Steve Smerdon: Publications

  • Pisco, JP; de Chiara, C; Pacholarz, KJ; Garza-Garcia, A; Ogrodowicz, RW; Walker, PA; Barran, PE; Smerdon, SJ and de Carvalho, LPS (2017)
    Uncoupling conformational states from activity in an allosteric enzyme.
    Nature Communications 8, 203 PubMed abstract
  • von Morgen, P; Burdova, K; Flower, TG; O'Reilly, NJ; Boulton, SJ; Smerdon, SJ; Macurek, L and Hořejší, Z (2017)
    MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.
    Oncogene 36, 4943-4950 PubMed abstract
  • Kyrieleis, OJP; McIntosh, PB; Webb, SR; Calder, LJ; Lloyd, J; Patel, NA; Martin, SR; Robinson, CV; Rosenthal, PB and Smerdon, SJ (2016)
    Three-dimensional architecture of the human BRCA1-A histone deubiquitinase core complex.
    Cell Reports 17, 3099-3106 PubMed abstract
  • Raz, R; Burlina, F; Ismail, M; Downward, J; Li, J; Smerdon, SJ; Quibell, M; White, PD and Offer, J (2016)
    HF-free Boc synthesis of peptide thioesters for ligation and cyclization.
    Angewandte Chemie International Edition 55, 13174-13179 PubMed abstract
  • Arnold, LH; Groom, HCT; Kunzelmann, S; Schwefel, D; Caswell, SJ; Ordonez, P; Mann, MC; Rueschenbaum, S; Goldstone, DC; Pennell, S; Howell, SA; Stoye, JP; Webb, M; Taylor, IA and Bishop, KN (2015)
    Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction.
    PLOS Pathogens 11, e1005194 PubMed abstract
  • Cherry, AL; Nott, TJ; Kelly, G; Rulten, SL; Caldecott, KW and Smerdon, SJ (2015)
    Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains.
    DNA Repair 35, 116-125 PubMed abstract
  • Martino, L; Pennell, S; Kelly, G; Busi, B; Brown, P; Atkinson, RA; Salisbury, NJH; Ooi, Z-H; See, K-W; Smerdon, SJ; Alfano, C; Bui, TTT and Conte, MR (2015)
    Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
    Nucleic Acids Research 43, 645-660 PubMed abstract
  • Ben-Addi, A; Mambole-Dema, A; Brender, C; Martin, SR; Janzen, J; Kjaer, S; Smerdon, SJ and Ley, SC (2014)
    IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
    Proceedings of the National Academy of Sciences of the United States of America 111, E2394-E2403 PubMed abstract
  • Hořejší, Z; Stach, L; Flower, TG; Joshi, D; Flynn, H; Skehel, JM; O'Reilly, NJ; Ogrodowicz, RW; Smerdon, SJ and Boulton, SJ (2014)
    Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.
    Cell Reports 7, 19-26 PubMed abstract
  • Larsen, DH; Hari, F; Clapperton, JA; Gwerder, M; Gutsche, K; Altmeyer, M; Jungmichel, S; Toledo, LI; Fink, D; Rask, M-B; Grofte, M; Lukas, C; Nielsen, ML; Smerdon, SJ; Lukas, J and Stucki, M (2014)
    The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage.
    Nature Cell Biology 16, 792-803 PubMed abstract
  • Pennell, S; Déclais, A-C; Li, J; Haire, LF; Berg, W; Saldanha, JW; Taylor, IA; Rouse, J; Lilley, DMJ and Smerdon, SJ (2014)
    FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.
    Cell Reports 8, 84-93 PubMed abstract
  • Smerdon, SJ (2014)
    A year in structural signaling: mTOR--the PIKK of the bunch?
    Science Signaling 7, pe6 PubMed abstract
  • Rock, JM; Lim, D; Stach, L; Ogrodowicz, RW; Keck, JM; Jones, MH; Wong, CCL; Yates, JR; Winey, M; Smerdon, SJ; Yaffe, MB and Amon, A (2013)
    Activation of the yeast hippo pathway by phosphorylation-dependent assembly of signaling complexes.
    Science 340, 871-875 PubMed abstract
  • Spivey, VL; Whalan, RH; Hirst, EMA; Smerdon, SJ and Buxton, RS (2013)
    An attenuated mutant of the Rv1747 ATP-binding cassette transporter of Mycobacterium tuberculosis and a mutant of its cognate kinase, PknF, show increased expression of the efflux pump-related iniBAC operon.
    FEMS Microbiology Letters 347, 107-115 PubMed abstract
  • Chapman, TM; Bouloc, N; Buxton, RS; Chugh, J; Lougheed, KEA; Osborne, SA; Saxty, B; Smerdon, SJ; Taylor, DL and Whalley, D (2012)
    Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.
    Bioorganic & Medicinal Chemistry Letters 22, 3349-3353 PubMed abstract
  • Jungmichel, S; Clapperton, JA; Lloyd, J; Hari, FJ; Spycher, C; Pavic, L; Li, J; Haire, LF; Bonalli, M; Larsen, DH; Lukas, C; Lukas, J; Macmillan, D; Nielsen, ML; Stucki, M and Smerdon, SJ (2012)
    The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.
    Nucleic Acids Research 40, 3913-3928 PubMed abstract
  • Martino, L; Pennell, S; Kelly, G; Bui, TTT; Kotik-Kogan, O; Smerdon, SJ; Drake, AF; Curry, S and Conte, MR (2012)
    Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein.
    Nucleic Acids Research 40, 1381-1394 PubMed abstract
  • Yata, K; Lloyd, J; Maslen, S; Bleuyard, J-Y; Skehel, M; Smerdon, SJ and Esashi, F (2012)
    Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
    Molecular Cell 45, 371-383 PubMed abstract
  • Alexander, J; Lim, D; Joughin, BA; Hegemann, B; Hutchins, JRA; Ehrenberger, T; Ivins, F; Sessa, F; Hudecz, O; Nigg, EA; Fry, AM; Musacchio, A; Stukenberg, PT; Mechtler, K; Peters, J-M; Smerdon, SJ and Yaffe, MB (2011)
    Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.
    Science Signaling 4, ra42 PubMed abstract
  • Croasdale, R; Ivins, FJ; Muskett, F; Daviter, T; Scott, DJ; Hardy, T; Smerdon, SJ; Fry, AM and Pfuhl, M (2011)
    An undecided coiled coil. The leucine zipper of Nek2 kinase exhibits atypical conformational exchaange dymanics.
    Journal of Biological Chemistry 286, 27537-27547 PubMed abstract
  • Spivey, VL; Molle, V; Whalan, RH; Rodgers, A; Leiba, J; Stach, L; Walker, KB; Smerdon, SJ and Buxton, RS (2011)
    Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis.
    Journal of Biological Chemistry 286, 26198-26209 PubMed abstract
  • Albesa-Jové, D; Bertrand, T; Carpenter, EP; Swain, GV; Lim, J; Zhang, J; Haire, LF; Vasisht, N; Braun, V; Lange, A; Von Eichel-Strelber, C; Svergun, DI; Fairweather, NF and Brown, KA (2010)
    Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS.
    Journal of Molecular Biology 396, 1260-1270 PubMed abstract
  • Becherel, OJ; Jakob, B; Cherry, AL; Gueven, N; Fusser, M; Kijas, AW; Peng, C; Katyal, S; McKinnon, PJ; Chen, J; Epe, B; Smerdon, SJ; Taucher-Scholz, G and Lavin, MF (2010)
    CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.
    Nucleic Acids Research 38, 1489-1503 PubMed abstract
  • Brierley, I; Gilbert, RJC and Pennell, S (2010)
    Pseudoknot-dependent programmed-1 ribosomal frameshifting: structures, mechanisms and models.
    Nucleic Acids and Molecular Biology 24, 149-174
  • Kadekoppala, M; Ogun, SA; Howell, S; Gunaratne, RS and Holder, AA (2010)
    Systematic genetic analysis of the Plasmodium falciparum MSP7-like family reveals differences in protein expression, location and importance in asexual growth of the blood stage parasite.
    Eukaryotic Cell 9, 1064-1074 PubMed abstract
  • Khurshid, S; Haire, LF and Chayen, NE (2010)
    Automated seeding for the optimization of crystal quality.
    Journal of Applied Crystallography 43, 752-756
  • Masania, J; Li, J; Smerdon, SJ and Macmillan, D (2010)
    Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer.
    Organic & Biomolecular Chemistry 8, 5113-5119 PubMed abstract
  • Pennell, S; Westcott, S; Ortiz-Lombardía, M; Patel, D; Li, J; Nott, TJ; Mohammed, D; Buxton, RS; Yaffe, MB; Verma, C and Smerdon, SJ (2010)
    Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.
    Structure 18, 1587-1595 PubMed abstract
  • Taylor, IA; Goldstone, DC; Pala, P; Haire, LF and Smerdon, SJ (2010)
    Structure of the amino-terminal domain from the cell-cycle regulator Swi6.
    Proteins 78, 2861-2865 PubMed abstract
  • van Vugt, MATM; Gardino, AK; Linding, R; Ostheimer, GJ; Reinhardt, HC; Ong, S-E; Tan, CS; Miao, H; Keezer, SM; Li, J; Pawson, T; Lewis, TA; Carr, SA; Smerdon, SJ; Brummelkamp, TR and Yaffe, MB (2010)
    A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G2/M DNA damage checkpoint.
    PLOS Biology 8, e1000287 PubMed abstract

[Page last updated 1 Nov 2017]

Steve Smerdon

steve.smerdon@crick.ac.uk
+44 (0)20 379 62284