Steve Ley: Publications

  • Kannan, Y; Entwistle, LJ; Pelly, VS; Perez-Lloret, J; Walker, AW; Ley, SC and Wilson, MS (2017)
    TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.
    PLOS Pathogens 13, e1006536 PubMed abstract
  • Kannan, Y; Li, Y; Coomes, SM; Okoye, IS; Pelly, VS; Sriskantharajah, S; Gückel, E; Webb, L; Czieso, S; Nikolov, N; MacDonald, AS; Ley, SC and Wilson, MS (2017)
    Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells.
    Journal of Allergy and Clinical Immunology 139, 655-666.e657 PubMed abstract
  • Ley, SC and de Carvalho, LPS (2017)
    Protein CoAlation: a redox-linked post-translational modification.
    Biochemical Journal 474, 2897-2899 PubMed abstract
  • Howes, A; O'Sullivan, PA; Breyer, F; Ghose, A; Cao, L; Krappmann, D; Bowcock, AM and Ley, SC (2016)
    Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.
    Biochemical Journal 473, 1759-1768 PubMed abstract
  • Kannan, Y; Perez-Lloret, J; Li, Y; Entwistle, LJ; Khoury, H; Papoutsopoulou, S; Mahmood, R; Mansour, NR; Ching-Cheng Huang, S; Pearce, EJ; de Carvalho, LPS; Ley, SC and Wilson, MS (2016)
    TPL-2 regulates macrophage lipid metabolism and M2 differentiation to control TH2-mediated immunopathology.
    PLOS Pathogens 12, e1005783 PubMed abstract
  • Pattison, MJ; Mitchell, O; Flynn, HR; Chen, C-S; Yang, H-T; Ben-Addi, H; Boeing, S; Snijders, AP and Ley, SC (2016)
    TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.
    Biochemical Journal 473, 2845-2861 PubMed abstract
  • Webb, LV; Ley, SC and Seddon, B (2016)
    TNF activation of NF-κB is essential for development of single-positive thymocytes.
    Journal of Experimental Medicine 213, 1399-1407 PubMed abstract
  • Jacque, E; Schweighoffer, E; Tybulewicz, VLJ and Ley, SC (2015)
    BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
    Journal of Experimental Medicine 212, 883-892 PubMed abstract
  • Ben-Addi, A; Mambole-Dema, A; Brender, C; Martin, SR; Janzen, J; Kjaer, S; Smerdon, SJ and Ley, SC (2014)
    IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
    Proceedings of the National Academy of Sciences of the United States of America 111, E2394-E2403 PubMed abstract
  • Jacque, E; Schweighoffer, E; Visekruna, A; Papoutsopoulou, S; Janzen, J; Zillwood, R; Tarlinton, DM; Tybulewicz, VLJ and Ley, SC (2014)
    IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.
    Journal of Experimental Medicine 211, 2085-2101 PubMed abstract
  • Ley, SC and Beyaert, R (2014)
    Priming IKKβ kinase for action.
    Biochemical Journal 463, e1-2 PubMed abstract
  • Silva, A; Cornish, G; Ley, SC and Seddon, B (2014)
    NF-κB signaling mediates homeostatic maturation of new T cells.
    Proceedings of the National Academy of Sciences of the United States of America 111, E846-E855 PubMed abstract
  • Sriskantharajah, S; Gückel, E; Tsakiri, N; Kierdorf, K; Brender, C; Ben-Addi, A; Veldhoen, M; Tsichlis, PN; Stockinger, B; O'Garra, A; Prinz, M; Kollias, G and Ley, SC (2014)
    Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
    Journal of Immunology 192, 3518-3529 PubMed abstract
  • Arthur, JSC and Ley, SC (2013)
    Mitogen-activated protein kinases in innate immunity.
    Nature Reviews Immunology 13, 679-692 PubMed abstract
  • Gantke, T; Boussouf, S; Janzen, J; Morrice, NA; Howell, S; Mühlberger, E and Ley, SC (2013)
    Ebola virus VP35 induces high-level production of recombinant TPL-2—ABIN-2—NF-κB1 p105 complex in co-transfected HEK-293 cells.
    Biochemical Journal 452, 359-365 PubMed abstract
  • McNab, FW; Ewbank, J; Rajsbaum, R; Stavropoulos, E; Martirosyan, A; Redford, PS; Wu, X; Graham, CM; Saraiva, M; Tsichlis, P; Chaussabel, D; Ley, SC and O'Garra, A (2013)
    TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production.
    Journal of Immunology 191, 1732-1743 PubMed abstract
  • Gantke, T; Sriskantharajah, S; Sadowski, M and Ley, SC (2012)
    IκB kinase regulation of the TPL-2/ERK MAPK pathway.
    Immunological Reviews 246, 168-182 PubMed abstract
  • Risco, A; del Fresno, C; Mambol, A; Alsina-Beauchamp, D; MacKenzie, KF; Yang, H-T; Barber, DF; Morcelle, C; Arthur, JSC; Ley, SC; Ardavin, C and Cuenda, A (2012)
    p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation.
    Proceedings of the National Academy of Sciences of the United States of America 109, 11200-11205 PubMed abstract
  • Roget, K; Ben-Addi, A; Mambole-Dema, A; Gantke, T; Yang, H-T; Janzen, J; Morrice, N; Abbott, D and Ley, SC (2012)
    IKK2 regulates TPL-2 activation of ERK-1/2 MAP kinases by direct phosphorylation of TPL-2 serine 400.
    Molecular and Cellular Biology 32, 4684-4690 PubMed abstract
  • Yang, H-T; Papoutsopoulou, S; Belich, M; Brender, C; Janzen, J; Gantke, T; Handley, M and Ley, SC (2012)
    Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.
    Molecular and Cellular Biology 32, 3438-3451 PubMed abstract
  • Bi, Y; Zeng, N; Chanudet, E; Huang, Y; Hamoudi, RA; Liu, H; Dong, G; Watkins, AJ; Ley, SC; Zhou, L; Chen, R; Zhu, X and Du, MQ (2011)
    A20 inactivation in ocular adnexal MALT lymphoma.
    Haematologica 97, 926-930 PubMed abstract
  • Gantke, T; Sriskantharajah, S and Ley, SC (2011)
    Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase.
    Cell Research 21, 131-145 PubMed abstract
  • Gao, L; Coope, H; Grant, S; Ma, A; Ley, SC and Harhaj, EW (2011)
    ABIN1 protein cooperates with TAX1BP1 and A20 to inhibit antiviral signaling.
    Journal of Biological Chemistry 288, 36592-33660 PubMed abstract
  • Yang, H-T; Wang, Y; Zhao, X; Demissie, E; Papoutsopoulou, S; Mambole, A; O'Garra, A; Tomczak, MF; Erdman, SE; Fox, JG; Ley, SC and Horwitz, BH (2011)
    NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2—dependent ERK activation.
    Journal of Immunology 186, 1989-1996 PubMed abstract
  • Mieulet, V; Yan, L; Choisy, C; Sully, K; Procter, J; Kouroumalis, A; Krywawych, S; Pende, M; Ley, SC; Moinard, C and Lamb, RF (2010)
    TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.
    Science Signaling 3, ra61 PubMed abstract
  • Sriskantharajah, S and Ley, SC (2010)
    Turning off inflammation signaling.
    Science 327, 1093-1094 PubMed abstract
  • Verstrepen, L; Verhelst, K; van Loo, G; Carpentier, I; Ley, SC and Beyaert, R (2010)
    Expression, biological activities and mechanisms of action of A20 (TNFAIP3).
    Biochemical Pharmacology 80, 2009-2020 PubMed abstract

[Page last updated 1 Nov 2017]

Steve Ley

Steve Ley

steve.ley@crick.ac.uk
+44 (0)20 379 62207

  • Qualifications and History
  • 1987 PhD Department of Pathology, University of Cambridge
  • 1987 - 1990  Post-doctoral Fellow, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
  • 1990 - 1992 Post-doctoral Fellow, Imperial Cancer Research Fund, London, UK
  • 1992 - 2015 Group Leader, MRC National Institute for Medical Research, London, UK
  • 2015 - Group Leader, The Francis Crick Institute, London, UK