Sharon Tooze: Publications

  • Galluzzi, L; Baehrecke, EH; Ballabio, A; Boya, P; Bravo-San Pedro, JM; Cecconi, F; Choi, AM; Chu, CT; Codogno, P; Colombo, MI; Cuervo, AM; Debnath, J; Deretic, V; Dikic, I; Eskelinen, E-L; Fimia, GM; Fulda, S; Gewirtz, DA; Green, DR; Hansen, M; Harper, JW; Jäättelä, M; Johansen, T; Juhasz, G; Kimmelman, AC; Kraft, C; Ktistakis, NT; Kumar, S; Levine, B; Lopez-Otin, C; Madeo, F; Martens, S; Martinez, J; Melendez, A; Mizushima, N; Münz, C; Murphy, LO; Penninger, JM; Piacentini, M; Reggiori, F; Rubinsztein, DC; Ryan, KM; Santambrogio, L; Scorrano, L; Simon, AK; Simon, H-U; Simonsen, A; Tavernarakis, N; Tooze, SA; Yoshimori, T; Yuan, J; Yue, Z; Zhong, Q and Kroemer, G (2017)
    Molecular definitions of autophagy and related processes.
    EMBO Journal 36, 1811-1836 PubMed abstract
  • Hannan, LA; Marks, MS; Schroer, TA and Tooze, SA (2017)
    So long Tom!.
    Traffic 18, 5 PubMed abstract
  • Joachim, J; Razi, M; Judith, D; Wirth, M; Calamita, E; Encheva, V; Dynlacht, BD; Snijders, AP; O'Reilly, N; Jefferies, HBJ and Tooze, SA (2017)
    Centriolar satellites control GABARAP ubiquitination and GABARAP-mediated autophagy.
    Current Biology 27, 2123-2136.e2127 PubMed abstract
  • Joachim, J and Tooze, SA (2017)
    Control of GABARAP-mediated autophagy by the Golgi complex, centrosome and centriolar satellites.
    Biology of the Cell [Epub ahead of print] PubMed abstract
  • Lamb, CA; Joachim, J and Tooze, SA (2017)
    Quantifying autophagic structures in mammalian cells using confocal microscopy.
    Methods in Enzymology 587, 21-42 PubMed abstract
  • Martinez-Martin, N; Maldonado, P; Gasparrini, F; Frederico, B; Aggarwal, S; Gaya, M; Tsui, C; Burbage, M; Keppler, SJ; Montaner, B; Jefferies, HBJ; Nair, U; Zhao, YG; Domart, M-C; Collinson, L; Bruckbauer, A; Tooze, SA and Batista, FD (2017)
    A switch from canonical to noncanonical autophagy shapes B cell responses.
    Science 355, 641-647 PubMed abstract
  • New, M; Van Acker, T; Long, JS; Sakamaki, J-i; Ryan, KM and Tooze, SA (2017)
    Molecular pathways controlling autophagy in pancreatic cancer.
    Frontiers in Oncology 7, 28 PubMed abstract
  • O'Prey, J; Sakamaki, J; Baudot, AD; New, M; Van Acker, T; Tooze, SA; Long, JS and Ryan, KM (2017)
    Application of CRISPR/Cas9 to autophagy research.
    Methods in Enzymology 588, 79-108 PubMed abstract
  • Sakamaki, J-i; Long, JS; New, M; Van Acker, T; Tooze, SA and Ryan, KM (2017)
    Emerging roles of transcriptional programs in autophagy regulation.
    Transcription [Epub ahead of print] PubMed abstract
  • Sakamaki, J-i; Wilkinson, S; Hahn, M; Tasdemir, N; O'Prey, J; Clark, W; Hedley, A; Nixon, C; Long, JS; New, M; Van Acker, T; Tooze, SA; Lowe, SW; Dikic, I and Ryan, KM (2017)
    Bromodomain protein BRD4 is a transcriptional repressor of autophagy and lysosomal function.
    Molecular Cell 66, 517-532 e519 PubMed abstract
  • Skytte Rasmussen, M; Mouilleron, S; Kumar Shrestha, B; Wirth, M; Lee, R; Bowitz Larsen, K; Abudu Princely, Y; O'Reilly, N; Sjøttem, E; Tooze, SA; Lamark, T and Johansen, T (2017)
    ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.
    Autophagy 13, 834-853 PubMed abstract
  • Tooze, SA and Chen, Q (2017)
    Editorial overview: Celebrating the advances in cell biology from China.
    Traffic 18, 335 PubMed abstract
  • Tooze, SA; Hannan, LA; Marks, MS; Stevens, TH and Schroer, TA (2017)
    Fundamental mechanisms deliver the Nobel Prize to Ohsumi.
    Traffic 18, 93-95 PubMed abstract
  • Tooze, SA and Hurley, JH (2017)
    Molecular mechanisms of autophagy-Part B.
    Journal of Molecular Biology 429, 455-456 PubMed abstract
  • Yu, L; Chen, Y and Tooze, SA (2017)
    Autophagy pathway: cellular and molecular mechanisms.
    Autophagy [Epub ahead of print] PubMed abstract
  • Joachim, J and Tooze, SA (2016)
    GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130.
    Autophagy 12, 892-893 PubMed abstract
  • Klionsky, DJ; Abdelmohsen, K; ...; Gutierrez, MG; ...; Swanton, C; ... and Tooze, SA (2016)
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
    Autophagy 12, 1-222 PubMed abstract
  • Ktistakis, NT and Tooze, SA (2016)
    Digesting the expanding mechanisms of autophagy.
    Trends in Cell Biology 26, 624-635 PubMed abstract
  • Lamb, CA; Longatti, A and Tooze, SA (2016)
    Rabs and GAPs in starvation-induced autophagy.
    Small GTPases 7, 265-269 PubMed abstract
  • Lamb, CA; Nühlen, S; Judith, D; Frith, D; Snijders, AP; Behrends, C and Tooze, SA (2016)
    TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic.
    EMBO Journal 35, 281-301 PubMed abstract
  • Lamb, CA and Tooze, SA (2016)
    TBC1D14 and TRAPP - regulating autophagy through ATG9.
    Cell Cycle 15, 1797-1798 PubMed abstract
  • Lamb, CA and Tooze, SA (2016)
    TBC1D14 sets the TRAPP for ATG9.
    Autophagy 12, 1212-1213 PubMed abstract
  • Manzoni, C; Mamais, A; Roosen, DA; Dihanich, S; Soutar, MPM; Plun-Favreau, H; Bandopadhyay, R; Hardy, J; Tooze, SA; Cookson, MR and Lewis, PA (2016)
    mTOR independent regulation of macroautophagy by Leucine rich repeat kinase 2 via Beclin-1.
    Scientific Reports 6, 35106 PubMed abstract
  • Mauthe, M; Langereis, M; Jung, J; Zhou, X; Jones, A; Omta, W; Tooze, SA; Stork, B; Paludan, SR; Ahola, T; Egan, D; Behrends, C; Mokry, M; de Haan, C; van Kuppeveld, F and Reggiori, F (2016)
    An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.
    Journal of Cell Biology 214, 619-635 PubMed abstract
  • Redmann, V; Lamb, CA; Hwang, S; Orchard, RC; Kim, S; Razi, M; Milam, A; Park, S; Yokoyama, CC; Kambal, A; Kreamalmeyer, D; Bosch, MK; Xiao, M; Green, K; Kim, J; Pruett-Miller, SM; Ornitz, DM; Allen, PM; Beatty, WL; Schmidt, RE; DiAntonio, A; Tooze, SA and Virgin, HW (2016)
    Clec16a is critical for autolysosome function and Purkinje cell survival.
    Scientific Reports 6, 23326 PubMed abstract
  • Tooze, SA and Dikic, I (2016)
    Autophagy captures the Nobel Prize.
    Cell 167, 1433-1435 PubMed abstract
  • Dooley, HC; Wilson, MI and Tooze, SA (2015)
    WIPI2B links PtdIns3P to LC3 lipidation through binding ATG16L1.
    Autophagy 11, 190-191 PubMed abstract
  • Gomez-Sanchez, JA; Carty, L; Iruarrizaga-Lejarreta, M; Palomo-Irigoyen, M; Varela-Rey, M; Griffith, M; Hantke, J; Macias-Camara, N; Azkargorta, M; Aurrekoetxea, I; De Juan, VG; Jefferies, HBJ; Aspichueta, P; Elortza, F; Aransay, AM; Martínez-Chantar, ML; Baas, F; Mato, JM; Mirsky, R; Woodhoo, A and Jessen, KR (2015)
    Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves.
    Journal of Cell Biology 210, 153-168 PubMed abstract
  • Joachim, J; Jefferies, HBJ; Razi, M; Frith, D; Snijders, AP; Chakravarty, P; Judith, D and Tooze, SA (2015)
    Activation of ULK kinase and autophagy by GABARAP trafficking from the centrosome is regulated by WAC and GM130.
    Molecular Cell 60, 899-913 PubMed abstract
  • Joachim, J; Jiang, M; McKnight, NC; Howell, M and Tooze, SA (2015)
    High-throughput screening approaches to identify regulators of mammalian autophagy.
    Methods 75, 96-104 PubMed abstract
  • Tooze, S and Zoncu, R (2015)
    Control of cellular homeostasis: organelles take the pilot's seat.
    Molecular Biology of the Cell 26, 1009-1010 PubMed abstract
  • Tooze, SA; Dooley, HC; Jefferies, HBJ; Joachim, J; Judith, D; Lamb, CA; Razi, M and Wirth, M (2015)
    Assessing mammalian autophagy.
    Methods in Molecular Biology 1270, 155-165 PubMed abstract
  • Dooley, HC; Razi, M; Polson, HEJ; Girardin, SE; Wilson, MI and Tooze, SA (2014)
    WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.
    Molecular Cell 55, 238-252 PubMed abstract
  • Duke, EMH; Razi, M; Weston, A; Guttmann, P; Werner, S; Henzler, K; Schneider, G; Tooze, SA and Collinson, LM (2014)
    Imaging endosomes and autophagosomes in whole mammalian cells using correlative cryo-fluorescence and cryo-soft X-ray microscopy (cryo-CLXM).
    Ultramicroscopy 143, 77-87 PubMed abstract
  • Ellis, RA; Horswell, S; Ness, T; Lumsdon, J; Tooze, SA; Kirkham, N; Armstrong, JL and Lovat, PE (2014)
    Prognostic impact of p62 expression in cutaneous malignant melanoma.
    Journal of Investigative Dermatology 134, 1476-1478 PubMed abstract
  • Henson, SM; Lanna, A; Riddell, NE; Franzese, O; Macaulay, R; Griffiths, SJ; Puleston, DJ; Watson, AS; Simon, AK; Tooze, SA and Akbar, AN (2014)
    p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells.
    Journal of Clinical Investigation 124, 4004-4016 PubMed abstract
  • Tooze, S; Dooley, H; Razi, M and Wilson, M (2014)
    Autophagosome formation and the role of WIPI2.
    Molecular Biology of the Cell 25, Abstract M91
  • Tooze, SA; Abada, A and Elazar, Z (2014)
    Endocytosis and autophagy: exploitation or cooperation?
    Cold Spring Harbor Perspectives in Biology 6, a018358 PubMed abstract
  • Wilson, MI; Dooley, HC and Tooze, SA (2014)
    WIPI2b and Atg16L1: setting the stage for autophagosome formation.
    Biochemical Society Transactions 42, 1327-1334 PubMed abstract
  • Kalie, E; Razi, M and Tooze, SA (2013)
    ULK1 regulates melanin levels in MNT-1 cells independently of mTORC1.
    PLOS ONE 8, e75313 PubMed abstract
  • Kögel, T; Rudolf, R; Hodneland, E; Copier, J; Regazzi, R; Tooze, SA and Gerdes, H-H (2013)
    Rab3D is critical for secretory granule maturation in PC12 cells.
    PLOS ONE 8, e57321 PubMed abstract
  • Ktistakis, NT and Tooze, SA (2013)
    PIPing on lysosome tubes.
    EMBO Journal 32, 315-317 PubMed abstract
  • Lamb, CA; Dooley, HC and Tooze, SA (2013)
    Endocytosis and autophagy: Shared machinery for degradation.
    Bioessays 35, 34-45 PubMed abstract
  • Lamb, CA; Yoshimori, T and Tooze, SA (2013)
    The autophagosome: origins unknown, biogenesis complex.
    Nature Reviews Molecular Cell Biology 14, 759-774 PubMed abstract
  • Manzoni, C; Mamais, A; Dihanich, S; Abeti, R; Soutar, MPM; Plun-Favreau, H; Giunti, P; Tooze, SA; Bandopadhyay, R and Lewis, PA (2013)
    Inhibition of LRRK2 kinase activity stimulates macroautophagy.
    Biochimica et Biophysica Acta 1833, 2900-2910 PubMed abstract
  • McAlpine, F; Williamson, LE; Tooze, SA and Chan, EYW (2013)
    Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.
    Autophagy 9, 361-373 PubMed abstract
  • Shoji-Kawata, S; Sumpter, R, Jr; Leveno, M; Campbell, GR; Zou, Z; Kinch, L; Wilkins, AD; Sun, Q; Pallauf, K; MacDuff, D; Huerta, C; Virgin, HW; Helms, JB; Eerland, R; Tooze, SA; Xavier, R; Lenschow, DJ; Yamamoto, A; King, D; Lichtarge, O; Grishin, NV; Spector, SA; Kaloyanova, DV and Levine, B (2013)
    Identification of a candidate therapeutic autophagy-inducing peptide.
    Nature 494, 201-206 PubMed abstract
  • Tattoli, I; Sorbara, MT; Yang, C; Tooze, SA; Philpott, DJ and Girardin, SE (2013)
    Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures.
    EMBO Journal 32, 3066-3078 PubMed abstract
  • Tooze, SA (2013)
    Current views on the source of the autophagosome membrane.
    Essays in Biochemistry 55, 29-38 PubMed abstract
  • Wirth, M; Joachim, J and Tooze, SA (2013)
    Autophagosome formation—The role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.
    Seminars in Cancer Biology 23, 301-309 PubMed abstract
  • Joachim, J; Wirth, M; McKnight, NC and Tooze, SA (2012)
    Coiling up with SCOC and WAC: two new regulators of starvation-induced autophagy.
    Autophagy 8, 1397-1400 PubMed abstract
  • Kalie, E and Tooze, SA (2012)
    Tales of the autophagy crusaders.
    EMBO Reports 13, 175-177 PubMed abstract
  • Kraft, C; Kijanska, M; Kalie, E; Siergiejuk, E; Lee, SS; Semplicio, G; Stoffel, I; Brezovich, A; Verma, M; Hansmann, I; Ammerer, G; Hofmann, K; Tooze, S and Peter, M (2012)
    Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.
    EMBO Journal 31, 3691-3703 PubMed abstract
  • Lee, AJX; Roylance, R; Sander, J; Gorman, P; Endesfelder, D; Kschischo, M; Jones, NP; East, P; Nicke, B; Spassieva, S; Obeid, LM; Birkbak, NJ; Szallasi, Z; McKnight, NC; Rowan, AJ; Speirs, V; Hanby, AM; Downward, J; Tooze, SA and Swanton, C (2012)
    CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction.
    Journal of Pathology 226, 482-494 PubMed abstract
  • Longatti, A; Lamb, CA; Razi, M; Yoshimura, S-i; Barr, FA and Tooze, SA (2012)
    TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.
    Journal of Cell Biology 197, 659-675 PubMed abstract
  • Longatti, A and Tooze, SA (2012)
    Recycling endosomes contribute to autophagosome formation.
    Autophagy 8, 1682-1683 PubMed abstract
  • McKnight, NC; Jefferies, HBJ; Alemu, EA; Saunders, RE; Howell, M; Johansen, T and Tooze, SA (2012)
    Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
    EMBO Journal 31, 1931-1946 PubMed abstract
  • Orsi, A; Razi, M; Dooley, HC; Robinson, D; Weston, AE; Collinson, LM and Tooze, SA (2012)
    Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.
    Molecular Biology of the Cell 23, 1860-1873 PubMed abstract
  • Reggiori, F and Tooze, SA (2012)
    Autophagy regulation through Atg9 traffic.
    Journal of Cell Biology 198, 151-153 PubMed abstract
  • DeSelm, CJ; Miller, BC; Zou, W; Beatty, WL; van Meel, E; Takahata, Y; Klumperman, J; Tooze, SA; Teitelbaum, SL and Virgin, HW (2011)
    Autophagy proteins regulate the secretory component of osteoclastic bone resorption.
    Developmental Cell 21, 966-974 PubMed abstract
  • Klionsky, DJ; Baehrecke, EH; Brumell, JH; Chu, CT; Codogno, P; Cuervo, AM; Debnath, J; Deretic, V; Elazar, Z; Eskelinen, E-L; Finkbeiner, S; Fueyo-Margareto, J; Gewirtz, D; Jäättelä, M; Kroemer, G; Levine, B; Melia, TJ; Mizushima, N; Rubinsztein, DC; Simonsen, A; Thorburn, A; Thumm, M and Tooze, SA (2011)
    A comprehensive glossary of autophagy-related molecules and processes (2nd edition).
    Autophagy 7, 1273-1294 PubMed abstract
  • Mari, M; Tooze, SA and Reggiori, F (2011)
    The puzzling origin of the autophagosomal membrane.
    F1000 Biology Reports 3, 25 PubMed abstract
  • Tooze, SA and Codogno, P (2011)
    Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2.
    EMBO Journal 30, 1185-1186 PubMed abstract
  • Klionsky, DJ; Codogno, P; Cuervo, AM; Deretic, V; Elazar, Z; Fueyo-Margareto, J; Gewirtz, DA; Kroemer, G; Levine, B; Mizushima, N; Rubinsztein, DC; Thumm, M and Tooze, SA (2010)
    A comprehensive glossary of autophagy-related molecules and processes.
    Autophagy 6, 438-448 PubMed abstract
  • Longatti, A; Orsi, A and Tooze, SA (2010)
    Autophagosome formation: not necessarily an inside job.
    Cell Research 20, 1181-1184 PubMed abstract
  • Orsi, A; Polson, HEJ and Tooze, SA (2010)
    Membrane trafficking events that partake in autophagy.
    Current Opinion in Cell Biology 22, 150-156 PubMed abstract
  • Otto, GP; Razi, M; Morvan, J; Stenner, F and Tooze, SA (2010)
    A novel Syntaxin 6-interacting protein, SHIP164, regulates Syntaxin 6-dependent sorting from early endosomes.
    Traffic 11, 688-705 PubMed abstract
  • Polson, HEJ; de Lartigue, J; Rigden, DJ; Reedijk, M; Urbé, S; Clague, MJ and Tooze, SA (2010)
    Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.
    Autophagy 6, 506-522 PubMed abstract
  • Tooze, SA (2010)
    The role of membrane proteins in mammalian autophagy.
    Seminars in Cell & Developmental Biology 21, 677-682 PubMed abstract
  • Tooze, SA; Jefferies, HBJ; Kalie, E; Longatti, A; Mcalpine, FE; Mcknight, NC; Orsi, A; Polson, HEJ; Razi, M; Robinson, DJ and Webber, JL (2010)
    Trafficking and signaling in mammalian autophagy.
    IUBMB life 62, 503-508 PubMed abstract
  • Tooze, SA and Yoshimori, T (2010)
    The origin of the autophagosomal membrane.
    Nature Cell Biology 12, 831-835 PubMed abstract
  • Webber, JL and Tooze, SA (2010)
    Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP.
    EMBO Journal 29, 27-40 PubMed abstract
  • Webber, JL and Tooze, SA (2010)
    New insights into the function of Atg9.
    FEBS Letters 584, 1319-1326 PubMed abstract

[Page last updated 1 Nov 2017]

Sharon Tooze

sharon.tooze@crick.ac.uk
+44 (0)20 379 61340

  • Qualifications and history
  • 1987 PhD, University of Heidelberg, Germany
  • 1990 Research Scientist, European Molecular Biology Laboratory, Germany
  • 1994  Established lab at Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2015 Group Leader, the Francis Crick Institute, London, UK