Vassilis Pachnis: Publications

  • Denaxa, M; Neves, G; Rabinowitz, A; Kemlo, S; Liodis, P; Burrone, J and Pachnis, V (2018)
    Modulation of apoptosis controls inhibitory interneuron number in the cortex.
    Cell Reports 22, 1710-1721 PubMed abstract
  • Memic, F; Knoflach, V; Morarach, K; Sadler, R; Laranjeira, C; Hjerling-Leffler, J; Sundström, E; Pachnis, V and Marklund, U (2018)
    Transcription and signaling regulators in developing neuronal subtypes of mouse and human enteric nervous system.
    Gastroenterology 154, 624-636 PubMed abstract
  • Lasrado, R; Boesmans, W; Kleinjung, J; Pin, C; Bell, D; Bhaw, L; McCallum, S; Zong, H; Luo, L; Clevers, H; Vanden Berghe, P and Pachnis, V (2017)
    Lineage-dependent spatial and functional organization of the mammalian enteric nervous system.
    Science 356, 722-726 PubMed abstract
  • Liu, K; Kim, J; Kim, DW; Zhang, YS; Bao, H; Denaxa, M; Lim, S-A; Kim, E; Liu, C; Wickersham, IR; Pachnis, V; Hattar, S; Song, J; Brown, SP and Blackshaw, S (2017)
    Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep.
    Nature 548, 582-587 PubMed abstract
  • Veiga-Fernandes, H and Pachnis, V (2017)
    Neuroimmune regulation during intestinal development and homeostasis.
    Nature Immunology 18, 116-122 PubMed abstract
  • Burns, AJ; Goldstein, AM; Newgreen, DF; Stamp, L; Schäfer, K-H; Metzger, M; Hotta, R; Young, HM; Andrews, PW; Thapar, N; Belkind-Gerson, J; Bondurand, N; Bornstein, JC; Chan, WY; Cheah, K; Gershon, MD; Heuckeroth, RO; Hofstra, RMW; Just, L; Kapur, RP; King, SK; McCann, CJ; Nagy, N; Ngan, E; Obermayr, F; Pachnis, V; Pasricha, PJ; Sham, MH; Tam, P and Berghe, PV (2016)
    White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.
    Developmental Biology 417, 229-251 PubMed abstract
  • Eldridge, S; Nalesso, G; Ismail, H; Vicente-Greco, K; Kabouridis, P; Ramachandran, M; Niemeier, A; Herz, J; Pitzalis, C; Perretti, M and Dell'Accio, F (2016)
    Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo.
    Annals of the Rheumatic Diseases 75, 1228-1235 PubMed abstract
  • Heanue, TA; Boesmans, W; Bell, DM; Kawakami, K; Vanden Berghe, P and Pachnis, V (2016)
    A novel zebrafish ret heterozygous model of Hirschsprung disease identifies a functional role for mapk10 as a modifier of enteric nervous system phenotype severity.
    PLOS Genetics 12, e1006439 PubMed abstract
  • Heanue, TA; Shepherd, IT and Burns, AJ (2016)
    Enteric nervous system development in avian and zebrafish models.
    Developmental Biology 417, 129-138 PubMed abstract
  • Kaucka, M; Ivashkin, E; Gyllborg, D; Zikmund, T; Tesarova, M; Kaiser, J; Xie, M; Petersen, J; Pachnis, V; Nicolis, SK; Yu, T; Sharpe, P; Arenas, E; Brismar, H; Blom, H; Clevers, H; Suter, U; Chagin, AS; Fried, K; Hellander, A and Adameyko, I (2016)
    Analysis of neural crest-derived clones reveals novel aspects of facial development.
    Science Advances 2, e1600060 PubMed abstract
  • Konstantinidou, C; Taraviras, S and Pachnis, V (2016)
    Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis.
    BMC Biology 14, 94 PubMed abstract
  • Memic, F; Knoflach, V; Sadler, R; Tegerstedt, G; Sundström, E; Guillemot, F; Pachnis, V and Marklund, U (2016)
    Ascl1 is required for the development of specific neuronal subtypes in the enteric nervous system.
