Markus Ralser: Publications

  • Campbell, K; Herrera-Dominguez, L; Correia-Melo, C; Zelezniak, A and Ralser, M (2018)
    Biochemical principles enabling metabolic cooperativity and phenotypic heterogeneity at the single cell level.
    Current Opinion in Systems Biology 8, 97-108
  • Vowinckel, J; Zelezniak, A; Bruderer, R; Mülleder, M; Reiter, L and Ralser, M (2018)
    Cost-effective generation of precise label-free quantitative proteomes in high-throughput by microLC and data-independent acquisition.
    Scientific Reports 8, 4346 PubMed abstract
  • Alam, MT; Olin-Sandoval, V; Stincone, A; Keller, MA; Zelezniak, A; Luisi, BF and Ralser, M (2017)
    The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization.
    Nature Communications 8, 16018 PubMed abstract
  • Caudy, AA; Mülleder, M and Ralser, M (2017)
    Metabolomics in yeast.
    Cold Spring Harbor Protocols 2017, 677-680 PubMed abstract
  • Gemayel, R; Yang, Y; Dzialo, MC; Kominek, J; Vowinckel, J; Saels, V; Van Huffel, L; van der Zande, E; Ralser, M; Steensels, J; Voordeckers, K and Verstrepen, KJ (2017)
    Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival.
    Nature Communications 8, 397 PubMed abstract
  • Haas, R; Zelezniak, A; Iacovacci, J; Kamrad, S; Townsend, S and Ralser, M (2017)
    Designing and interpreting 'multi-omic' experiments that may change our understanding of biology.
    Current Opinion in Systems Biology 6, 37-45
  • Keller, MA; Kampjut, D; Harrison, SA and Ralser, M (2017)
    Sulfate radicals enable a non-enzymatic Krebs cycle precursor.
    Nature Ecology & Evolution 1, 0083 PubMed abstract
  • Leung, K-Y; Pai, YJ; Chen, Q; Santos, C; Calvani, E; Sudiwala, S; Savery, D; Ralser, M; Gross, SS; Copp, AJ and Greene, NDE (2017)
    Partitioning of one-carbon units in folate and methionine metabolism is essential for neural tube closure.
    Cell Reports 21, 1795-1808 PubMed abstract
  • Messner, CB; Driscoll, PC; Piedrafita, G; De Volder, MFL and Ralser, M (2017)
    Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice.
    Proceedings of the National Academy of Sciences of the United States of America 114, 7403-7407 PubMed abstract
  • Moraru, A; Cakan-Akdogan, G; Strassburger, K; Males, M; Mueller, S; Jabs, M; Muelleder, M; Frejno, M; Braeckman, BP; Ralser, M and Teleman, AA (2017)
    THADA regulates the organismal balance between energy storage and heat production.
    Developmental Cell 41, 72-81, e71-e76 PubMed abstract
  • Mülleder, M; Bluemlein, K and Ralser, M (2017)
    A high-throughput method for the quantitative determination of free amino acids in Saccharomyces cerevisiae by hydrophilic interaction chromatography-tandem mass spectrometry.
    Cold Spring Harbor Protocols 2017, 729-734 PubMed abstract
  • Ponomarova, O; Gabrielli, N; Sévin, DC; Mülleder, M; Zirngibl, K; Bulyha, K; Andrejev, S; Kafkia, E; Typas, A; Sauer, U; Ralser, M and Patil, KR (2017)
    Yeast creates a niche for symbiotic lactic acid bacteria through nitrogen overflow.
    Cell Systems 5, 345-357 e346 PubMed abstract
  • Weber, RJM; Lawson, TN; Salek, RM; Ebbels, TMD; Glen, RC; Goodacre, R; Griffin, JL; Haug, K; Koulman, A; Moreno, P; Ralser, M; Steinbeck, C; Dunn, WB and Viant, MR (2017)
    Computational tools and workflows in metabolomics: an international survey highlights the opportunity for harmonisation through Galaxy.
