Thomas Surrey: Publications

  • Fallesen, T; Roostalu, J; Duellberg, C; Pruessner, G and Surrey, T (2017)
    Ensembles of bidirectional kinesin Cin8 produce additive forces in both directions of movement.
    Biophysical Journal 113, 2055-2067 PubMed abstract
  • Jha, R; Roostalu, J; Cade, NI; Trokter, M and Surrey, T (2017)
    Combinatorial regulation of the balance between dynein microtubule end accumulation and initiation of directed motility.
    EMBO Journal 36, 3387-3404 PubMed abstract
  • Matsuo, Y; Maurer, SP; Surrey, T and Toda, T (2017)
    Purification and characterisation of the fission yeast Ndc80 complex.
    Protein Expression and Purification 135, 61-69 PubMed abstract
  • Rickman, J; Duellberg, C; Cade, NI; Griffin, LD and Surrey, T (2017)
    Steady-state EB cap size fluctuations are determined by stochastic microtubule growth and maturation.
    Proceedings of the National Academy of Sciences of the United States of America 114, 3427-3432 PubMed abstract
  • Roostalu, J and Surrey, T (2017)
    Microtubule nucleation: beyond the template.
    Nature Reviews Molecular Cell Biology 18, 702-710 PubMed abstract
  • Zhang, R; Roostalu, J; Surrey, T and Nogales, E (2017)
    Structural insight into TPX2-stimulated microtubule assembly.
    eLife 6, e30959 PubMed abstract
  • Bohner, G; Gustafsson, N; Cade, NI; Maurer, SP; Griffin, LD and Surrey, T (2016)
    Important factors determining the nanoscale tracking precision of dynamic microtubule ends.
    Journal of Microscopy 261, 67-78 PubMed abstract
  • Duellberg, C; Cade, NI; Holmes, D and Surrey, T (2016)
    The size of the EB cap determines instantaneous microtubule stability.
    eLife 5, e13470 PubMed abstract
  • Duellberg, C; Cade, NI and Surrey, T (2016)
    Microtubule aging probed by microfluidics-assisted tubulin washout.
    Molecular Biology of the Cell 27, 3563-3573 PubMed abstract
  • Matsuo, Y; Maurer, SP; Yukawa, M; Zakian, S; Singleton, MR; Surrey, T and Toda, T (2016)
    An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation.
    Journal of Cell Science 129, 4592-4606 PubMed abstract
  • Ti, S-C; Pamula, MC; Howes, SC; Duellberg, C; Cade, NI; Kleiner, RE; Forth, S; Surrey, T; Nogales, E and Kapoor, TM (2016)
    Mutations in human tubulin proximal to the kinesin-binding site alter dynamic instability at microtubule plus- and minus-ends.
    Developmental Cell 37, 72-84 PubMed abstract
  • Baumann, H and Surrey, T (2015)
    Self-organization of motors and microtubules in lipid-monolayered droplets.
    Methods in Cell Biology 128, 39-55 PubMed abstract
  • Janiesch, J-W; Weiss, M; Kannenberg, G; Hannabuss, J; Surrey, T; Platzman, I and Spatz, JP (2015)
    Key factors for stable retention of fluorophores and labeled biomolecules in droplet-based microfluidics.
    Analytical Chemistry 87, 2063-2067 PubMed abstract
  • Jha, R and Surrey, T (2015)
    Regulation of processive motion and microtubule localization of cytoplasmic dynein.
    Biochemical Society Transactions 43, 48-57 PubMed abstract
  • Roostalu, J; Cade, NI and Surrey, T (2015)
    Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.
    Nature Cell Biology 17, 1422-1434 PubMed abstract
  • Baumann, H and Surrey, T (2014)
    Motor-mediated cortical versus astral microtubule organization in lipid-monolayered droplets.
    Journal of Biological Chemistry 289, 22524-22535 PubMed abstract
  • Duellberg, C; Trokter, M; Jha, R; Sen, I; Steinmetz, MO and Surrey, T (2014)
    Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein.
    Nature Cell Biology 16, 804-811 PubMed abstract
  • Fourniol, FJ; Li, T-D; Bieling, P; Mullins, RD; Fletcher, DA and Surrey, T (2014)
    Micropattern-guided assembly of overlapping pairs of dynamic microtubules.
    Methods in Enzymology 540, 339-360 PubMed abstract
  • Maurer, SP; Cade, NI; Bohner, G; Gustafsson, N; Boutant, E and Surrey, T (2014)
    EB1 accelerates two conformational transitions important for microtubule maturation and dynamics.
    Current Biology 24, 372-384 PubMed abstract
  • Maurer, SP; Fourniol, FJ; Hoenger, A and Surrey, T (2014)
    Seeded microtubule growth for cryoelectron microscopy of end-binding proteins.
    Methods in Molecular Biology 1136, 247-260 PubMed abstract
  • Dogterom, M and Surrey, T (2013)
    Microtubule organization in vitro.
    Current Opinion in Cell Biology 25, 23-29 PubMed abstract
  • Duellberg, C; Fourniol, FJ; Maurer, SP; Roostalu, J and Surrey, T (2013)
    End-binding proteins and Ase1/PRC1 define local functionality of structurally distinct parts of the microtubule cytoskeleton.
    Trends in Cell Biology 23, 54-63 PubMed abstract
  • Ghosh, S; Hentrich, C and Surrey, T (2013)
    Micropattern-controlled local microtubule nucleation, transport, and mesoscale organization.
    ACS Chemical Biology 8, 673-678 PubMed abstract
  • Roostalu, J and Surrey, T (2013)
    The multiple talents of kinesin-8.
    Nature Cell Biology 15, 889-891 PubMed abstract
  • Telley, IA; Gáspár, I; Ephrussi, A and Surrey, T (2013)
    A single Drosophila embryo extract for the study of mitosis ex vivo.
    Nature Protocols 8, 310-324 PubMed abstract
  • Gropeanu, RA; Baumann, H; Ritz, S; Mailänder, V; Surrey, T and del Campo, A (2012)
    Phototriggerable 2',7-caged paclitaxel.
    PLOS ONE 7, e43657 PubMed abstract
  • Maurer, SP; Fourniol, FJ; Bohner, G; Moores, CA and Surrey, T (2012)
    EBs recognize a nucleotide-dependent structural cap at growing microtubule ends.
    Cell 149, 371-382 PubMed abstract
  • Pecqueur, L; Duellberg, C; Dreier, B; Jiang, Q; Wang, C; Plückthun, A; Surrey, T; Gigant, B and Knossow, M (2012)
    A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end.
    Proceedings of the National Academy of Sciences of the United States of America 109, 12011-12016 PubMed abstract
  • Telley, IA; Gáspár, I; Ephrussi, A and Surrey, T (2012)
    Aster migration determines the length scale of nuclear separation in the Drosophila syncytial embryo.
    Journal of Cell Biology 197, 887-895 PubMed abstract
  • Trokter, M; Mücke, N and Surrey, T (2012)
    Reconstitution of the human cytoplasmic dynein complex.
    Proceedings of the National Academy of Sciences of the United States of America 109, 20895-20900 PubMed abstract
  • Trokter, M and Surrey, T (2012)
    LIS1 clamps dynein to the microtubule.
    Cell 150, 877-879 PubMed abstract
  • Maurer, SP; Bieling, P; Cope, J; Hoenger, A and Surrey, T (2011)
    GTPγS microtubules mimic the growing microtubule end structure recognized by end-binding proteins (EBs).
    Proceedings of the National Academy of Sciences of the United States of America 108, 3988-3993 PubMed abstract
  • Roostalu, J; Hentrich, C; Bieling, P; Telley, IA; Schiebel, E and Surrey, T (2011)
    Directional switching of the kinesin Cin8 through motor coupling.
    Science 332, 94-99 PubMed abstract
  • Telley, IA; Bieling, P and Surrey, T (2011)
    Reconstitution and quantification of dynamic microtubule end tracking in vitro using TIRF microscopy.
    Methods in Molecular Biology 777, 127-145 PubMed abstract
  • Bieling, P; Kronja, I and Surrey, T (2010)
    Microtubule motility on reconstituted meiotic chromatin.
    Current Biology 20, 763-769 PubMed abstract
  • Bieling, P; Telley, IA; Hentrich, C; Piehler, J and Surrey, T (2010)
    Fluorescence microscopy assays on chemically functionalized surfaces for quantitative imaging of microtubule, motor, and +TIP dynamics.
    Methods in Cell Biology 95, 555-580 PubMed abstract
  • Bieling, P; Telley, IA and Surrey, T (2010)
    A minimal midzone protein module controls formation and length of antiparallel microtubule overlaps.
    Cell 142, 420-432 PubMed abstract
  • Hentrich, C and Surrey, T (2010)
    Microtubule organization by the antagonistic mitotic motors kinesin-5 and kinesin-14.
    Journal of Cell Biology 189, 465-480 PubMed abstract

[Page last updated 1 Dec 2017]

Thomas Surrey

thomas.surrey@crick.ac.uk
+44 (0)20 379 62044

  • Qualifications and history
  • 1995 PhD, University of Tuebingen and Max-Planck Institute for Biology, Germany
  • 1995 Postdoctoral Fellow, Princeton University, USA
  • 1998  Postdoctoral fellow and staff scientist,  European Molecular Biology Laboratory, Germany
  • 2002  Team and group leader, European Molecular Biology Laboratory, Germany
  • 2011 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK