Victor Tybulewicz: Publications

  • Naert, G; Ferré, V; Keller, E; Slender, A; Gibbins, D; Fisher, EMC; Tybulewicz, VLJ and Maurice, T (2018)
    In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome.
    Journal of Psychopharmacology 32, 174-190 PubMed abstract
  • Watson-Scales, S; Kalmar, B; Lana-Elola, E; Gibbins, D; La Russa, F; Wiseman, F; Williamson, M; Saccon, R; Slender, A; Olerinyova, A; Mahmood, R; Nye, E; Cater, H; Wells, S; Yu, YE; Bennett, DLH; Greensmith, L; Fisher, EMC and Tybulewicz, VLJ (2018)
    Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.
    PLOS Genetics 14, e1007383 PubMed abstract
  • Dekker, AD; Vermeiren, Y; Albac, C; Lana-Elola, E; Watson-Scales, S; Gibbins, D; Aerts, T; Van Dam, D; Fisher, EMC; Tybulewicz, VLJ; Potier, M-C and De Deyn, PP (2017)
    Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models.
    Neurobiology of Disease 105, 235-244 PubMed abstract
  • Herault, Y; Delabar, JM; Fisher, EMC; Tybulewicz, VLJ; Yu, E and Brault, V (2017)
    Rodent models in Down syndrome research: impact and future opportunities.
    Disease Models & Mechanisms 10, 1165-1186 PubMed abstract
  • Schweighoffer, E; Nys, J; Vanes, L; Smithers, N and Tybulewicz, VLJ (2017)
    TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
    Journal of Experimental Medicine 214, 1269-1280 PubMed abstract
  • Schweighoffer, E and Tybulewicz, VLJ (2017)
    Signalling for B cell survival.
    Current Opinion in Cell Biology 51, 8-14 PubMed abstract
  • Brazão, TF; Johnson, JS; Müller, J; Heger, A; Ponting, CP and Tybulewicz, VLJ (2016)
    Long noncoding RNAs in B-cell development and activation.
    Blood 128, e10-e19 PubMed abstract
  • Hall, JH; Wiseman, FK; Fisher, EMC; Tybulewicz, VLJ; Harwood, JL and Good, MA (2016)
    Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory.
    Neurobiology of Learning and Memory 130, 118-128 PubMed abstract
  • Karmiloff-Smith, A; Al-Janabi, T; D'Souza, H; Groet, J; Massand, E; Mok, K; Startin, C; Fisher, E; Hardy, J; Nizetic, D; Tybulewicz, V and Strydom, A (2016)
    The importance of understanding individual differences in Down syndrome.
    F1000Research 5, pii: F1000 Faculty Rev-1389 PubMed abstract
  • Köchl, R; Thelen, F; Vanes, L; Brazão, TF; Fountain, K; Xie, J; Huang, C-L; Lyck, R; Stein, JV and Tybulewicz, VLJ (2016)
    WNK1 kinase balances T cell adhesion versus migration in vivo.
    Nature Immunology 17, 1075-1083 PubMed abstract
  • Lana-Elola, E; Watson-Scales, S; Slender, A; Gibbins, D; Martineau, A; Douglas, C; Mohun, T; Fisher, EMC and Tybulewicz, VLJ (2016)
    Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel.
    eLife 5, e11614 PubMed abstract
  • Peiris, H; Duffield, MD; Fadista, J; Jessup, CF; Kashmir, V; Genders, AJ; McGee, SL; Martin, AM; Saiedi, M; Morton, N; Carter, R; Cousin, MA; Kokotos, AC; Oskolkov, N; Volkov, P; Hough, TA; Fisher, EMC; Tybulewicz, VLJ; Busciglio, J; Coskun, PE; Becker, A; Belichenko, PV; Mobley, WC; Ryan, MT; Chan, JY; Laybutt, DR; Coates, PT; Yang, S; Ling, C; Groop, L; Pritchard, MA and Keating, DJ (2016)
    A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in type 2 diabetes.
    PLOS Genetics 12, e1006033 PubMed abstract
  • Powell, NM; Modat, M; Cardoso, MJ; Ma, D; Holmes, HE; Yu, Y; O'Callaghan, J; Cleary, JO; Sinclair, B; Wiseman, FK; Tybulewicz, VLJ; Fisher, EMC; Lythgoe, MF and Ourselin, S (2016)
    Fully-automated μMRI morphometric phenotyping of the Tc1 mouse model of Down syndrome.
