LJ; Varela, I; McBride, DJ; Bignell, GR; Cooke, SL; Shlien, A; Gamble, J; Whitmore, I; Maddison, M; Tarpey, PS; Davies, HR; Papaemmanuil, E; Stephens, PJ; McLaren, S; Butler, AP; Teague, JW; Jönsson, G; Garber, JE; Silver, D; Miron, P; Fatima, A; Boyault, S; Langerod, A; Tutt, A; Martens, JWM; Aparicio, SAJR; Borg, Å; Salomon, AV; Thomas, G; Borresen-Dale, A-L; Richardson, AL; Neuberger, MS; Futreal, PA; Campbell, PJ; Stratton, MR and Breast Cancer Working Group of the International Cancer Genome Consortium (2012)
    Mutational processes molding the genomes of 21 breast cancers.
    Cell 149, 979-993 PubMed abstract
  • Nik-Zainal, S; Van Loo, P; Wedge, DC; Alexandrov, LB; Greenman, CD; Lau, KW; Raine, K; Jones, D; Marshall, J; Ramakrishna, M; Shlien, A; Cooke, SL; Hinton, J; Menzies, A; Stebbings, LA; Leroy, C; Jia, M; Rance, R; Mudie, LJ; Gamble, SJ; Stephens, PJ; McLaren, S; Tarpey, PS; Papaemmanuil, E; Davies, HR; Varela, I; McBride, DJ; Bignell, GR; Leung, K; Butler, AP; Teague, JW; Martin, S; Jönsson, G; Mariani, O; Boyault, S; Miron, P; Fatima, A; Langerød, A; Aparicio, SAJR; Tutt, A; Sieuwerts, AM; Borg, Å; Thomas, G; Salomon, AV; Richardson, AL; Børresen-Dale, A-L; Futreal, PA; Stratton, MR; Campbell, PJ and Breast Cancer Working Group of the International Cancer Genome Consortium (2012)
    The life history of 21 breast cancers.
    Cell 149, 994-1007 PubMed abstract
  • Nilsen, G; Liestøl, K; Van Loo, P; Moen Vollan, HK; Eide, MB; Rueda, OM; Chin, S-F; Russell, R; Baumbusch, LO; Caldas, C; Børresen-Dale, A-L and Lingjærde, OC (2012)
    Copynumber: Efficient algorithms for single- and multi-track copy number segmentation.
    BMC Genomics 13, 591 PubMed abstract
  • Reumers, J; De Rijk, P; Zhao, H; Liekens, A; Smeets, D; Cleary, J; Van Loo, P; Van Den Bossche, M; Catthoor, K; Sabbe, B; Despierre, E; Vergote, I; Hilbush, B; Lambrechts, D and Del-Favero, J (2012)
    Optimized filtering reduces the error rate in detecting genomic variants by short-read sequencing.
    Nature Biotechnology 30, 61-68 PubMed abstract
  • Stephens, PJ; Tarpey, PS; Davies, H; Van Loo, P; Greenman, C; Wedge, DC; Nik-Zainal, S; Martin, S; Varela, I; Bignell, GR; Yates, LR; Papaemmanuil, E; Beare, D; Butler, A; Cheverton, A; Gamble, J; Hinton, J; Jia, M; Jayakumar, A; Jones, D; Latimer, C; Lau, KW; McLaren, S; McBride, DJ; Menzies, A; Mudie, L; Raine, K; Rad, R; Chapman, MS; Teague, J; Easton, D; Langerød, A; OSBREAC; Lee, MTM; Shen, C-Y; Tee, BTK; Huimin, BW; Broeks, A; Vargas, AC; Turashvili, G; Martens, J; Fatima, A; Miron, P; Chin, S-F; Thomas, G; Boyault, S; Mariani, O; Lakhani, SR; van de Vijver, M; van 't Veer, L; Foekens, J; Desmedt, C; Sotiriou, C; Tutt, A; Caldas, C; Reis-Filho, JS; Aparicio, SAJR; Salomon, AV; Børresen-Dale, A-L; Richardson, AL; Campbell, PJ; Futreal, PA and Stratton, MR (2012)
    The landscape of cancer genes and mutational processes in breast cancer.
    Nature 486, 400-404 PubMed abstract
  • Stewart, DR; Pemov, A; Van Loo, P; Beert, E; Brems, H; Sciot, R; Claes, K; Pak, E; Dutra, A; Lee, C-CR and Legius, E (2012)
    Mitotic recombination of chromosome arm 17q as a cause of loss of heterozygosity of NF1 in neurofibromatosis type 1-associated glomus tumors.
    Genes, Chromosomes & Cancer 51, 429-437 PubMed abstract
  • Urbankova, H; Baens, M; Michaux, L; Tousseyn, T; Rack, K; Katrincsakova, B; Ferreiro, JF; van Loo, P; de Kelver, W; Dierickx, D; Demuynck, H; Delannoy, A; Verschuere, J; Jarošová, M; de Wolf-Peeters, C; Vandenberghe, P and Wlodarska, I (2012)
    Recurrent breakpoints in 14q32.13/TCL1A region in mature B-cell neoplasms with villous lymphocytes.
    Leukemia & Lymphoma 53, 2449-2455 PubMed abstract
  • Van Loo, P and Campbell, PJ (2012)
    ABSOLUTE cancer genomics.
    Nature Biotechnology 30, 620-621 PubMed abstract
  • Van Loo, P; Nilsen, G; Nordgard, SH; Vollan, HKM; Børresen-Dale, A-L; Kristensen, VN and Lingjærde, OC (2012)
    Analyzing cancer samples with SNP arrays.
    Methods in Molecular Biology 802, 57-72 PubMed abstract
  • Wibom, C; Ghasimi, S; Van Loo, P; Brännström, T; Trygg, J; Lau, C; Henriksson, R; Bergenheim, T; Andersson, U; Rydén, P and Melin, B (2012)
    EGFR gene variants are associated with specific somatic aberrations in glioma.
    PLOS ONE 7, e47929 PubMed abstract
  • Rosebeck, S; Madden, L; Jin, X; Gu, S; Apel, IJ; Appert, A; Hamoudi, RA; Noels, H; Sagaert, X; Van Loo, P; Baens, M; Du, M-Q; Lucas, PC and McAllister-Lucas, LM (2011)
    Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-κB activation.
    Science 331, 468-472 PubMed abstract
  • Barriot, R; Breckpot, J; Thienpont, B; Brohée, S; Van Vooren, S; Coessens, B; Tranchevent, L-C; Van Loo, P; Gewillig, M; Devriendt, K and Moreau, Y (2010)
    Collaboratively charting the gene-to-phenotype network of human congenital heart defects.
    Genome Medicine 2, 16 PubMed abstract
  • Sagaert, X; Tousseyn, T; Vanhentenrijk, V; Van Loo, P; Baens, M; Marynen, P; De Hertogh, G; Geboes, K and De Wolf-Peeters, C (2010)
    Comparative expressed sequence hybridization studies of t(11;18)(q21;q21)-positive and -negative gastric MALT lymphomas reveal both unique and overlapping gene programs.
    Modern Pathology 23, 458-469 PubMed abstract
  • Thienpont, B; Zhang, L; Postma, AV; Breckpot, J; Tranchevent, L-C; Van Loo, P; Møllgård, K; Tommerup, N; Bache, I; Tümer, Z; van Engelen, K; Menten, B; Mortier, G; Waggoner, D; Gewillig, M; Moreau, Y; Devriendt, K and Larsen, LA (2010)
    Haploinsufficiency of TAB2 causes congenital heart defects in humans.
    American Journal of Human Genetics 86, 839-849 PubMed abstract
  • Van Loo, P; Nordgard, SH; Lingjærde, OC; Russnes, HG; Rye, IH; Sun, W; Weigman, VJ; Marynen, P; Zetterberg, A; Naume, B; Perou, CM; Børresen-Dale, A-L and Kristensen, VN (2010)
    Allele-specific copy number analysis of tumors.
    Proceedings of the National Academy of Sciences of the United States of America 107, 16910-16915 PubMed abstract
  • Van Loo, P; Tousseyn, T; Vanhentenrijk, V; Dierickx, D; Malecka, A; Vanden Bempt, I; Verhoef, G; Delabie, J; Marynen, P; Matthys, P and De Wolf-Peeters, C (2010)
    T-cell/histiocyte-rich large B-cell lymphoma shows transcriptional features suggestive of a tolerogenic host immune response.
    Haematologica 95, 440-448 PubMed abstract

[Page last updated 1 Nov 2017]

Peter Van Loo

peter.vanloo@crick.ac.uk
+44 (0)20 379 61719

  • Qualifications and history
  • 2008 PhD in Medical Sciences, University of Leuven, Belgium
  • 2008 Postdoctoral Fellow, Institute for Cancer Research, University of Oslo, Norway
  • 2009 Postdoctoral Fellow, VIB and University of Leuven, Belgium
  • 2010 Postdoctoral Fellow, Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, UK
  • 2014 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Winton Group Leader, the Francis Crick Institute, London, UK