    Journal of Neuroscience 36, 4339-4350 PubMed abstract
  • Obata, Y and Pachnis, V (2016)
    The effect of microbiota and the immune system on the development and organization of the enteric nervous system.
    Gastroenterology 151, 836-844 PubMed abstract
  • Stathopoulou, A; Natarajan, D; Nikolopoulou, P; Patmanidi, AL; Lygerou, Z; Pachnis, V and Taraviras, S (2016)
    Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis.
    Developmental Biology 409, 392-405 PubMed abstract
  • Uesaka, T; Young, HM; Pachnis, V and Enomoto, H (2016)
    Development of the intrinsic and extrinsic innervation of the gut.
    Developmental Biology 417, 158-167 PubMed abstract
  • Boesmans, W; Lasrado, R; Vanden Berghe, P and Pachnis, V (2015)
    Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system.
    Glia 63, 229-241 PubMed abstract
  • Jiang, Q; Arnold, S; Heanue, T; Kilambi, KP; Doan, B; Kapoor, A; Ling, AY; Sosa, MX; Guy, M; Jiang, Q; Burzynski, G; West, K; Bessling, S; Griseri, P; Amiel, J; Fernandez, RM; Verheij, JBGM; Hofstra, RMW; Borrego, S; Lyonnet, S; Ceccherini, I; Gray, JJ; Pachnis, V; McCallion, AS and Chakravarti, A (2015)
    Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with Ret are critical to Hirschsprung disease liability.
    American Journal of Human Genetics 96, 581-596 PubMed abstract
  • Kabouridis, PS; Lasrado, R; McCallum, S; Chng, SH; Snippert, HJ; Clevers, H; Pettersson, S and Pachnis, V (2015)
    The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system.
    Gut Microbes 6, 398-403 PubMed abstract
  • Kabouridis, PS; Lasrado, R; McCallum, S; Chng, SH; Snippert, HJ; Clevers, H; Pettersson, S and Pachnis, V (2015)
    Microbiota controls the homeostasis of glial cells in the gut lamina propria.
    Neuron 85, 289-295 PubMed abstract
  • Kabouridis, PS and Pachnis, V (2015)
    Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system.
    Journal of Clinical Investigation 125, 956-964 PubMed abstract
  • Ren, Y; Suzuki, H; Jagarlamudi, K; Golnoski, K; McGuire, M; Lopes, R; Pachnis, V and Rajkovic, A (2015)
    Lhx8 regulates primordial follicle activation and postnatal folliculogenesis.
    BMC Biology 13, 39 PubMed abstract
  • Tivodar, S; Kalemaki, K; Kounoupa, Z; Vidaki, M; Theodorakis, K; Denaxa, M; Kessaris, N; DeCurtis, I; Pachnis, V and Karagogeos, D (2015)
    Rac-GTPases regulate microtubule stability and axon growth of cortical GABAergic interneurons.
    Cerebral Cortex 25, 2370-2382 PubMed abstract
  • Dyachuk, V; Furlan, A; Shahidi, MK; Giovenco, M; Kaukua, N; Konstantinidou, C; Pachnis, V; Memic, F; Marklund, U; Müller, T; Birchmeier, C; Fried, K; Ernfors, P and Adameyko, I (2014)
    Parasympathetic neurons originate from nerve-associated peripheral glial progenitors.
    Science 345, 82-87 PubMed abstract
  • Kaukua, N; Shahidi, MK; Konstantinidou, C; Dyachuk, V; Kaucka, M; Furlan, A; An, Z; Wang, L; Hultman, I; Ährlund-Richter, L; Blom, H; Brismar, H; Lopes, NA; Pachnis, V; Suter, U; Clevers, H; Thesleff, I; Sharpe, P; Ernfors, P; Fried, K and Adameyko, I (2014)
    Glial origin of mesenchymal stem cells in a tooth model system.
    Nature 513, 551-554 PubMed abstract
  • Xu, Q; Heanue, T and Pachnis, V (2014)
    Travelling within the fetal gut: simple rules for an arduous journey.
    BMC Biology 12, 50 PubMed abstract
  • Neves, G; Shah, MM; Liodis, P; Achimastou, A; Denaxa, M; Roalfe, G; Sesay, A; Walker, MC and Pachnis, V (2013)
    The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex.
    Cerebral Cortex 23, 1811-1823 PubMed abstract
  • Sasselli, V; Boesmans, W; Berghe, PV; Tissir, F; Goffinet, A, M. and Pachnis, V (2013)
    Planar cell polarity genes control the connectivity of enteric neurons.
    Journal of Clinical Investigation 123, 1763-1772 PubMed abstract
  • Almeida, ARM; Arroz-Madeira, S; Fonseca-Pereira, D; Ribeiro, H; Lasrado, R; Pachnis, V and Veiga-Fernandes, H (2012)
    RET/GFRα signals are dispensable for thymic T cell development In Vivo.
    PLOS ONE 7, e52949 PubMed abstract
  • Denaxa, M; Kalaitzidou, M; Garefalaki, A; Achimastou, A; Lasrado, R; Maes, T and Pachnis, V (2012)
    Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons.
    Cell Reports 2, 1351-1362 PubMed abstract
  • Lopes, R; Verhey van Wijk, N; Neves, G and Pachnis, V (2012)
    Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum.
    Proceedings of the National Academy of Sciences of the United States of America 109, 3119-3124 PubMed abstract
  • Patel, A; Harker, N; Moreira-Santos, L; Ferreira, M; Alden, K; Timmis, J; Foster, K; Garefalaki, A; Pachnis, P; Andrews, P; Enomoto, H; Milbrandt, J; Pachnis, V; Coles, MC; Kioussis, D and Veiga-Fernandes, H (2012)
    Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems.
    Science Signaling 5, ra55 PubMed abstract
  • Sasselli, V; Pachnis, V and Burns, AJ (2012)
    The enteric nervous system.
    Developmental Biology 366, 64-73 PubMed abstract
  • Vidaki, M; Tivodar, S; Doulgeraki, K; Tybulewicz, V; Kessaris, N; Pachnis, V and Karagogeos, D (2012)
    Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex.
    Cerebral Cortex 22, 680-692 PubMed abstract
  • Heanue, TA and Pachnis, V (2011)
    Prospective identification and isolation of enteric nervous system progenitors using Sox2.
    Stem Cells 29, 128-140 PubMed abstract
  • Knight, RD; Mebus, K; d'Angelo, A; Yokoya, K; Heanue, T; Tübingen 2000 Screen Consortium and Roehl, H (2011)
    Ret signalling integrates a craniofacial muscle module during development.
    Development 138, 2015-2024
  • Laranjeira, C; Sandgren, K; Kessaris, N; Richardson, W; Potocnik, A; Vanden Berghe, P and Pachnis, V (2011)
    Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury.
    Journal of Clinical Investigation 121, 3412-3424 PubMed abstract
  • Spella, M; Kyrousi, C; Kritikou, E; Stathopoulou, A; Guillemot, F; Kioussis, D; Pachnis, V; Lygerou, Z and Taraviras, S (2011)
    Geminin regulates cortical progenitor proliferation and differentiation.
    Stem Cells 29, 1269-1282 PubMed abstract
  • Karamitros, D; Kotantaki, P; Lygerou, Z; Veiga-Fernandes, H; Pachnis, V; Kioussis, D and Taraviras, S (2010)
    Differential Geminin requirement for proliferation of thymocytes and mature T cells.
    Journal of Immunology 184, 2432-2441 PubMed abstract
  • Karamitros, D; Kotantaki, P; Lygerou, Z; Veiga-Fernandes, H; Pachnis, V; Kioussis, D and Taraviras, S (2010)
    Life without geminin.
    Cell Cycle 9, 3181-3185 PubMed abstract

[Page last updated 1 Jun 2018]

Vassilis Pachnis
+44 (0)20 379 61556

  • Qualifications and history
  • 1980 MD University of Athens Medical School, Greece
  • 1986 PhD University of Pennsylvania, USA
  • 1986 Postdoctoral Fellow, Columbia University, USA
  • 1991 Group Leader, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK