Frank Uhlmann: Publications

  • Chao, WCH; Murayama, Y; Muñoz, S; Jones, AW; Wade, BO; Purkiss, AG; Hu, X-W; Borg, A; Snijders, AP; Uhlmann, F and Singleton, MR (2017)
    Structure of the cohesin loader Scc2.
    Nature Communications 8, 13952 PubMed abstract
  • Chao, WCH; Wade, BO; Bouchoux, C; Jones, AW; Purkiss, AG; Federico, S; O'Reilly, N; Snijders, AP; Uhlmann, F and Singleton, MR (2017)
    Structural basis of Eco1-mediated cohesin acetylation.
    Scientific Reports 7, 44313 PubMed abstract
  • Godfrey, M; Touati, SA; Kataria, M; Jones, A; Snijders, AP and Uhlmann, F (2017)
    PP2ACdc55 phosphatase imposes ordered cell-cycle phosphorylation by opposing threonine phosphorylation.
    Molecular Cell 65, 393-402 e393 PubMed abstract
  • Grey, W; Ivey, A; Milne, TA; Haferlach, T; Grimwade, D; Uhlmann, F; Voisset, E and Yu, V (2017)
    The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukemia cell viability.
    Biochimica et Biophysica Acta [Epub ahead of print] PubMed abstract
  • Kakui, Y; Rabinowitz, A; Barry, DJ and Uhlmann, F (2017)
    Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast.
    Nature Genetics 49, 1553-1557 PubMed abstract
  • Kakui, Y and Uhlmann, F (2017)
    Building chromosomes without bricks.
    Science 356, 1233-1234 PubMed abstract
  • Kakui, Y and Uhlmann, F (2017)
    SMC complexes orchestrate the mitotic chromatin interaction landscape.
    Current Genetics [Epub ahead of print] PubMed abstract
  • Murayama, Y and Uhlmann, F (2017)
    An in vitro assay for monitoring topological DNA entrapment by the chromosomal cohesin complex.
    Methods in Molecular Biology 1515, 23-35 PubMed abstract
  • Singleton, MR and Uhlmann, F (2017)
    Separase-securin complex: a cunning way to control chromosome segregation.
    Nature Structural & Molecular Biology 24, 337-339 PubMed abstract
  • Wade, BO; Liu, HW; Samora, CP; Uhlmann, F and Singleton, MR (2017)
    Structural studies of RFCCtf18 reveal a novel chromatin recruitment role for Dcc1.
    EMBO Reports 18, 558-568 PubMed abstract
  • Davidson, IF; Goetz, D; Zaczek, MP; Molodtsov, MI; Huis in 't Veld, PJ; Weissmann, F; Litos, G; Cisneros, DA; Ocampo-Hafalla, M; Ladurner, R; Uhlmann, F; Vaziri, A and Peters, J-M (2016)
    Rapid movement and transcriptional re-localization of human cohesin on DNA.
    EMBO Journal 35, 2671-2685 PubMed abstract
  • Kakui, Y and Sato, M (2016)
    Differentiating the roles of microtubule-associated proteins at meiotic kinetochores during chromosome segregation.
    Chromosoma 125, 309-320 PubMed abstract
  • Ocampo-Hafalla, M; Muñoz, S; Samora, CP and Uhlmann, F (2016)
    Evidence for cohesin sliding along budding yeast chromosomes.
    Open Biology 6, 150178 PubMed abstract
  • Samora, CP; Saksouk, J; Goswami, P; Wade, BO; Singleton, MR; Bates, PA; Lengronne, A; Costa, A and Uhlmann, F (2016)
    Ctf4 links DNA replication with sister chromatid cohesion establishment by recruiting the Chl1 helicase to the replisome.
    Molecular Cell 63, 371-384 PubMed abstract
  • Uhlmann, F (2016)
    SMC complexes: from DNA to chromosomes.
    Nature Reviews Molecular Cell Biology 17, 399-412 PubMed abstract
  • Chao, WCH; Murayama, Y; Muñoz, S; Costa, A; Uhlmann, F and Singleton, MR (2015)
    Structural studies reveal the functional modularity of the Scc2-Scc4 cohesin loader.
    Cell Reports 12, 719-725 PubMed abstract
  • Cheng, TMK; Heeger, S; Chaleil, RAG; Matthews, N; Stewart, A; Wright, J; Lim, C; Bates, PA and Uhlmann, F (2015)
    A simple biophysical model emulates budding yeast chromosome condensation.
    eLife 4, e05565 PubMed abstract
  • Godfrey, M; Kuilman, T and Uhlmann, F (2015)
    Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast.
    PLOS Genetics 11, e1004907 PubMed abstract
  • Kakui, Y; Sunaga, T; Arai, K; Dodgson, J; Ji, L; Csikász-Nagy, A; Carazo-Salas, R and Sato, M (2015)
    Module-based construction of plasmids for chromosomal integration of the fission yeast Schizosaccharomyces pombe.
    Open Biology 5, 150054 PubMed abstract
  • Kuilman, T; Maiolica, A; Godfrey, M; Scheidel, N; Aebersold, R and Uhlmann, F (2015)
    Identification of Cdk targets that control cytokinesis.
    EMBO Journal 34, 81-96 PubMed abstract
  • Murayama, Y and Uhlmann, F (2015)
    DNA entry into and exit out of the cohesin ring by an interlocking gate mechanism.
    Cell 163, 1628-1640 PubMed abstract
  • Thadani, R and Uhlmann, F (2015)
    Chromosome condensation: Weaving an untangled web.
    Current Biology 25, R663-R666 PubMed abstract
  • Charbin, A; Bouchoux, C and Uhlmann, F (2014)
    Condensin aids sister chromatid decatenation by topoisomerase II.
    Nucleic Acids Research 42, 340-348 PubMed abstract
  • Lopez-Serra, L; Kelly, G; Patel, H; Stewart, A and Uhlmann, F (2014)
    The Scc2-Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions.
    Nature Genetics 46, 1147-1151 PubMed abstract
  • Murayama, Y and Uhlmann, F (2014)
    Biochemical reconstitution of topological DNA binding by the cohesin ring.
    Nature 505, 367-371 PubMed abstract
  • Uhlmann, F (2014)
    A silent revolution in chromosome biology.
    Nature Reviews Molecular Cell Biology 15, 431 PubMed abstract
  • Borges, V; Smith, DJ; Whitehouse, I and Uhlmann, F (2013)
    An Eco1-independent sister chromatid cohesion establishment pathway in S. cerevisiae.
    Chromosoma 122, 121-134 PubMed abstract
  • Lopez-Serra, L; Lengronne, A; Borges, V; Kelly, G and Uhlmann, F (2013)
    Budding yeast Wapl controls sister chromatid cohesion maintenance and chromosome condensation.
    Current Biology 23, 64-69 PubMed abstract
  • Murayama, Y and Uhlmann, F (2013)
    Chromosome segregation: how to open cohesin without cutting the ring?
    EMBO Journal 32, 614-616 PubMed abstract
  • Uhlmann, F (2013)
    Open questions: Chromosome condensation - why does a chromosome look like a chromosome?
    BMC Biology 11, 9 PubMed abstract
  • O'Reilly, N; Charbin, A; Lopez-Serra, L and Uhlmann, F (2012)
    Facile synthesis of budding yeast a-factor and its use to synchronize cells of α mating type.
    Yeast 29, 233-240 PubMed abstract
  • Petronczki, M and Uhlmann, F (2012)
    Cell biology. ESCRTing DNA at the cleavage site during cytokinesis.
    Science 336, 166-167 PubMed abstract
  • Thadani, R; Uhlmann, F and Heeger, S (2012)
    Condensin, chromatin crossbarring and chromosome condensation.
    Current Biology 22, R1012-R1021 PubMed abstract
  • Bouchoux, C and Uhlmann, F (2011)
    A quantitative model for ordered Cdk substrate dephosphorylation during mitotic exit.
    Cell 147, 803-814 PubMed abstract
  • He, E; Kapuy, O; Oliveira, RA; Uhlmann, F; Tyson, JJ and Novák, B (2011)
    System-level feedbacks make the anaphase switch irreversible.
    Proceedings of the National Academy of Sciences of the United States of America 108, 10016-10021 PubMed abstract
  • Ocampo-Hafalla, MT and Uhlmann, F (2011)
    Cohesin loading and sliding.
    Journal of Cell Science 124, 685-691 PubMed abstract
  • Uhlmann, F (2011)
    Cohesin subunit Rad21L, the new kid on the block has new ideas.
    EMBO Reports 12, 183-184 PubMed abstract
  • Uhlmann, F; Bouchoux, C and Lopez-Aviles, S (2011)
    A quantitative model for cyclin-dependent kinase control of the cell cycle: revisited.
    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 366, 3572-3583 PubMed abstract
  • Vinod, PK; Freire, P; Rattani, A; Ciliberto, A; Uhlmann, F and Novak, B (2011)
    Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles.
    Journal of the Royal Society Interface 8, 1128-1141 PubMed abstract
  • Borges, V; Lehane, C; Lopez-Serra, L; Flynn, H; Skehel, M; Rolef Ben-Shahar, T and Uhlmann, F (2010)
    Hos1 deacetylates Smc3 to close the cohesin acetylation cycle.
    Molecular Cell 39, 677-688 PubMed abstract
  • López-Avilés, S and Uhlmann, F (2010)
    Cell cycle: the art of multi-tasking.
    Current Biology 20, R101-R103 PubMed abstract
  • Mirchenko, L and Uhlmann, F (2010)
    Sli15INCENP dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset.
    Current Biology 20, 1396-1401 PubMed abstract
  • Uhlmann, F and Salvesen, G (2010)
    Divide and die another day.
    Current Opinion in Cell Biology 22, 764-765 PubMed abstract
  • Vázquez-Novelle, MD; Mirchenko, L; Uhlmann, F and Petronczki, M (2010)
    The 'anaphase problem': how to disable the mitotic checkpoint when sisters split.
    Biochemical Society Transactions 38, 1660-1666 PubMed abstract

[Page last updated 1 Nov 2017]

Frank Uhlmann

frank.uhlmann@crick.ac.uk
+44 (0)20 379 62059

  • Qualifications and history
  • 1997 PhD, University of Tübingen/ Memorial Sloan-Kettering Cancer Center, Germany/ USA
  • 1997 Postdoctoral Fellow, Research Institute of Molecular Pathology, Austria
  • 2000 Established lab at the Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2015 Group Leader, the Francis Crick Institute, London, UK