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Breadcrumb Sila Ultanir Ultanir lab Kinases and Brain Development Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies PublicationsYear published2024 (1)2023 (8)2022 (2)2021 (1)2020 (3)2018 (3)2017 (1)2014 (1)2012 (1) Facet Year publishedResearch topicsNeurosciences (18)Cell Biology (17)Chemical Biology & High Throughput (17)Developmental Biology (17)Signalling & Oncogenes (17)Computational & Systems Biology (8)Biochemistry & Proteomics (6)Model Organisms (6)Genetics & Genomics (5)Tumour Biology (5)Genome Integrity & Repair (4)Imaging (3)Stem Cells (3)Gene Expression (2)Structural Biology & Biophysics (1) Facet Research topicsCrick/Pre-CrickCrick publications (19)Pre-Crick publications (1) Facet Crick/Pre-CrickPublication typeJournal article (20)Primary research (16)Review (3)Method (1) Facet Publication typeJournalNature Communications (4)eLife (2)Life Science Alliance (2)Neuron (2)ACS Chemical Neuroscience (1)EMBO Journal (1)Frontiers in Molecular Neuroscience (1)Journal of Biological Chemistry (1)Molecular Psychiatry (1)Nature Protocols (1)Progress in Neuro-psychopharmacology & Biological Psychiatry (1)Science advances (1)Science Translational Medicine (1)Trends in Neurosciences (1) Facet Journal Publications Displaying 1 - 20 of 21Last updated : 29 March 2024 02:21 Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain Authors (5)Margaux SilvestreKelvin DempsterSimeon MihaylovSuzanne ClaxtonSila Ultanir Molecular Psychiatry Published 8 February 2024 Crick labs/ facilitiesSila UltanirGenetic Modification ServiceBiological Research FacilityFull details Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability Authors (10)Marisol Sampedro CastanedaLucas BaltussenAndre Teixeira Lopes Yichen Qiu Liina SirvioSimeon MihaylovSuzanne Claxton Jill C Richardson Gabriele LignaniSila Ultanir Nature Communications Published 11 December 2023 Crick labs/ facilitiesSila UltanirProteomicsGenetic Modification ServiceBiological Research FacilityFull details A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia Authors (15) Anna LaddachSong Hui ChngReena LasradoFranze ProgatzkyMichael Shapiro Alek Erickson[...] Jens Kleinjung Stefan BoeingSila Ultanir Igor AdameykoVassilis Pachnis Nature Communications Published 22 September 2023 Crick labs/ facilitiesSila UltanirVassilis PachnisBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function Authors (16)Simeon Mihaylov Lydia M Castelli Ya-Hui Lin Aytac Gül Nikita Soni Christopher Hastings[...] Oliver Bandmann Tatyana A Shelkovnikova Heather MortiboysSila Ultanir Guillaume M Hautbergue Nature Communications Published 7 September 2023 Crick labs/ facilitiesSila UltanirFrancois GuillemotProteomicsBioinformatics and BiostatisticsFull details Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology Authors (19) Anna CastanoMargaux Silvestre Carrow I Wells Jennifer L Sanderson Carla A Ferrer Han Wee Ong[...] Navlot S Pabla Alex N Bullock Tim A BenkeSila Ultanir Alison D Axtman eLife Published 25 July 2023 Crick labsSila UltanirFull details Activity-dependent membrane sculpting deficits in TAOK1-linked neurodevelopmental disease Authors (2)Marisol Sampedro CastanedaSila Ultanir Trends in Neurosciences Published 1 August 2023 Crick labsSila UltanirFull details Discovery of a potent and selective CDKL5/GSK3 chemical probe that is neuroprotective Authors (16) Han Wee Ong Yi Liang William Richardson Emily R Lowry Carrow I Wells Xiangrong Chen[...] Navjot S PablaSila Ultanir Alex N Bullock David H Drewry Alison D Axtman ACS Chemical Neuroscience Published 3 May 2023 Crick labsSila UltanirFull details Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis Authors (9) Pranetha BaskaranSimeon Mihaylov Elin Vinsland Kriti Shah Lucy GranatSila Ultanir Andrew R Tee Jernej Murn Joseph M Bateman Journal of Biological Chemistry Published 1 January 2023 Crick labsSila UltanirFull details Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration Authors (14) Flavia RoşianuSimeon MihaylovNoreen Eder Antonie MartiniucSuzanne Claxton Helen R Flynn[...]Mark SkehelBram Snijders Matthias KrauseSharon ToozeSila Ultanir Life Science Alliance Published 1 February 2023 Crick labs/ facilitiesSila UltanirSharon ToozeProteomicsElectron MicroscopyExperimental HistopathologyFull details Mechanistic target of rapamycin signaling in human nervous system development and disease Authors (3) Marie GirodengoSila Ultanir Joseph M Bateman Frontiers in Molecular Neuroscience Published 26 September 2022 Crick labsSila UltanirFull details Molecular profiling of enteric nervous system cell lineages Authors (10)Yuuki ObataAlvaro Castano MedinaTodd FallesenAna Carina Bon Frauches Oliveira Stefan BoeingAlmaz HuseynovaSarah MccallumReena LasradoTiffany HeanueVassilis Pachnis Nature Protocols Published 1 August 2022 Crick labs/ facilitiesSila UltanirVassilis PachnisLight MicroscopyBioinformatics and BiostatisticsScientific computingFull details Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes Authors (8) Daniela Ivanova Katharine L Dobson Akshada Gajbhiye Elizabeth C Davenport Daniela HackerSila Ultanir Matthias Trost Michael A Cousin Science advances Published 30 April 2021 Crick labsSila UltanirFull details Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme Authors (11)Roman Fedoryshchak Magdalena Přechová Abbey M Butler Rebecca LeeNicola O'Reilly Helen R FlynnBram SnijdersNoreen EderSila UltanirStephane MouilleronRichard Treisman eLife Published 25 September 2020 Crick labs/ facilitiesSila UltanirRichard TreismanStructural BiologyProteomicsLight MicroscopyFermentationBiological Research FacilityAdvanced SequencingFull details Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models Authors (22) Paolo La Montanara Arnau HerveraLucas Baltussen Thomas H Hutson Ilaria Palmisano Francesco De Virgiliis[...] Hongwei Yu David S Millar Nagy Istvan Nicholas D Mazarakis Simone Di Giovanni Science Translational Medicine Published 8 July 2020 Crick labsSila UltanirFull details YAP1/TAZ drives ependymoma-like tumour formation in mice Authors (15)Noreen Eder Federico Roncaroli Marie-Charlotte Dolmart Stuart Horswell Felipe Andreiuolo Helen Flynn[...] Jun-Hao Mao Torsten Pietsch Barry ThompsonBram SnijdersSila Ultanir Nature Communications Published 1 December 2020 Crick labs/ facilitiesSila UltanirBarry ThompsonProteomicsElectron MicroscopyBioinformatics and BiostatisticsFull details Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase Authors (10) Amy W Lin Kalbinder K GillMarisol Sampedro Castaneda Irene MatucciNoreen EderSuzanne Claxton Helen FlynnBram SnijdersRoger GeorgeSila Ultanir Life Science Alliance Published 31 December 2018 Crick labs/ facilitiesSila UltanirStructural BiologyProteomicsLight MicroscopyGenetic Modification ServiceBiological Research FacilityFull details Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics Authors (10)Lucas Baltussen Priscilla D NegraesMargaux SilvestreSuzanne Claxton M Moeskops Evangelos Christodoulou Helen R FlynnBram Snijders Alysson R MuotriSila Ultanir EMBO Journal Published 28 September 2018 Crick labs/ facilitiesSila UltanirStructural BiologyProteomicsLight MicroscopyFull details Kinases in synaptic development and neurological diseases Authors (3)Lucas BaltussenFlavia RosianuSila Ultanir Progress in Neuro-psychopharmacology & Biological Psychiatry Published 8 June 2018 Crick labsSila UltanirFull details MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development Authors (9)Sila Ultanir Smita Yadav Nicholas T Hertz Juan A Oses-PrietoSuzanne Claxton Alma L Burlingame Kevan M Shokat Lily Y Jan Yuh-Nung Jan Neuron Published 1 January 2014 Crick labsSila UltanirFull details Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 uncovers their roles in dendrite arborization and spine development Authors (9)Sila Ultanir Nicholas T Hertz Guangnan Li Woo-Ping Ge Alma L Burlingame Samuel J Pleasure Kevan M Shokat Lily Yeh Jan Yuh-Nung Jan Neuron Published 1 January 2012 Crick labsSila UltanirFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain Authors (5)Margaux SilvestreKelvin DempsterSimeon MihaylovSuzanne ClaxtonSila Ultanir Molecular Psychiatry Published 8 February 2024 Crick labs/ facilitiesSila UltanirGenetic Modification ServiceBiological Research FacilityFull details
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability Authors (10)Marisol Sampedro CastanedaLucas BaltussenAndre Teixeira Lopes Yichen Qiu Liina SirvioSimeon MihaylovSuzanne Claxton Jill C Richardson Gabriele LignaniSila Ultanir Nature Communications Published 11 December 2023 Crick labs/ facilitiesSila UltanirProteomicsGenetic Modification ServiceBiological Research FacilityFull details
A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia Authors (15) Anna LaddachSong Hui ChngReena LasradoFranze ProgatzkyMichael Shapiro Alek Erickson[...] Jens Kleinjung Stefan BoeingSila Ultanir Igor AdameykoVassilis Pachnis Nature Communications Published 22 September 2023 Crick labs/ facilitiesSila UltanirVassilis PachnisBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function Authors (16)Simeon Mihaylov Lydia M Castelli Ya-Hui Lin Aytac Gül Nikita Soni Christopher Hastings[...] Oliver Bandmann Tatyana A Shelkovnikova Heather MortiboysSila Ultanir Guillaume M Hautbergue Nature Communications Published 7 September 2023 Crick labs/ facilitiesSila UltanirFrancois GuillemotProteomicsBioinformatics and BiostatisticsFull details
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology Authors (19) Anna CastanoMargaux Silvestre Carrow I Wells Jennifer L Sanderson Carla A Ferrer Han Wee Ong[...] Navlot S Pabla Alex N Bullock Tim A BenkeSila Ultanir Alison D Axtman eLife Published 25 July 2023 Crick labsSila UltanirFull details
Activity-dependent membrane sculpting deficits in TAOK1-linked neurodevelopmental disease Authors (2)Marisol Sampedro CastanedaSila Ultanir Trends in Neurosciences Published 1 August 2023 Crick labsSila UltanirFull details
Discovery of a potent and selective CDKL5/GSK3 chemical probe that is neuroprotective Authors (16) Han Wee Ong Yi Liang William Richardson Emily R Lowry Carrow I Wells Xiangrong Chen[...] Navjot S PablaSila Ultanir Alex N Bullock David H Drewry Alison D Axtman ACS Chemical Neuroscience Published 3 May 2023 Crick labsSila UltanirFull details
Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis Authors (9) Pranetha BaskaranSimeon Mihaylov Elin Vinsland Kriti Shah Lucy GranatSila Ultanir Andrew R Tee Jernej Murn Joseph M Bateman Journal of Biological Chemistry Published 1 January 2023 Crick labsSila UltanirFull details
Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration Authors (14) Flavia RoşianuSimeon MihaylovNoreen Eder Antonie MartiniucSuzanne Claxton Helen R Flynn[...]Mark SkehelBram Snijders Matthias KrauseSharon ToozeSila Ultanir Life Science Alliance Published 1 February 2023 Crick labs/ facilitiesSila UltanirSharon ToozeProteomicsElectron MicroscopyExperimental HistopathologyFull details
Mechanistic target of rapamycin signaling in human nervous system development and disease Authors (3) Marie GirodengoSila Ultanir Joseph M Bateman Frontiers in Molecular Neuroscience Published 26 September 2022 Crick labsSila UltanirFull details
Molecular profiling of enteric nervous system cell lineages Authors (10)Yuuki ObataAlvaro Castano MedinaTodd FallesenAna Carina Bon Frauches Oliveira Stefan BoeingAlmaz HuseynovaSarah MccallumReena LasradoTiffany HeanueVassilis Pachnis Nature Protocols Published 1 August 2022 Crick labs/ facilitiesSila UltanirVassilis PachnisLight MicroscopyBioinformatics and BiostatisticsScientific computingFull details
Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes Authors (8) Daniela Ivanova Katharine L Dobson Akshada Gajbhiye Elizabeth C Davenport Daniela HackerSila Ultanir Matthias Trost Michael A Cousin Science advances Published 30 April 2021 Crick labsSila UltanirFull details
Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme Authors (11)Roman Fedoryshchak Magdalena Přechová Abbey M Butler Rebecca LeeNicola O'Reilly Helen R FlynnBram SnijdersNoreen EderSila UltanirStephane MouilleronRichard Treisman eLife Published 25 September 2020 Crick labs/ facilitiesSila UltanirRichard TreismanStructural BiologyProteomicsLight MicroscopyFermentationBiological Research FacilityAdvanced SequencingFull details
Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models Authors (22) Paolo La Montanara Arnau HerveraLucas Baltussen Thomas H Hutson Ilaria Palmisano Francesco De Virgiliis[...] Hongwei Yu David S Millar Nagy Istvan Nicholas D Mazarakis Simone Di Giovanni Science Translational Medicine Published 8 July 2020 Crick labsSila UltanirFull details
YAP1/TAZ drives ependymoma-like tumour formation in mice Authors (15)Noreen Eder Federico Roncaroli Marie-Charlotte Dolmart Stuart Horswell Felipe Andreiuolo Helen Flynn[...] Jun-Hao Mao Torsten Pietsch Barry ThompsonBram SnijdersSila Ultanir Nature Communications Published 1 December 2020 Crick labs/ facilitiesSila UltanirBarry ThompsonProteomicsElectron MicroscopyBioinformatics and BiostatisticsFull details
Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase Authors (10) Amy W Lin Kalbinder K GillMarisol Sampedro Castaneda Irene MatucciNoreen EderSuzanne Claxton Helen FlynnBram SnijdersRoger GeorgeSila Ultanir Life Science Alliance Published 31 December 2018 Crick labs/ facilitiesSila UltanirStructural BiologyProteomicsLight MicroscopyGenetic Modification ServiceBiological Research FacilityFull details
Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics Authors (10)Lucas Baltussen Priscilla D NegraesMargaux SilvestreSuzanne Claxton M Moeskops Evangelos Christodoulou Helen R FlynnBram Snijders Alysson R MuotriSila Ultanir EMBO Journal Published 28 September 2018 Crick labs/ facilitiesSila UltanirStructural BiologyProteomicsLight MicroscopyFull details
Kinases in synaptic development and neurological diseases Authors (3)Lucas BaltussenFlavia RosianuSila Ultanir Progress in Neuro-psychopharmacology & Biological Psychiatry Published 8 June 2018 Crick labsSila UltanirFull details
MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development Authors (9)Sila Ultanir Smita Yadav Nicholas T Hertz Juan A Oses-PrietoSuzanne Claxton Alma L Burlingame Kevan M Shokat Lily Y Jan Yuh-Nung Jan Neuron Published 1 January 2014 Crick labsSila UltanirFull details
Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 uncovers their roles in dendrite arborization and spine development Authors (9)Sila Ultanir Nicholas T Hertz Guangnan Li Woo-Ping Ge Alma L Burlingame Samuel J Pleasure Kevan M Shokat Lily Yeh Jan Yuh-Nung Jan Neuron Published 1 January 2012 Crick labsSila UltanirFull details