Martin Singleton: Publications

  • Leber, V; Nans, A and Singleton, MR (2018)
    Structural basis for assembly of the CBF3 kinetochore complex.
    EMBO Journal 37, 269-281 PubMed abstract
  • Chao, WCH; Murayama, Y; Muñoz, S; Jones, AW; Wade, BO; Purkiss, AG; Hu, X-W; Borg, A; Snijders, AP; Uhlmann, F and Singleton, MR (2017)
    Structure of the cohesin loader Scc2.
    Nature Communications 8, 13952 PubMed abstract
  • Chao, WCH; Wade, BO; Bouchoux, C; Jones, AW; Purkiss, AG; Federico, S; O'Reilly, N; Snijders, AP; Uhlmann, F and Singleton, MR (2017)
    Structural basis of Eco1-mediated cohesin acetylation.
    Scientific Reports 7, 44313 PubMed abstract
  • Sansregret, L; Patterson, JO; Dewhurst, S; López-García, C; Koch, A; McGranahan, N; Chao, WCH; Barry, DJ; Rowan, A; Instrell, R; Horswell, S; Way, M; Howell, M; Singleton, MR; Medema, RH; Nurse, P; Petronczki, M and Swanton, C (2017)
    APC/C dysfunction limits excessive cancer chromosomal instability.
    Cancer Discovery 7, 218-233 PubMed abstract
  • Singleton, MR (2017)
    A molecular gate for DNA (comment on DOI 10.1002/bies.201600207).
    Bioessays 39, 1700021 PubMed abstract
  • Singleton, MR and Uhlmann, F (2017)
    Separase-securin complex: a cunning way to control chromosome segregation.
    Nature Structural & Molecular Biology 24, 337-339 PubMed abstract
  • Wade, BO; Liu, HW; Samora, CP; Uhlmann, F and Singleton, MR (2017)
    Structural studies of RFCCtf18 reveal a novel chromatin recruitment role for Dcc1.
    EMBO Reports 18, 558-568 PubMed abstract
  • Matsuo, Y; Maurer, SP; Yukawa, M; Zakian, S; Singleton, MR; Surrey, T and Toda, T (2016)
    An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation.
    Journal of Cell Science 129, 4592-4606 PubMed abstract
  • Samora, CP; Saksouk, J; Goswami, P; Wade, BO; Singleton, MR; Bates, PA; Lengronne, A; Costa, A and Uhlmann, F (2016)
    Ctf4 links DNA replication with sister chromatid cohesion establishment by recruiting the Chl1 helicase to the replisome.
    Molecular Cell 63, 371-384 PubMed abstract
  • Singleton, MR (2016)
    Getting to the heart of an unusual kinetochore.
    Open Biology 6, 160040 PubMed abstract
  • Chao, WCH; Murayama, Y; Muñoz, S; Costa, A; Uhlmann, F and Singleton, MR (2015)
    Structural studies reveal the functional modularity of the Scc2-Scc4 cohesin loader.
    Cell Reports 12, 719-725 PubMed abstract
  • Lipinszki, Z; Lefevre, S; Savoian, MS; Singleton, MR; Glover, DM and Przewloka, MR (2015)
    Centromeric binding and activity of Protein Phosphatase 4.
    Nature Communications 6, 5894 PubMed abstract
  • Drechsler, H; McHugh, T; Singleton, MR; Carter, NJ and McAinsh, AD (2014)
    The Kinesin-12 Kif15 is a processive track-switching tetramer.
    eLife 3, e01724 PubMed abstract
  • Chatterjee, A; Zakian, S; Hu, X-W and Singleton, MR (2013)
    Structural insights into the regulation of cohesion establishment by Wpl1.
    EMBO Journal 32, 677-687 PubMed abstract
  • Perriches, T and Singleton, MR (2012)
    Structure of yeast kinetochore Ndc10 DNA-binding domain reveals unexpected evolutionary relationship to tyrosine recombinases.
    Journal of Biological Chemistry 287, 5173-5179 PubMed abstract
  • Zhang, G; Kelstrup, CD; Hu, X-W; Kaas Hansen, MJ; Singleton, MR; Olsen, JV and Nilsson, J (2012)
    The Ndc80 internal loop is required for recruitment of the Ska complex to establish end-on microtubule attachment to kinetochores.
    Journal of Cell Science 125, 3243-3253 PubMed abstract
  • Kingston, IJ; Yung, JSY and Singleton, MR (2011)
    Biophysical characterization of the centromere-specific nucleosome from budding yeast.
    Journal of Biological Chemistry 286, 4021-4026 PubMed abstract
  • Maskell, DP; Hu, X-W and Singleton, MR (2010)
    Molecular architecture and assembly of the yeast kinetochore MIND complex.
    Journal of Cell Biology 190, 823-834 PubMed abstract
  • Rass, U; Compton, SA; Matos, J; Singleton, MR; Ip, SCY; Blanco, MG; Griffith, JD and West, SC (2010)
    Mechanism of Holliday junction resolution by the human GEN1 protein.
    Genes & Development 24, 1559-1569 PubMed abstract

[Page last updated 1 Jun 2018]

Martin Singleton

Martin Singleton
+44 (0)20 379 62034

  • Qualifications and history
  • 1997 PhD in Biochemistry, University of Exeter, UK
  • 1998 Postdoctoral Research Assistant, Oxford University, UK
  • 2000 Postdoctoral Fellow, Imperial Cancer Research Fund, UK
  • 2005 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK