Peter Ratcliffe: Publications

  • Tiana, M; Acosta-Iborra, B; Puente-Santamaría, L; Hernansanz-Agustin, P; Worsley-Hunt, R; Masson, N; García-Rio, F; Mole, D; Ratcliffe, P; Wasserman, WW; Jimenez, B and del Peso, L (2018)
    The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia.
    Nucleic Acids Research 46, 120-133 PubMed abstract
  • Grampp, S; Schmid, V; Salama, R; Lauer, V; Kranz, F; Platt, JL; Smythies, J; Choudhry, H; Goppelt-Struebe, M; Ratcliffe, PJ; Mole, DR and Schödel, J (2017)
    Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.
    PLOS Genetics 13, e1006872 PubMed abstract
  • Paolini, NA; Attwood, M; Sondalle, SB; Vieira, CMDS; van Adrichem, AM; di Summa, FM; O'Donohue, M-F; Gleizes, P-E; Rachuri, S; Briggs, JW; Fischer, R; Ratcliffe, PJ; Wlodarski, MW; Houtkooper, RH; von Lindern, M; Kuijpers, TW; Dinman, JD; Baserga, SJ; Cockman, ME and MacInnes, AW (2017)
    A ribosomopathy reveals decoding defective ribosomes driving human dysmorphism.
    American Journal of Human Genetics 100, 506-522 PubMed abstract
  • Pugh, CW and Ratcliffe, PJ (2017)
    New horizons in hypoxia signaling pathways.
    Experimental Cell Research 356, 116-121 PubMed abstract
  • Ratcliffe, P; Koivunen, P; Myllyharju, J; Ragoussis, J; Bovée, JVMG; Batinic-Haberle, I; Vinatier, C; Trichet, V; Robriquet, F; Oliver, L and Gardie, B (2017)
    Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.
    Hypoxia 5, 11-20 PubMed abstract
  • Sadiku, P; Willson, JA; Dickinson, RS; Murphy, F; Harris, AJ; Lewis, A; Sammut, D; Mirchandani, AS; Ryan, E; Watts, ER; Thompson, AAR; Marriott, HM; Dockrell, DH; Taylor, CT; Schneider, M; Maxwell, PH; Chilvers, ER; Mazzone, M; Moral, V; Pugh, CW; Ratcliffe, PJ; Schofield, CJ; Ghesquiere, B; Carmeliet, P; Whyte, MKB and Walmsley, SR (2017)
    Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.
    Journal of Clinical Investigation 127, 3407-3420 PubMed abstract
  • Yeh, T-L; Leissing, TM; Abboud, MI; Thinnes, CC; Atasoylu, O; Holt-Martyn, JP; Zhang, D; Tumber, A; Lippl, K; Lohans, CT; Leung, IKH; Morcrette, H; Clifton, IJ; Claridge, TDW; Kawamura, A; Flashman, E; Lu, X; Ratcliffe, PJ; Chowdhury, R; Pugh, CW and Schofield, CJ (2017)
    Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
    Chemical Science 8, 7651-7668 PubMed abstract
  • Anon. (2016)
    Making sense of the unexpected.
    Cell 167, 35-38 PubMed abstract
  • Bardella, C; Al-Dalahmah, O; Krell, D; Brazauskas, P; Al-Qahtani, K; Tomkova, M; Adam, J; Serres, S; Lockstone, H; Freeman-Mills, L; Pfeffer, I; Sibson, N; Goldin, R; Schuster-Böeckler, B; Pollard, PJ; Soga, T; McCullagh, JS; Schofield, CJ; Mulholland, P; Ansorge, O; Kriaucionis, S; Ratcliffe, PJ; Szele, FG and Tomlinson, I (2016)
    Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis.
    Cancer Cell 30, 578-594 PubMed abstract
  • Camps, C; Petousi, N; Bento, C; Cario, H; Copley, RR; McMullin, MF; van Wijk, R; WGS500 Consortium; Ratcliffe, PJ; Robbins, PA and Taylor, JC (2016)
    Gene panel sequencing improves the diagnostic work-up of patients with idiopathic erythrocytosis and identifies new mutations.
