Ian Taylor: Publications

  • Ballandras-Colas, A; Maskell, DP; Serrao, E; Locke, J; Swuec, P; Jónsson, SR; Kotecha, A; Cook, NJ; Pye, VE; Taylor, IA; Andrésdóttir, V; Engelman, AN; Costa, A and Cherepanov, P (2017)
    A supramolecular assembly mediates lentiviral DNA integration.
    Science 355, 93-95 PubMed abstract
  • Carroni, M; De March, M; Medagli, B; Krastanova, I; Taylor, IA; Amenitsch, H; Araki, H; Pisani, FM; Patwardhan, A and Onesti, S (2017)
    New insights into the GINS complex explain the controversy between existing structural models.
    Scientific Reports 7, 40188 PubMed abstract
  • Collins, KM; Kainov, YA; Christodolou, E; Ray, D; Morris, Q; Hughes, T; Taylor, IA; Makeyev, EV and Ramos, A (2017)
    An RRM-ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion.
    Nucleic Acids Research 45, 6761-6774 PubMed abstract
  • Nicastro, G; Candel, AM; Uhl, M; Oregioni, A; Hollingworth, D; Backofen, R; Martin, SR and Ramos, A (2017)
    Mechanism of β-actin mRNA recognition by ZBP1.
    Cell Reports 18, 1187-1199 PubMed abstract
  • Ordonez, P; Kunzelmann, S; Groom, HCT; Yap, MW; Weising, S; Meier, C; Bishop, KN; Taylor, IA and Stoye, JP (2017)
    SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.
    Scientific Reports 7, 42824 PubMed abstract
  • Taylor, WR; Stoye, JP and Taylor, IA (2017)
    A comparative analysis of the foamy and ortho virus capsid structures reveals an ancient domain duplication.
    BMC Structural Biology 17, 3 PubMed abstract
  • Ball, NJ; Nicastro, G; Dutta, M; Pollard, DJ; Goldstone, DC; Sanz-Ramos, M; Ramos, A; Müllers, E; Stirnnagel, K; Stanke, N; Lindemann, D; Stoye, JP; Taylor, WR; Rosenthal, PB and Taylor, IA (2016)
    Structure of a spumaretrovirus gag central domain reveals an ancient retroviral capsid.
    PLOS Pathogens 12, e1005981 PubMed abstract
  • Buseyne, F; Gessain, A; Soares, MA; Santos, AF; Materniak-Kornas, M; Lesage, P; Zamborlini, A; Löchelt, M; Qiao, W; Lindemann, D; Wöhrl, BM; Stoye, JP; Taylor, IA and Khan, AS (2016)
    Eleventh International Foamy Virus Conference—meeting report.
    Viruses 8, 318 PubMed abstract
  • Chen, N-Y; Zhou, L; Gane, PJ; Opp, S; Ball, NJ; Nicastro, G; Zufferey, M; Buffone, C; Luban, J; Selwood, D; Diaz-Griffero, F; Taylor, I and Fassati, A (2016)
    HIV-1 capsid is involved in post-nuclear entry steps.
    Retrovirology 13, 28 PubMed abstract
  • Koliopoulos, MG; Esposito, D; Christodoulou, E; Taylor, IA and Rittinger, K (2016)
    Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
    EMBO Journal 35, 1204-1218 PubMed abstract
  • Yan, R; Friemel, M; Aloisi, C; Huynen, M; Taylor, IA; Leimkühler, S and Pastore, A (2016)
    The eukaryotic-specific ISD11 is a complex-orphan protein with ability to bind the prokaryotic IscS.
    PLOS ONE 11, e0157895 PubMed abstract
  • Arnold, LH; Groom, HCT; Kunzelmann, S; Schwefel, D; Caswell, SJ; Ordonez, P; Mann, MC; Rueschenbaum, S; Goldstone, DC; Pennell, S; Howell, SA; Stoye, JP; Webb, M; Taylor, IA and Bishop, KN (2015)
    Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction.
    PLOS Pathogens 11, e1005194 PubMed abstract
  • Arnold, LH; Kunzelmann, S; Webb, MR and Taylor, IA (2015)
    A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1.
    Antimicrobial Agents and Chemotherapy 59, 186-192 PubMed abstract
  • Huang, J; Zhao, Y; Liu, H; Huang, D; Cheng, X; Zhao, W; Taylor, IA; Liu, J and Peng, Y-L (2015)
    Substitution of tryptophan 89 with tyrosine switches the DNA binding mode of PC4.
    Scientific Reports 5, 8789 PubMed abstract
  • Liu, J; Huang, J; Zhao, Y; Liu, H; Wang, D; Yang, J; Zhao, W; Taylor, IA and Peng, Y-L (2015)
    Structural basis of DNA recognition by PCG2 reveals a novel DNA binding mode for winged helix-turn-helix domains.
    Nucleic Acids Research 43, 1231-1240 PubMed abstract
  • Morrissey, C; Schwefel, D; Ennis-Adeniran, V; Taylor, IA; Crow, YJ and Webb, M (2015)
    The eukaryotic elongation factor eEF1A1 interacts with SAMHD1.
    Biochemical Journal 466, 69-76 PubMed abstract
  • Nicastro, G; Taylor, IA and Ramos, A (2015)
    KH-RNA interactions: back in the groove.
    Current Opinion in Structural Biology 30, 63-70 PubMed abstract
  • Schwefel, D; Boucherit, VC; Christodoulou, E; Walker, PA; Stoye, JP; Bishop, KN and Taylor, IA (2015)
    Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.
    Cell Host & Microbe 17, 489-499 PubMed abstract
  • Taylor, IA; Rittinger, K and Eccleston, JF (2015)
    Sedimentation equilibrium studies.
    Methods in Molecular Biology 1278, 205-222 PubMed abstract
  • Goldstone, DC; Walker, PA; Calder, LJ; Coombs, PJ; Kirkpatrick, J; Ball, NJ; Hilditch, L; Yap, MW; Rosenthal, PB; Stoye, JP and Taylor, IA (2014)
    Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.
    Proceedings of the National Academy of Sciences of the United States of America 111, 9609-9614 PubMed abstract
  • Pennell, S; Déclais, A-C; Li, J; Haire, LF; Berg, W; Saldanha, JW; Taylor, IA; Rouse, J; Lilley, DMJ and Smerdon, SJ (2014)
    FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.
    Cell Reports 8, 84-93 PubMed abstract
  • Schwefel, D; Groom, HCT; Boucherit, VC; Christodoulou, E; Walker, PA; Stoye, JP; Bishop, KN and Taylor, IA (2014)
    Structural basis of lentiviral subversion of a cellular protein degradation pathway.
    Nature 505, 234-238 PubMed abstract
  • Goldstone, DC; Flower, TG; Ball, NJ; Sanz-Ramos, M; Yap, MW; Ogrodowicz, RW; Stanke, N; Reh, J; Lindemann, D; Stoye, JP and Taylor, IA (2013)
    A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid.
    PLOS Pathogens 9, e1003376 PubMed abstract
  • Newman, ER; Kneale, GG; Ravelli, RBG; Karuppasamy, M; Nejadasl, FK; Taylor, IA and McGeehan, JE (2012)
    Large multimeric assemblies of nucleosome assembly protein and histones revealed by small-angle X-ray scattering and electron microscopy.
    Journal of Biological Chemistry 287, 26657-26665 PubMed abstract
  • Wight, DJ; Boucherit, VC; Nader, M; Allen, DJ; Taylor, IA and Bishop, KN (2012)
    The gammaretroviral p12 protein has multiple domains that function during the early stages of replication.
    Retrovirology 9, 83 PubMed abstract
  • Arnold, LH; Butt, LE; Prior, SH; Read, CM; Fields, GB and Pickford, AR (2011)
    The interface between catalytic and hemopexin domains in matrix metalloproteinase-1 conceals a collagen binding exosite.
    Journal of Biological Chemistry 286, 45073-45082 PubMed abstract
  • Goldstone, DC; Ennis-Adeniran, V; Hedden, JJ; Groom, HCT; Rice, GI; Christodoulou, E; Walker, PA; Kelly, G; Haire, LF; Yap, MW; de Carvalho, LP; Stoye, JP; Crow, YJ; Taylor, IA and Webb, M (2011)
    HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.
    Nature 480, 379-382 PubMed abstract
  • Hilditch, L; Matadeen, R; Goldstone, DC; Rosenthal, PB; Taylor, IA and Stoye, JP (2011)
    Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1.
    Proceedings of the National Academy of Sciences of the United States of America 108, 5771-5776 PubMed abstract
  • Ohkura, S; Goldstone, DC; Yap, MW; Holden-Dye, K; Taylor, IA and Stoye, JP (2011)
    Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein.
    PLOS Pathogens 7, e1002011 PubMed abstract
  • Welberry, TR; Heerdegen, AP; Goldstone, DC and Taylor, IA (2011)
    Diffuse scattering resulting from macromolecular frustration.
    Acta Crystallographica. Section B, Structural Science 67, 516-524 PubMed abstract
  • Goldstone, DC; Yap, MW; Robertson, LE; Haire, LF; Taylor, WR; Katzourakis, A; Stoye, JP and Taylor, IA (2010)
    Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface.
    Cell Host & Microbe 8, 248-259 PubMed abstract
  • Montgomery, MG; Coker, AR; Taylor, IA and Wood, SP (2010)
    Assembly of a 20nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase (MhpD).
    Journal of Molecular Biology 396, 1379-1391 PubMed abstract
  • Pancevac, C; Goldstone, DC; Ramos, A and Taylor, IA (2010)
    Structure of the Rna15 RRM-RNA complex reveals the molecular basis of GU specificity in transcriptional 3'-end processing factors.
    Nucleic Acids Research 38, 3119-3132 PubMed abstract
  • Taylor, IA; Goldstone, DC; Pala, P; Haire, LF and Smerdon, SJ (2010)
    Structure of the amino-terminal domain from the cell-cycle regulator Swi6.
    Proteins 78, 2861-2865 PubMed abstract

[Page last updated 1 Nov 2017]

Ian Taylor

ian.taylor@crick.ac.uk
+44 (0)20 379 62288

  • Qualifications and history
  • 1993 PhD, SERC University of Portsmouth, UK
  • 1994 Post doctoral fellow Medical Research Council National Institute for Medical Research (MRC-NIMR), London, UK
  • 1999 Post doctoral fellow University of Oxford, UK
  • 2001 Group Leader, MRC-NIMR, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK