Richard Treisman: Publications

  • Foster, CT; Gualdrini, F and Treisman, R (2018)
    Mutual dependence of the MRTF-SRF and YAP-TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics.
    Genes & Development 31, 2361-2375 PubMed abstract
  • Esnault, C; Gualdrini, F; Horswell, S; Kelly, G; Stewart, A; East, P; Matthews, N and Treisman, R (2017)
    ERK-induced activation of TCF family of SRF cofactors initiates a chromatin modification cascade associated with transcription.
    Molecular Cell 65, 1081-1095 e1085 PubMed abstract
  • Mylona, A; Carr, S; Aller, P; Moraes, I; Treisman, R; Evans, G and Foadi, J (2017)
    A novel approach to data collection for difficult structures: Data management for large numbers of crystals with the BLEND software.
    Crystals 7, 242 PubMed abstract
  • Yu-Wai-Man, C; Spencer-Dene, B; Lee, RMH; Hutchings, K; Lisabeth, EM; Treisman, R; Bailly, M; Larsen, SD; Neubig, RR and Khaw, PT (2017)
    Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis.
    Scientific Reports 7, 518 PubMed abstract
  • Gruber, R; Panayiotou, R; Nye, E; Spencer-Dene, B; Stamp, G and Behrens, A (2016)
    YAP1 and TAZ control pancreatic cancer initiation in mice by direct up-regulation of JAK-STAT3 signaling.
    Gastroenterology 151, 526-539 PubMed abstract
  • Gualdrini, F; Esnault, C; Horswell, S; Stewart, A; Matthews, N and Treisman, R (2016)
    SRF co-factors control the balance between cell proliferation and contractility.
    Molecular Cell 64, 1048-1061 PubMed abstract
  • Mylona, A; Theillet, F-X; Foster, C; Cheng, TM; Miralles, F; Bates, PA; Selenko, P and Treisman, R (2016)
    Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation.
    Science 354, 233-237 PubMed abstract
  • Panayiotou, R; Miralles, F; Pawlowski, R; Diring, J; Flynn, HR; Skehel, M and Treisman, R (2016)
    Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity.
    eLife 5, e15460 PubMed abstract
  • Costello, P; Sargent, M; Maurice, D; Esnault, C; Foster, K; Anjos-Afonso, F and Treisman, R (2015)
    MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development.
    Blood 125, 1244-1255 PubMed abstract
  • Rajakylä, EK; Viita, T; Kyheröinen, S; Huet, G; Treisman, R and Vartiainen, MK (2015)
    RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.
    Nature Communications 6, 5978 PubMed abstract
  • Wiese, KE; Haikala, HM; von Eyss, B; Wolf, E; Esnault, C; Rosenwald, A; Treisman, R; Klefström, J and Eilers, M (2015)
    Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.
    EMBO Journal 34, 1554-1571 PubMed abstract
  • Yu-Wai-Man, C; Treisman, R; Khaw, PT and Bailly, M (2015)
    Matrix stiffness plays a key role in modulating the MRTF / SRF pathway and genes associated with conjunctival fibrosis.
    Investigative Ophthalmology & Visual Science 56, Abstract no. 2675
  • Diring, J; Mouilleron, S and Treisman, R (2014)
    Minding the GAPs: A novel RhoGAP family of RPEL proteins as target for regulation by G-actin.
    Molecular Biology of the Cell 25, Abstract P2176
  • Esnault, C; Stewart, A; Gualdrini, F; East, P; Horswell, S; Matthews, N and Treisman, R (2014)
    Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts.
    Genes & Development 28, 943-958 PubMed abstract
  • Yu-Wai-Man, C; Treisman, R; Bailly, M and Khaw, PT (2014)
    The role of the MRTF-A/SRF pathway in ocular fibrosis.
    Investigative Ophthalmology & Visual Science 55, 4560-4567 PubMed abstract
  • Gerber, A; Esnault, C; Aubert, G; Treisman, R; Pralong, F and Schibler, U (2013)
    Blood-borne circadian signal stimulates daily oscillations in actin dynamics and SRF activity.
    Cell 152, 492-503 PubMed abstract
  • Nurse, P; Treisman, R and Smith, J (2013)
    Building better institutions.
    Science 341, 10 PubMed abstract
  • Treisman, R (2013)
    Shedding light on nuclear actin dynamics and function.
    Trends in Biochemical Sciences 38, 376-377 PubMed abstract
  • Mouilleron, S; Wiezlak, M; O'Reilly, N; Treisman, R and McDonald, NQ (2012)
    Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity.
    Structure 20, 1960-1970 PubMed abstract
  • Wiezlak, M; Diring, J; Abella, J; Mouilleron, S; Way, M; McDonald, NQ and Treisman, R (2012)
    G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly.
    Journal of Cell Science 125, 5860-5872 PubMed abstract
  • McGee, KM; Vartiainen, MK; Khaw, PT; Treisman, R and Bailly, M (2011)
    Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis.
    EMBO Reports 12, 963-970 PubMed abstract
  • Mouilleron, S; Langer, CA; Guettler, S; McDonald, NQ and Treisman, R (2011)
    Structure of a pentavalent G-actin•MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
    Science Signaling 4, ra40 PubMed abstract
  • Mylona, A; Nicolas, R; Maurice, D; Sargent, M; Tuil, D; Daegelen, D; Treisman, R and Costello, P (2011)
    The essential function for serum response factor in T-cell development reflects its specific coupling to extracellular signal-regulated kinase signaling.
    Molecular and Cellular Biology 31, 267-276 PubMed abstract
  • Costello, P; Nicolas, R; Willoughby, J; Wasylyk, B; Nordheim, A and Treisman, R (2010)
    Ternary complex factors SAP-1 and Elk-1, but not Net, are functionally equivalent in thymocyte development.
    Journal of Immunology 185, 1082-1092 PubMed abstract
  • Pawłowski, R; Rajakylä, EK; Vartiainen, MK and Treisman, R (2010)
    An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.
    EMBO Journal 29, 3448-3458 PubMed abstract
  • Medjkane, S; Perez-Sanchez, C; Gaggioli, C; Sahai, E and Treisman, R (2009)
    Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.
    Nature Cell Biology 11, 257-268 PubMed abstract

[Page last updated 1 Jun 2018]

Richard Treisman
+44 (0)20 379 61104

  • Qualifications and history
  • 1981 PhD, Imperial Cancer Research Fund/University College London, UK (Advisor: Bob Kamen)
  • 1981 Postdoctoral Fellow, Harvard University, USA (Advisor: Tom Maniatis)
  • 1984 Scientific Staff, MRC Laboratory of Molecular Biology, UK
  • 1988 Established lab at the Imperial Cancer Research Fund (ICRF; became Cancer Research UK in 2002)
  • 2000 Director of Laboratory Research, ICRF
  • 2002 Director, London Research Institute, Cancer Research UK
  • 2009 Research Director, the Francis Crick Institute, London, UK