Caetano Reis e Sousa

Immunobiology Laboratory

Dendritic cells (DC) play a key role in the initiation and regulation of adaptive immune responses and, therefore, the manipulation of DC has tremendous potential for cancer immunotherapy and for vaccination against infectious agents.

We study innate immune receptors and signalling pathways that trigger DC activation and promote T cell priming or that generally act to modulate the function of DC. Many of these pathways are shared with other cell types and are triggered in response to infection or cell death.

In a related research programme, we study DC and myeloid cell heterogeneity and ontogeny with a view to understand the role of distinct DC subtypes in mouse and in human.

Figure 1

Dendritic cells stained for F-actin (Click to view larger image)

Selected publications

Zelenay, S., A.G. van der Veen, J.P. Böttcher, K.J. Snelgrove, N. Rogers, S.E. Acton, P. Chakravarty, M.R. Girotti, R. Marais, S.A. Quezada, E. Sahai, and C. Reis e Sousa. 2015. Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity. Cell 162:1257-1270.

Acton, S.E., A.J. Farrugia, J.L. Astarita, D. Mourão-Sá, R.P. Jenkins, E. Nye, S. Hooper, J. van Blijswijk, N.C. Rogers, K.J. Snelgrove, I. Rosewell, L.F. Moita, G. Stamp, S.J. Turley, E. Sahai, and C. Reis e Sousa. 2014. Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature 514:498-502

Schraml, B.U., J. van Blijswijk, S. Zelenay, P.G. Whitney, A. Filby, S.E. Acton, N.C. Rogers, N. Moncaut, J. Carvajal, and C. Reis e Sousa. 2013. Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage. Cell 154:843-858.

Sancho D, Joffre O, Keller A, Rogers NC, Martinez D, Hernanz-Falcón P, Rosewell I, Reis e Sousa C. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature. 2009;458:899-903

LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nature Immunol. 2007;8:630-638

Pichlmair A, Schulz O, Tan CP, Näslund TI, Liljeström P, Weber F, Reis e Sousa C. RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5' Phosphates. Science. 2006;314: 997-1001

Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Reis e Sousa C. Syk-dependent cytokine induction by dectin-1 reveals a novel pattern recognition pathway for C-type lectins. Immunity. 2005;22:507-517

Diebold, S., T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529-1531.

Reis e Sousa Caetano

Caetano Reis e Sousa

caetano@crick.ac.uk
+44 (0)20 379 61310

  • Qualifications and history
  • 1992 DPhil, University of Oxford, UK
  • 1993 Postdoc, National Institute of Allergy and Infectious Diseases, National Institute of Health, USA
  • 1998 Established lab at the Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2015 Senior Group Leader, the Francis Crick Institute, London, UK