Katrin Rittinger: Publications

  • Esposito, D; Günster, RA; Martino, L; El Omari, K; Wagner, A; Thurston, TLM and Rittinger, K (2018)
    Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3.
    Journal of Biological Chemistry 293, 5064-5078 PubMed abstract
  • Koliopoulos, MG; Lethier, M; van der Veen, AG; Haubrich, K; Hennig, J; Kowalinski, E; Stevens, RV; Martin, SR; Reis e Sousa, C; Cusack, S and Rittinger, K (2018)
    Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
    Nature Communications 9, 1820 PubMed abstract
  • Martino, L; Brown, NR; Masino, L; Esposito, D and Rittinger, K (2018)
    Determinants of E2-ubiquitin conjugate recognition by RBR E3 ligases.
    Scientific Reports 8, 68 PubMed abstract
  • Walden, H and Rittinger, K (2018)
    RBR ligase-mediated ubiquitin transfer: a tale with many twists and turns.
    Nature Structural & Molecular Biology [Epub ahead of print] PubMed abstract
  • Dove, KK; Olszewski, JL; Martino, L; Duda, DM; Wu, XS; Miller, DJ; Reiter, KH; Rittinger, K; Schulman, BA and Klevit, RE (2017)
    Structural studies of HHARI/UbcH7∼Ub reveal unique E2∼Ub conformational restriction by RBR RING1.
    Structure 25, 890-900 e895 PubMed abstract
  • Esposito, D; Koliopoulos, MG and Rittinger, K (2017)
    Structural determinants of TRIM protein function.
    Biochemical Society Transactions 45, 183-191 PubMed abstract
  • Geymonat, M; Spanos, A and Rittinger, K (2017)
    In vitro analysis of Tem1 GTPase activity and regulation by the Bfa1/Bub2 GAP.
    Methods in Molecular Biology 1505, 71-80 PubMed abstract
  • Oregioni, A; Stieglitz, B; Kelly, G; Rittinger, K and Frenkiel, T (2017)
    Determination of the pKa of the N-terminal amino group of ubiquitin by NMR.
    Scientific Reports 7, 43748 PubMed abstract
  • Rittinger, K and Ikeda, F (2017)
    Linear ubiquitin chains: enzymes, mechanisms and biology.
    Open Biology 7, 170026 PubMed abstract
  • Sanders, J; Blundy, J; Donaldson, A; Brown, S; Ivison, R; Padgett, M; Padian, K; Rittinger, K; Rowe, K; Stace, A; Viding, E; Chambers, C and Chaplain, M (2017)
    Transparency and openness in science.
    Royal Society Open Science 4, 160979 PubMed abstract
  • Asaoka, T; Almagro, J; Ehrhardt, C; Tsai, I; Schleiffer, A; Deszcz, L; Junttila, S; Ringrose, L; Mechtler, K; Kavirayani, A; Gyenesei, A; Hofmann, K; Duchek, P; Rittinger, K and Ikeda, F (2016)
    Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.
    EMBO Reports 17, 1624-1640 PubMed abstract
  • Dove, KK; Stieglitz, B; Duncan, ED; Rittinger, K and Klevit, RE (2016)
    Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms.
    EMBO Reports 17, 1221-1235 PubMed abstract
  • Koliopoulos, MG; Esposito, D; Christodoulou, E; Taylor, IA and Rittinger, K (2016)
    Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
    EMBO Journal 35, 1204-1218 PubMed abstract
  • Kupka, S; De Miguel, D; Draber, P; Martino, L; Surinova, S; Rittinger, K and Walczak, H (2016)
    SPATA2-mediated binding of CYLD to HOIP enables CYLD recruitment to signaling complexes.
    Cell Reports 16, 2271-2280 PubMed abstract
  • Martino, L; Holland, L; Christodoulou, E; Kunzelmann, S; Esposito, D and Rittinger, K (2016)
    The biophysical characterisation and SAXS analysis of human NLRP1 uncover a new level of complexity of NLR proteins.
    PLOS ONE 11, e0164662 PubMed abstract
  • Dove, KK; Klevit, RE and Rittinger, K (2015)
    pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit.
    EMBO Journal 34, 2486-2488 PubMed abstract
  • Draber, P; Kupka, S; Reichert, M; Draberova, H; Lafont, E; de Miguel, D; Spilgies, L; Surinova, S; Taraborrelli, L; Hartwig, T; Rieser, E; Martino, L; Rittinger, K and Walczak, H (2015)
    LUBAC-recruited CYLD and A20 regulate gene activation and cell death by exerting opposing effects on linear ubiquitin in signaling complexes.