    PLOS ONE 11, e0162974 PubMed abstract
  • Qiu, J; McQueen, J; Bilican, B; Dando, O; Magnani, D; Punovuori, K; Selvaraj, BT; Livesey, M; Haghi, G; Heron, S; Burr, K; Patani, R; Rajan, R; Sheppard, O; Kind, PC; Simpson, TI; Tybulewicz, VLJ; Wyllie, DJA; Fisher, EMC; Lowell, S; Chandran, S and Hardingham, GE (2016)
    Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.
    eLife 5, e20337 PubMed abstract
  • Roth, S; Bergmann, H; Jaeger, M; Yeroslaviz, A; Neumann, K; Koenig, P-A; Prazeres da Costa, C; Vanes, L; Kumar, V; Johnson, M; Menacho-Márquez, M; Habermann, B; Tybulewicz, VL; Netea, M; Bustelo, XR and Ruland, J (2016)
    Vav proteins are key regulators of Card9 signaling for innate antifungal immunity.
    Cell Reports 17, 2572-2583 PubMed abstract
  • Ackermann, JA; Nys, J; Schweighoffer, E; McCleary, S; Smithers, N and Tybulewicz, VLJ (2015)
    Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.
    Journal of Immunology 194, 4650-4656 PubMed abstract
  • Atif, SM; Lee, S-J; Li, L-X; Uematsu, S; Akira, S; Gorjestani, S; Lin, X; Schweighoffer, E; Tybulewicz, VLJ and McSorley, SJ (2015)
    Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.
    European Journal of Immunology 45, 513-524 PubMed abstract
  • Jacque, E; Schweighoffer, E; Tybulewicz, VLJ and Ley, SC (2015)
    BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
    Journal of Experimental Medicine 212, 883-892 PubMed abstract
  • Wiseman, FK; Al-Janabi, T; Hardy, J; Karmiloff-Smith, A; Nizetic, D; Tybulewicz, VLJ; Fisher, EMC and Strydom, A (2015)
    A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.
    Nature Reviews Neuroscience 16, 564-574 PubMed abstract
  • Witton, J; Padmashri, R; Zinyuk, LE; Popov, VI; Kraev, I; Line, SJ; Jensen, TP; Tedoldi, A; Cummings, DM; Tybulewicz, VLJ; Fisher, EMC; Bannerman, DM; Randall, AD; Brown, JT; Edwards, FA; Rusakov, DA; Stewart, MG and Jones, MW (2015)
    Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome.
    Nature Neuroscience 18, 1291-1298 PubMed abstract
  • Hartweger, H; Schweighoffer, E; Davidson, S; Peirce, MJ; Wack, A and Tybulewicz, VLJ (2014)
    Themis2 is not required for B cell development, activation, and antibody responses.
    Journal of Immunology 193, 700-707 PubMed abstract
  • Jacque, E; Schweighoffer, E; Visekruna, A; Papoutsopoulou, S; Janzen, J; Zillwood, R; Tarlinton, DM; Tybulewicz, VLJ and Ley, SC (2014)
    IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.
    Journal of Experimental Medicine 211, 2085-2101 PubMed abstract
  • Ma, D; Cardoso, MJ; Modat, M; Powell, N; Wells, J; Holmes, H; Wiseman, F; Tybulewicz, V; Fisher, E; Lythgoe, MF and Ourselin, S (2014)
    Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion.
    PLOS ONE 9, e86576 PubMed abstract
  • Zenker, S; Panteleev-Ivlev, J; Wirtz, S; Kishimoto, T; Waldner, MJ; Ksionda, O; Tybulewicz, VLJ; Neurath, MF and Atreya, I (2014)
    A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.
    Journal of Immunology 192, 2830-2836 PubMed abstract
  • Ahmed, MM; Dhanasekaran, AR; Tong, S; Wiseman, FK; Fisher, EMC; Tybulewicz, VLJ and Gardiner, KJ (2013)
    Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.
    Human Molecular Genetics 22, 1709-1724 PubMed abstract
  • Gribble, SM; Wiseman, FK; Clayton, S; Prigmore, E; Langley, E; Yang, F; Maguire, S; Fu, B; Rajan, D; Sheppard, O; Scott, C; Hauser, H; Stephens, PJ; Stebbings, LA; Ng, BL; Fitzgerald, T; Quail, MA; Banerjee, R; Rothkamm, K; Tybulewicz, VLJ; Fisher, EMC and Carter, NP (2013)
    Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.
    PLOS ONE 8, e60482 PubMed abstract
  • Haas, MA; Bell, D; Slender, A; Lana-Elola, E; Watson-Scales, S; Fisher, EMC; Tybulewicz, VLJ and Guillemot, F (2013)
    Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down Syndrome.
    PLOS ONE 8, e78561 PubMed abstract
  • Hara, H; Tsuchiya, K; Kawamura, I; Fang, R; Hernandez-Cuellar, E; Shen, Y; Mizuguchi, J; Schweighoffer, E; Tybulewicz, V and Mitsuyama, M (2013)
    Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity.
    Nature Immunology 14, 1247-1255 PubMed abstract
  • Schweighoffer, E; Vanes, L; Nys, J; Cantrell, D; McCleary, S; Smithers, N and Tybulewicz, Victor LJ (2013)
    The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.
    Immunity 38, 475-488 PubMed abstract
  • Devoy, A; Bunton-Stasyshyn, RKA; Tybulewicz, VLJ; Smith, AJH and Fisher, EMC (2012)
    Genomically humanized mice: technologies and promises.
    Nature Reviews Genetics 13, 14-20 PubMed abstract
  • Finney, BA; Schweighoffer, E; Navarro-Núñez, L; Bénézech, C; Barone, F; Hughes, CE; Langan, SA; Lowe, KL; Pollitt, AY; Mourao-Sa, D; Sheardown, S; Nash, GB; Smithers, N; Reis e Sousa, C; Tybulewicz, VLJ and Watson, SP (2012)
    CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
    Blood 119, 1747-1756 PubMed abstract
  • Grizenkova, J; Akhtar, S; Hummerich, H; Tomlinson, A; Asante, EA; Wenborn, A; Fizet, J; Poulter, M; Wiseman, FK; Fisher, EMC; Tybulewicz, VLJ; Brandner, S; Collinge, J and Lloyd, SE (2012)
    Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.
    Proceedings of the National Academy of Sciences of the United States of America 109, 13722-13727 PubMed abstract
  • Haubert, D; Li, J; Saveliev, A; Calzascia, T; Sutter, E; Metzler, B; Kaiser, D; Tybulewicz, VLJ and Weckbecker, G (2012)
    Vav1 GEF activity is required for T cell mediated allograft rejection.
    Transplant Immunology 26, 212-219 PubMed abstract
  • Ksionda, O; Saveliev, A; Kochl, R; Rapley, J; Faroudi, M; Smith-Garvin, JE; Wulfing, C; Rittinger, K; Carter, T and Tybulewicz, VLJ (2012)
    Mechanism and function of Vav1 localization in TCR signaling.
    Journal of Cell Science 125, 5302-5314 PubMed abstract
  • Sheppard, O; Plattner, F; Rubin, A; Slender, A; Linehan, JM; Brandner, S; Tybulewicz, VLJ; Fisher, EMC and Wiseman, FK (2012)
    Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.
    Neurobiology of Aging 33, 828.e831- 828.e844 PubMed abstract
  • Sheppard, O; Wiseman, FK; Ruparelia, A; Tybulewicz, VLJ and Fisher, EMC (2012)
    Mouse models of aneuploidy.
    Scientific World Journal 2012, 214078 PubMed abstract
  • Vidaki, M; Tivodar, S; Doulgeraki, K; Tybulewicz, V; Kessaris, N; Pachnis, V and Karagogeos, D (2012)
    Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex.
    Cerebral Cortex 22, 680-692 PubMed abstract
  • Cleary, JO; Wiseman, FK; Norris, FC; Price, AN; Choy, M; Tybulewicz, VLJ; Ordidge, RJ; Brandner, S; Fisher, EMC and Lythgoe, MF (2011)
    Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain.
    NeuroImage 56, 974-983 PubMed abstract
  • da Gloria Sousa, M; Reid, DM; Schweighoffer, E; Tybulewicz, V; Ruland, J; Langhorne, J; Yamasaki, S; Taylor, PR; Almeida, SR and Brown, GD (2011)
    Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin.
    Cell Host & Microbe 9, 436-443 PubMed abstract
  • Duchon, A; Pothion, S; Brault, V; Sharp, AJ; Tybulewicz, VLJ; Fisher, EMC and Herault, Y (2011)
    The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.
    Behavioural Brain Research 217, 271-281 PubMed abstract
  • Lana-Elola, E; Watson-Scales, SD; Fisher, EMC and Tybulewicz, VLJ (2011)
    Down syndrome: searching for the genetic culprits.
    Disease Models & Mechanisms 4, 586-595
  • Singleton, KL; Gosh, M; Dandekar, RD; Au-Yeung, BB; Ksionda, O; Tybulewicz, VLJ; Altman, A; Fowell, DJ and Wülfing, C (2011)
    Itk controls the spatiotemporal organization of T cell activation.
    Science Signaling 4, ra66 PubMed abstract
  • Alford, K; Slender, A; Vanes, L; Li, Z; Fisher, EMC; Nizetic, D; Orkin, SH; Roberts, I and Tybulewicz, VLJ (2010)
    Perturbed hematopoiesis in the Tc1 mouse model of Down Syndrome.
    Blood 115, 2928-2937 PubMed abstract
  • Anderson, KE; Chessa, TAM; Davidson, K; Henderson, RB; Walker, S; Tolmachova, T; Grys, K; Rausch, O; Seabra, M; Tybulewicz, VLJ; Stephens, LR and Hawkins, PT (2010)
    PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils.
    Blood 116, 4978-4989 PubMed abstract
  • D'Amico, G; Robinson, SD; Germain, M; Reynolds, LE; Thomas, GJ; Elia, G; Saunders, G; Fruttiger, M; Tybulewicz, V; Mavria, G and Hodivala-Dilke, KM (2010)
    Endothelial-Rac1 is not required for tumor angiogenesis unless αvβ3-integrin is absent.
    PLOS ONE 5, e9766 PubMed abstract
  • De Vita, S; Canzonetta, C; Mulligan, C; Delom, F; Groet, J; Baldo, C; Vanes, L; Dagna-Bricarelli, F; Hoischen, A; Veltman, J; Fisher, EMC; Tybulewicz, VLJ and Nizetic, D (2010)
    Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome.
    Oncogene 29, 6102-6114 PubMed abstract
  • Dunlevy, L; Bennett, M; Slender, A; Lana-Elola, E; Tybulewicz, VL; Fisher, EMC and Mohun, T (2010)
    Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse.
    Cardiovascular Research 88, 287-295 PubMed abstract
  • Faroudi, M; Hons, M; Zachacz, A; Dumont, C; Lyck, R; Stein, JV and Tybulewicz, VLJ (2010)
    Critical roles for Rac GTPases in T cell migration to and within lymph nodes.
    Blood 116, 5536-5547 PubMed abstract
  • Henderson, RB; Grys, K; Vehlow, A; de Bettignies, C; Zachacz, A; Henley, T; Turner, M; Batista, F and Tybulewicz, VLJ (2010)
    A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
    Journal of Experimental Medicine 207, 837-853 PubMed abstract
  • Mócsai, A; Ruland, J and Tybulewicz, VLJ (2010)
    The SYK tyrosine kinase: a crucial player in diverse biological functions.
    Nature Reviews Immunology 10, 387-402 PubMed abstract
  • Reynolds, LE; Watson, AR; Baker, M; Jones, TA; D'Amico, G; Robinson, SD; Joffre, C; Garrido-Urbani, S; Rodriguez-Manzaneque, JC; Martino-Echarri, E; Aurrand-Lions, M; Sheer, D; Dagna-Bricarelli, F; Nizetic, D; McCabe, CJ; Turnell, AS; Kermorgant, S; Imhof, BA; Adams, R; Fisher, EMC; Tybulewicz, VLJ; Hart, IR and Hodivala-Dilke, KM (2010)
    Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.
    Nature 465, 813-817 PubMed abstract
  • Wiseman, FK; Sheppard, O; Linehan, JM; Brandner, S; Tybulewicz, VLJ and Fisher, EMC (2010)
    Generation of a panel of antibodies against proteins encoded on human chromosome 21.
    Journal of Negative Results in Biomedicine 9, 7 PubMed abstract

[Page last updated 1 Jun 2018]

Victor Tybulewicz portrait

Victor Tybulewicz
+44 (0)20 379 61612

  • Qualifications and history
  • 1984 PhD MRC Laboratory of Molecular Biology, Cambridge, UK
  • 1986-1991 Postdoctoral fellow, Whitehead Institute, MIT, Cambridge, MA, USA
  • 1991-2015 Group Leader, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK