Publications

SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export

Authors (7)

PLOS Pathogens

Published 25 August 2022

Crick labs/ facilities

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Virus restriction: Repurposing an essential cellular function to defend against viruses

Authors (2)

Current Biology

Published 11 April 2022

Crick labs

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ICTV Virus Taxonomy Profile: Retroviridae 2021

Authors (11)

John Coffin
Jonas Blomberg
Hung Fan
Robert Gifford
Theodora Hatziioannou
Dirk Lindemann
Jens Mayer
Jonathan Stoye
Michael Tristem
Welkin Johnson
ICTV Report Consortium

Journal of General Virology

Published 1 December 2021

Crick labs

Jonathan Stoye

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Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control

Authors (8)

Matthew Cottee
Sean L Beckwith
Suzanne C Letham
Sarah J Kim
George Young
Jonathan Stoye
David J Garfinkel
Ian Taylor

Nature Communications

Published 22 September 2021

Crick labs/ facilities

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E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion

Authors (15)

Oncogene

Published 16 September 2021

Crick labs/ facilities

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Analysis of SAMHD1 restriction by flow cytometry in human myeloid U937 cells

Authors (4)

Paula Ordonez Suarez
Kate Bishop
Jonathan Stoye
Harriet Cordelia Theed Groom

Journal of Visualized Experiments

Published 13 June 2021

Crick labs

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Gv1, a zinc finger gene controlling endogenous MLV expression

Authors (7)

Molecular Biology and Evolution

Published 1 June 2021

Crick labs/ facilities

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Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option

Authors (9)

Nature Genetics

Published 1 December 2020

Crick labs/ facilities

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Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses

Authors (5)

Melvyn Yap
George Young
Renata Varnaite
Serge Morand
Jonathan Stoye

PLOS Genetics

Published 11 June 2020

Crick labs

Jonathan Stoye

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Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event

Authors (5)

PLOS Pathogens

Published 26 May 2020

Crick labs/ facilities

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Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Authors (12)

Huipeng Jiao
Laurens Wachsmuth
Snehlata Kumari
Robin Schwarzer
Juan Lin
Remzi Onur Eren
[...]
Rebecca Lane
George Young
George Kassiotis
William J Kaiser
Manolis Pasparakis

Nature

Published 16 April 2020

Crick labs

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Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag

Authors (5)

Science advances

Published 1 January 2020

Crick labs

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Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression

Authors (12)

Anastasiya Kazachenka
George Young
Jan Attig
Chrysoula Kordella
Eleftheria Lamprianidou
Emmanuela Zoulia
[...]
Menelaos Papoutselis
Elsa Bernard
Elli Papaemmanuil
Ioannis Kotsianidis
George Kassiotis

Genome Medicine: medicine in the post-genomic era

Published 23 December 2019

Crick labs/ facilities

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Structural basis for Fullerene geometry in a human endogenous retrovirus capsid

Authors (12)

Oliver Acton
Tim Grant
Giuseppe Nicastro
Neil J Ball
David C Goldstone
Laura E Robertson
[...]
Andrea Nans
Andres Ramos
Jonathan Stoye
Ian Taylor
Peter Rosenthal

Nature Communications

Published 20 December 2019

Crick labs/ facilities

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Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

Authors (7)

Kevin Ng
Jan Attig
George Young
Eleonora Ottina
Spyros I Papamichos
Ioannis Kotsianidis
George Kassiotis

eLife

Published 15 November 2019

Crick labs/ facilities

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LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly

Authors (9)

Jan Attig
George Young
Louise Hosie
David Perkins
Vesela Encheva-Yokoya
Jonathan Stoye
Bram Snijders
Nicola Ternette
George Kassiotis

Genome Research

Published 1 October 2019

Crick labs/ facilities

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Positive selection in dNTPase SAMHD1 throughout mammalian evolution

Authors (12)

Christopher Monit
Liz Morris
Christopher Ruis
Bart Szafran
Grant Thiltgen
Chloe Tsai
[...]
Kate Bishop
Jonathan Stoye
Ian Taylor
Ariberto Fassati
Richard A Goldstein

Proceedings of the National Academy of Sciences of the United States of America

Published 10 September 2019

Crick labs

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MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells

Authors (8)

Blood

Published 30 January 2019

Crick labs/ facilities

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A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins

Authors (8)

Jeremy R Keown
Moyra M Black
Aaron Ferron
Melvyn Yap
Michael J Barnett
F Grant Pearce
Jonathan Stoye
David C Goldstone

Journal of Biological Chemistry

Published 23 November 2018

Crick labs

Jonathan Stoye

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Evolutionary journey of the retroviral restriction gene Fv1

Authors (5)

George Young
Melvyn Yap
Johan R Michaux
Scott J Steppan
Jonathan Stoye

Proceedings of the National Academy of Sciences of the United States of America

Published 2 October 2018

Crick labs

Jonathan Stoye

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SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export

Virus restriction: Repurposing an essential cellular function to defend against viruses

ICTV Virus Taxonomy Profile: Retroviridae 2021

Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control

E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion

Analysis of SAMHD1 restriction by flow cytometry in human myeloid U937 cells

Gv1, a zinc finger gene controlling endogenous MLV expression

Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option

Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses

Antibody-induced internalisation of retroviral envelope glycoproteins is a signal initiation event

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag

Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression

Structural basis for Fullerene geometry in a human endogenous retrovirus capsid

Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

LTR retroelement expansion of the human cancer transcriptome and immunopeptidome revealed by de novo transcript assembly

Positive selection in dNTPase SAMHD1 throughout mammalian evolution

MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins

Evolutionary journey of the retroviral restriction gene Fv1

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