Douglas Young: Publications

  • Comas, I; Hailu, E; Kiros, T; Bekele, S; Mekonnen, W; Gumi, B; Tschopp, R; Ameni, G; Hewinson, RG; Robertson, BD; Goig, GA; Stucki, D; Gagneux, S; Aseffa, A; Young, D and Berg, S (2015)
    Population genomics of Mycobacterium tuberculosis in Ethiopia contradicts the virgin soil hypothesis for human tuberculosis in Sub-Saharan Africa.
    Current Biology 25, 3260-3266 PubMed abstract
  • Cortes, T and Cox, RA (2015)
    Transcription and translation of the rpsJ, rplN and rRNA operons of the tubercle bacillus.
    Microbiology 161, 719-728 PubMed abstract
  • Torres, M; García-García, L; Cruz-Hervert, P; Guio, H; Carranza, C; Ferreyra-Reyes, L; Canizales, S; Molina, S; Ferreira-Guerrero, E; Téllez, N; Montero-Campos, R; Delgado-Sánchez, G; Mongua-Rodriguez, N; Sifuentes-Osornio, J; Ponce-de Leon, A; Sada, E; Young, DB and Wilkinson, RJ (2015)
    Effect of isoniazid on antigen-specific interferon-γ secretion in latent tuberculosis.
    European Respiratory Journal 45, 473-482 PubMed abstract
  • Tschopp, R; Bekele, S; Moti, T; Young, D and Aseffa, A (2015)
    Brucellosis and bovine tuberculosis prevalence in livestock from pastoralist communities adjacent to Awash National Park, Ethiopia.
    Preventive Veterinary Medicine 120, 187-194 PubMed abstract
  • Young, D (2015)
    Let's keep dancing.
    Tuberculosis 95, 87-88 PubMed abstract
  • Young, DB; Comas, I and de Carvalho, LPS (2015)
    Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis.
    Frontiers in Molecular Biosciences 2, 6 PubMed abstract
  • Bos, KI; Harkins, KM; Herbig, A; Coscolla, M; Weber, N; Comas, I; Forrest, SA; Bryant, JM; Harris, SR; Schuenemann, VJ; Campbell, TJ; Majander, K; Wilbur, AK; Guichon, RA; Wolfe Steadman, DL; Cook, DC; Niemann, S; Behr, MA; Zumarraga, M; Bastida, R; Huson, D; Nieselt, K; Young, D; Parkhill, J; Buikstra, JE; Gagneux, S; Stone, AC and Krause, J (2014)
    Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis.
    Nature 514, 494-497 PubMed abstract
  • Esmail, H; Barry, CE; Young, DB and Wilkinson, RJ (2014)
    The ongoing challenge of latent tuberculosis.
    Philosophical Transactions of the Royal Society B: Biological Sciences 369, 20130437 PubMed abstract
  • Kahramanoglou, C; Cortes, T; Matange, N; Hunt, DM; Visweswariah, SS; Young, DB and Buxton, RS (2014)
    Genomic mapping of cAMP receptor protein (CRPMt) in Mycobacterium tuberculosis: relation to transcriptional start sites and the role of CRPMt as a transcription factor.
    Nucleic Acids Research 42, 8320-8329 PubMed abstract
  • Young, D (2014)
    On the sociology of Mycobacterium tuberculosis.
    Tuberculosis 94, 535-537 PubMed abstract
  • Balhana, RJC; Swanston, SN; Coade, S; Withers, M; Sikder, MH; Stoker, NG and Kendall, SL (2013)
    bkaR is a TetR-type repressor that controls an operon associated with branched-chain keto-acid metabolism in Mycobacteria.
    FEMS Microbiology Letters 345, 132-140 PubMed abstract
  • Blanc, L; Castanier, R; Mishra, AK; Ray, A; Besra, GS; Sutcliffe, I; Vercellone, A and Nigou, J (2013)
    Gram-positive bacterial lipoglycans based on a glycosylated diacylglycerol lipid anchor are microbe-associated molecular patterns recognized by TLR2.
    PLOS ONE 8, e81593 PubMed abstract
  • Comas, I; Coscolla, M; Luo, T; Borrell, S; Holt, KE; Kato-Maeda, M; Parkhill, J; Malla, B; Berg, S; Thwaites, G; Yeboah-Manu, D; Bothamley, G; Mei, J; Wei, LH; Bentley, S; Harris, SR; Niemann, S; Diel, R; Aseffa, A; Gao, Q; Young, D and Gagneux, S (2013)
    Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans.
    Nature Genetics 45, 1176-1182 PubMed abstract
  • Cortes, T; Schubert, OT; Rose, G; Arnvig, KB; Comas, I; Aebersold, R and Young, DB (2013)
    Genome-wide mapping of transcriptional start sites defines an extensive leaderless transcriptome in Mycobacterium tuberculosis.
    Cell Reports 5, 1121-1131 PubMed abstract
  • Everitt, AR; Clare, S; McDonald, JU; Kane, L; Harcourt, K; Ahras, M; Lall, A; Hale, C; Rodgers, A; Young, DB; Haque, A; Billker, O; Tregoning, JS; Dougan, G and Kellam, P (2013)
    Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.
    PLOS ONE 8, e80723 PubMed abstract
  • Firdessa, R; Berg, S; Hailu, E; Schelling, E; Gumi, B; Erenso, G; Gadisa, E; Kiros, T; Habtamu, M; Hussein, J; Zinsstag, J; Robertson, BD; Ameni, G; Lohan, AJ; Loftus, B; Comas, I; Gagneux, S; Tschopp, R; Yamuah, L; Hewinson, G; Gordon, SV; Young, DB and Aseffa, A (2013)
    Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia.
    Emerging Infectious Diseases 19, 460-463 PubMed abstract
  • Godfray, HCJ; Donnelly, CA; Kao, RR; Macdonald, DW; McDonald, RA; Petrokofsky, G; Wood, JLN; Woodroffe, R; Young, DB and McLean, AR (2013)
    A restatement of the natural science evidence base relevant to the control of bovine tuberculosis in Great Britain.
    Proceedings of the Royal Society B: Biological Sciences 280, 20131634 PubMed abstract
  • Houghton, J; Cortes, T; Schubert, O; Rose, G; Rodgers, A; De Ste Croix, M; Aebersold, R; Young, DB and Arnvig, KB (2013)
    A small RNA encoded in the Rv2660c locus of Mycobacterium tuberculosis is induced during starvation and infection.
    PLOS ONE 8, e80047 PubMed abstract
  • Lamichhane, G; Arnvig, KB and McDonough, KA (2013)
    Definition and annotation of (myco)bacterial non-coding RNA.
    Tuberculosis 93, 26-29 PubMed abstract
  • Matange, N; Hunt, DM; Buxton, RS and Visweswariah, SS (2013)
    Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response.
    Tuberculosis 93, 492-500 PubMed abstract
  • Osório, NS; Rodrigues, F; Gagneux, S; Pedrosa, J; Pinto-Carbó, M; Castro, AG; Young, D; Comas, I and Saraiva, M (2013)
    Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure.
    Molecular Biology and Evolution 30, 1326-1336 PubMed abstract
  • Portevin, D and Young, D (2013)
    Natural killer cell cytokine response to M. bovis BCG is associated with inhibited proliferation, increased apoptosis and ultimate depletion of NKp44+CD56bright cells.
    PLOS ONE 8, e68864 PubMed abstract
  • Rose, G; Cortes, T; Comas, I; Coscolla, M; Gagneux, S and Young, DB (2013)
    Mapping of genotype-phenotype diversity among clinical isolates of Mycobacterium tuberculosis by sequence-based transcriptional profiling.
    Genome Biology and Evolution 5, 1849-1862 PubMed abstract
  • Schuessler, DL; Cortes, T; Fivian-Hughes, AS; Lougheed, KEA; Harvey, E; Buxton, RS; Davis, EO and Young, DB (2013)
    Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA.
    Molecular Microbiology 90, 195-207 PubMed abstract
  • Stoop, EJM; Mishra, AK; Driessen, NN; van Stempvoort, G; Bouchier, P; Verboom, T; van Leeuwen, LM; Sparrius, M; Raadsen, SA; van Zon, M; van der Wel, NN; Besra, GS; Geurtsen, J; Bitter, W; Appelmelk, BJ and van der Sar, AM (2013)
    Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity.
    Cellular Microbiology 15, 2093-2108 PubMed abstract
  • Tschopp, R; Abera, B; Sourou, SY; Guerne-Bleich, E; Aseffa, A; Wubete, A; Zinsstag, J and Young, D (2013)
    Bovine tuberculosis and brucellosis prevalence in cattle from selected milk cooperatives in Arsi zone, Oromia region, Ethiopia.
    BMC Veterinary Research 9, 163 PubMed abstract
  • Via, LE; Weiner, DM; Schimel, D; Lin, PL; Dayao, E; Tankersley, SL; Cai, Y; Coleman, MT; Tomko, J; Paripati, P; Orandle, M; Kastenmayer, RJ; Tartakovsky, M; Rosenthal, A; Portevin, D; Eum, SY; Lahouar, S; Gagneux, S; Young, DB; Flynn, JL and Barry, CE (2013)
    Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus).
    Infection and Immunity 81, 2909-2919 PubMed abstract
  • Arnvig, K and Young, D (2012)
    Non-coding RNA and its potential role in Mycobacterium tuberculosis pathogenesis.
    RNA Biology 9, 427-436 PubMed abstract
  • Coussens, AK; Wilkinson, RJ; Hanifa, Y; Nikolayevskyy, V; Elkington, PT; Islam, K; Timms, PM; Venton, TR; Bothamley, GH; Packe, GE; Darmalingam, M; Davidson, RN; Milburn, HJ; Baker, LV; Barker, RD; Mein, CA; Bhaw-Rosun, L; Nuamah, R; Young, DB; Drobniewski, FA; Griffiths, CJ and Martineau, AR (2012)
    Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment.
    Proceedings of the National Academy of Sciences of the United States of America 109, 15449-15454 PubMed abstract
  • Gideon, HP; Wilkinson, KA; Rustad, TR; Oni, T; Guio, H; Sherman, DR; Vordermeier, HM; Robertson, BD; Young, DB and Wilkinson, RJ (2012)
    Bioinformatic and empirical analysis of novel hypoxia-inducible targets of the human antituberculosis T cell response.
    Journal of Immunology 189, 5867-5876 PubMed abstract
  • Pitt, JM; Stavropoulos, E; Redford, PS; Beebe, AM; Bancroft, GJ; Young, DB and O'Garra, A (2012)
    Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.
    Journal of Immunology 189, 4079-4087 PubMed abstract
  • Portevin, D; Via, LE; Eum, S and Young, D (2012)
    Natural killer cell are recruited during pulmonary tuberculosis and ex-vivo, their response to mycobacteria vary between healthy human donors in association with KIR haplotype.
    Cellular Microbiology 14, 1734-1744 PubMed abstract
  • Robertson, BD; Altmann, D; Barry, C; Bishai, B; Cole, S; Dick, T; Duncan, K; Dye, C; Ehrt, S; Esmail, H; Flynn, J; Hafner, R; Handley, G; Hanekom, W; van Helden, P; Kaplan, G; Kaufmann, SHE; Kim, P; Lienhardt, C; Mizrahi, V; Rubin, E; Schnappinger, D; Sherman, D; Thole, J; Vandal, O; Walzl, G; Warner, D; Wilkinson, R and Young, D (2012)
    Detection and treatment of subclinical tuberculosis.
    Tuberculosis 92, 447-452 PubMed abstract
  • Snelgrove, RJ; Cornere, MM; Edwards, L; Dagg, B; Keeble, J; Rodgers, A; Lyonga, DE; Stewart, GR; Young, DB; Walker, B and Hussell, T (2012)
    OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection.
    Journal of Infectious Diseases 205, 975-983 PubMed abstract
  • Vordermeier, HM; Hewinson, RG; Wilkinson, RJ; Wilkinson, KA; Gideon, HP; Young, DB and Sampson, SL (2012)
    Conserved immune recognition hierarchy of mycobacterial PE/PPE proteins during infection in natural hosts.
    PLOS ONE 7, e40890 PubMed abstract
  • Young, D and Verreck, FAW (2012)
    Creativity in tuberculosis research and discovery.
    Tuberculosis 92, S14-S16 PubMed abstract
  • Arnvig, KB; Comas, I; Thomson, NR; Houghton, J; Boshoff, HI; Croucher, NJ; Rose, G; Perkins, TT; Parkhill, J; Dougan, G and Young, DB (2011)
    Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis.
    PLOS Pathogens 7, e1002342 PubMed abstract
  • Krishnan, N; Malaga, W; Constant, P; Caws, M; Tran Thi Hoang, C; Salmons, J; Nguyen Thi Ngoc, L; Nguyen Duc, B; Daffé, M; Young, DB; Robertson, BD; Guilhot, C and Thwaites, GE (2011)
    Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles.
    PLOS ONE 6, e23870
  • Barry, CE, 3rd; Boshoff, HI; Dartois, V; Dick, T; Ehrt, S; Flynn, J; Schnappinger, D; Wilkinson, RJ and Young, D (2010)
    Spectrum of latent tuberculosis - existing tests cannot resolve the underlying phenotypes: authors' reply.
    Nature Reviews Microbiology 8, 242 PubMed abstract
  • Garcia, MJ; Nuñez, MC and Cox, RA (2010)
    Measurement of the rates of synthesis of three components of ribosomes of Mycobacterium fortuitum: A theoretical approach to qRT-PCR experimentation.
    PLOS ONE 5, e11575 PubMed abstract
  • Gideon, HP; Wilkinson, KA; Rustad, TR; Oni, T; Guio, H; Kozak, RA; Sherman, DR; Meintjes, G; Behr, MA; Vordermeier, HM; Young, DB and Wilkinson, RJ (2010)
    Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines.
    PLOS Pathogens 6, e1001237 PubMed abstract
  • Kirschner, DE; Young, D and Flynn, JL (2010)
    Tuberculosis: global approaches to a global disease.
    Current Opinion in Biotechnology 21, 524-531 PubMed abstract

[Page last updated 1 Nov 2017]

Douglas Young

douglas.young@crick.ac.uk
+44 (0)20 379 62308

  • Qualifications and History
  • 1978 DPhil University of Oxford, UK
  • 1978 Post-doctoral Fellow, Foundation for Medical Research, Mumbai, India
  • 1980 Post-doctoral Fellow, London School of Hygiene and Tropical Medicine, UK
  • 1982 Assistant Professor, University of Washington, Seattle, USA
  • 1985 Career Scientist, MRC Tuberculosis and Related Infections Unit, London, UK
  • 1993 Fleming Professor of Medical Microbiology, Imperial College London, UK
  • 2007 Head of Division of Mycobacterial Research, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK