Nic Tapon: Publications

  • Fletcher, GC; Diaz-de-la-Loza, M-d-C; Borreguero-Muñoz, N; Holder, M; Aguilar-Aragon, M and Thompson, BJ (2018)
    Mechanical strain regulates the Hippo pathway in Drosophila.
    Development 145, dev159467 PubMed abstract
  • Banerjee, JJ; Aerne, BL; Holder, MV; Hauri, S; Gstaiger, M and Tapon, N (2017)
    Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division.
    eLife 6, e25014 PubMed abstract
  • Fulford, A; Tapon, N and Ribeiro, PS (2017)
    Upstairs, downstairs: spatial regulation of Hippo signalling.
    Current Opinion in Cell Biology 51, 22-32 PubMed abstract
  • Kulaberoglu, Y; Lin, K; Holder, M; Gai, Z; Gomez, M; Assefa Shifa, B; Mavis, M; Hoa, L; Sharif, AAD; Lujan, C; Smith, ESJ; Bjedov, I; Tapon, N; Wu, G and Hergovich, A (2017)
    Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.
    Nature Communications 8, 695 PubMed abstract
  • Heller, D; Hoppe, A; Restrepo, S; Gatti, L; Tournier, AL; Tapon, N; Basler, K and Mao, Y (2016)
    EpiTools: an open-source image analysis toolkit for quantifying epithelial growth dynamics.
    Developmental Cell 36, 103-116 PubMed abstract
  • Aerne, BL; Gailite, I; Sims, D and Tapon, N (2015)
    Hippo stabilises its adaptor Salvador by antagonising the HECT ubiquitin ligase Herc4.
    PLOS ONE 10, e0131113 PubMed abstract
  • Di Cara, F; Maile, TM; Parsons, BD; Magico, A; Basu, S; Tapon, N and King-Jones, K (2015)
    The Hippo pathway promotes cell survival in response to chemical stress.
    Cell Death and Differentiation 22, 1526-1539 PubMed abstract
  • Fletcher, GC; Elbediwy, A; Khanal, I; Ribeiro, PS; Tapon, N and Thompson, BJ (2015)
    The Spectrin cytoskeleton regulates the Hippo signalling pathway.
    EMBO Journal 34, 940-954 PubMed abstract
  • Gailite, I; Aerne, BL and Tapon, N (2015)
    Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system.
    Proceedings of the National Academy of Sciences of the United States of America 112, E5169-E5178 PubMed abstract
  • Gaspar, P; Holder, MV; Aerne, BL; Janody, F and Tapon, N (2015)
    Zyxin antagonizes the FERM protein expanded to couple F-actin and Yorkie-dependent organ growth.
    Current Biology 25, 679-689 PubMed abstract
  • Keder, A; Rives-Quinto, N; Aerne, BL; Franco, M; Tapon, N and Carmena, A (2015)
    The Hippo pathway core cassette regulates asymmetric cell division.
    Current Biology 25, 2739-2750 PubMed abstract
  • Ray, RP; Matamoro-Vidal, A; Ribeiro, PS; Tapon, N; Houle, D; Salazar-Ciudad, I and Thompson, BJ (2015)
    Patterned anchorage to the apical extracellular matrix defines tissue shape in the developing appendages of Drosophila.
    Developmental Cell 34, 310-322 PubMed abstract
  • Zaessinger, S; Zhou, Y; Bray, SJ; Tapon, N and Djiane, A (2015)
    Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye.
    Development 142, 1102-1112 PubMed abstract
  • Doughton, G; Wei, J; Tapon, N; Welham, MJ and Chalmers, AD (2014)
    Formation of a polarised primitive endoderm layer in embryoid bodies requires Fgfr/Erk signalling.
    PLOS ONE 9, e95434 PubMed abstract
  • Gaspar, P and Tapon, N (2014)
    Sensing the local environment: actin architecture and Hippo signalling.
    Current Opinion in Cell Biology 31, 74-83 PubMed abstract
  • Ribeiro, P; Holder, M; Frith, D; Snijders, AP and Tapon, N (2014)
    Crumbs promotes expanded recognition and degradation by the SCFSlimb/β-TrCP ubiquitin ligase.
    Proceedings of the National Academy of Sciences of the United States of America 111, E1980-E1989 PubMed abstract
  • Hauri, S; Wepf, A; van Drogen, A; Varjosalo, M; Tapon, N; Aebersold, R and Gstaiger, M (2013)
    Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
    Molecular Systems Biology 9, 713 PubMed abstract
  • Lucas, EP; Khanal, I; Gaspar, P; Fletcher, GC; Polesello, C; Tapon, N and Thompson, BJ (2013)
    The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells.
    Journal of Cell Biology 201, 875-885 PubMed abstract
  • Mao, Y; Tournier, AL; Hoppe, A; Kester, L; Thompson, BJ and Tapon, N (2013)
    Differential proliferation rates generate patterns of mechanical tension that orient tissue growth.
    EMBO Journal 32, 2790-2803 PubMed abstract
  • Wehr, MC; Holder, MV; Gailite, I; Saunders, RE; Maile, TM; Ciirdaeva, E; Instrell, R; Jiang, M; Howell, M; Rossner, MJ and Tapon, N (2013)
    Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.
    Nature Cell Biology 15, 61-71 PubMed abstract
  • Tapon, N and Harvey, KF (2012)
    The Hippo pathway--from top to bottom and everything in between.
    Seminars in Cell & Developmental Biology 23, 768-769 PubMed abstract
  • Genevet, A and Tapon, N (2011)
    The Hippo pathway and apico-basal cell polarity.
    Biochemical Journal 436, 213-224 PubMed abstract
  • Mao, Y; Tournier, AL; Bates, PA; Gale, JE; Tapon, N and Thompson, BJ (2011)
    Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila.
    Genes & Development 25, 131-136 PubMed abstract
  • Andersen, DS; Raja, SJ; Colombani, J; Shaw, RL; Langton, PF; Akhtar, A and Tapon, N (2010)
    Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription.
    Molecular and Cellular Biology 30, 4744-4755 PubMed abstract
  • Cully, M; Genevet, A; Warne, P; Treins, C; Liu, T; Bastien, J; Baum, B; Tapon, N; Leevers, SJ and Downward, J (2010)
    A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.
    Molecular and Cellular Biology 30, 481-495 PubMed abstract
  • Genevet, A; Wehr, MC; Brain, R; Thompson, BJ and Tapon, N (2010)
    Kibra is a regulator of the Salvador/Warts/Hippo signaling network.
    Developmental Cell 18, 300-308 PubMed abstract
  • Ribeiro, PS; Josué, F; Wepf, A; Wehr, MC; Rinner, O; Kelly, G; Tapon, N and Gstaiger, M (2010)
    Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.
    Molecular Cell 39, 521-534 PubMed abstract
  • Shaw, RL; Kohlmaier, A; Polesello, C; Veelken, C; Edgar, BA and Tapon, N (2010)
    The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration.
    Development 137, 4147-4158 PubMed abstract

[Page last updated 1 Jun 2018]

Nic Tapon
+44 (0)20 379 62050

  • Qualifications and history
  • 1997 PhD in Biochemistry, University College London, UK.
  • 1998 Postdoctoral Fellow, Massachusetts General Hospital Cancer Centre, USA
  • 2003 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK