Jim Smith: Publications

  • Bozatzi, P; Dingwell, KS; Wu, KZL; Cooper, F; Cummins, TD; Hutchinson, LD; Vogt, J; Wood, NT; Macartney, TJ; Varghese, J; Gourlay, R; Campbell, DG; Smith, JC and Sapkota, GP (2018)
    PAWS1 controls Wnt signalling through association with casein kinase 1α.
    EMBO Reports 19, e44807 PubMed abstract
  • Christov, CP; Dingwell, KS; Skehel, M; Wilkes, HS; Sale, JE; Smith, JC and Krude, T (2018)
    A NuRD complex from Xenopus laevis eggs is essential for DNA replication during early embryogenesis.
    Cell Reports 22, 2265-2278 PubMed abstract
  • Cummins, TD; Wu, KZL; Bozatzi, P; Dingwell, KS; Macartney, TJ; Wood, NT; Varghese, J; Gourlay, R; Campbell, DG; Prescott, A; Griffis, E; Smith, JC and Sapkota, GP (2018)
    PAWS1 controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP.
    Journal of Cell Science 131, jcs202390 PubMed abstract
  • Dingwell, KS and Smith, JC (2018)
    Dissecting and culturing animal cap explants.
    Cold Spring Harbor Protocols 2018, [Epub ahead of print] PubMed abstract
  • Fulcher, LJ; Bozatzi, P; Tachie-Menson, T; Wu, KZL; Cummins, TD; Bufton, JC; Pinkas, DM; Dunbar, K; Shrestha, S; Wood, NT; Weidlich, S; Macartney, TJ; Varghese, J; Gourlay, R; Campbell, DG; Dingwell, KS; Smith, JC; Bullock, AN and Sapkota, GP (2018)
    The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.
    Science Signaling 11, eaao2341 PubMed abstract
  • Gentsch, GE; Spruce, T; Monteiro, RS; Owens, NDL; Martin, SR and Smith, JC (2018)
    Innate immune response and off-target mis-splicing are common morpholino-induced side effects in Xenopus.
    Developmental Cell 44, 597-610.e510 PubMed abstract
  • Monteiro, RS; Gentsch, GE and Smith, JC (2018)
    Transcriptomics of dorso-ventral axis determination in Xenopus tropicalis.
    Developmental Biology [Epub ahead of print] PubMed abstract
  • Perez-Garcia, V; Fineberg, E; Wilson, R; Murray, A; Mazzeo, CI; Tudor, C; Sienerth, A; White, JK; Tuck, E; Ryder, EJ; Gleeson, D; Siragher, E; Wardle-Jones, H; Staudt, N; Wali, N; Collins, J; Geyer, S; Busch-Nentwich, EM; Galli, A; Smith, JC; Robertson, E; Adams, DJ; Weninger, WJ; Mohun, T and Hemberger, M (2018)
    Placentation defects are highly prevalent in embryonic lethal mouse mutants.
    Nature 555, 463-468 PubMed abstract
  • Collart, C; Smith, JC and Zegerman, P (2017)
    Chk1 inhibition of the replication factor Drf1 guarantees cell-cycle elongation at the Xenopus laevis mid-blastula transition.
    Developmental Cell 42, 82-96 e83 PubMed abstract
  • Eve, AMJ; Place, ES and Smith, JC (2017)
    Comparison of Zebrafish tmem88a mutant and morpholino knockdown phenotypes.
    PLOS ONE 12, e0172227 PubMed abstract
  • Eve, AMJ and Smith, JC (2017)
    Knockdown of Laminin gamma-3 (Lamc3) impairs motoneuron guidance in the zebrafish embryo.
    Wellcome Open Research 2, 111 PubMed abstract
  • Gentsch, GE; Monteiro, RS and Smith, JC (2017)
    Cooperation between T-box factors regulates the continuous segregation of germ layers during vertebrate embryogenesis.
    Current Topics in Developmental Biology 122, 117-159 PubMed abstract
  • Gentsch, GE and Smith, JC (2017)
    Efficient preparation of high-complexity ChIP-Seq profiles from early Xenopus embryos.
    Methods in Molecular Biology 1507, 23-42 PubMed abstract
  • Peters, K and Smith, J (2017)
    The Francis Crick Institute.
    Clinical Medicine 17, 105-107 PubMed abstract
  • Place, ES and Smith, JC (2017)
    Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes.
    PLOS ONE 12, e0171143 PubMed abstract
  • Langley, AR; Gräf, S; Smith, JC and Krude, T (2016)
    Genome-wide identification and characterisation of human DNA replication origins by initiation site sequencing (ini-seq).
    Nucleic Acids Research 44, 10230-10247 PubMed abstract
  • Morrell, NW; Bloch, DB; ten Dijke, P; Goumans, M-JTH; Hata, A; Smith, J; Yu, PB and Bloch, KD (2016)
    Targeting BMP signalling in cardiovascular disease and anaemia.
    Nature Reviews Cardiology 13, 106-120 PubMed abstract
  • Villa, M; Crotta, S; Dingwell, KS; Hirst, EMA; Gialitakis, M; Ahlfors, H; Smith, JC; Stockinger, B and Wack, A (2016)
    The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis.
    Nature Communications 7, 12652 PubMed abstract
  • Wilson, R; Geyer, SH; Reissig, L; Rose, J; Szumska, D; Hardman, E; Prin, F; McGuire, C; Ramirez-Solis, R; White, J; Galli, A; Tudor, C; Tuck, E; Mazzeo, C; Smith, JC; Robertson, E; Adams, DJ; Mohun, T and Weninger, WJ (2016)
    Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice.
    Wellcome Open Research 1, 1 PubMed abstract
  • Faial, T; Bernardo, AS; Mendjan, S; Diamanti, E; Ortmann, D; Gentsch, GE; Mascetti, VL; Trotter, MWB; Smith, JC and Pedersen, RA (2015)
    Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells.
    Development 142, 2121-2135 PubMed abstract
  • Gentsch, GE; Patrushev, I and Smith, JC (2015)
    Genome-wide snapshot of chromatin regulators and states in Xenopus embryos by ChIP-Seq.
    Journal of Visualized Experiments 96, e52535 PubMed abstract
  • Boname, JM; Bloor, S; Wandel, MP; Nathan, JA; Antrobus, R; Dingwell, KS; Thurston, TL; Smith, DL; Smith, JC; Randow, F and Lehner, PJ (2014)
    Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.
    Journal of Cell Biology 205, 847-862 PubMed abstract
  • Collart, C; Owens, NDL; Bhaw-Rosun, L; Cooper, B; De Domenico, E; Patrushev, I; Sesay, AK; Smith, JN; Smith, JC and Gilchrist, MJ (2014)
    High-resolution analysis of gene activity during the Xenopus mid-blastula transition.
    Development 141, 1927-1939 PubMed abstract
  • Gentsch, GE and Smith, JC (2014)
    Investigating physical chromatin associations across the Xenopus genome by chromatin immunoprecipitation.
    Cold Spring Harbor Protocols 2014, pdb.prot080614 PubMed abstract
  • Herhaus, L; Al-Salihi, MA; Dingwell, KS; Cummins, TD; Wasmus, L; Vogt, J; Ewan, R; Bruce, D; Macartney, T; Weidlich, S; Smith, JC and Sapkota, GP (2014)
    USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.
    Open Biology 4, 140065 PubMed abstract
  • Langley, AR; Smith, JC; Stemple, DL and Harvey, SA (2014)
    New insights into the maternal to zygotic transition.
    Development 141, 3834-3841 PubMed abstract
  • Vogt, J; Dingwell, KS; Herhaus, L; Gourlay, R; Macartney, T; Campbell, D; Smith, JC and Sapkota, GP (2014)
    Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.
    Open Biology 4, 130210 PubMed abstract
  • Cannon, JE; Place, ES; Eve, AMJ; Bradshaw, CR; Sesay, A; Morrell, NW and Smith, JC (2013)
    Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development.
    Mechanisms of Development 130, 122-131 PubMed abstract
  • Collart, C; Allen, GE; Bradshaw, CR; Smith, JC and Zegerman, P (2013)
    Titration of four replication factors is essential for the Xenopus laevis midblastula transition.
    Science 341, 893-896 PubMed abstract
  • Gentsch, GE; Owens, NDL; Martin, SR; Piccinelli, P; Faial, T; Trotter, MWB; Gilchrist, MJ and Smith, JC (2013)
    In vivo T-box transcription factor profiling reveals joint regulation of embryonic neuromesodermal bipotency.
    Cell Reports 4, 1185-1196 PubMed abstract
  • Harvey, SA; Sealy, I; Kettleborough, R; Fenyes, F; White, R; Stemple, D and Smith, JC (2013)
    Identification of the zebrafish maternal and paternal transcriptomes.
    Development 140, 2703-2710 PubMed abstract
  • Mohun, T; Adams, DJ; Baldock, R; Bhattacharya, S; Copp, AJ; Hemberger, M; Houart, C; Hurles, ME; Robertson, E; Smith, JC; Weaver, T and Weninger, W (2013)
    Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice.
    Disease Models & Mechanisms 6, 562-566 PubMed abstract
  • Nurse, P; Treisman, R and Smith, J (2013)
    Building better institutions.
    Science 341, 10 PubMed abstract
  • Sato, S; Sesay, AK and Holder, AA (2013)
    The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi.
    PLOS ONE 8, e61778 PubMed abstract
  • Callery, EM; Park, CY; Xu, X; Zhu, H; Smith, JC and Thomsen, GH (2012)
    Eps15R is required for bone morphogenetic protein signalling and differentially compartmentalizes with Smad proteins.
    Open Biology 2, 120060 PubMed abstract
  • Evans, AL; Faial, T; Gilchrist, MJ; Down, T; Vallier, L; Pedersen, RA; Wardle, FC and Smith, JC (2012)
    Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells.
    PLOS ONE 7, e33346 PubMed abstract
  • Bernardo, AS; Faial, T; Gardner, L; Niakan, KK; Ortmann, D; Senner, CE; Callery, EM; Trotter, MW; Hemberger, M; Smith, JC; Bardwell, L; Moffett, A and Pedersen, RA (2011)
    BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
    Cell Stem Cell 9, 144-155 PubMed abstract
  • Collart, C; Christov, CP; Smith, JC and Krude, T (2011)
    The mid-blastula transition defines the onset of Y RNA-dependent DNA replication in Xenopus laevis.
    Molecular and Cellular Biology 31, 3857-3387 PubMed abstract
  • Rana, AA; Roper, SJ; Palmer, EA and Smith, JC (2011)
    Loss of Xenopus tropicalis EMSY causes impairment of gastrulation and upregulation of p53.
    New Biotechnology 28, 334-341 PubMed abstract
  • Callery, EM; Thomsen, GH and Smith, JC (2010)
    A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus.
    Developmental Biology 340, 75-87 PubMed abstract
  • Cannon, JE; Upton, PD; Smith, JC and Morrell, NW (2010)
    Intersegmental vessel formation in zebrafish: requirement for VEGF but not BMP signalling revealed by selective and non-selective BMP antagonists.
    British Journal of Pharmacology 161, 140-149 PubMed abstract
  • Harvey, SA; Tümpel, S; Dubrulle, J; Schier, AF and Smith, JC (2010)
    no tail integrates two modes of mesoderm induction.
    Development 137, 1127-1135 PubMed abstract
  • Scott, CE; Wynn, SL; Sesay, A; Cruz, C; Cheung, M; Gaviro, M-VG; Booth, S; Gao, B; Cheah, KSE; Lovell-Badge, R and Briscoe, J (2010)
    SOX9 induces and maintains neural stem cells.
    Nature Neuroscience 13, 1181-1189 PubMed abstract

[Page last updated 1 Jun 2018]

Jim Smith

Jim Smith

+44 (0)20 379 61103

  • Qualifications and history
  • 1979 PhD Middlesex Hospital Medical School, London, UK
  • 1979 Postdoctoral Fellow Harvard Medical School, Boston MA, USA
  • 1981 Postdoctoral Fellow, Imperial Cancer Research Fund, London, UK
  • 1984 Group Leader, then Head of Division and Head of Group, MRC-NIMR, London, UK
  • 2000 Director, Wellcome Trust/Cancer Research UK Gurdon Institute
  • 2009 Director, Medical Research Council National Institute for Medical Research, London, UK
  • 2014 Deputy CEO and Chief of Strategy, Medical Research Council
  • 2015 Director of Research, Francis Crick Institute