Robin Lovell-Badge: Publications

  • Cheung, L; Le Tissier, P; Goldsmith, SGJ; Treier, M; Lovell-Badge, R and Rizzoti, K (2018)
    NOTCH activity differentially affects alternative cell fate acquisition and maintenance.
    eLife 7, e33318 PubMed abstract
  • Arrizabalaga, O; Moreno-Cugnon, L; Auzmendi-Iriarte, J; Aldaz, P; de Cáceres, II; Garros-Regulez, L; Moncho-Amor, V; Torres-Bayona, S; Pernía, O; Pintado-Berninches, L; Carrasco-Ramirez, P; Cortes-Sempere, M; Rosas, R; Sanchez-Gomez, P; Ruiz, I; Caren, H; Pollard, S; Garcia, I; Sacido, A-A; Lovell-Badge, R; Belda-Iniesta, C; Sampron, N; Perona, R and Matheu, A (2017)
    High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response.
    Oncogenesis 6, 401 PubMed abstract
  • Gonen, N; Quinn, A; O'Neill, HC; Koopman, P and Lovell-Badge, R (2017)
    Normal levels of Sox9 expression in the developing mouse testis depend on the TES/TESCO enhancer, but this does not act alone.
    PLOS Genetics 13, e1006520 PubMed abstract
  • Greenfield, A; Braude, P; Flinter, F; Lovell-Badge, R; Ogilvie, C and Perry, ACF (2017)
    Assisted reproductive technologies to prevent human mitochondrial disease transmission.
    Nature Biotechnology 35, 1059-1068 PubMed abstract
  • Hurlbut, JB; Hyun, I; Levine, AD; Lovell-Badge, R; Lunshof, JE; Matthews, KRW; Mills, P; Murdoch, A; Pera, MF; Scott, CT; Tizzard, J; Warnock, M; Zernicka-Goetz, M; Zhou, Q and Zoloth, L (2017)
    Revisiting the Warnock rule.
    Nature Biotechnology 35, 1029-1042 PubMed abstract
  • Pei, D; Beier, DW; Levy-Lahad, E; Marchant, G; Rossant, J; Izpisua Belmonte, JC; Lovell-Badge, R; Jaenisch, R; Charo, A and Baltimore, D (2017)
    Human embryo editing: Opportunities and importance of transnational cooperation.
    Cell Stem Cell 21, 423-426 PubMed abstract
  • Rizzoti, K and Lovell-Badge, R (2017)
    Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis.
    Molecular and Cellular Endocrinology 445, 7-13 PubMed abstract
  • Burgoyne, PS and Arnold, AP (2016)
    A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues.
    Biology of Sex Differences 7, 68 PubMed abstract
  • Cartier-Lacave, N; Ali, R; Ylä-Herttuala, S; Kato, K; Baetschi, B; Lovell-Badge, R; Naldini, L and Thrasher, A (2016)
    Debate on Germline Gene Editing.
    Human Gene Therapy Methods 27, 135-142 PubMed abstract
  • Garros-Regulez, L; Aldaz, P; Arrizabalaga, O; Moncho-Amor, V; Carrasco-Garcia, E; Manterola, L; Moreno-Cugnon, L; Barrena, C; Villanua, J; Ruiz, I; Pollard, S; Lovell-Badge, R; Sampron, N; Garcia, I and Matheu, A (2016)
    mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance.
    Expert Opinion on Therapeutic Targets 20, 393-405 PubMed abstract
  • Goldsmith, S; Lovell-Badge, R and Rizzoti, K (2016)
    SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary.
    Development 143, 2376-2388 PubMed abstract
  • Guioli, S and Lovell-Badge, R (2016)
    RNA FISH, DNA FISH and chromosome painting of chicken oocytes.
    Methods in Molecular Biology 1457, 191-208 PubMed abstract
  • Koopman, P; Sinclair, A and Lovell-Badge, R (2016)
    Of sex and determination: marking 25 years of Randy, the sex-reversed mouse.
    Development 143, 1633-1637 PubMed abstract
  • Rizzoti, K; Pires, C and Lovell-Badge, R (2016)
    Perspective on stem cells in developmental biology, with special reference to neuroendocrine systems.
    In: Stem Cells in Neuroendocrinology. Edited by Pfaff, D and Christen, Y.
    Cham CH, 2016, The Author(s). 2016. 135-156. (Research and Perspectives in Endocrine Interactions).
  • Bosley, KS; Botchan, M; Bredenoord, AL; Carroll, D; Charo, RA; Charpentier, E; Cohen, R; Corn, J; Doudna, J; Feng, G; Greely, HT; Isasi, R; Ji, W; Kim, J-S; Knoppers, B; Lanphier, E; Li, J; Lovell-Badge, R; Martin, GS; Moreno, J; Naldini, L; Pera, M; Perry, ACF; Venter, JC; Zhang, F and Zhou, Q (2015)
    CRISPR germline engineering-the community speaks.
    Nature Biotechnology 33, 478-486 PubMed abstract
  • Carrasco-Garcia, E; Arrizabalaga, O; Serrano, M; Lovell-Badge, R and Matheu, A (2015)
    Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline.
    Aging Cell 14, 710-714 PubMed abstract
  • Chan, S; Donovan, PJ; Douglas, T; Gyngell, C; Harris, J; Lovell-Badge, R; Mathews, DJH and Regenberg, A (2015)
    Genome editing technologies and human germline genetic modification: the Hinxton Group consensus statement.
    American Journal of Bioethics 15, 42-47 PubMed abstract
  • Mathews, DJH; Lovell-Badge, R; Chan, S; Donovan, PJ; Douglas, T; Gyngell, C; Harris, J and Regenberg, A (2015)
    CRISPR: A path through the thicket.
    Nature 527, 159-161 PubMed abstract
  • Pera, MF; de Wert, G; Dondorp, W; Lovell-Badge, R; Mummery, CL; Munsie, M and Tam, PP (2015)
    What if stem cells turn into embryos in a dish?
    Nature Methods 12, 917-919 PubMed abstract
  • Rizzoti, K (2015)
    Genetic regulation of murine pituitary development.
    Journal of Molecular Endocrinology 54, R55-R73 PubMed abstract
  • Cheng, CW; Niu, B; Warren, M; Pevny, LH; Lovell-Badge, R; Hwa, T and Cheah, KSE (2014)
    Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse.
    Proceedings of the National Academy of Sciences of the United States of America 111, 2596-2601 PubMed abstract
  • Geraghty, RJ; Capes-Davis, A; Davis, JM; Downward, J; Freshney, RI; Knezevic, I; Lovell-Badge, R; Masters, JRW; Meredith, J; Stacey, GN; Thraves, P and Vias, M (2014)
    Guidelines for the use of cell lines in biomedical research.
    British Journal of Cancer 111, 1021-1046 PubMed abstract
  • Guioli, S; Nandi, S; Zhao, D; Burgess-Shannon, J; Lovell-Badge, R and Clinton, M (2014)
    Gonadal asymmetry and sex determination in birds.
    Sexual Development 8, 227-242 PubMed abstract
  • Hoffmann, SA; Hos, D; Küspert, M; Lang, RA; Lovell-Badge, R; Wegner, M and Reiprich, S (2014)
    Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.
    Development 141, 39-50 PubMed abstract
  • Kicheva, A; Bollenbach, T; Ribeiro, A; Valle, HP; Lovell-Badge, R; Episkopou, V and Briscoe, J (2014)
    Coordination of progenitor specification and growth in mouse and chick spinal cord.
    Science 345, 1254927 PubMed abstract
  • Yoshida, M; Uchikawa, M; Rizzoti, K; Lovell-Badge, R; Takemoto, T and Kondoh, H (2014)
    Regulation of mesodermal precursor production by low-level expression of B1 Sox genes in the caudal lateral epiblast.
    Mechanisms of Development 132, 59-68 PubMed abstract
  • Cheung, LYM; Rizzoti, K; Lovell-Badge, R and Le Tissier, PR (2013)
    Pituitary phenotypes of mice lacking the Notch signalling ligand Delta-like 1 homologue (Dlk1).
    Journal of Neuroendocrinology 25, 391-401 PubMed abstract
  • Gómez Gaviro, MV; Sánchez Fernández, PL; Lovell Badge, R and Fernández Avilés, F (2013)
    Looking for the niche: substance delivery into the lateral ventricle of the brain: the osmotic minipump system.
    Methods in Molecular Biology 1035, 135-140 PubMed abstract
  • Lee, B; Song, H; Rizzoti, K; Son, Y; Yoon, J; Baek, K and Jeong, Y (2013)
    Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain.
