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Breadcrumb Frank Uhlmann Uhlmann lab Chromosome Segregation Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Chromosomes (pink) in the fission yeast S. pombe, one of the model organisms used in our research. Toggle to view hero caption PublicationsYear published2024 (1)2023 (5)2022 (4)2021 (7)2020 (6)2019 (3)2018 (7)2017 (9)2016 (6)2015 (6)2014 (5)2013 (4)2012 (3)2011 (6)2010 (5) Facet Year publishedResearch topicsCell Cycle & Chromosomes (53)Computational & Systems Biology (53)Genetics & Genomics (53)Model Organisms (53)Biochemistry & Proteomics (52)Chemical Biology & High Throughput (17)Structural Biology & Biophysics (17)Genome Integrity & Repair (14)Imaging (9)Tumour Biology (9)Cell Biology (6)Microfabrication & Bioengineering (4)Infectious Disease (1) Facet Research topicsPublication typeJournal article (77)Primary research (54)Commentary (11)Review (7)Method (4)Editorial (1) Facet Publication typeJournalMolecular Cell (7)Current Biology (6)Cell (4)Cell Reports (4)EMBO Journal (4)Chromosoma (3)Methods in Molecular Biology (3)Current Genetics (2)Current Opinion in Cell Biology (2)eLife (2)EMBO Reports (2)Life Science Alliance (2)Nature Communications (2)Nature Genetics (2)Nature Reviews Molecular Cell Biology (2)Nature Structural & Molecular Biology (2)Nucleic Acids Research (2)Open Biology (2)Science (2)Science advances (2)Yeast (2)Biochemical Society Transactions (1)Biochimica et Biophysica Acta (1)Bioinformatics (1)BMC Biology (1)Genes & Development (1)Genome Biology (1)Journal of Cell Science (1)Journal of the Royal Society, Interface / the Royal Society (1)Microbial Cell (1)Nature (1)Nature Structural and Molecular Biology (1)Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1)PLOS Genetics (1)PLOS ONE (1)Proceedings of the National Academy of Sciences of the United States of America (1)Scientific Reports (1)STAR Protocols (1)The EMBO Journal (1) Facet Journal Publications Displaying 1 - 20 of 77Last updated : 28 March 2024 03:37 Telomere-to-telomere Schizosaccharomyces japonicus genome assembly reveals hitherto unknown genome features Authors (5) Graham J Etherington Pei-Shang WuSnezhka OliferenkoFrank Uhlmann Conrad A Nieduszynski Yeast Published 1 March 2024 Crick labsFrank UhlmannSnezhana OliferenkoFull details Mechanical disengagement of the cohesin ring Authors (6)Martina RicheldiGeorge PobegalovTorahiko HigashiKarolina GmurczykFrank UhlmannMaxim Molodtsov Nature Structural and Molecular Biology Published 1 January 2024 Crick labsFrank UhlmannMaxim MolodtsovFull details Establishment of dsDNA-dsDNA interactions by the condensin complex Authors (8)Tony TangGeorge Pobegalov Hideki Tanizawa Zhuo A Chen Juri RappsilberMaxim Molodtsov Ken-ichi NomaFrank Uhlmann Molecular Cell Published 1 November 2023 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovFermentationBioinformatics and BiostatisticsFull details Replication-induced DNA secondary structures drive fork uncoupling and breakage Authors (12) Sophie L Williams Corella S Casas-Delucchi Federica Raguseo Dilek Guneri Yunxuan LiMasashi Minamino[...] Joseph TP Yeeles Ulrich F Keyser Zoë AE WallerMarco di Antonio Gideon Coster The EMBO Journal Published 15 November 2023 Crick labsFrank UhlmannMarco Di AntonioFull details Replisome-cohesin interactions provided by the Tof1-Csm3 and Mrc1 cohesion establishment factors Authors (6)Sudikchya ShresthaMasashi Minamino Zhuo A ChenCeline Bouchoux Juri RappsilberFrank Uhlmann Chromosoma Published 1 June 2023 Crick labs/ facilitiesFrank UhlmannFermentationBioinformatics and BiostatisticsFull details A replication fork determinant for the establishment of sister chromatid cohesion Authors (5)Masashi MinaminoCeline BouchouxBerta CanalJohn DiffleyFrank Uhlmann Cell Published 16 February 2023 Crick labs/ facilitiesFrank UhlmannJohn DiffleyStructural BiologyFermentationFull details Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline Bouchoux Tegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details Chromosome arm length, and a species-specific determinant, define chromosome arm width Authors (7)Yasutaka Kakui Christopher Barrington Yoshiharu Kusano Rahul ThadaniTodd Fallesen Toru HirotaFrank Uhlmann Cell Reports Published 6 December 2022 Crick labs/ facilitiesFrank UhlmannLight MicroscopyBioinformatics and BiostatisticsFull details Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion Authors (9) Mark Mattingly Chris SeidelSofia Munoz-Felix Yan Hao Ying Zhang Zhihui Wen Laurence FlorensFrank Uhlmann Jennifer L Gerton Current Biology Published 11 July 2022 Crick labsFrank UhlmannFull details SMC complexes: Lifting the lid on loop extrusion Authors (2)Torahiko HigashiFrank Uhlmann Current Opinion in Cell Biology Published 1 February 2022 Crick labsFrank UhlmannFull details A Brownian ratchet model for DNA loop extrusion by the cohesin complex Authors (5)Torahiko HigashiGeorge PobegalovTony TangMaxim MolodtsovFrank Uhlmann eLife Published 26 July 2021 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovStructural BiologyFull details Analysis of cell cycle progression in the budding yeast S. cerevisiae Authors (2)Deniz Pirincci ErcanFrank Uhlmann Methods in Molecular Biology Published 1 January 2021 Crick labsFrank UhlmannFull details Budding yeast relies on G1 cyclin specificity to couple cell cycle progression with morphogenetic development Authors (6)Deniz Pirincci Ercan Florine Chrétien Probir Chakravarty Helen R FlynnBram SnijdersFrank Uhlmann Science advances Published 4 June 2021 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyFull details A role for condensin in mediating transcriptional adaptation to environmental stimuli Authors (4)Lucy Lancaster Harshil PatelGavin KellyFrank Uhlmann Life Science Alliance Published 1 July 2021 Crick labs/ facilitiesFrank UhlmannBioinformatics and BiostatisticsAdvanced SequencingFull details Structural characterisation of the Chaetomium thermophilum Chl1 helicase Authors (8)Zuzana HodakovaAndrea NansSimone KunzelmannShahid MehmoodIan TaylorFrank UhlmannPeter Cherepanov Martin R Singleton PLOS ONE Published 10 May 2021 Crick labs/ facilitiesFrank UhlmannIan TaylorMartin SingletonPeter Cherepanov Structural BiologyProteomicsFull details Bridging-induced phase separation induced by cohesin SMC protein complexes Authors (12) Je-Kyung RyuCeline BouchouxHon-Wing Liu Eugene KimMasashi Minamino Ralph de Groot[...] Andrea Bonato Davide Marenduzzo Davide MichielettoFrank Uhlmann Cees Dekker Science advances Published 10 February 2021 Crick labsFrank UhlmannFull details Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast Authors (7)Tereza ClarenceXiao FuYasutaka Kakui Bhavin S Khatri Christopher BarringtonPaul BatesFrank Uhlmann Nucleic Acids Research Published 22 February 2021 Crick labs/ facilitiesFrank UhlmannPaul BatesBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage Authors (8)Yasutaka Kakui Christopher BarringtonDavid BarryTereza ClarenceXiao FuPaul Bates Bhavin S KhatriFrank Uhlmann Genome Biology Published 5 November 2020 Crick labs/ facilitiesFrank UhlmannPaul BatesLight MicroscopyBioinformatics and BiostatisticsAdvanced SequencingFull details CSynth: an interactive modelling and visualization tool for 3D chromatin structure Authors (8) Stephen Todd Peter Todd Simon J McGowan James R HughesYasutaka Kakui Frederic Fol Leymarie William Latham Stephen Taylor Bioinformatics Published 1 April 2021 Crick labsFrank UhlmannFull details A structure-based mechanism for DNA entry into the cohesin ring Authors (14)Torahiko HigashiCarl Eickhoff Joana S SousaJulia LockeAndrea Nans Helen R Flynn[...] Zhuo A Chen Francis J O’Reilly Juri RappsilberAlessandro CostaFrank Uhlmann Molecular Cell Published 17 September 2020 Crick labs/ facilitiesFrank UhlmannAlessandro CostaStructural BiologyProteomicsFermentationFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Telomere-to-telomere Schizosaccharomyces japonicus genome assembly reveals hitherto unknown genome features Authors (5) Graham J Etherington Pei-Shang WuSnezhka OliferenkoFrank Uhlmann Conrad A Nieduszynski Yeast Published 1 March 2024 Crick labsFrank UhlmannSnezhana OliferenkoFull details
Mechanical disengagement of the cohesin ring Authors (6)Martina RicheldiGeorge PobegalovTorahiko HigashiKarolina GmurczykFrank UhlmannMaxim Molodtsov Nature Structural and Molecular Biology Published 1 January 2024 Crick labsFrank UhlmannMaxim MolodtsovFull details
Establishment of dsDNA-dsDNA interactions by the condensin complex Authors (8)Tony TangGeorge Pobegalov Hideki Tanizawa Zhuo A Chen Juri RappsilberMaxim Molodtsov Ken-ichi NomaFrank Uhlmann Molecular Cell Published 1 November 2023 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovFermentationBioinformatics and BiostatisticsFull details
Replication-induced DNA secondary structures drive fork uncoupling and breakage Authors (12) Sophie L Williams Corella S Casas-Delucchi Federica Raguseo Dilek Guneri Yunxuan LiMasashi Minamino[...] Joseph TP Yeeles Ulrich F Keyser Zoë AE WallerMarco di Antonio Gideon Coster The EMBO Journal Published 15 November 2023 Crick labsFrank UhlmannMarco Di AntonioFull details
Replisome-cohesin interactions provided by the Tof1-Csm3 and Mrc1 cohesion establishment factors Authors (6)Sudikchya ShresthaMasashi Minamino Zhuo A ChenCeline Bouchoux Juri RappsilberFrank Uhlmann Chromosoma Published 1 June 2023 Crick labs/ facilitiesFrank UhlmannFermentationBioinformatics and BiostatisticsFull details
A replication fork determinant for the establishment of sister chromatid cohesion Authors (5)Masashi MinaminoCeline BouchouxBerta CanalJohn DiffleyFrank Uhlmann Cell Published 16 February 2023 Crick labs/ facilitiesFrank UhlmannJohn DiffleyStructural BiologyFermentationFull details
Functional crosstalk between the cohesin loader and chromatin remodelers Authors (6)Sofia Munoz-FelixAndrew JonesCeline Bouchoux Tegan Gilmore Harshil PatelFrank Uhlmann Nature Communications Published 13 December 2022 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyHigh Throughput ScreeningFermentationFull details
Chromosome arm length, and a species-specific determinant, define chromosome arm width Authors (7)Yasutaka Kakui Christopher Barrington Yoshiharu Kusano Rahul ThadaniTodd Fallesen Toru HirotaFrank Uhlmann Cell Reports Published 6 December 2022 Crick labs/ facilitiesFrank UhlmannLight MicroscopyBioinformatics and BiostatisticsFull details
Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion Authors (9) Mark Mattingly Chris SeidelSofia Munoz-Felix Yan Hao Ying Zhang Zhihui Wen Laurence FlorensFrank Uhlmann Jennifer L Gerton Current Biology Published 11 July 2022 Crick labsFrank UhlmannFull details
SMC complexes: Lifting the lid on loop extrusion Authors (2)Torahiko HigashiFrank Uhlmann Current Opinion in Cell Biology Published 1 February 2022 Crick labsFrank UhlmannFull details
A Brownian ratchet model for DNA loop extrusion by the cohesin complex Authors (5)Torahiko HigashiGeorge PobegalovTony TangMaxim MolodtsovFrank Uhlmann eLife Published 26 July 2021 Crick labs/ facilitiesFrank UhlmannMaxim MolodtsovStructural BiologyFull details
Analysis of cell cycle progression in the budding yeast S. cerevisiae Authors (2)Deniz Pirincci ErcanFrank Uhlmann Methods in Molecular Biology Published 1 January 2021 Crick labsFrank UhlmannFull details
Budding yeast relies on G1 cyclin specificity to couple cell cycle progression with morphogenetic development Authors (6)Deniz Pirincci Ercan Florine Chrétien Probir Chakravarty Helen R FlynnBram SnijdersFrank Uhlmann Science advances Published 4 June 2021 Crick labs/ facilitiesFrank UhlmannProteomicsBioinformatics and BiostatisticsStructural BiologyFull details
A role for condensin in mediating transcriptional adaptation to environmental stimuli Authors (4)Lucy Lancaster Harshil PatelGavin KellyFrank Uhlmann Life Science Alliance Published 1 July 2021 Crick labs/ facilitiesFrank UhlmannBioinformatics and BiostatisticsAdvanced SequencingFull details
Structural characterisation of the Chaetomium thermophilum Chl1 helicase Authors (8)Zuzana HodakovaAndrea NansSimone KunzelmannShahid MehmoodIan TaylorFrank UhlmannPeter Cherepanov Martin R Singleton PLOS ONE Published 10 May 2021 Crick labs/ facilitiesFrank UhlmannIan TaylorMartin SingletonPeter Cherepanov Structural BiologyProteomicsFull details
Bridging-induced phase separation induced by cohesin SMC protein complexes Authors (12) Je-Kyung RyuCeline BouchouxHon-Wing Liu Eugene KimMasashi Minamino Ralph de Groot[...] Andrea Bonato Davide Marenduzzo Davide MichielettoFrank Uhlmann Cees Dekker Science advances Published 10 February 2021 Crick labsFrank UhlmannFull details
Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast Authors (7)Tereza ClarenceXiao FuYasutaka Kakui Bhavin S Khatri Christopher BarringtonPaul BatesFrank Uhlmann Nucleic Acids Research Published 22 February 2021 Crick labs/ facilitiesFrank UhlmannPaul BatesBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage Authors (8)Yasutaka Kakui Christopher BarringtonDavid BarryTereza ClarenceXiao FuPaul Bates Bhavin S KhatriFrank Uhlmann Genome Biology Published 5 November 2020 Crick labs/ facilitiesFrank UhlmannPaul BatesLight MicroscopyBioinformatics and BiostatisticsAdvanced SequencingFull details
CSynth: an interactive modelling and visualization tool for 3D chromatin structure Authors (8) Stephen Todd Peter Todd Simon J McGowan James R HughesYasutaka Kakui Frederic Fol Leymarie William Latham Stephen Taylor Bioinformatics Published 1 April 2021 Crick labsFrank UhlmannFull details
A structure-based mechanism for DNA entry into the cohesin ring Authors (14)Torahiko HigashiCarl Eickhoff Joana S SousaJulia LockeAndrea Nans Helen R Flynn[...] Zhuo A Chen Francis J O’Reilly Juri RappsilberAlessandro CostaFrank Uhlmann Molecular Cell Published 17 September 2020 Crick labs/ facilitiesFrank UhlmannAlessandro CostaStructural BiologyProteomicsFermentationFull details