    Haematologica 101, 1306-1318 PubMed abstract
  • Chan, MC; Holt-Martyn, JP; Schofield, CJ and Ratcliffe, PJ (2016)
    Pharmacological targeting of the HIF hydroxylases- A new field in medicine development.
    Molecular Aspects of Medicine 47-48, 54-75 PubMed abstract
  • Chan, MC; Ilott, NE; Schödel, J; Sims, D; Tumber, A; Lippl, K; Mole, DR; Pugh, CW; Ratcliffe, PJ; Ponting, CP and Schofield, CJ (2016)
    Tuning the transcriptional response to hypoxia by inhibiting hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases.
    Journal of Biological Chemistry 291, 20661-20673 PubMed abstract
  • Chowdhury, R; Leung, IKH; Tian, Y-M; Abboud, MI; Ge, W; Domene, C; Cantrelle, F-X; Landrieu, I; Hardy, AP; Pugh, CW; Ratcliffe, PJ; Claridge, TDW and Schofield, CJ (2016)
    Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.
    Nature Communications 7, 12673 PubMed abstract
  • Cole, MA; Abd Jamil, AH; Heather, LC; Murray, AJ; Sutton, ER; Slingo, M; Sebag-Montefiore, L; Tan, SC; Aksentijević, D; Gildea, OS; Stuckey, DJ; Yeoh, KK; Carr, CA; Evans, RD; Aasum, E; Schofield, CJ; Ratcliffe, PJ; Neubauer, S; Robbins, PA and Clarke, K (2016)
    On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.
    FASEB Journal 30, 2684-2697 PubMed abstract
  • Frise, MC; Cheng, H-Y; Nickol, AH; Curtis, MK; Pollard, KA; Roberts, DJ; Ratcliffe, PJ; Dorrington, KL and Robbins, PA (2016)
    Clinical iron deficiency disturbs normal human responses to hypoxia.
    Journal of Clinical Investigation 126, 2139-2150 PubMed abstract
  • Grampp, S; Platt, JL; Lauer, V; Salama, R; Kranz, F; Neumann, VK; Wach, S; Stöhr, C; Hartmann, A; Eckardt, K-U; Ratcliffe, PJ; Mole, DR and Schödel, J (2016)
    Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.
    Nature Communications 7, 13183 PubMed abstract
  • Hodson, EJ; Nicholls, LG; Turner, PJ; Llyr, R; Fielding, JW; Douglas, G; Ratnayaka, I; Robbins, PA; Pugh, CW; Buckler, KJ; Ratcliffe, PJ and Bishop, T (2016)
    Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway.
    Journal of Physiology 594, 1179-1195 PubMed abstract
  • Kaelin, WG, Jr.; Ratcliffe, PJ and Semenza, GL (2016)
    Pathways for oxygen regulation and homeostasis: The 2016 Albert Lasker Basic Medical Research Award.
    JAMA 316, 1252-1253 PubMed abstract
  • Pan, J; Bishop, T; Ratcliffe, PJ; Yeger, H and Cutz, E (2016)
    Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice.
    Hypoxia 4, 69-80 PubMed abstract
  • Platt, JL; Salama, R; Smythies, J; Choudhry, H; Davies, JOJ; Hughes, JR; Ratcliffe, PJ and Mole, DR (2016)
    Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.
    EMBO Reports 17, 1410-1421 PubMed abstract
  • Schödel, J; Grampp, S; Maher, ER; Moch, H; Ratcliffe, PJ; Russo, P and Mole, DR (2016)
    Hypoxia, hypoxia-inducible transcription factors, and renal cancer.
    European Urology 69, 646-657 PubMed abstract
  • Vukovic, M; Sepulveda, C; Subramani, C; Guitart, AV; Mohr, J; Allen, L; Panagopoulou, TI; Paris, J; Lawson, H; Villacreces, A; Armesilla-Diaz, A; Gezer, D; Holyoake, TL; Ratcliffe, PJ and Kranc, KR (2016)
    Adult hematopoietic stem cells lacking Hif-1α self-renew normally.
    Blood 127, 2841-2846 PubMed abstract
  • Bishop, T and Ratcliffe, PJ (2015)
    HIF hydroxylase pathways in cardiovascular physiology and medicine.
    Circulation Research 117, 65-79 PubMed abstract
  • Castro-Giner, F; Ratcliffe, P and Tomlinson, I (2015)
    The mini-driver model of polygenic cancer evolution.
    Nature Reviews Cancer 15, 680-685 PubMed abstract
  • Chan, MC; Atasoylu, O; Hodson, E; Tumber, A; Leung, IKH; Chowdhury, R; Gómez-Pérez, V; Demetriades, M; Rydzik, AM; Holt-Martyn, J; Tian, Y-M; Bishop, T; Claridge, TDW; Kawamura, A; Pugh, CW; Ratcliffe, PJ and Schofield, CJ (2015)
    Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain.
    PLOS ONE 10, e0132004 PubMed abstract
  • Choudhry, H; Albukhari, A; Morotti, M; Haider, S; Moralli, D; Smythies, J; Schödel, J; Green, CM; Camps, C; Buffa, F; Ratcliffe, P; Ragoussis, J; Harris, AL and Mole, DR (2015)
    Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.
    Oncogene 34, 4482-4490 PubMed abstract
  • Kovac, M; Navas, C; Horswell, S; Salm, M; Bardella, C; Rowan, A; Stares, M; Castro-Giner, F; Fisher, R; de Bruin, EC; Kovacova, M; Gorman, M; Makino, S; Williams, J; Jaeger, E; Jones, A; Howarth, K; Larkin, J; Pickering, L; Gore, M; Nicol, DL; Hazell, S; Stamp, G; O'Brien, T; Challacombe, B; Matthews, N; Phillimore, B; Begum, S; Rabinowitz, A; Varela, I; Chandra, A; Horsfield, C; Polson, A; Tran, M; Bhatt, R; Terracciano, L; Eppenberger-Castori, S; Protheroe, A; Maher, E; El Bahrawy, M; Fleming, S; Ratcliffe, P; Heinimann, K; Swanton, C and Tomlinson, I (2015)
    Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution.
    Nature Communications 6, 6336 PubMed abstract
  • Livermore, S; Pan, J; Yeger, H; Ratcliffe, P; Bishop, T and Cutz, E (2015)
    Augmented 5-HT secretion in pulmonary neuroepithelial bodies from PHD1 null mice.
    Advances in Experimental Medicine and Biology 860, 309-313 PubMed abstract
  • Michailidou, Z; Morton, NM; Moreno Navarrete, JM; West, CC; Stewart, KJ; Fernández-Real, JM; Schofield, CJ; Seckl, JR and Ratcliffe, PJ (2015)
    Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.
    Diabetes 64, 733-745 PubMed abstract
  • Nickol, AH; Frise, MC; Cheng, H-Y; McGahey, A; McFadyen, BM; Harris-Wright, T; Bart, NK; Curtis, MK; Khandwala, S; O'Neill, DP; Pollard, KA; Hardinge, FM; Rahman, NM; Armitage, AE; Dorrington, KL; Drakesmith, H; Ratcliffe, PJ and Robbins, PA (2015)
    A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.
    BMJ Open 5, e007911 PubMed abstract
  • Salama, R; Masson, N; Simpson, P; Sciesielski, LK; Sun, M; Tian, Y-M; Ratcliffe, PJ and Mole, DR (2015)
    Heterogeneous effects of direct hypoxia pathway activation in kidney cancer.
    PLOS ONE 10, e0134645 PubMed abstract
  • Simpson, PD; Eipper, BA; Katz, MJ; Gandara, L; Wappner, P; Fischer, R; Hodson, EJ; Ratcliffe, PJ and Masson, N (2015)
    Striking oxygen sensitivity of the peptidylglycine α-amidating monooxygenase (PAM) in neuroendocrine cells.
    Journal of Biological Chemistry 290, 24891-24901 PubMed abstract
  • Taylor, JC; Martin, HC; Lise, S; Broxholme, J; Cazier, J-B; Rimmer, A; Kanapin, A; Lunter, G; Fiddy, S; Allan, C; Aricescu, AR; Attar, M; Babbs, C; Becq, J; Beeson, D; Bento, C; Bignell, P; Blair, E; Buckle, VJ; Bull, K; Cais, O; Cario, H; Chapel, H; Copley, RR; Cornall, R; Craft, J; Dahan, K; Davenport, EE; Dendrou, C; Devuyst, O; Fenwick, AL; Flint, J; Fugger, L; Gilbert, RD; Goriely, A; Green, A; Greger, IH; Grocock, R; Gruszczyk, AV; Hastings, R; Hatton, E; Higgs, D; Hill, A; Holmes, C; Howard, M; Hughes, L; Humburg, P; Johnson, D; Karpe, F; Kingsbury, Z; Kini, U; Knight, JC; Krohn, J; Lamble, S; Langman, C; Lonie, L; Luck, J; McCarthy, D; McGowan, SJ; McMullin, MF; Miller, KA; Murray, L; Németh, AH; Nesbit, MA; Nutt, D; Ormondroyd, E; Oturai, AB; Pagnamenta, A; Patel, SY; Percy, M; Petousi, N; Piazza, P; Piret, SE; Polanco-Echeverry, G; Popitsch, N; Powrie, F; Pugh, C; Quek, L; Robbins, PA; Robson, K; Russo, A; Sahgal, N; van Schouwenburg, PA; Schuh, A; Silverman, E; Simmons, A; Sørensen, PS; Sweeney, E; Taylor, J; Thakker, RV; Tomlinson, I; Trebes, A; Twigg, SRF; Uhlig, HH; Vyas, P; Vyse, T; Wall, SA; Watkins, H; Whyte, MP; Witty, L; Wright, B; Yau, C; Buck, D; Humphray, S; Ratcliffe, PJ; Bell, JI; Wilkie, AOM; Bentley, D; Donnelly, P and McVean, G (2015)
    Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.
    Nature Genetics 47, 717-726 PubMed abstract
  • Thinnes, CC; Tumber, A; Yapp, C; Scozzafava, G; Yeh, T; Chan, MC; Tran, TA; Hsu, K; Tarhonskaya, H; Walport, LJ; Wilkins, SE; Martinez, ED; Müller, S; Pugh, CW; Ratcliffe, PJ; Brennan, PE; Kawamura, A and Schofield, CJ (2015)
    Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.
    Chemical Communications 51, 15458-15461 PubMed abstract
  • Vukovic, M; Guitart, AV; Sepulveda, C; Villacreces, A; O'Duibhir, E; Panagopoulou, TI; Ivens, A; Menendez-Gonzalez, J; Iglesias, JM; Allen, L; Glykofrydis, F; Subramani, C; Armesilla-Diaz, A; Post, AEM; Schaak, K; Gezer, D; So, CWE; Holyoake, TL; Wood, A; O'Carroll, D; Ratcliffe, PJ and Kranc, KR (2015)
    Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.
    Journal of Experimental Medicine 212, 2223-2234 PubMed abstract
  • Choudhry, H; Schödel, J; Oikonomopoulos, S; Camps, C; Grampp, S; Harris, AL; Ratcliffe, PJ; Ragoussis, J and Mole, DR (2014)
    Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.
    EMBO Reports 15, 70-76 PubMed abstract
  • Couvé, S; Ladroue, C; Laine, E; Mahtouk, K; Guégan, J; Gad, S; Le Jeune, H; Le Gentil, M; Nuel, G; Kim, WY; Lecomte, B; Pagès, J-C; Collin, C; Lasne, F; Benusiglio, PR; Bressac-de Paillerets, B; Feunteun, J; Lazar, V; Gimenez-Roqueplo, A-P; Mazure, NM; Dessen, P; Tchertanov, L; Mole, DR; Kaelin, W; Ratcliffe, P; Richard, S and Gardie, B (2014)
    Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis.
    Cancer Research 74, 6554-6564 PubMed abstract
  • Feng, T; Yamamoto, A; Wilkins, SE; Sokolova, E; Yates, LA; Münzel, M; Singh, P; Hopkinson, RJ; Fischer, R; Cockman, ME; Shelley, J; Trudgian, DC; Schödel, J; McCullagh, JSO; Ge, W; Kessler, BM; Gilbert, RJ; Frolova, LY; Alkalaeva, E; Ratcliffe, PJ; Schofield, CJ and Coleman, ML (2014)
    Optimal translational termination requires C4 lysyl hydroxylation of eRF1.
    Molecular Cell 53, 645-654 PubMed abstract
  • Katz, MJ; Acevedo, JM; Loenarz, C; Galagovsky, D; Liu-Yi, P; Pérez-Pepe, M; Thalhammer, A; Sekirnik, R; Ge, W; Melani, M; Thomas, MG; Simonetta, S; Boccaccio, GL; Schofield, CJ; Cockman, ME; Ratcliffe, PJ and Wappner, P (2014)
    Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth.
    Proceedings of the National Academy of Sciences of the United States of America 111, 4025-4030 PubMed abstract
  • Loenarz, C; Sekirnik, R; Thalhammer, A; Ge, W; Spivakovsky, E; Mackeen, MM; McDonough, MA; Cockman, ME; Kessler, BM; Ratcliffe, PJ; Wolf, A and Schofield, CJ (2014)
    Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.
    Proceedings of the National Academy of Sciences of the United States of America 111, 4019-4024 PubMed abstract
  • Masson, N and Ratcliffe, PJ (2014)
    Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.
    Cancer & Metabolism 2, 3 PubMed abstract
  • Petousi, N; Copley, RR; Lappin, TRJ; Haggan, SE; Bento, CM; Cario, H; Percy, MJ; The WGS Consortium; Ratcliffe, PJ; Robbins, PA and McMullin, MF (2014)
    Erythrocytosis associated with a novel missense mutation in the BPGM gene.
    Haematologica 99, e201-e204 PubMed abstract
  • Petousi, N; Croft, QPP; Cavalleri, GL; Cheng, H-Y; Formenti, F; Ishida, K; Lunn, D; McCormack, M; Shianna, KV; Talbot, NP; Ratcliffe, PJ and Robbins, PA (2014)
    Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia.
    Journal of Applied Physiology 116, 893-904 PubMed abstract
  • Singleton, RS; Liu-Yi, P; Formenti, F; Ge, W; Sekirnik, R; Fischer, R; Adam, J; Pollard, PJ; Wolf, A; Thalhammer, A; Loenarz, C; Flashman, E; Yamamoto, A; Coleman, ML; Kessler, BM; Wappner, P; Schofield, CJ; Ratcliffe, PJ and Cockman, ME (2014)
    OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
    Proceedings of the National Academy of Sciences of the United States of America 111, 4031-4036 PubMed abstract
  • Adam, J; Yang, M; Bauerschmidt, C; Kitagawa, M; O'Flaherty, L; Maheswaran, P; Özkan, G; Sahgal, N; Baban, D; Kato, K; Saito, K; Iino, K; Igarashi, K; Stratford, M; Pugh, C; Tennant, DA; Ludwig, C; Davies, B; Ratcliffe, PJ; El-Bahrawy, M; Ashrafian, H; Soga, T and Pollard, PJ (2013)
    A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.
    Cell Reports 3, 1440-1448 PubMed abstract
  • Bishop, T; Talbot, NP; Turner, PJ; Nicholls, LG; Pascual, A; Hodson, EJ; Douglas, G; Fielding, JW; Smith, TG; Demetriades, M; Schofield, CJ; Robbins, PA; Pugh, CW; Buckler, KJ and Ratcliffe, PJ (2013)
    Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.
