Jean-Paul Vincent: Publications

  • McGough, IJ and Vincent, JP (2018)
    APC moonlights to prevent wnt signalosome assembly.
    Developmental Cell 44, 535-537 PubMed abstract
  • Hecht, S and Vauchelet, N (2017)
    Incompressible limit of a mechanical model for tissue growth with non-overlapping constraint.
    Communications in Mathematical Sciences 15, 1913-1932 PubMed abstract
  • Kopke, DL; Lima, SC; Alexandre, C and Broadie, K (2017)
    Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling.
    Development 144, 3499-3510 PubMed abstract
  • Sanchez Bosch, P; Ziukaite, R; Alexandre, C; Basler, K and Vincent, J-P (2017)
    Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action.
    eLife 6, e22546 PubMed abstract
  • Anvarian, Z; Nojima, H; van Kappel, EC; Madl, T; Spit, M; Viertler, M; Jordens, I; Low, TY; van Scherpenzeel, RC; Kuper, I; Richter, K; Heck, AJR; Boelens, R; Vincent, J-P; Rüdiger, SGD and Maurice, MM (2016)
    Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.
    Nature Structural & Molecular Biology 23, 324-332 PubMed abstract
  • Langton, PF; Kakugawa, S and Vincent, J-P (2016)
    Making, exporting, and modulating Wnts.
    Trends in Cell Biology 26, 756-765 PubMed abstract
  • McGough, IJ and Vincent, J-P (2016)
    Exosomes in developmental signalling.
    Development 143, 2482-2493 PubMed abstract
  • Vincent, J-P; Ziukaite, R and Alexandre, C (2016)
    Developmental biology: Decapentaplegic controls growth at a distance.
    Current Biology 26, R209-R212 PubMed abstract
  • Wang, Z; Tacchelly-Benites, O; Yang, E; Thorne, CA; Nojima, H; Lee, E and Ahmed, Y (2016)
    Wnt/Wingless pathway activation is promoted by a critical threshold of axin maintained by the tumor suppressor APC and the ADP-ribose polymerase tankyrase.
    Genetics 203, 269-281 PubMed abstract
  • Wang, Z; Tian, A; Benchabane, H; Tacchelly-Benites, O; Yang, E; Nojima, H and Ahmed, Y (2016)
    The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis in Drosophila.
    Development 143, 1710-1720 PubMed abstract
  • Yamazaki, Y; Palmer, L; Alexandre, C; Kakugawa, S; Beckett, K; Gaugue, I; Palmer, RH and Vincent, J-P (2016)
    Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs.
    Nature Cell Biology 18, 451-457 PubMed abstract
  • Kakugawa, S; Langton, PF; Zebisch, M; Howell, SA; Chang, T-H; Liu, Y; Feizi, T; Bineva, G; O'Reilly, N; Snijders, AP; Jones, EY and Vincent, J-P (2015)
    Notum deacylates Wnt proteins to suppress signalling activity.
    Nature 519, 187-192 PubMed abstract
  • Alexandre, C; Baena-Lopez, A and Vincent, J-P (2014)
    Patterning and growth control by membrane-tethered Wingless.
    Nature 505, 180-185 PubMed abstract
  • Beira, JV; Springhorn, A; Gunther, S; Hufnagel, L; Pyrowolakis, G and Vincent, J-P (2014)
    The Dpp/TGFβ-dependent corepressor Schnurri protects epithelial cells from JNK-induced apoptosis in Drosophila embryos.
    Developmental Cell 31, 240-247 PubMed abstract
  • Gagliardi, M; Hernandez, A; McGough, IJ and Vincent, J-P (2014)
    Inhibitors of endocytosis prevent Wnt/Wingless signalling by reducing the level of basal β-catenin/Armadillo.
    Journal of Cell Science 127, 4918-4926 PubMed abstract
  • Gerlach, JP; Emmink, BL; Nojima, H; Kranenburg, O and Maurice, MM (2014)
    Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.
    Open Biology 4, 140120 PubMed abstract
  • Saavedra, P; Vincent, J-P; Palacios, IM; Lawrence, PA and Casal, J (2014)
    Plasticity of both planar cell polarity and cell identity during the development of Drosophila.
    eLife 3, e01569 PubMed abstract
  • Vincent, J-P (2014)
    Modulating and measuring Wingless signalling.
    Methods 68, 194-198 PubMed abstract
  • Baena-Lopez, LA; Alexandre, C; Mitchell, A; Pasakarnis, L and Vincent, J-P (2013)
    Accelerated homologous recombination and subsequent genome modification in Drosophila.
    Development 140, 4818-4825 PubMed abstract
  • Beckett, K; Monier, S; Palmer, L; Alexandre, C; Green, H; Bonneil, E; Raposo, G; Thibault, P; Borgne, RL and Vincent, J-P (2013)
    Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
    Traffic 14, 82-96 PubMed abstract
  • Briscoe, J and Vincent, J-P (2013)
    Hedgehog threads to spread.
    Nature Cell Biology 15, 1265-1267 PubMed abstract
  • Vincent, J-P; Fletcher, AG and Baena-Lopez, LA (2013)
    Mechanisms and mechanics of cell competition in epithelia.
    Nature Reviews Molecular Cell Biology 14, 581-591 PubMed abstract
  • Baena-Lopez, LA; Nojima, H and Vincent, JP (2012)
    Integration of morphogen signalling within the growth regulatory network.
    Current Opinion in Cell Biology 24, 166-172 PubMed abstract
  • Vincent, J-P and Magee, T (2012)
    Tiki casts a spell on Wnt.
    Cell 149, 1426-1427 PubMed abstract
  • Kolahgar, G; Bardet, P-L; Langton, PF; Alexandre, C and Vincent, J-P (2011)
    Apical deficiency triggers JNK-dependent apoptosis in the embryonic epidermis of Drosophila.
    Development 138, 3021-3031 PubMed abstract
  • Palmer, L; Vincent, JP and Beckett, K (2011)
    Wnts need a p(assport)24 to leave the ER.
    EMBO Reports 12, 1207-1208 PubMed abstract
  • Vincent, JP; Kolahgar, G; Gagliardi, M and Piddini, E (2011)
    Steep differences in wingless signaling trigger Myc-independent competitive cell interactions.
    Developmental Cell 21, 366-374 PubMed abstract
  • Vincent, J-P and Beckett, K (2011)
    Off-track takes Frizzled off the canonical path.
    EMBO Journal 30, 3665-3666 PubMed abstract
  • Briscoe, J; Lawrence, PA and Vincent, JP (editors).
    Generation and Interpretation of Morphogen Gradients.
    New York, Cold Spring Harbor Laboratory Press, 2010.
  • Strutt, D and Vincent, J-P (2010)
    Frizzled signaling: Gαo and Rab5 at the crossroads of the canonical and PCP pathways?
    Science Signaling 3, pe43 PubMed abstract
  • Wendler, F; Gillingham, AK; Sinka, R; Rosa-Ferreira, C; Gordon, DE; Franch-Marro, X; Peden, AA; Vincent, J-P and Munro, S (2010)
    A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway.
    EMBO Journal 29, 304-314 PubMed abstract
  • Ziosi, M; Baena-López, LA; Grifoni, D; Froldi, F; Pession, A; Garoia, F; Trotta, V; Bellosta, P; Cavicchi, S and Pession, A (2010)
    dMyc functions downstream of Yorkie to promote the supercompetitive behavior of Hippo pathway mutant cells.
    PLOS Genetics 6, e1001140 PubMed abstract

[Page last updated 1 Jun 2018]

Jean-Paul Vincent
+44 (0)20 379 62174

  • Qualifications and history
  • 1982: Ph.D. in Biophysics, University of California, Berkeley, USA
  • 1987: Post doctoral fellow, University of California, San Francisco, USA
  • 1993: Group Leader, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK
  • 1997: Group Leader, MRC National Institute for Medical Research, London, UK
  • 2015: Group Leader, the Francis Crick Institute, London