Tim Mohun: Publications

  • Aiello, VD; Spicer, DE; Anderson, RH; Brown, NA and Mohun, TJ (2017)
    The independence of the infundibular building blocks in the setting of double-outlet right ventricle.
    Cardiology in the Young 27, 825-836 PubMed abstract
  • Anderson, RH; Jensen, B; Mohun, TJ; Petersen, SE; Aung, N; Zemrak, F; Planken, RN and MacIver, DH (2017)
    Key questions relating to left ventricular noncompaction cardiomyopathy: Is the emperor still wearing any clothes?
    Canadian Journal of Cardiology 33, 747-757 PubMed abstract
  • Dupays, L and Mohun, T (2017)
    Spatiotemporal regulation of enhancers during cardiogenesis.
    Cellular and Molecular Life Sciences 74, 257-265 PubMed abstract
  • Geyer, SH; Reissig, L; Rose, J; Wilson, R; Prin, F; Szumska, D; Ramirez-Solis, R; Tudor, C; White, J; Mohun, TJ and Weninger, WJ (2017)
    A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5).
    Journal of Anatomy 230, 710-719 PubMed abstract
  • Geyer, SH; Reissig, LF; Hüsemann, M; Höfle, C; Wilson, R; Prin, F; Szumska, D; Galli, A; Adams, DJ; White, J; Mohun, TJ and Weninger, WJ (2017)
    Morphology, topology and dimensions of the heart and arteries of genetically normal and mutant mouse embryos at stages S21-S23.
    Journal of Anatomy 231, 600-614 PubMed abstract
  • Anderson, RH; Brown, NA and Mohun, TJ (2016)
    Insights regarding the normal and abnormal formation of the atrial and ventricular septal structures.
    Clinical Anatomy 29, 290-304 PubMed abstract
  • Anderson, RH; Mori, S; Spicer, DE; Brown, NA and Mohun, TJ (2016)
    Development and morphology of the ventricular outflow tracts.
    World Journal for Pediatric & Congenital Heart Surgery 7, 561-577 PubMed abstract
  • Captur, G; Ho, CY; Schlossarek, S; Kerwin, J; Mirabel, M; Wilson, R; Rosmini, S; Obianyo, C; Reant, P; Bassett, P; Cook, AC; Lindsay, S; McKenna, WJ; Mills, K; Elliott, PM; Mohun, TJ; Carrier, L and Moon, JC (2016)
    The embryological basis of subclinical hypertrophic cardiomyopathy.
    Scientific Reports 6, 27714 PubMed abstract
  • Captur, G; Wilson, R; Bennett, MF; Luxán, G; Nasis, A; de la Pompa, JL; Moon, JC and Mohun, TJ (2016)
    Morphogenesis of myocardial trabeculae in the mouse embryo.
    Journal of Anatomy 229, 314-325 PubMed abstract
  • Dickinson, ME; Flenniken, AM; Ji, X; Teboul, L; Wong, MD; White, JK; Meehan, TF; Weninger, WJ; Westerberg, H; Adissu, H; Baker, CN; Bower, L; Brown, JM; Caddle, LB; Chiani, F; Clary, D; Cleak, J; Daly, MJ; Denegre, JM; Doe, B; Dolan, ME; Edie, SM; Fuchs, H; Gailus-Durner, V; Galli, A; Gambadoro, A; Gallegos, J; Guo, S; Horner, NR; Hsu, C-W; Johnson, SJ; Kalaga, S; Keith, LC; Lanoue, L; Lawson, TN; Lek, M; Mark, M; Marschall, S; Mason, J; McElwee, ML; Newbigging, S; Nutter, LMJ; Peterson, KA; Ramirez-Solis, R; Rowland, DJ; Ryder, E; Samocha, KE; Seavitt, JR; Selloum, M; Szoke-Kovacs, Z; Tamura, M; Trainor, AG; Tudose, I; Wakana, S; Warren, J; Wendling, O; West, DB; Wong, L; Yoshiki, A; The International Mouse Phenotyping Consortium; MacArthur, DG; Tocchini-Valentini, GP; Gao, X; Flicek, P; Bradley, A; Skarnes, WC; Justice, MJ; Parkinson, HE; Moore, M; Wells, S; Braun, RE; Svenson, KL; de Angelis, MH; Herault, Y; Mohun, T; Mallon, A-M; Henkelman, RM; Brown, SDM; Adams, DJ; Lloyd, KCK; McKerlie, C; Beaudet, AL; Bućan, M and Murray, SA (2016)
    High-throughput discovery of novel developmental phenotypes.
    Nature 537, 508-514 PubMed abstract
  • Dilg, D; Saleh, RNM; Phelps, SEL; Rose, Y; Dupays, L; Murphy, C; Mohun, T; Anderson, RH; Scambler, PJ and Chapgier, ALA (2016)
    HIRA is required for heart development and directly regulates Tnni2 and Tnnt3.
    PLOS ONE 11, e0161096 PubMed abstract
  • Henkelman, RM; Friedel, M; Lerch, JP; Wilson, R and Mohun, T (2016)
    Comparing homologous microscopic sections from multiple embryos using HREM.
    Developmental Biology 415, 1-5 PubMed abstract
  • Lana-Elola, E; Watson-Scales, S; Slender, A; Gibbins, D; Martineau, A; Douglas, C; Mohun, T; Fisher, EMC and Tybulewicz, VLJ (2016)
    Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel.
    eLife 5, e11614 PubMed abstract
  • Smith, SJ; Towers, N; Saldanha, JW; Shang, CA; Mahmood, SR; Taylor, WR and Mohun, TJ (2016)
    The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly.
    Developmental Biology 416, 373-388 PubMed abstract
  • Wilson, R; Geyer, SH; Reissig, L; Rose, J; Szumska, D; Hardman, E; Prin, F; McGuire, C; Ramirez-Solis, R; White, J; Galli, A; Tudor, C; Tuck, E; Mazzeo, C; Smith, JC; Robertson, E; Adams, DJ; Mohun, T and Weninger, WJ (2016)
    Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice.
    Wellcome Open Research 1, 1 PubMed abstract
  • Zak, J; Vives, V; Szumska, D; Vernet, A; Schneider, JE; Miller, P; Slee, EA; Joss, S; Lacassie, Y; Chen, E; Escobar, LF; Tucker, M; Aylsworth, AS; Dubbs, HA; Collins, AT; Andrieux, J; Dieux-Coeslier, A; Haberlandt, E; Kotzot, D; Scott, DA; Parker, MJ; Zakaria, Z; Choy, YS; Wieczorek, D; Innes, AM; Jun, KR; Zinner, S; Prin, F; Lygate, CA; Pretorius, P; Rosenfeld, JA; Mohun, TJ and Lu, X (2016)
    ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome.
    Cell Death and Differentiation 23, 1973-1984 PubMed abstract
  • Anderson, RH; Mohun, TJ and Brown, NA (2015)
    Clarifying the morphology of the ostium primum defect.
    Journal of Anatomy 226, 244-257 PubMed abstract
  • Anderson, RH; Spicer, DE; Henry, GW; Rigsby, C; Hlavacek, AM and Mohun, TJ (2015)
    The significance of aortic overriding and pulmonary stenosis in tetralogy of Fallot. Reply.
    Cardiology in the Young 25, 627 PubMed abstract
  • Anderson, RH; Spicer, DE; Henry, GW; Rigsby, C; Hlavacek, AM and Mohun, TJ (2015)
    What is aortic overriding?
    Cardiology in the Young 25, 612-625 PubMed abstract
  • Bailliard, F; Spicer, DE; Mohun, TJ; Henry, GW and Anderson, RH (2015)
    The problems that exist when considering the anatomic variability between the channels that permit interventricular shunting.
    Cardiology in the Young 25, 15-28 PubMed abstract
  • Bharucha, T; Spicer, DE; Mohun, TJ; Black, D; Henry, GW and Anderson, RH (2015)
    Cor triatriatum or divided atriums: which approach provides the better understanding?
    Cardiology in the Young 25, 193-207 PubMed abstract
  • Dupays, L; Shang, C; Wilson, R; Kotecha, S; Wood, S; Towers, N and Mohun, T (2015)
    Sequential binding of MEIS1 and NKX2-5 on the Popdc2 gene: a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.
    Cell Reports 13, 183-195 PubMed abstract
  • Ivins, S; Chappell, J; Vernay, B; Suntharalingham, J; Martineau, A; Mohun, TJ and Scambler, PJ (2015)
    The CXCL12/CXCR4 axis plays a critical role in coronary artery development.
    Developmental Cell 33, 455-468 PubMed abstract
  • Matsui, H; Ho, SY; Mohun, TJ and Gardiner, HM (2015)
    Postmortem high-resolution episcopic microscopy (HREM) of small human fetal hearts.
    Ultrasound in Obstetrics & Gynecology 45, 492-493 PubMed abstract
  • Notari, M; Hu, Y; Sutendra, G; Dedeić, Z; Lu, M; Dupays, L; Yavari, A; Carr, CA; Zhong, S; Opel, A; Tinker, A; Clarke, K; Watkins, H; Ferguson, DJP; Kelsell, DP; de Noronha, S; Sheppard, MN; Hollinshead, M; Mohun, TJ and Lu, X (2015)
    iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death.
    Proceedings of the National Academy of Sciences of the United States of America 112, E973-E981 PubMed abstract
  • Spicer, DE; Henderson, DJ; Chaudhry, B; Mohun, TJ and Anderson, RH (2015)
    The anatomy and development of normal and abnormal coronary arteries.
    Cardiology in the Young 25, 1493-1503 PubMed abstract
  • Wilson, R; McGuire, C; Mohun, T and The DMDD Project (2015)
    Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines.
    Nucleic Acids Research 44, D855-D861 PubMed abstract
  • Anderson, RH; Spicer, DE; Brown, NA and Mohun, TJ (2014)
    The development of septation in the four-chambered heart.
    Anatomical Record 297, 1414-1429 PubMed abstract
  • Captur, G; Lopes, LR; Mohun, TJ; Patel, V; Li, C; Bassett, P; Finocchiaro, G; Ferreira, VM; Esteban, MT; Muthurangu, V; Sherrid, MV; Day, SM; Canter, CE; McKenna, WJ; Seidman, CE; Bluemke, DA; Elliott, PM; Ho, CY and Moon, JC (2014)
    Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy.
    Circulation: Cardiovascular Imaging 7, 863-871 PubMed abstract
  • Captur, G; Lopes, LR; Patel, V; Li, C; Bassett, P; Syrris, P; Sado, DM; Maestrini, V; Mohun, TJ; McKenna, WJ; Muthurangu, V; Elliott, PM and Moon, JC (2014)
    Abnormal cardiac formation in hypertrophic cardiomyopathy: fractal analysis of trabeculae and preclinical gene expression.
    Circulation Cardiovascular Genetics 7, 241-248 PubMed abstract
  • Geyer, SH; Nöhammer, MM; Mathä, M; Reissig, L; Tinhofer, IE and Weninger, WJ (2014)
    High-resolution episcopic microscopy (HREM): a tool for visualizing skin biopsies.
    Microscopy and Microanalysis 20, 1356-1364 PubMed abstract
  • López-Olañeta, MM; Villalba, M; Gómez-Salinero, JM; Jiménez-Borreguero, LJ; Breckenridge, R; Ortiz-Sánchez, P; García-Pavía, P; Ibáñez, B and Lara-Pezzi, E (2014)
    Induction of the calcineurin variant CnAβ1 after myocardial infarction reduces post-infarction ventricular remodelling by promoting infarct vascularization.
    Cardiovascular Research 102, 396-406 PubMed abstract
  • Neary, MT; Neary, JM; Lund, GK; Garry, FB; Holt, TN; Mohun, TJ and Breckenridge, RA (2014)
    Technical note: A comparison of DNA collection methods in cattle and yaks.
    Journal of Animal Science 92, 3811-3815 PubMed abstract
  • Neary, MT; Neary, JM; Lund, GK; Holt, TN; Garry, FB; Mohun, TJ and Breckenridge, RA (2014)
    Myosin heavy chain 15 is associated with bovine pulmonary arterial pressure.
    Pulmonary Circulation 4, 496-503 PubMed abstract
  • Neary, MT; Ng, K-E; Ludtmann, MHR; Hall, AR; Piotrowska, I; Ong, S-B; Hausenloy, DJ; Mohun, TJ; Abramov, AY and Breckenridge, RA (2014)
    Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function.
    Journal of Molecular and Cellular Cardiology 74, 340-352 PubMed abstract
  • Rana, MS; Théveniau-Ruissy, M; De Bono, C; Mesbah, K; Francou, A; Rammah, M; Domínguez, JN; Roux, M; Laforest, B; Anderson, RH; Mohun, T; Zaffran, S; Christoffels, VM and Kelly, RG (2014)
    Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.
    Circulation Research 115, 790-799 PubMed abstract
  • Rochais, F; Sturny, R; Chao, C-M; Mesbah, K; Bennett, M; Mohun, TJ; Bellusci, S and Kelly, RG (2014)
    FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry.
    Cardiovascular Research 104, 432-442 PubMed abstract
  • Spicer, DE; Bridgeman, JM; Brown, NA; Mohun, TJ and Anderson, RH (2014)
    The anatomy and development of the cardiac valves.
    Cardiology in the Young 24, 1008-1022 PubMed abstract
  • Weninger, WJ; Geyer, SH; Martineau, A; Galli, A; Adams, DJ; Wilson, R and Mohun, TJ (2014)
    Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy.
    Disease Models & Mechanisms 7, 1143-1152 PubMed abstract
  • Zielonka, D; Piotrowska, I; Marcinkowski, JT and Mielcarek, M (2014)
    Skeletal muscle pathology in Huntington's disease.
    Frontiers in Physiology 5, 380 PubMed abstract
  • Adams, D; Baldock, R; Bhattacharya, S; Copp, AJ; Dickinson, M; Greene, NDE; Henkelman, M; Justice, M; Mohun, T; Murray, SA; Pauws, E; Raess, M; Rossant, J; Weaver, T and West, D (2013)
    Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening.
    Disease Models & Mechanisms 6, 571-579 PubMed abstract
  • Anderson, RH; Brown, NA; Mohun, TJ and Moorman, AFM (2013)
    Insights from cardiac development relevant to congenital defects and adult clinical anatomy.
    Journal of Cardiovascular Translational Research 6, 107-117 PubMed abstract
  • Anderson, RH; Spicer, DE; Giroud, JM and Mohun, TJ (2013)
    Tetralogy of Fallot: nosological, morphological, and morphogenetic considerations.
    Cardiology in the Young 23, 857-865 PubMed abstract
  • Bamforth, SD; Chaudhry, B; Bennett, M; Wilson, R; Mohun, TJ; Van Mierop, LHS; Henderson, DJ and Anderson, RH (2013)
    Clarification of the identity of the mammalian fifth pharyngeal arch artery.
    Clinical Anatomy 26, 173-182 PubMed abstract
  • Breckenridge, RA (2013)
    Animal models of myocardial disease.
    In: Animal Models for the Study of Human Disease. Edited by Conn, PM.
    Academic Press, 2013. 145-171.
  • Breckenridge, RA; Piotrowska, I; Ng, K-E; Ragan, TJ; West, JA; Kotecha, S; Towers, N; Bennett, M; Kienesberger, PC; Smolenski, RT; Siddall, HK; Offer, JL; Mocanu, MM; Yelon, DM; Dyck, JRB; Griffin, JL; Abramov, AY; Gould, AP and Mohun, TJ (2013)
    Hypoxic regulation of Hand1 controls the fetal-neonatal switch in cardiac metabolism.
    PLOS Biology 11, e1001666 PubMed abstract
  • Captur, G; Muthurangu, V; Cook, C; Flett, AS; Wilson, R; Barison, A; Sado, DM; Anderson, S; McKenna, WJ; Mohun, TJ; Elliott, PM and Moon, JC (2013)
    Quantification of left ventricular trabeculae using fractal analysis.
    Journal of Cardiovascular Magnetic Resonance 15, 36 PubMed abstract
  • Mohun, T; Adams, DJ; Baldock, R; Bhattacharya, S; Copp, AJ; Hemberger, M; Houart, C; Hurles, ME; Robertson, E; Smith, JC; Weaver, T and Weninger, W (2013)
    Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice.
    Disease Models & Mechanisms 6, 562-566 PubMed abstract
  • Neary, MT and Breckenridge, RA (2013)
    Hypoxia at the heart of sudden infant death syndrome?
    Pediatric Research 74, 375-379 PubMed abstract
  • Neary, MT; Mohun, TJ and Breckenridge, RA (2013)
    A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome.
    Disease Models & Mechanisms 6, 503-507 PubMed abstract
  • Norris, FC; Wong, MD; Greene, NDE; Scambler, PJ; Weaver, T; Weninger, WJ; Mohun, TJ; Henkelman, RM and Lythgoe, MF (2013)
    A coming of age: advanced imaging technologies for characterising the developing mouse.
    Trends in Genetics 29, 700-711 PubMed abstract
  • Vettukattil, JJ; Ahmed, Z; Salmon, AP; Mohun, T and Anderson, RH (2013)
    Defects in the oval fossa: morphologic variations and impact on transcatheter closure.
    Journal of the American Society of Echocardiography 26, 192-199 PubMed abstract
  • Anderson, RH; Chaudhry, B; Mohun, TJ; Bamforth, SD; Hoyland, D; Phillips, HM; Webb, S; Moorman, AFJ; Brown, NA and Henderson, DJ (2012)
    Normal and abnormal development of the intrapericardial arterial trunks in humans and mice.
    Cardiovascular Research 95, 108-115
  • Anderson, RH; Mohun, TJ and Moorman, AFM (2012)
    What is a ventricle?
    Cardiology in the Young 21, 14-22
  • Gindes, L; Matsui, H; Achiron, R; Mohun, T; Ho, SY and Gardiner, H (2012)
    Comparison of ex-vivo high-resolution episcopic microscopy with in-vivo four-dimensional high-resolution transvaginal sonography of the first-trimester fetal heart.
    Ultrasound in Obstetrics & Gynecology 39, 196-202
  • Lescroart, F; Mohun, T; Meilhac, SM; Bennett, M and Buckingham, M (2012)
    A lineage tree for the venous pole of the heart: clonal analysis clarifies controversial genealogy based on genetic tracing.
    Circulation Research 111, 1313-1322 PubMed abstract
  • Mohun, TJ and Weninger, WJ (2012)
    Embedding embryos for episcopic fluorescence image capturing (EFIC).
    Cold Spring Harbor Protocols 7, 675-677 PubMed abstract
  • Mohun, TJ and Weninger, WJ (2012)
    Embedding embryos for high-resolution episcopic microscopy (HREM).
    Cold Spring Harbor Protocols 7, 678-680 PubMed abstract
  • Mohun, TJ and Weninger, WJ (2012)
    Episcopic three-dimensional imaging of embryos.
    Cold Spring Harbor Protocols 7, 641-646 PubMed abstract
  • Mohun, TJ and Weninger, WJ (2012)
    Generation of volume data by episcopic three-dimensional imaging of embryos.
    Cold Spring Harbor Protocols 7, 681-682 PubMed abstract
  • Sizarov, A; Lamers, WH; Mohun, TJ; Brown, NA; Anderson, RH and Moorman, AFM (2012)
    Three-dimensional and molecular analysis of the arterial pole of the developing human heart.
    Journal of Anatomy 220, 336-349 PubMed abstract
  • Abu-Daya, A; Nishimoto, S; Fairclough, L; Mohun, TJ; Logan, MPO and Zimmerman, LB (2011)
    The secreted integrin ligand nephronectin is necessary for forelimb formation in Xenopus tropicalis.
    Developmental Biology 349, 204-212 PubMed abstract
  • Costa, MW; Lee, S; Furtado, MB; Xin, L; Sparrow, DB; Martinez, CG; Dunwoodie, SL; Kurtenbach, E; Mohun, T; Rosenthal, N and Harvey, RP (2011)
    Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.
    PLOS ONE 6, e24812
  • de Boer, BA; Soufan, AT; Hagoort, J; Mohun, TJ; van den Hoff, MJB; Hasman, A; Voorbraak, FPJM; Moorman, AFM and Ruijter, JM (2011)
    The interactive presentation of 3D information obtained from reconstructed datasets and 3D placement of single histological sections with the 3D portable document format.
    Development 138, 159-167 PubMed abstract
  • Love, NR; Chen, Y; Bonev, B; Gilchrist, MJ; Fairclough, L; Lea, R; Mohun, TJ; Paredes, R; Zeef, LAH and Amaya, E (2011)
    Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration.
    BMC Developmental Biology 11, 70 PubMed abstract
  • Mohun, TJ and Weninger, WJ (2011)
    Imaging heart development using high-resolution episcopic microscopy.
    Current Opinion in Genetics & Development 21, 573-578 PubMed abstract
  • Smith, SJ and Mohun, TJ (2011)
    Early cardiac morphogenesis defects caused by loss of embryonic macrophage function in Xenopus.
    Mechanisms of Development 128, 303-315 PubMed abstract
  • Breckenridge, R (2010)
    Heart failure and mouse models.
    Disease Models & Mechanisms 3, 138-143 PubMed abstract
  • Breckenridge, RA; Kelly, P; Nandi, M; Vallance, PJ; Mohun, TJ and Leiper, J (2010)
    A role for Dimethylarginine Dimethylaminohydrolase 1 (DDAH1) in mammalian development.
    International Journal of Developmental Biology 54, 215-220 PubMed abstract
  • Dunlevy, L; Bennett, M; Slender, A; Lana-Elola, E; Tybulewicz, VL; Fisher, EMC and Mohun, T (2010)
    Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse.
    Cardiovascular Research 88, 287-295 PubMed abstract
  • Hasson, P; DeLaurier, A; Bennett, M; Grigorieva, E; Naiche, LA; Papaioannou, VE; Mohun, TJ and Logan, MPO (2010)
    Tbx4 and Tbx5 acting in connective tissue are required for limb muscle and tendon patterning.
    Developmental Cell 18, 148-156 PubMed abstract
  • Matsui, H; Mohun, T and Gardiner, HM (2010)
    Three-dimensional reconstruction imaging of the human foetal heart in the first trimester.
    European Heart Journal 31, 415 PubMed abstract
  • Medioni, C; Bertrand, N; Mesbah, K; Hudry, B; Dupays, L; Wolstein, O; Washkowitz, AJ; Papaioannou, VE; Mohun, TJ; Harvey, RP and Zaffran, S (2010)
    Expression of Slit and Robo genes in the developing mouse heart.
    Developmental Dynamics 239, 3303-3311 PubMed abstract
  • Miquerol, L; Moreno-Rascon, N; Beyer, S; Dupays, L; Meilhac, SM; Buckingham, ME; Franco, D and Kelly, RG (2010)
    Biphasic development of the mammalian ventricular conduction system.
    Circulation Research 107, 153-161 PubMed abstract

[Page last updated 1 Nov 2017]