    Cell Reports 13, 2258-2272 PubMed abstract
  • Taylor, IA; Rittinger, K and Eccleston, JF (2015)
    Sedimentation equilibrium studies.
    Methods in Molecular Biology 1278, 205-222 PubMed abstract
  • Bunney, TD; Cole, AR; Broncel, M; Esposito, D; Tate, EW and Katan, M (2014)
    Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.
    Structure 22, 1831-1843 PubMed abstract
  • Fass, D and Rittinger, K (2014)
    Editorial overview: Multi-protein assemblies in signaling.
    Current Opinion in Structural Biology 29, vi-viii PubMed abstract
  • Parkhouse, R; Boyle, JP; Mayle, S; Sawmynaden, K; Rittinger, K and Monie, TP (2014)
    Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.
    FEBS Letters 588, 2830-2836 PubMed abstract
  • Stieglitz, B; Rana, RR; Koliopoulos, MG; Morris-Davies, AC; Schaeffer, V; Christodoulou, E; Howell, S; Brown, NR; Dikic, I and Rittinger, K (2013)
    Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
    Nature 503, 422-426 PubMed abstract
  • Fridh, V and Rittinger, K (2012)
    The tandem CARDs of NOD2: intramolecular interactions and recognition of RIP2.
    PLOS ONE 7, e34375 PubMed abstract
  • Ksionda, O; Saveliev, A; Kochl, R; Rapley, J; Faroudi, M; Smith-Garvin, JE; Wulfing, C; Rittinger, K; Carter, T and Tybulewicz, VLJ (2012)
    Mechanism and function of Vav1 localization in TCR signaling.
    Journal of Cell Science 125, 5302-5314 PubMed abstract
  • Stieglitz, B; Haire, LF; Dikic, I and Rittinger, K (2012)
    Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold.
    Journal of Biological Chemistry 287, 20823-20829 PubMed abstract
  • Stieglitz, B; Morris-Davies, AC; Koliopoulos, MG; Christodoulou, E and Rittinger, K (2012)
    LUBAC synthesizes linear ubiquitin chains via a thioester intermediate.
    EMBO Reports 13, 840-846 PubMed abstract
  • Stieglitz, B; Rittinger, K and Haire, LF (2012)
    Crystallization of SHARPIN using an automated two-dimensional grid screen for optimization.
    Acta Crystallographica Section F 68, 816-819 PubMed abstract
  • Ikeda, F; Deribe, YL; Skånland, SS; Stieglitz, B; Grabbe, C; Franz-Wachtel, M; van Wijk, SJL; Goswami, P; Nagy, V; Terzic, J; Tokunaga, F; Androulidaki, A; Nakagawa, T; Pasparakis, M; Iwai, K; Sundberg, JP; Schaefer, L; Rittinger, K; Macek, B and Dikic, I (2011)
    SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
    Nature 471, 637-641 PubMed abstract
  • Autore, F; Pagano, B; Fornili, A; Rittinger, K and Fraternali, F (2010)
    In silico phosphorylation of the autoinhibited form of p47phox: insights into the mechanism of activation.
    Biophysical Journal 99, 3716-3725 PubMed abstract
  • Dutta, S and Rittinger, K (2010)
    Regulation of NOXO1 activity through reversible interactions with p22phox and NOXA1.
    PLOS ONE 5, e10478 PubMed abstract
  • Esposito, D; Sankar, A; Morgner, N; Robinson, CV; Rittinger, K and Driscoll, PC (2010)
    Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus.
    Structure 18, 1378-1390 PubMed abstract
  • Groves, E; Rittinger, K; Amstutz, M; Berry, S; Holden, DW; Cornelis, GR and Caron, E (2010)
    Sequestering of Rac by the Yersinia effector YopO blocks Fcγ receptor-mediated phagocytosis.
    Journal of Biological Chemistry 285, 4087-4098 PubMed abstract

[Page last updated 1 Jun 2018]

KatrinĀ Rittinger

+44 (0)20 379 62274

  • Qualifications and history
  • 1994 PhD in Chemistry, University of Heidelberg and Max-Planck Institute (MPI) for Medical Research, Germany
  • 1995 Postdoctoral Fellow at MPI for Molecular Physiology, Dortmund, Germany
  • 1996 Postdoctoral Fellow at MRC-NIMR, London, UK (EMBO Long-term and Marie-Curie Fellow)
  • 2000 Group Leader, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK