Andreas Wack: Publications

  • Kostrzewski, T; Borg, AJ; Meng, Y; Filipovic, I; Male, V; Wack, A; DiMaggio, PA and Brady, HJM (2018)
    Multiple levels of control determine how E4bp4/Nfil3 regulates NK cell development.
    Journal of Immunology 200, 1370-1381 PubMed abstract
  • Wack, A (2018)
    Influenza virus: interfering with transmission.
    eLife 7, e37552 PubMed abstract
  • Smith, N; Pietrancosta, N; Davidson, S; Dutrieux, J; Chauveau, L; Cutolo, P; Dy, M; Scott-Algara, D; Manoury, B; Zirafi, O; McCort-Tranchepain, I; Durroux, T; Bachelerie, F; Schwartz, O; Münch, J; Wack, A; Nisole, S and Herbeuval, J-P (2017)
    Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement.
    Nature Communications 8, 14253 PubMed abstract
  • Davidson, S; McCabe, TM; Crotta, S; Gad, HH; Hessel, EM; Beinke, S; Hartmann, R and Wack, A (2016)
    IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.
    EMBO Molecular Medicine 8, 1099-1112 PubMed abstract
  • Villa, M; Crotta, S; Dingwell, KS; Hirst, EMA; Gialitakis, M; Ahlfors, H; Smith, JC; Stockinger, B and Wack, A (2016)
    The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis.
    Nature Communications 7, 12652 PubMed abstract
  • Davidson, S; Maini, MK and Wack, A (2015)
    Disease-promoting effects of type I interferons in viral, bacterial, and coinfections.
    Journal of Interferon & Cytokine Research 35, 252-264 PubMed abstract
  • Dittmann, M; Hoffmann, H-H; Scull, MA; Gilmore, RH; Bell, KL; Ciancanelli, M; Wilson, SJ; Crotta, S; Yu, Y; Flatley, B; Xiao, JW; Casanova, J-L; Wack, A; Bieniasz, PD and Rice, CM (2015)
    A serpin shapes the extracellular environment to prevent influenza A virus maturation.
    Cell 160, 631-643 PubMed abstract
  • Ellis, GT; Davidson, S; Crotta, S; Branzk, N; Papayannopoulos, V and Wack, A (2015)
    TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection.
    EMBO Reports 16, 1203-1218 PubMed abstract
  • McNab, F; Mayer-Barber, K; Sher, A; Wack, A and O'Garra, A (2015)
    Type I interferons in infectious disease.
    Nature Reviews Immunology 15, 87-103 PubMed abstract
  • Wack, A (2015)
    Stop the executioners.
    Nature Immunology 16, 6-8 PubMed abstract
  • Wack, A; Davidson, S; Crotta, S; McCabe, T; Hessel, E and Hartmann, R (2015)
    Unique and overlapping roles of type I and type III interferons in influenza pathology and therapy.
    Cytokine 76, 63, Meeting Abstract 151
  • Wack, A; Terczyńska-Dyla, E and Hartmann, R (2015)
    Guarding the frontiers: the biology of type III interferons.
    Nature Immunology 16, 802-809 PubMed abstract
  • Crotta, S; Gkioka, A; Male, V; Duarte, JH; Davidson, S; Nisoli, I; Brady, HJM and Wack, A (2014)
    The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development.
    Journal of Immunology 192, 2677-2688 PubMed abstract
  • Davidson, S; Crotta, S; McCabe, TM and Wack, A (2014)
    Pathogenic potential of interferon αβ in acute influenza infection.
    Nature Communications 5, 3864 PubMed abstract
  • Hartweger, H; Schweighoffer, E; Davidson, S; Peirce, MJ; Wack, A and Tybulewicz, VLJ (2014)
    Themis2 is not required for B cell development, activation, and antibody responses.
    Journal of Immunology 193, 700-707 PubMed abstract
  • Male, V; Nisoli, I; Kostrzewski, T; Allan, DSJ; Carlyle, JR; Lord, GM; Wack, A and Brady, HJM (2014)
    The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
    Journal of Experimental Medicine 211, 635-642 PubMed abstract
  • McCabe, T; Ellis, G and Wack, A (2014)
    Investigating the epithelial response to a combined viral-bacterial stimulus.
    Immunology 143, 111, Abstract 712
  • Redford, PS; Mayer-Barber, KD; McNab, FW; Stavropoulos, E; Wack, A; Sher, A and O'Garra, A (2014)
    Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway.
    Journal of Infectious Diseases 209, 270-274 PubMed abstract
  • Cantisani, R; Borgogni, E; Valentini, S; Wack, A and Piccioli, D (2013)
    Toll-like receptor 9-independent responsiveness of human monocytes to microbial DNA.
    Scandinavian Journal of Immunology 78, 557-558 PubMed abstract
  • Crotta, S; Davidson, S; Mahlakoiv, T; Desmet, CJ; Buckwalter, MR; Albert, ML; Staeheli, P and Wack, A (2013)
    Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia.
    PLOS Pathogens 9, e1003773 PubMed abstract
  • Wack, A; Davidson, S and Crotta, S (2013)
    Pathogenic potential of type I IFN in influenza infection.
    Immunology 140, 14, Abstract 767
  • Calabro, S; Tortoli, M; Baudner, BC; Pacitto, A; Cortese, M; O'Hagan, DT; De Gregorio, E; Seubert, A and Wack, A (2011)
    Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes.
    Vaccine 29, 1812-1823 PubMed abstract
  • Cantisani, R; Sammicheli, C; Tavarini, S; D'Oro, U; Wack, A and Piccioli, D (2011)
    Surface molecules on stimulated plasmacytoid dendritic cells are sufficient to cross-activate resting myeloid dendritic cells.
    Human Immunology 72, 1018-1021 PubMed abstract
  • Seubert, A; Calabro, S; Santini, L; Galli, B; Genovese, A; Valentini, S; Aprea, S; Colaprico, A; D'Oro, U; Giuliani, MM; Pallaoro, M; Pizza, M; O'Hagan, DT; Wack, A; Rappuoli, R and De Gregorio, E (2011)
    Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88.
    Proceedings of the National Academy of Sciences of the United States of America 108, 11169-11174 PubMed abstract
  • Wack, A; Openshaw, P and O' Garra, A (2011)
    Contribution of cytokines to pathology and protection in virus infection.
    Current Opinion in Virology 1, 184-195 PubMed abstract
  • Crotta, S; Brazzoli, M; Piccioli, D; Valiante, NM and Wack, A (2010)
    Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection.
    Journal of Hepatology 52, 183-190 PubMed abstract
  • Pesce, I; Monaci, E; Muzzi, A; Tritto, E; Tavarini, S; Nuti, S; De Gregorio, E and Wack, A (2010)
    Intranasal administration of CpG induces a rapid and transient cytokine response followed by dendritic and natural killer cell activation and recruitment in the mouse lung.
    Journal of Innate Immunity 2, 144-159 PubMed abstract

[Page last updated 1 Jun 2018]

Andreas Wack
+44 (0)20 379 61624

  • Qualifications and history
  • 1999 PhD, MRC-NIMR and University of Konstanz, Germany
  • 1999-2009 Post doctoral fellow then group leader, Novartis Vaccines, Siena, Italy
  • 2009 Group Leader, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK