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Parker lab Protein Phosphorylation Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members PublicationsYear published2024 (1)2023 (7)2022 (5)2021 (5)2020 (6)2019 (6)2018 (7)2017 (7)2016 (7)2015 (4)2014 (14)2013 (6)2012 (2)2011 (8)2010 (8) Facet Year publishedResearch topicsBiochemistry & Proteomics (53)Cell Biology (52)Cell Cycle & Chromosomes (52)Chemical Biology & High Throughput (52)Signalling & Oncogenes (52)Computational & Systems Biology (14)Genetics & Genomics (12)Tumour Biology (11)Model Organisms (10)Genome Integrity & Repair (8)Structural Biology & Biophysics (8)Human Biology & Physiology (7)Imaging (7)Developmental Biology (5)Gene Expression (5)Metabolism (2)Neurosciences (2)Immunology (1)Infectious Disease (1)Microfabrication & Bioengineering (1)Stem Cells (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (93)Primary research (74)Review (15)Commentary (1)Editorial (1)Method (1)Obituary (1) Facet Publication typeJournalNature Communications (11)Biochemical Journal (9)Journal of Cell Science (6)Biochemical Society Transactions (5)Cancer Research (5)PLOS ONE (4)Science Signaling (4)Biochimica et Biophysica Acta (2)Cell Reports (2)eLife (2)Scientific Reports (2)Advances in Biological Regulation (1)Advances in Enzyme Regulation (1)Annals of the New York Academy of Sciences (1)Autophagy (1)BBA Clinical (1)Bio-Protocol (1)Biochemical Pharmacology (1)Biophysical Journal (1)Breast Cancer Research (1)British Journal of Cancer (1)Carcinogenesis (1)Cardiovascular Research (1)Cell (1)Cells (1)Developmental Cell (1)FASEB Journal (1)FEBS Letters (1)Frontiers in Cell and Developmental Biology (1)Gastroenterology (1)Immunity (1)International Journal of Cancer (1)Journal of Biological Chemistry (1)Journal of Clinical Investigation (1)Journal of Clinical Oncology (1)Journal of Proteome Research (1)Journal of the European Academy of Dermatology and Venereology (1)Lab on a Chip (1)Molecular and Cellular Biology (1)Molecular and Cellular Proteomics (1)Molecular Biology of the Cell (1)Molecular Cancer Research (1)Nature Medicine (1)Nature Reviews Cancer (1)Nature Reviews Molecular Cell Biology (1)Nucleic Acids Research (1)Oncotarget (1)Pathogens (1)PLOS Biology (1)Proceedings of the National Academy of Sciences of the United States of America (1)Protein & cell (1)The Journal of Cell Biology (1) Facet Journal Publications Displaying 1 - 20 of 93Last updated : 18 April 2024 03:04 Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers Authors (13) R Sumanth Iyer Sarah R Needham Ioannis Galdadas Benjamin M Davis Selene K Roberts Rico CH Man[...] Gilbert O FruhwirthPeter Parker Daniel J Rolfe Francesco L Gervasio Marisa L Martin-Fernandez Nature Communications Published 19 March 2024 Crick labsPeter ParkerFull details Into the fold: advances in understanding aPKC membrane dynamics Authors (3)Mathias CobbautPeter ParkerNeil McDonald Biochemical Journal Published 15 December 2023 Crick labsPeter ParkerNeil McDonaldFull details Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications Authors (4) Tanya N Soliman Daniel KeifenheimPeter Parker Duncan J Clarke The Journal of Cell Biology Published 4 December 2023 Crick labsPeter ParkerFull details Michael D. Waterfield Authors (3)Julian DownwardPeter Parker Bart Vanhaesebroeck Biochemical Journal Published 27 September 2023 Crick labsPeter ParkerJulian DownwardFull details Copy number architectures define treatment-mediated selection of lethal prostate cancer clones Authors (24) AM Mahedi Hasan Paolo Cremaschi Daniel Wetterskog Anuradha Jayaram Stephen Q Wong Scott Williams[...]Charles Swanton Mariam Jamal-Hanjani Stefano Lise Shahneen Sandhu Gerhardt Attard Nature Communications Published 10 August 2023 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonPeter ParkerExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface Authors (3)Mathias CobbautNeil McDonaldPeter Parker Journal of Biological Chemistry Published 1 July 2023 Crick labs/ facilitiesPeter ParkerNeil McDonaldStructural BiologyLight MicroscopyFull details Chemical genetic identification of PKC epsilon substrates in mouse brain Authors (8) Michael P Dugan Laura B Ferguson Nicholas T Hertz Robert J Chalkley Alma L Burlingame Kevan M ShokatPeter Parker Robert O Messing Molecular and Cellular Proteomics Published 1 April 2023 Crick labsPeter ParkerFull details Functional engagement of the PD-1/PD-L1 complex but not PD-L1 expression is highly predictive of patient response to immunotherapy in non-small-cell lung cancer Authors (29) Lissete Sánchez-Magraner Juan Gumuzio James Miles Nicole Quimi Purificación Martínez Del Prado María Teresa Abad-Villar[...] Sandra del Castillo Charles Evans Fernando AguirrePeter Parker Véronique Calleja Journal of Clinical Oncology Published 10 May 2023 Crick labsPeter ParkerFull details PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses Authors (22)Jacqui Marshall Joshua J Cull Hajed O Alharbi May Zaw Thin Susanna TE Cooper Christopher Barrington[...] Owen JL Rackham Daniel Meijles Tim Mohun Angela ClerkPeter Parker Biochemical Journal Published 1 July 2022 Crick labs/ facilitiesPeter ParkerTim MohunIn Vivo ImagingExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsFull details The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways Authors (10)Spyridoula Nikou Chunsheng Zhou James S Griffiths Natalia K Kotowicz Bianca M ColemanMary Green David L Moyes Sarah L Gaffen Julian R Naglik Peter J Parker Science Signaling Published 5 April 2022 Crick labs/ facilitiesPeter ParkerExperimental HistopathologyCell ServicesFull details Genome-protective topoisomerase 2a-dependent G2arrest requires p53 in hTERT-positive cancer cells Authors (12)Nicola LockwoodSilvia Martini Ainara Lopez-Pardo Katharina Deiss Hendrika A Segeren Robert K Semple[...]Dimitra RepanaMathias Cobbaut Tanya SolimanFrancesca CiccarelliPeter Parker Cancer Research Published 1 March 2022 Crick labs/ facilitiesPeter ParkerFrancesca CiccarelliLight MicroscopyHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion Authors (27) Elizabeth R Murray Shinelle Menezes Jack C Henry Josie L Williams Lorena Alba-Castellón Priththivika Baskaran[...] Nuria Gavara Oliver Pearce Pedro Cutillas John F Marshall Angus JM Cameron Cell Reports Published 25 January 2022 Crick labs/ facilitiesPeter ParkerGenetic Modification ServiceBiological Research FacilityExperimental HistopathologyFull details Editorial: Signaling by small GTPases in metastatic disease Authors (2)Peter Parker Uday Kishore Frontiers in Cell and Developmental Biology Published 21 January 2022 Crick labsPeter ParkerFull details A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division Authors (12)Silvia MartiniKhalil DavisRupert Faraway Lisa ElzeNicola LockwoodAndrew Jones[...]Neil McDonald David J Mann Alan ArmstrongJernej UlePeter Parker Nature Communications Published 26 November 2021 Crick labs/ facilitiesJernej UlePeter ParkerPaul NurseNeil McDonaldProteomicsLight MicroscopyFull details Immunogenomics of colorectal cancer response to checkpoint blockade: analysis of the KEYNOTE 177 trial and validation cohorts Authors (29)Michele BortolomeazziMohamed Reda Keddar Lucia MontorsiAmelia AchaLorena BenedettiDamjan Temelkovski[...]Peter Parker Manuel Rodriguez-Justo Kai-Keen Shiu Jo SpencerFrancesca Ciccarelli Gastroenterology Published 1 October 2021 Crick labs/ facilitiesCharles SwantonPeter ParkerJohannes KohlFrancesca CiccarelliExperimental HistopathologyAdvanced SequencingFlow CytometryFull details Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention Authors (14)Lisa WatsonTanya SolimanKhalil Davis Joanna KellyNicola Lockwood Xiaoping Yang[...]Neil McDonald David J Mann Alan Armstrong Ulrike Eggert Peter J Parker Biochemical Journal Published 25 June 2021 Crick labs/ facilitiesPeter ParkerNeil McDonaldStructural BiologyFull details ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data Authors (18) James W Opzoomer Jessica A Timms Kevin Blighe Thanos P Mourikis Nicolas Chapuis Richard Bekoe[...]Peter Parker Michaela Fontenay Paul R Barber James N Arnold Shahram Kordasti eLife Published 30 April 2021 Crick labsPeter ParkerFrancesca CiccarelliFull details Quantification of biomarker functionality predicts patient outcomes Authors (4) Banafshé Larijani James Miles Stephen G WardPeter Parker British Journal of Cancer Published 11 May 2021 Crick labsPeter ParkerFull details Equivocal, explicit and emergent actions of PKC isoforms in cancer Authors (11)Peter ParkerSophie BrownVeronique Calleja Probir ChakravartyMathias Cobbaut Mark LinchJacqui MarshallSilvia MartiniNeil McDonald Tanya SolimanLisa Watson Nature Reviews Cancer Published 1 January 2021 Crick labs/ facilitiesPeter ParkerNeil McDonaldBioinformatics and BiostatisticsFull details A cancer-associated, genome protective programme engaging PKCε Authors (10)Peter ParkerNicola LockwoodKhalil Davis Joanna R Kelly Tanya N Soliman Ainara Lopez PardoJacqui MarshallJoanna Redmond Marco Vitale Silvia Martini Advances in Biological Regulation Published 1 December 2020 Crick labsPeter ParkerFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers Authors (13) R Sumanth Iyer Sarah R Needham Ioannis Galdadas Benjamin M Davis Selene K Roberts Rico CH Man[...] Gilbert O FruhwirthPeter Parker Daniel J Rolfe Francesco L Gervasio Marisa L Martin-Fernandez Nature Communications Published 19 March 2024 Crick labsPeter ParkerFull details
Into the fold: advances in understanding aPKC membrane dynamics Authors (3)Mathias CobbautPeter ParkerNeil McDonald Biochemical Journal Published 15 December 2023 Crick labsPeter ParkerNeil McDonaldFull details
Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications Authors (4) Tanya N Soliman Daniel KeifenheimPeter Parker Duncan J Clarke The Journal of Cell Biology Published 4 December 2023 Crick labsPeter ParkerFull details
Michael D. Waterfield Authors (3)Julian DownwardPeter Parker Bart Vanhaesebroeck Biochemical Journal Published 27 September 2023 Crick labsPeter ParkerJulian DownwardFull details
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones Authors (24) AM Mahedi Hasan Paolo Cremaschi Daniel Wetterskog Anuradha Jayaram Stephen Q Wong Scott Williams[...]Charles Swanton Mariam Jamal-Hanjani Stefano Lise Shahneen Sandhu Gerhardt Attard Nature Communications Published 10 August 2023 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonPeter ParkerExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface Authors (3)Mathias CobbautNeil McDonaldPeter Parker Journal of Biological Chemistry Published 1 July 2023 Crick labs/ facilitiesPeter ParkerNeil McDonaldStructural BiologyLight MicroscopyFull details
Chemical genetic identification of PKC epsilon substrates in mouse brain Authors (8) Michael P Dugan Laura B Ferguson Nicholas T Hertz Robert J Chalkley Alma L Burlingame Kevan M ShokatPeter Parker Robert O Messing Molecular and Cellular Proteomics Published 1 April 2023 Crick labsPeter ParkerFull details
Functional engagement of the PD-1/PD-L1 complex but not PD-L1 expression is highly predictive of patient response to immunotherapy in non-small-cell lung cancer Authors (29) Lissete Sánchez-Magraner Juan Gumuzio James Miles Nicole Quimi Purificación Martínez Del Prado María Teresa Abad-Villar[...] Sandra del Castillo Charles Evans Fernando AguirrePeter Parker Véronique Calleja Journal of Clinical Oncology Published 10 May 2023 Crick labsPeter ParkerFull details
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses Authors (22)Jacqui Marshall Joshua J Cull Hajed O Alharbi May Zaw Thin Susanna TE Cooper Christopher Barrington[...] Owen JL Rackham Daniel Meijles Tim Mohun Angela ClerkPeter Parker Biochemical Journal Published 1 July 2022 Crick labs/ facilitiesPeter ParkerTim MohunIn Vivo ImagingExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsFull details
The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways Authors (10)Spyridoula Nikou Chunsheng Zhou James S Griffiths Natalia K Kotowicz Bianca M ColemanMary Green David L Moyes Sarah L Gaffen Julian R Naglik Peter J Parker Science Signaling Published 5 April 2022 Crick labs/ facilitiesPeter ParkerExperimental HistopathologyCell ServicesFull details
Genome-protective topoisomerase 2a-dependent G2arrest requires p53 in hTERT-positive cancer cells Authors (12)Nicola LockwoodSilvia Martini Ainara Lopez-Pardo Katharina Deiss Hendrika A Segeren Robert K Semple[...]Dimitra RepanaMathias Cobbaut Tanya SolimanFrancesca CiccarelliPeter Parker Cancer Research Published 1 March 2022 Crick labs/ facilitiesPeter ParkerFrancesca CiccarelliLight MicroscopyHigh Throughput ScreeningFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion Authors (27) Elizabeth R Murray Shinelle Menezes Jack C Henry Josie L Williams Lorena Alba-Castellón Priththivika Baskaran[...] Nuria Gavara Oliver Pearce Pedro Cutillas John F Marshall Angus JM Cameron Cell Reports Published 25 January 2022 Crick labs/ facilitiesPeter ParkerGenetic Modification ServiceBiological Research FacilityExperimental HistopathologyFull details
Editorial: Signaling by small GTPases in metastatic disease Authors (2)Peter Parker Uday Kishore Frontiers in Cell and Developmental Biology Published 21 January 2022 Crick labsPeter ParkerFull details
A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division Authors (12)Silvia MartiniKhalil DavisRupert Faraway Lisa ElzeNicola LockwoodAndrew Jones[...]Neil McDonald David J Mann Alan ArmstrongJernej UlePeter Parker Nature Communications Published 26 November 2021 Crick labs/ facilitiesJernej UlePeter ParkerPaul NurseNeil McDonaldProteomicsLight MicroscopyFull details
Immunogenomics of colorectal cancer response to checkpoint blockade: analysis of the KEYNOTE 177 trial and validation cohorts Authors (29)Michele BortolomeazziMohamed Reda Keddar Lucia MontorsiAmelia AchaLorena BenedettiDamjan Temelkovski[...]Peter Parker Manuel Rodriguez-Justo Kai-Keen Shiu Jo SpencerFrancesca Ciccarelli Gastroenterology Published 1 October 2021 Crick labs/ facilitiesCharles SwantonPeter ParkerJohannes KohlFrancesca CiccarelliExperimental HistopathologyAdvanced SequencingFlow CytometryFull details
Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention Authors (14)Lisa WatsonTanya SolimanKhalil Davis Joanna KellyNicola Lockwood Xiaoping Yang[...]Neil McDonald David J Mann Alan Armstrong Ulrike Eggert Peter J Parker Biochemical Journal Published 25 June 2021 Crick labs/ facilitiesPeter ParkerNeil McDonaldStructural BiologyFull details
ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data Authors (18) James W Opzoomer Jessica A Timms Kevin Blighe Thanos P Mourikis Nicolas Chapuis Richard Bekoe[...]Peter Parker Michaela Fontenay Paul R Barber James N Arnold Shahram Kordasti eLife Published 30 April 2021 Crick labsPeter ParkerFrancesca CiccarelliFull details
Quantification of biomarker functionality predicts patient outcomes Authors (4) Banafshé Larijani James Miles Stephen G WardPeter Parker British Journal of Cancer Published 11 May 2021 Crick labsPeter ParkerFull details
Equivocal, explicit and emergent actions of PKC isoforms in cancer Authors (11)Peter ParkerSophie BrownVeronique Calleja Probir ChakravartyMathias Cobbaut Mark LinchJacqui MarshallSilvia MartiniNeil McDonald Tanya SolimanLisa Watson Nature Reviews Cancer Published 1 January 2021 Crick labs/ facilitiesPeter ParkerNeil McDonaldBioinformatics and BiostatisticsFull details
A cancer-associated, genome protective programme engaging PKCε Authors (10)Peter ParkerNicola LockwoodKhalil Davis Joanna R Kelly Tanya N Soliman Ainara Lopez PardoJacqui MarshallJoanna Redmond Marco Vitale Silvia Martini Advances in Biological Regulation Published 1 December 2020 Crick labsPeter ParkerFull details