    Metabolomics 13, 12 PubMed abstract
  • Alam, MT; Zelezniak, A; Mülleder, M; Shliaha, P; Schwarz, R; Capuano, F; Vowinckel, J; Radmaneshfar, E; Krüger, A; Calvani, E; Michel, S; Börno, S; Christen, S; Patil, KR; Timmermann, B; Lilley, KS and Ralser, M (2016)
    The metabolic background is a global player in Saccharomyces gene expression epistasis.
    Nature Microbiology 1, 15030 PubMed abstract
  • Campbell, K; Vowinckel, J; Keller, MA and Ralser, M (2016)
    Methionine metabolism alters oxidative stress resistance via the pentose phosphate pathway.
    Antioxidants & Redox Signaling 24, 543-547 PubMed abstract
  • Campbell, K; Vowinckel, J and Ralser, M (2016)
    Cell-to-cell heterogeneity emerges as consequence of metabolic cooperation in a synthetic yeast community.
    Biotechnology Journal 11, 1169-1178 PubMed abstract
  • Fabre, B; Korona, D; Groen, A; Vowinckel, J; Gatto, L; Deery, MJ; Ralser, M; Russell, S and Lilley, KS (2016)
    Analysis of the Drosophila melanogaster proteome dynamics during embryonic development by a combination of label-free proteomics approaches.
    Proteomics 16, 2068-2080 PubMed abstract
  • Keller, MA; Zylstra, A; Castro, C; Turchyn, AV; Griffin, JL and Ralser, M (2016)
    Conditional iron and pH-dependent activity of a non-enzymatic glycolysis and pentose phosphate pathway.
    Science Advances 2, e1501235 PubMed abstract
  • Mülleder, M; Calvani, E; Alam, MT; Wang, RK; Eckerstorfer, F; Zelezniak, A and Ralser, M (2016)
    Functional metabolomics describes the yeast biosynthetic regulome.
    Cell 167, 553-565 e512 PubMed abstract
  • Mülleder, M; Campbell, K; Matsarskaia, O; Eckerstorfer, F and Ralser, M (2016)
    Saccharomyces cerevisiae single-copy plasmids for auxotrophy compensation, multiple marker selection, and for designing metabolically cooperating communities.
    F1000Research 5, 2351 PubMed abstract
  • Watson, E; Olin-Sandoval, V; Hoy, MJ; Li, C-H; Louisse, T; Yao, V; Mori, A; Holdorf, AD; Troyanskaya, OG; Ralser, M and Walhout, AJM (2016)
    Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans.
    eLife 5, e17670 PubMed abstract
  • Buescher, JM; Antoniewicz, MR; Boros, LG; Burgess, SC; Brunengraber, H; Clish, CB; DeBerardinis, RJ; Feron, O; Frezza, C; Ghesquiere, B; Gottlieb, E; Hiller, K; Jones, RG; Kamphorst, JJ; Kibbey, RG; Kimmelman, AC; Locasale, JW; Lunt, SY; Maddocks, OD; Malloy, C; Metallo, CM; Meuillet, EJ; Munger, J; Nöh, K; Rabinowitz, JD; Ralser, M; Sauer, U; Stephanopoulos, G; St-Pierre, J; Tennant, DA; Wittmann, C; Vander Heiden, MG; Vazquez, A; Vousden, K; Young, JD; Zamboni, N and Fendt, S-M (2015)
    A roadmap for interpreting 13C metabolite labeling patterns from cells.
    Current Opinion in Biotechnology 34, 189-201 PubMed abstract
  • Campbell, K; Vowinckel, J; Muelleder, M; Malmsheimer, S; Lawrence, N; Calvani, E; Miller-Fleming, L; Alam, MT; Christen, S; Keller, MA and Ralser, M (2015)
    Self-establishing communities enable cooperative metabolite exchange in a eukaryote.
    eLife 4, e09943 PubMed abstract
  • Dick, TP and Ralser, M (2015)
    Metabolic remodeling in times of stress: who shoots faster than his shadow?
    Molecular Cell 59, 519-521 PubMed abstract
  • Frankl-Vilches, C; Kuhl, H; Werber, M; Klages, S; Kerick, M; Bakker, A; de Oliveira, EHC; Reusch, C; Capuano, F; Vowinckel, J; Leitner, S; Ralser, M; Timmermann, B and Gahr, M (2015)
    Using the canary genome to decipher the evolution of hormone-sensitive gene regulation in seasonal singing birds.
    Genome Biology 16, 19 PubMed abstract
  • Jack, CV; Cruz, C; Hull, RM; Keller, MA; Ralser, M and Houseley, J (2015)
    Regulation of ribosomal DNA amplification by the TOR pathway.
    Proceedings of the National Academy of Sciences of the United States of America 112, 9674-9679 PubMed abstract
  • Jeffares, DC; Rallis, C; Rieux, A; Speed, D; Převorovský, M; Mourier, T; Marsellach, FX; Iqbal, Z; Lau, W; Cheng, TMK; Pracana, R; Mülleder, M; Lawson, JLD; Chessel, A; Bala, S; Hellenthal, G; O'Fallon, B; Keane, T; Simpson, JT; Bischof, L; Tomiczek, B; Bitton, DA; Sideri, T; Codlin, S; Hellberg, JEEU; van Trigt, L; Jeffery, L; Li, J-J; Atkinson, S; Thodberg, M; Febrer, M; McLay, K; Drou, N; Brown, W; Hayles, J; Salas, REC; Ralser, M; Maniatis, N; Balding, DJ; Balloux, F; Durbin, R and Bähler, J (2015)
    The genomic and phenotypic diversity of Schizosaccharomyces pombe.
    Nature Genetics 47, 235-241 PubMed abstract
  • Keller, MA; Piedrafita, G and Ralser, M (2015)
    The widespread role of non-enzymatic reactions in cellular metabolism.
    Current Opinion in Biotechnology 34, 153-161 PubMed abstract
  • Michel, S; Keller, MA; Wamelink, MMC and Ralser, M (2015)
    A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance.
    BMC Genetics 16, 13 PubMed abstract
  • Miller-Fleming, L; Olin-Sandoval, V; Campbell, K and Ralser, M (2015)
    Remaining mysteries of Molecular Biology: The role of polyamines in the cell.
    Journal of Molecular Biology 427, 3389-3406 PubMed abstract
  • Paglia, G; Stocchero, M; Cacciatore, S; Lai, S; Angel, P; Alam, MT; Keller, M; Ralser, M and Astarita, G (2015)
    Unbiased metabolomic investigation of the Alzheimer's disease brain points to a dysregulation of the mitochondrial aspartate metabolism.
    Journal of Proteome Research 15, 608-618 PubMed abstract
  • Piedrafita, G; Keller, MA and Ralser, M (2015)
    The impact of non-enzymatic reactions and enzyme promiscuity on cellular metabolism during (oxidative) stress conditions.
    Biomolecules 5, 2101-2122 PubMed abstract
  • Timm, KN; Hartl, J; Keller, MA; Hu, D-E; Kettunen, MI; Rodrigues, TB; Ralser, M and Brindle, KM (2015)
    Hyperpolarized [U-2H, U-13C]glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells.
    Magnetic Resonance in Medicine 74, 1543-1547 PubMed abstract
  • Vowinckel, J; Hartl, J; Butler, R and Ralser, M (2015)
    MitoLoc: A method for the simultaneous quantification mitochondrial network morphology and membrane potential in single cells.
    Mitochondrion 24, 77-86 PubMed abstract
  • Watschinger, K; Keller, MA; McNeill, E; Alam, MT; Lai, S; Sailer, S; Rauch, V; Patel, J; Hermetter, A; Golderer, G; Geley, S; Werner-Felmayer, G; Plumb, RS; Astarita, G; Ralser, M; Channon, KM and Werner, ER (2015)
    Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome.
    Proceedings of the National Academy of Sciences of the United States of America 112, 2431-2436 PubMed abstract
  • Breitenbach, M; Rinnerthaler, M; Hartl, J; Stincone, A; Vowinckel, J; Breitenbach-Koller, H and Ralser, M (2014)
    Mitochondria in ageing: there is metabolism beyond the ROS.
    FEMS Yeast Research 14, 198-212 PubMed abstract
  • Capuano, F; Mülleder, M; Kok, RM; Blom, HJ and Ralser, M (2014)
    Cytosine DNA methylation is found in Drosophila melanogaster but absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe and other yeast species.
    Analytical Chemistry 86, 3697-3702 PubMed abstract
  • Grüning, N-M; Du, D; Keller, MA; Luisi, BF and Ralser, M (2014)
    Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis.
    Open Biology 4, 130232 PubMed abstract
  • Keller, MA; Turchyn, AV and Ralser, M (2014)
    Non-enzymatic glycolysis and pentose phosphate pathway-like reactions in a plausible Archean ocean.
    Molecular Systems Biology 10, 725 PubMed abstract
  • Keller, MA; Zander, U; Fuchs, JE; Kreutz, C; Watschinger, K; Mueller, T; Golderer, G; Liedl, KR; Ralser, M; Kräutler, B; Werner, ER and Marquez, JA (2014)
    A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.
    Nature Communications 5, 4439 PubMed abstract
  • Prigione, A; Rohwer, N; Hoffmann, S; Mlody, B; Drews, K; Bukowiecki, R; Blümlein, K; Wanker, EE; Ralser, M; Cramer, T and Adjaye, J (2014)
    HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.
    Stem Cells 32, 364-376 PubMed abstract
  • Ralser, M (2014)
    The RNA world and the origin of metabolic enzymes.
    Biochemical Society Transactions 42, 985-988 PubMed abstract
  • Stincone, A; Prigione, A; Cramer, T; Wamelink, MMC; Campbell, K; Cheung, E; Olin-Sandoval, V; Grüning, N-M; Krüger, A; Tauqeer Alam, M; Keller, MA; Breitenbach, M; Brindle, KM; Rabinowitz, JD and Ralser, M (2014)
    The return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
    Biological Reviews 90, 927-963 PubMed abstract
  • Breitenbach, M; Ralser, M; Perrone, GG; Iglseder, B; Rinnerthaler, M and Dawes, IW (2013)
    Oxidative stress and neurodegeneration: the yeast model system.
    Frontiers in Bioscience 18, 1174-1193 PubMed abstract
  • Krüger, A; Vowinckel, J; Mülleder, M; Grote, P; Capuano, F; Bluemlein, K and Ralser, M (2013)
    Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response.
    EMBO Reports 14, 1113-1119 PubMed abstract
  • Sarper, N; Zengin, E; Jakobs, C; Salomons, GS; Wamelink, MMC; Ralser, M; Kurt, K and Kara, B (2013)
    Mild hemolytic anemia, progressive neuromotor retardation and fatal outcome: A disorder of glycolysis, triose-phosphate isomerase deficiency.
    Turkish Journal of Pediatrics 55, 198-202 PubMed abstract
  • Bluemlein, K; Glückmann, M; Grüning, N-M; Feichtinger, R; Krüger, A; Wamelink, M; Lehrach, H; Tate, S; Neureiter, D; Kofler, B and Ralser, M (2012)
    Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis.
    Oncotarget 3, 1356-1369 PubMed abstract
  • Breitenbach, M; Laun, P; Dickinson, JR; Klocker, A; Rinnerthaler, M; Dawes, IW; Aung-Htut, MT; Breitenbach-Koller, L; Caballero, A; Nyström, T; Büttner, S; Eisenberg, T; Madeo, F and Ralser, M (2012)
    The role of mitochondria in the aging processes of yeast.
    Subcellular Biochemistry 57, 55-78 PubMed abstract
  • Habermann, K; Mirgorodskaya, E; Gobom, J; Lehmann, V; Müller, H; Blümlein, K; Deery, MJ; Czogiel, I; Erdmann, C; Ralser, M; von Kries, JP and Lange, BMH (2012)
    Functional analysis of centrosomal kinase substrates in Drosophila melanogaster reveals a new function of the nuclear envelope component otefin in cell cycle progression.
    Molecular and Cellular Biology 32, 3554-3569 PubMed abstract
  • Mülleder, M; Capuano, F; Pir, P; Christen, S; Sauer, U; Oliver, SG and Ralser, M (2012)
    A prototrophic deletion mutant collection for yeast metabolomics and systems biology.
    Nature Biotechnology 30, 1176-1178 PubMed abstract
  • Ralser, M; Kuhl, H; Ralser, M; Werber, M; Lehrach, H; Breitenbach, M and Timmermann, B (2012)
    The Saccharomyces cerevisiae W303-K6001 cross-platform genome sequence: insights into ancestry and physiology of a laboratory mutt.
    Open Biology 2, 120093 PubMed abstract
  • Ralser, M; Michel, S and Breitenbach, M (2012)
    Sirtuins as regulators of the yeast metabolic network.
    Frontiers in Pharmacology 3, 32 PubMed abstract
  • Tosato, V; Grüning, N-M; Breitenbach, M; Arnak, R; Ralser, M and Bruschi, CV (2012)
    Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells.
    Frontiers in Oncology 2, 212 PubMed abstract
  • Vowinckel, J; Stahlberg, S; Paulmann, N; Bluemlein, K; Grohmann, M; Ralser, M and Walther, DJ (2012)
    Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling.
    FEBS Letters 586, 3819-3824 PubMed abstract
  • Bluemlein, K; Grüning, N-M; Feichtinger, RG; Lehrach, H; Kofler, B and Ralser, M (2011)
    No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis.
    Oncotarget 2, 393-400 PubMed abstract
  • Bluemlein, K and Ralser, M (2011)
    Monitoring protein expression in whole-cell extracts by targeted label- and standard-free LC-MS/MS.
    Nature Protocols 6, 859-869 PubMed abstract
  • Grüning, N-M and Ralser, M (2011)
    Cancer: Sacrifice for survival.
    Nature 480, 190-191 PubMed abstract
  • Grüning, N-M; Rinnerthaler, M; Bluemlein, K; Mülleder, M; Wamelink, MMC; Lehrach, H; Jakobs, C; Breitenbach, M and Ralser, M (2011)
    Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells.
    Cell Metabolism 14, 415-427 PubMed abstract
  • Hallen, L; Klein, H; Stoschek, C; Wehrmeyer, S; Nonhoff, U; Ralser, M; Wilde, J; Röhr, C; Schweiger, MR; Zatloukal, K; Vingron, M; Lehrach, H; Konthur, Z and Krobitsch, S (2011)
    The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2.
    Human Molecular Genetics 20, 104-114 PubMed abstract
  • Krüger, A; Grüning, N-M; Wamelink, MMC; Kerick, M; Kirpy, A; Parkhomchuk, D; Bluemlein, K; Schweiger, M-R; Soldatov, A; Lehrach, H; Jakobs, C and Ralser, M (2011)
    The pentose phosphate pathway is a metabolic redox sensor and regulates transcription during the antioxidant response.
    Antioxidants & Redox Signaling 15, 311-324 PubMed abstract
  • Krüger, A and Ralser, M (2011)
    ATM is a redox sensor linking genome stability and carbon metabolism.
    Science Signaling 4, pe17 PubMed abstract
  • Prigione, A; Lichtner, B; Kuhl, H; Struys, EA; Wamelink, M; Lehrach, H; Ralser, M; Timmermann, B and Adjaye, J (2011)
    Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.
    Stem Cells 29, 1338-1348 PubMed abstract
  • Grüning, N-M; Lehrach, H and Ralser, M (2010)
    Regulatory crosstalk of the metabolic network.
    Trends in Biochemical Sciences 35, 220-227 PubMed abstract
  • Timmermann, B; Jarolim, S; Rußmayer, H; Kerick, M; Michel, S; Krüger, A; Bluemlein, K; Laun, P; Grillari, J; Lehrach, H; Breitenbach, M and Ralser, M (2010)
    A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging.
    Aging 2, 475-486 PubMed abstract
  • Wamelink, MMC; Grüning, N-M; Jansen, EEW; Bluemlein, K; Lehrach, H; Jakobs, C and Ralser, M (2010)
    The difference between rare and exceptionally rare: molecular characterization of ribose 5-phosphate isomerase deficiency.
    Journal of Molecular Medicine 88, 931-939 PubMed abstract

[Page last updated 1 Jun 2018]

Markus Ralser
+44 (0)20 379 62385