Jonathan Stoye: Publications

  • Grohme, MA; Schloissnig, S; Rozanski, A; Pippel, M; Young, GR; Winkler, S; Brandl, H; Henry, I; Dahl, A; Powell, S; Hiller, M; Myers, E and Rink, JC (2018)
    The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms.
    Nature 554, 56-61 PubMed abstract
  • Krupovic, M; Blomberg, J; Coffin, JM; Dasgupta, I; Fan, H; Geering, AD; Gifford, R; Harrach, B; Hull, R; Johnson, W; Kreuze, JF; Lindemann, D; Llorens, C; Lockhart, B; Mayer, J; Muller, E; Olszewski, N; Pappu, HR; Pooggin, M; Richert-Pöggeler, KR; Sabanadzovic, S; Sanfaçon, H; Schoelz, JE; Seal, S; Stavolone, L; Stoye, JP; Teycheney, P-Y; Tristem, M; Koonin, EV and Kuhn, JH (2018)
    Ortervirales: A new viral order unifying five families of reverse-transcribing viruses.
    Journal of Virology [Epub ahead of print] PubMed abstract
  • Nowoshilow, S; Schloissnig, S; Fei, J-F; Dahl, A; Pang, AWC; Pippel, M; Winkler, S; Hastie, AR; Young, G; Roscito, JG; Falcon, F; Knapp, D; Powell, S; Cruz, A; Cao, H; Habermann, B; Hiller, M; Tanaka, EM and Myers, EW (2018)
    The axolotl genome and the evolution of key tissue formation regulators.
    Nature 554, 50-55 PubMed abstract
  • Young, GR; Terry, SN; Manganaro, L; Cuesta-Dominguez, A; Deikus, G; Bernal-Rubio, D; Campisi, L; Fernandez-Sesma, A; Sebra, R; Simon, V and Mulder, LCF (2018)
    HIV-1 infection of primary CD4+ T cells regulates the expression of specific human endogenous retrovirus HERV-K (HML-2) elements.
    Journal of Virology 92, e01507-01517 PubMed abstract
  • Attig, J; Young, GR; Stoye, JP and Kassiotis, G (2017)
    Physiological and pathological transcriptional activation of endogenous retroelements assessed by RNA-sequencing of B lymphocytes.
    Frontiers in Microbiology 8, 2489 PubMed abstract
  • Eksmond, U; Jenkins, B; Merkenschlager, J; Mothes, W; Stoye, JP and Kassiotis, G (2017)
    Mutation of the putative immunosuppressive domain of the retroviral envelope glycoprotein compromises infectivity.
    Journal of Virology 91, e01152-01117 PubMed abstract
  • Kassiotis, G and Stoye, JP (2017)
    Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer.
    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 372, 20160277 PubMed abstract
  • Ordonez, P; Kunzelmann, S; Groom, HCT; Yap, MW; Weising, S; Meier, C; Bishop, KN; Taylor, IA and Stoye, JP (2017)
    SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.
    Scientific Reports 7, 42824 PubMed abstract
  • Taylor, WR; Stoye, JP and Taylor, IA (2017)
    A comparative analysis of the foamy and ortho virus capsid structures reveals an ancient domain duplication.
    BMC Structural Biology 17, 3 PubMed abstract
  • Ball, NJ; Nicastro, G; Dutta, M; Pollard, DJ; Goldstone, DC; Sanz-Ramos, M; Ramos, A; Müllers, E; Stirnnagel, K; Stanke, N; Lindemann, D; Stoye, JP; Taylor, WR; Rosenthal, PB and Taylor, IA (2016)
    Structure of a spumaretrovirus gag central domain reveals an ancient retroviral capsid.
    PLOS Pathogens 12, e1005981 PubMed abstract
  • Buseyne, F; Gessain, A; Soares, MA; Santos, AF; Materniak-Kornas, M; Lesage, P; Zamborlini, A; Löchelt, M; Qiao, W; Lindemann, D; Wöhrl, BM; Stoye, JP; Taylor, IA and Khan, AS (2016)
    Eleventh International Foamy Virus Conference—meeting report.
    Viruses 8, 318 PubMed abstract
  • Donnarumma, T; Young, GR; Merkenschlager, J; Eksmond, U; Bongard, N; Nutt, SL; Boyer, C; Dittmer, U; Le-Trilling, VTK; Trilling, M; Bayer, W and Kassiotis, G (2016)
    Opposing development of cytotoxic and follicular helper CD4 T cells controlled by the TCF-1-Bcl6 nexus.
    Cell Reports 17, 1571-1583 PubMed abstract
  • Kassiotis, G and Stoye, JP (2016)
    Immune responses to endogenous retroelements: taking the bad with the good.
    Nature Reviews Immunology 16, 207-219 PubMed abstract
  • Li, W; Yap, MW; Voss, V and Stoye, JP (2016)
    Expression levels of Fv1: effects on retroviral restriction specificities.
    Retrovirology 13, 42 PubMed abstract
  • Mavrommatis, B; Baudino, L; Levy, P; Merkenschlager, J; Eksmond, U; Donnarumma, T; Young, G; Stoye, J and Kassiotis, G (2016)
    Dichotomy between T cell and B cell tolerance to neonatal retroviral infection permits T cell therapy.
    Journal of Immunology 197, 3628-3638 PubMed abstract
  • Arnold, LH; Groom, HCT; Kunzelmann, S; Schwefel, D; Caswell, SJ; Ordonez, P; Mann, MC; Rueschenbaum, S; Goldstone, DC; Pennell, S; Howell, SA; Stoye, JP; Webb, M; Taylor, IA and Bishop, KN (2015)
    Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction.
    PLOS Pathogens 11, e1005194 PubMed abstract
  • Mager, DL and Stoye, JP (2015)
    Mammalian endogenous retroviruses.
    Microbiology Spectrum 3, MDNA3-0009-2014 PubMed abstract
  • Schwefel, D; Boucherit, VC; Christodoulou, E; Walker, PA; Stoye, JP; Bishop, KN and Taylor, IA (2015)
    Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.
    Cell Host & Microbe 17, 489-499 PubMed abstract
  • Brinzevich, D; Young, GR; Sebra, R; Ayllon, J; Maio, SM; Deikus, G; Chen, BK; Fernandez-Sesma, A; Simon, V and Mulder, LCF (2014)
    HIV-1 interacts with human endogenous retrovirus K (HML-2) envelopes derived from human primary lymphocytes.
    Journal of Virology 88, 6213-6223 PubMed abstract
  • Goldstone, DC; Walker, PA; Calder, LJ; Coombs, PJ; Kirkpatrick, J; Ball, NJ; Hilditch, L; Yap, MW; Rosenthal, PB; Stoye, JP and Taylor, IA (2014)
    Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.
    Proceedings of the National Academy of Sciences of the United States of America 111, 9609-9614 PubMed abstract
  • Schwefel, D; Groom, HCT; Boucherit, VC; Christodoulou, E; Walker, PA; Stoye, JP; Bishop, KN and Taylor, IA (2014)
    Structural basis of lentiviral subversion of a cellular protein degradation pathway.
    Nature 505, 234-238 PubMed abstract
  • Yap, MW; Colbeck, E; Ellis, SA and Stoye, JP (2014)
    Evolution of the retroviral restriction gene Fv1: inhibition of non-MLV retroviruses.
    PLOS Pathogens 10, e1003968 PubMed abstract
  • Goldstone, DC; Flower, TG; Ball, NJ; Sanz-Ramos, M; Yap, MW; Ogrodowicz, RW; Stanke, N; Reh, J; Lindemann, D; Stoye, JP and Taylor, IA (2013)
    A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid.
    PLOS Pathogens 9, e1003376 PubMed abstract
  • Ohkura, S and Stoye, JP (2013)
    A comparison of murine leukemia viruses that escape from human and rhesus macaque TRIM5αs.
    Journal of Virology 87, 6455-6468 PubMed abstract
  • Sanz-Ramos, M and Stoye, JP (2013)
    Capsid-binding retrovirus restriction factors: discovery, restriction specificity and implications for the development of novel therapeutics.
    Journal of General Virology 94, 2587-2598 PubMed abstract
  • Weiss, RA and Stoye, JP (2013)
    Our viral inheritance.
    Science 340, 820-821 PubMed abstract
  • Yap, MW and Stoye, JP (2013)
    Apparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αs.
    Philosophical Transactions of the Royal Society B: Biological Sciences 368, 20120498 PubMed abstract
  • Young, GR; Stoye, JP and Kassiotis, G (2013)
    Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis.
    Bioessays 35, 794-803 PubMed abstract
  • Stoye, JP (2012)
    Studies of endogenous retroviruses reveal a continuing evolutionary saga.
    Nature Reviews Microbiology 10, 395-406 PubMed abstract
  • Young, GR; Eksmond, U; Salcedo, R; Alexopoulou, L; Stoye, JP and Kassiotis, G (2012)
    Resurrection of endogenous retroviruses in antibody-deficient mice.
    Nature 491, 774-778 PubMed abstract
  • Young, GR; Kassiotis, G and Stoye, JP (2012)
    Emv2, the only endogenous ecotropic murine leukemia virus of C57BL/6J mice.
    Retrovirology 9, 23 PubMed abstract
  • Young, GR; Ploquin, MJ; Eksmond, U; Wadwa, M; Stoye, JP and Kassiotis, G (2012)
    Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.
    PLOS Pathogens 8, e1002709 PubMed abstract
  • Goldstone, DC; Ennis-Adeniran, V; Hedden, JJ; Groom, HCT; Rice, GI; Christodoulou, E; Walker, PA; Kelly, G; Haire, LF; Yap, MW; de Carvalho, LP; Stoye, JP; Crow, YJ; Taylor, IA and Webb, M (2011)
    HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.
    Nature 480, 379-382 PubMed abstract
  • Gray, ER; Illingworth, CJR; Coffin, JM and Stoye, JP (2011)
    Binding of more than one Tva800 molecule is required for ASLV-A entry.
    Retrovirology 8, 96 PubMed abstract
  • Hilditch, L; Matadeen, R; Goldstone, DC; Rosenthal, PB; Taylor, IA and Stoye, JP (2011)
    Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1.
    Proceedings of the National Academy of Sciences of the United States of America 108, 5771-5776 PubMed abstract
  • Laurson, J and Raj, K (2011)
    Localisation of human papillomavirus 16 E7 oncoprotein changes with cell confluence.
    PLOS ONE 6, e21501
  • McNab, FW; Rajsbaum, R; Stoye, JP and O'Garra, A (2011)
    Tripartite-motif proteins and innate immune regulation.
    Current Opinion in Immunology 23, 46-56 PubMed abstract
  • Ohkura, S; Goldstone, DC; Yap, MW; Holden-Dye, K; Taylor, IA and Stoye, JP (2011)
    Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein.
    PLOS Pathogens 7, e1002011 PubMed abstract
  • Rahm, N; Yap, M; Snoeck, J; Zoete, V; Munoz, M; Radespiel, U; Zimmermann, E; Michielin, O; Stoye, JP; Ciuffi, A and Telenti, A (2011)
    Unique spectrum of activity of prosimian TRIM5α against exogenous and endogenous retroviruses.
    Journal of Virology 85, 4173-4183 PubMed abstract
  • Tuke, PW; Tettmar, KI; Tamuri, A; Stoye, JP and Tedder, RS (2011)
    PCR master mixes harbour murine DNA sequences. Caveat emptor!.
    PLOS ONE 6, e19953 PubMed abstract
  • Goldstone, DC; Yap, MW; Robertson, LE; Haire, LF; Taylor, WR; Katzourakis, A; Stoye, JP and Taylor, IA (2010)
    Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface.
    Cell Host & Microbe 8, 248-259 PubMed abstract
  • Groom, HCT; Boucherit, VC; Makinson, K; Randal, E; Baptista, S; Hagan, S; Gow, JW; Mattes, FM; Breuer, J; Kerr, JR; Stoye, JP and Bishop, KN (2010)
    Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.
    Retrovirology 7, 10 PubMed abstract
  • Stoye, JP; Silverman, RH; Boucher, CA and Le Grice, SFJ (2010)
    The xenotropic murine leukemia virus-related retrovirus debate continues at first international workshop.
    Retrovirology 7, 113 PubMed abstract

[Page last updated 1 Jun 2018]

Jonathan Stoye
+44 (0)20 379 62439

  • Qualifications and history
  • 1978-1981 PhD Friedrich Miescher Institute, Basel, Switzerland
  • 1982-1989 Research Associate Tufts University School of Medicine, Boston, USA
  • 1989-2015 Team Leader Medical Research Council National Institute for Medical Research (MRC-NIMR), London, UK
  • 2001-2015 Head, Division of Virology, MRC-NIMR, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK