Jesper Svejstrup: Publications

  • Gregersen, LH and Svejstrup, JQ (2018)
    The cellular response to transcription-blocking DNA damage.
    Trends in Biochemical Sciences 43, 327-341 PubMed abstract
  • Weems, JC; Slaughter, BD; Unruh, JR; Boeing, S; Hall, SM; McLaird, MB; Yasukawa, T; Aso, T; Svejstrup, JQ; Conaway, JW and Conaway, RC (2017)
    Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.
    Journal of Biological Chemistry 292, 6431-6437 PubMed abstract
  • Williamson, L; Saponaro, M; Boeing, S; East, P; Mitter, R; Kantidakis, T; Kelly, GP; Lobley, A; Walker, J; Spencer-Dene, B; Howell, M; Stewart, A and Svejstrup, JQ (2017)
    UV irradiation induces a non-coding RNA that functionally opposes the protein encoded by the same gene.
    Cell 168, 843-855 PubMed abstract
  • Boeing, S; Williamson, L; Encheva, V; Gori, I; Saunders, RE; Instrell, R; Aygün, O; Rodriguez-Martinez, M; Weems, JC; Kelly, GP; Conaway, JW; Conaway, RC; Stewart, A; Howell, M; Snijders, AP and Svejstrup, JQ (2016)
    Multiomic analysis of the UV-induced DNA damage response.
    Cell Reports 15, 1597-1610 PubMed abstract
  • Kantidakis, T; Saponaro, M; Mitter, R; Horswell, S; Kranz, A; Boeing, S; Aygün, O; Kelly, GP; Matthews, N; Stewart, A; Stewart, AF and Svejstrup, JQ (2016)
    Mutation of cancer driver MLL2 results in transcription stress and genome instability.
    Genes & Development 30, 408-420 PubMed abstract
  • Ranes, M; Boeing, S; Wang, Y; Wienholz, F; Menoni, H; Walker, J; Encheva, V; Chakravarty, P; Mari, P-O; Stewart, A; Giglia-Mari, G; Snijders, AP; Vermeulen, W and Svejstrup, JQ (2016)
    A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.
    Nucleic Acids Research 44, 5246-5255 PubMed abstract
  • Wang, Y; Jones-Tabah, J; Chakravarty, P; Stewart, A; Muotri, A; Laposa, RR and Svejstrup, JQ (2016)
    Pharmacological bypass of Cockayne syndrome B function in neuronal differentiation.
    Cell Reports 14, 2554-2561 PubMed abstract
  • Ehrensberger, AH; Franchini, D-M; East, P; George, R; Matthews, N; Maslen, SL and Svejstrup, JQ (2015)
    Retention of the native epigenome in purified mammalian chromatin.
    PLOS ONE 10, e0133246 PubMed abstract
  • Godin-Heymann, N; Brabetz, S; Murillo, MM; Saponaro, M; Santos, CR; Lobley, A; East, P; Chakravarty, P; Matthews, N; Kelly, G; Jordan, S; Castellano, E and Downward, J (2015)
    Tumour-suppression function of KLF12 through regulation of anoikis.
    Oncogene 35, 3324-3334 PubMed abstract
  • Saponaro, M; Kantidakis, T; Mitter, R; Kelly, GP; Heron, M; Williams, H; Söding, J; Stewart, A and Svejstrup, JQ (2014)
    RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress.
    Cell 157, 1037-1049 PubMed abstract
  • Wang, Y; Chakravarty, P; Ranes, M; Kelly, G; Brooks, PJ; Neilan, E; Stewart, A; Schiavo, G and Svejstrup, JQ (2014)
    Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.
    Proceedings of the National Academy of Sciences of the United States of America 111, 14454-14459 PubMed abstract
  • Ehrensberger, AH; Kelly, GP and Svejstrup, JQ (2013)
    Mechanistic interpretation of promoter-proximal peaks and RNAPII density maps.
    Cell 154, 713-715 PubMed abstract
  • Svejstrup, JQ (2013)
    RNA polymerase II transcript elongation.
    Biochimica et Biophysica Acta 1829, 1 PubMed abstract
  • Svejstrup, JQ (2013)
    Synovial sarcoma mechanisms: a series of unfortunate events.
    Cell 153, 11-12 PubMed abstract
  • Wilson, MD; Harreman, M and Svejstrup, JQ (2013)
    Ubiquitylation and degradation of elongating RNA polymerase II: the last resort.
    Biochimica et Biophysica Acta 1829, 151-157 PubMed abstract
  • Wilson, MD; Harreman, M; Taschner, M; Reid, J; Walker, J; Erdjument-Bromage, H; Tempst, P and Svejstrup, JQ (2013)
    Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress.
    Cell 154, 983-995 PubMed abstract
  • Close, P; East, P; Dirac-Svejstrup, AB; Hartmann, H; Heron, M; Maslen, S; Chariot, A; Söding, J; Skehel, M and Svejstrup, JQ (2012)
    DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.
    Nature 484, 386-389 PubMed abstract
  • Close, P; Gillard, M; Ladang, A; Jiang, Z; Papuga, J; Hawkes, N; Laurent, N; Chapelle, J-P; Bouillenne, F; Svejstrup, J; Fillet, M and Chariot, A (2012)
    DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.
    Journal of Biological Chemistry 287, 32535-32545
  • Ehrensberger, AH and Svejstrup, JQ (2012)
    Reprogramming chromatin.
    Critical Reviews in Biochemistry and Molecular Biology 47, 464-482 PubMed abstract
  • Hobson, DJ; Wei, W; Steinmetz, LM and Svejstrup, JQ (2012)
    RNA polymerase II collision interrupts convergent transcription.
    Molecular Cell 48, 365-374 PubMed abstract
  • Svejstrup, JQ (2012)
    Transcription: another mark in the tail.
    EMBO Journal 31, 2753-2754 PubMed abstract
  • Wilson, MD; Saponaro, M; Leidl, MA and Svejstrup, JQ (2012)
    MultiDsk: a ubiquitin-specific affinity resin.
    PLOS ONE 7, e46398 PubMed abstract
  • Selth, LA; Close, P and Svejstrup, JQ (2011)
    Studying RNA-protein interactions in vivo by RNA immunoprecipitation.
    Methods in Molecular Biology 791, 253-264 PubMed abstract
  • Staresincic, L; Walker, J; Dirac-Svejstrup, AB; Mitter, R and Svejstrup, JQ (2011)
    GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein.
    Journal of Biological Chemistry 286, 35553-35561 PubMed abstract
  • Walker, J; Kwon, SY; Badenhorst, P; East, P; McNeill, H and Svejstrup, JQ (2011)
    Role of Elongator subunit Elp3 in Drosophila melanogaster larval development and immunity.
    Genetics 187, 1067-1075 PubMed abstract
  • Anindya, R; Mari, P-O; Kristensen, U; Kool, H; Giglia-Mari, G; Mullenders, LH; Fousteri, M; Vermeulen, W; Egly, J-M and Svejstrup, JQ (2010)
    A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.
    Molecular Cell 38, 637-648 PubMed abstract
  • Aygün, O and Svejstrup, JQ (2010)
    RECQL5 helicase: connections to DNA recombination and RNA polymerase II transcription.
    DNA Repair 9, 345-353 PubMed abstract
  • Ertel, F; Dirac-Svejstrup, AB; Hertel, CB; Blaschke, D; Svejstrup, JQ and Korber, P (2010)
    In vitro reconstitution of PHO5 promoter chromatin remodeling points to a role for activator-nucleosome competition in vivo.
    Molecular and Cellular Biology 30, 4060-4076 PubMed abstract
  • Kainov, DE; Selth, LA; Svejstrup, JQ; Egly, J-M and Poterzsman, A (2010)
    Interacting partners of the Tfb2 subunit from yeast TFIIH.
    DNA Repair 9, 33-39 PubMed abstract
  • Selth, LA; Sigurdsson, S and Svejstrup, JQ (2010)
    Transcript elongation by RNA polymerase II.
    Annual Review of Biochemistry 79, 271-293 PubMed abstract
  • Sigurdsson, S; Dirac-Svejstrup, AB and Svejstrup, JQ (2010)
    Evidence that transcript cleavage is essential for RNA polymerase II transcription and cell viability.
    Molecular Cell 38, 202-210 PubMed abstract
  • Svejstrup, JQ (2010)
    The interface between transcription and mechanisms maintaining genome integrity.
    Trends in Biochemical Sciences 35, 333-338 PubMed abstract
  • Taschner, M; Harreman, M; Teng, Y; Gill, H; Anindya, R; Maslen, SL; Skehel, JM; Waters, R and Svejstrup, JQ (2010)
    A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae.
    Molecular and Cellular Biology 30, 436-446 PubMed abstract

[Page last updated 1 Jun 2018]

An image of Jesper Svejstrup.

Jesper Svejstrup
+44 (0)20 379 62045

  • Qualifications and history
  • 1993 PhD, Aarhus University, Denmark
  • 1993 Postdoctoral Fellow, Stanford School of Medicine, USA
  • 1996 Established lab at the Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2011 Adjunct Professor, University of Copenhagen, Denmark
  • 2015 Group Leader, the Francis Crick Institute, London, UK