Victor Tybulewicz: Biography

Victor Tybulewicz is a Group Leader and Head of Division of Immune Cell Biology at the Francis Crick Institute (previously the Medical Research Council National Institute for Medical Research; NIMR).

He obtained his BSc from Imperial College London and then studied for a PhD at the MRC Laboratory of Molecular Biology in Cambridge, under the supervision of Dr John Walker, working on the ATP synthases of bacteria and mitochondria. As a postdoctoral fellow at the Whitehead Institute, Massachusetts Institute of Technology, under the supervision of Professor Richard Mulligan, he worked on methods to target mouse embryonic stem cells.

On returning to the UK in 1991 he set up a group at NIMR using mouse genetics to study signal transduction in lymphocytes, exploring the roles of signaling molecules such as Syk, Vav1, Rac1 and Rac2 in B and T cell development, activation and survival.

In addition, with Elizabeth Fisher of UCL he used his knowledge of genetic manipulation of mice to generate a novel model of Down Syndrome, the Tc1 mouse strain. This strain of mice carries a freely segregating copy of human chromosome 21 (Hsa21). Analysis of the mice showed that they have a series of phenotypes resembling the human condition, including defects in learning and memory, cardiac and craniofacial defects, and altered megakaryopoiesis.

Currently Tybulewicz and Fisher are generating a large panel of mice trisomic for different sets of Hsa21 genes or their mouse orthologues, and using these to identify 'dosage-sensitive' genes that are required in three copies to cause specific Down syndrome phenotypes.

Victor Tybulewicz

victor.t@crick.ac.uk
+44 (0)20 379 61612

  • Qualifications and history
  • 1984 PhD MRC Laboratory of Molecular Biology, Cambridge, UK
  • 1986-1991 Postdoctoral fellow, Whitehead Institute, MIT, Cambridge, MA, USA
  • 1991-2015 Group Leader, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK