Richard Treisman: Biography

Richard Treisman conducted his thesis research on polyomavirus transcription and RNA processing with Bob Kamen at the Imperial Cancer Research Fund (ICRF), receiving his PhD in 1981, following which he moved to Boston for postdoctoral work on globin gene expression and thalassemia genes with Tom Maniatis.

In 1984, he joined the staff of the Medical Research Council Laboratory for Molecular Biology (MRC-LMB) in Cambridge, where he started working on how transcription is regulated by growth factors. Initially focusing on the Fos gene, he identified the transcription factor SRF and cloned its gene. He returned to the ICRF in 1988 to focus on SRF's regulatory cofactors and their cognate signalling pathways. This led to molecular characterisation of the TCF family of SRF cofactors as targets for MAP kinase signalling, and the demonstration that the MRTF transcription cofactors are novel G-actin binding proteins that sense fluctuations in G-actin concentration.

Richard is member of EMBO, and a Fellow of the Royal Society and Academy of Medical Sciences; he was awarded the EMBO medal in 1995 and the Jeantet Prize for Medicine in 2002. In 2000 be became Director of the Cancer Research UK London Research Institute (formerly the ICRF laboratories), and became a Research Director of the Francis Crick Institute in 2009.

Richard's current research seeks to understand: (i) the relationship between signalling to transcription factors and steps in the transcription activation process; (ii) the role played by G-actin in regulation of the RPEL family of G-actin binding proteins; (iii) and the functional significance of actin signalling and the SRF network in immune cell and cancer models.

Richard Treisman

richard.treisman@crick.ac.uk
+44 (0)20 379 61104

  • Qualifications and history
  • 1981 PhD, Imperial Cancer Research Fund/University College London, UK (Advisor: Bob Kamen)
  • 1981 Postdoctoral Fellow, Harvard University, USA (Advisor: Tom Maniatis)
  • 1984 Scientific Staff, MRC Laboratory of Molecular Biology, UK
  • 1988 Established lab at the Imperial Cancer Research Fund (ICRF; became Cancer Research UK in 2002)
  • 2000 Director of Laboratory Research, ICRF
  • 2002 Director, London Research Institute, Cancer Research UK
  • 2009 Research Director, the Francis Crick Institute, London, UK