    Journal of Physiology 591, 3565-3577 PubMed abstract
  • Chowdhury, R; Candela-Lena, JI; Chan, MC; Greenald, DJ; Yeoh, KK; Tian, Y-M; McDonough, MA; Tumber, A; Rose, NR; Conejo-Garcia, A; Demetriades, M; Mathavan, S; Kawamura, A; Lee, MK; van Eeden, F; Pugh, CW; Ratcliffe, PJ and Schofield, CJ (2013)
    Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
    ACS Chemical Biology 8, 1488-1496 PubMed abstract
  • Guitart, AV; Subramani, C; Armesilla-Diaz, A; Smith, G; Sepulveda, C; Gezer, D; Vukovic, M; Dunn, K; Pollard, P; Holyoake, TL; Enver, T; Ratcliffe, PJ and Kranc, KR (2013)
    Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.
    Blood 122, 1741-1745 PubMed abstract
  • Hopkinson, RJ; Tumber, A; Yapp, C; Chowdhury, R; Aik, W; Che, KH; Li, XS; Kristensen, JBL; King, ONF; Chan, MC; Yeoh, KK; Choi, H; Walport, LJ; Thinnes, CC; Bush, JT; Lejeune, C; Rydzik, AM; Rose, NR; Bagg, EA; McDonough, MA; Krojer, TJ; Yue, WW; Ng, SS; Olsen, L; Brennan, PE; Oppermann, U; Müller, S; Klose, RJ; Ratcliffe, PJ; Schofield, CJ and Kawamura, A (2013)
    5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation.
    Chemical Science 4, 3110-3117 PubMed abstract
  • Ratcliffe, PJ (2013)
    Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.
    Journal of Physiology 591, 2027-2042 PubMed abstract
  • Schödel, J; Mole, DR and Ratcliffe, PJ (2013)
    Pan-genomic binding of hypoxia-inducible transcription factors.
    Biological Chemistry 394, 507-517 PubMed abstract
  • Yeoh, KK; Chan, MC; Thalhammer, A; Demetriades, M; Chowdhury, R; Tian, Y-M; Stolze, I; McNeill, LA; Lee, MK; Woon, ECY; Mackeen, MM; Kawamura, A; Ratcliffe, PJ; Mecinovic, J and Schofield, CJ (2013)
    Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
    Organic & Biomolecular Chemistry 11, 732-745 PubMed abstract
  • Yosef, N; Shalek, AK; Gaublomme, JT; Jin, H; Lee, Y; Awasthi, A; Wu, C; Karwacz, K; Xiao, S; Jorgolli, M; Gennert, D; Satija, R; Shakya, A; Lu, DY; Trombetta, JJ; Pillai, MR; Ratcliffe, PJ; Coleman, ML; Bix, M; Tantin, D; Park, H; Kuchroo, VK and Regev, A (2013)
    Dynamic regulatory network controlling TH17 cell differentiation.
    Nature 496, 461-468 PubMed abstract
  • Chen, R-L; Nagel, S; Papadakis, M; Bishop, T; Pollard, P; Ratcliffe, PJ; Pugh, CW and Buchan, AM (2012)
    Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.
    Journal of Physiology 590, 4079-4091 PubMed abstract
  • Demetriades, M; Leung, IKH; Chowdhury, R; Chan, MC; McDonough, MA; Yeoh, KK; Tian, Y-M; Claridge, TDW; Ratcliffe, PJ; Woon, ECY and Schofield, CJ (2012)
    Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.
    Angewandte Chemie International Edition 51, 6672-6675 PubMed abstract
  • Foxler, DE; Bridge, KS; James, V; Webb, TM; Mee, M; Wong, SCK; Feng, Y; Constantin-Teodosiu, D; Petursdottir, TE; Bjornsson, J; Ingvarsson, S; Ratcliffe, PJ; Longmore, GD and Sharp, TV (2012)
    The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
    Nature Cell Biology 14, 201-208 PubMed abstract
  • Ge, W; Wolf, A; Feng, T; Ho, C-h; Sekirnik, R; Zayer, A; Granatino, N; Cockman, ME; Loenarz, C; Loik, ND; Hardy, AP; Claridge, TDW; Hamed, RB; Chowdhury, R; Gong, L; Robinson, CV; Trudgian, DC; Jiang, M; Mackeen, MM; Mccullagh, JS; Gordiyenko, Y; Thalhammer, A; Yamamoto, A; Yang, M; Liu-Yi, P; Zhang, Z; Schmidt-Zachmann, M; Kessler, BM; Ratcliffe, PJ; Preston, GM; Coleman, ML and Schofield, CJ (2012)
    Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
    Nature Chemical Biology 8, 960-962 PubMed abstract
  • Masson, N and Ratcliffe, PJ (2012)
    Oxygen sensing by HIF hydroxylases.
    In: Tumour hypoxia: Molecular mechanisms and clinical implications. Edited by Pastoreková, S and Kopáček, J.
    Bratislava, VEDA Publishing House of the Slovak Academy of Sciences, 2012. 11-63.
  • Masson, N; Singleton, RS; Sekirnik, R; Trudgian, DC; Ambrose, LJ; Miranda, MX; Tian, Y-M; Kessler, BM; Schofield, CJ and Ratcliffe, PJ (2012)
    The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
    EMBO Reports 13, 251-257 PubMed abstract
  • Michailidou, Z; Turban, S; Miller, E; Zou, X; Schrader, J; Ratcliffe, PJ; Hadoke, PWF; Walker, BR; Iredale, JP; Morton, NM and Seckl, JR (2012)
    Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.
    Journal of Biological Chemistry 287, 4188-4197 PubMed abstract
  • Pan, J; Yeger, H; Ratcliffe, P; Bishop, T and Cutz, E (2012)
    Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice.
    Advances in Experimental Medicine and Biology 758, 149-155 PubMed abstract
  • Rose, NR; Woon, ECY; Tumber, A; Walport, LJ; Chowdhury, R; Li, XS; King, ONF; Lejeune, C; Ng, SS; Krojer, T; Chan, MC; Rydzik, AM; Hopkinson, RJ; Che, KH; Daniel, M; Strain-Damerell, C; Gileadi, C; Kochan, G; Leung, IKH; Dunford, J; Yeoh, KK; Ratcliffe, PJ; Burgess-Brown, N; von Delft, F; Muller, S; Marsden, B; Brennan, PE; McDonough, MA; Oppermann, U; Klose, RJ; Schofield, CJ and Kawamura, A (2012)
    Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
    Journal of Medicinal Chemistry 55, 6639-6643 PubMed abstract
  • Schödel, J; Bardella, C; Sciesielski, LK; Brown, JM; Pugh, CW; Buckle, V; Tomlinson, IP; Ratcliffe, PJ and Mole, DR (2012)
    Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.
    Nature Genetics 44, 420-425 PubMed abstract
  • Trudgian, DC; Singleton, R; Cockman, ME; Ratcliffe, PJ and Kessler, BM (2012)
    ModLS: post-translational modification localization scoring with automatic specificity expansion.
    Journal of Proteomics & Bioinformatics 5, 283-289

[Page last updated 1 Jun 2018]

Peter Ratcliffe

Peter Ratcliffe
+44 (0)20 379 63153

  • Qualifications and history
  • 1978 MB ChB, Cambridge University and St Bartholomew's Hospital, London
  • 1987 MD, University of Cambridge
  • 1990 Wellcome Trust Senior Fellow in Clinical Science, Oxford
  • 1996 Professor of Nephrology, University of Oxford
  • 2004 Nuffield Professor of Medicine, University of Oxford
  • 2016 Director, Target Discovery Institute, University of Oxford
  • 2016 Clinical Research Director, the Francis Crick Institute, London