Sharon Tooze: Biography

Sharon A. Tooze has a long-standing interest in molecular cell biology, starting with her PhD work done at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. At the EMBL, studying the transport of a viral glycoprotein from a SARS virus, she was able to show that O-linked glycosylation starts in the ER-Golgi intermediate compartment (Tooze et al., JCB 1988). Following this she became interested in organelle biogenesis, and in how immature secretory granules formed from the trans-Golgi network in neuroendocrine cells (Tooze et al., Cell, 1990, Nature 1990).

She maintained her interest in the biogenesis of secretory granules moving to the Imperial Cancer Research Fund, later the Cancer Research UK London Research Institute (and now part of the Francis Crick Institute), and in 2006 developed her interest in autophagy, and the biogenesis of autophagosomes.

Since 2006 Sharon's lab has identified several mammalian Atg proteins and continues to contribute to understanding autophagy at the molecular cell biological level.

Sharon Tooze
+44 (0)20 379 61340

  • Qualifications and history
  • 1987 PhD, University of Heidelberg, Germany
  • 1990 Research Scientist, European Molecular Biology Laboratory, Germany
  • 1994  Established lab at Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2015 Group Leader, the Francis Crick Institute, London, UK