    Developmental Biology 381, 491-501 PubMed abstract
  • Mansuy-Aubert, V; Zhou, Qiong L; Xie, X; Gong, Z; Huang, J-Y; Khan, Abdul R; Aubert, G; Candelaria, K; Thomas, S; Shin, D-J; Booth, S; Baig, Shahid M; Bilal, A; Hwang, D; Zhang, H; Lovell-Badge, R; Smith, Steven R; Awan, Fazli R and Jiang, Zhen Y (2013)
    Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure.
    Cell Metabolism 17, 534-548 PubMed abstract
  • Real, FM; Sekido, R; Lupiáñez, DG; Lovell-Badge, R; Jiménez, R and Burgos, M (2013)
    A microRNA (mmu-miR-124) prevents Sox9 expression in developing mouse ovarian cells.
    Biology of Reproduction 89, 78 PubMed abstract
  • Rizzoti, K; Akiyama, H and Lovell-Badge, R (2013)
    Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand.
    Cell Stem Cell 13, 419-432 PubMed abstract
  • Sekido, R and Lovell-Badge, R (2013)
    Genetic control of testis development.
    Sexual Development 7, 21-32 PubMed abstract
  • Wang, P; Lai, W-F; Li, MJ; Xu, F; Yalamanchili, HK; Lovell-Badge, R and Wang, J (2013)
    Inference of gene-phenotype associations via protein-protein interaction and orthology.
    PLOS ONE 8, e77478 PubMed abstract
  • Bagheri-Fam, S; Sreenivasan, R; Bernard, P; Knower, KC; Sekido, R; Lovell-Badge, R; Just, W and Harley, VR (2012)
    Sox9 gene regulation and the loss of the XY/XX sex-determining mechanism in the mole vole Ellobius lutescens.
    Chromosome Research 20, 191-199 PubMed abstract
  • Castillo, SD; Matheu, A; Mariani, N; Carretero, J; López-Ríos, F; Lovell-Badge, R and Sanchez-Cespedes, M (2012)
    Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer.
    Cancer Research 72, 176-186 PubMed abstract
  • Gómez-Gaviro, M; Lovell-Badge, R; Fernández-Avilés, F and Lara-Pezzi, E (2012)
    The vascular stem cell niche.
    Journal of Cardiovascular Translational Research 5, 618-630 PubMed abstract
  • Gómez-Gaviro, MV; Scott, CE; Sesay, AK; Matheu, A; Booth, S; Galichet, C and Lovell-Badge, R (2012)
    Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis.
    Proceedings of the National Academy of Sciences of the United States of America 109, 1317-1322 PubMed abstract
  • Guioli, S; Lovell-Badge, R and Turner, JMA (2012)
    Error-prone ZW pairing and no evidence for meiotic sex chromosome inactivation in the chicken germ line.
    PLOS Genetics 8, e1002560 PubMed abstract
  • Lee, B; Rizzoti, K; Kwon, DS; Kim, S-Y; Oh, S; Epstein, DJ; Son, Y; Yoon, J; Baek, K and Jeong, Y (2012)
    Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer.
    Developmental Biology 366, 393-403 PubMed abstract
  • Lee, K; Tan, J; Morris, MB; Rizzoti, K; Hughes, J; Cheah, PS; Felquer, F; Liu, X; Piltz, S; Lovell-Badge, R and Thomas, PQ (2012)
    Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice.
    PLOS ONE 7, e29041 PubMed abstract
  • Li, H; Collado, M; Villasante, A; Matheu, A; Lynch, CJ; Canamero, M; Rizzoti, K; Carneiro, C; Martinez, G; Vidal, A; Lovell-Badge, R and Serrano, M (2012)
    p27Kip1 directly represses Sox2 during embryonic stem cell differentiation.
    Cell Stem Cell 11, 845-852 PubMed abstract
  • Ludbrook, LM; Bernard, P; Bagheri-Fam, S; Ryan, J; Sekido, R; Wilhelm, D; Lovell-Badge, R and Harley, VR (2012)
    Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9).
    Endocrinology 153, 1948-1958 PubMed abstract
  • Matheu, A; Collado, M; Wise, C; Manterola, L; Cekaite, L; Tye, AJ; Canamero, M; Bujanda, L; Schedl, A; Cheah, KSE; Skotheim, RI; Lothe, RA; López de Munain, A; Briscoe, J; Serrano, M and Lovell-Badge, R (2012)
    Oncogenicity of the developmental transcription factor Sox9.
    Cancer Research 72, 1301-1315 PubMed abstract
  • Mollard, P; Hodson, DJ; Lafont, C; Rizzoti, K and Drouin, J (2012)
    A tridimensional view of pituitary development and function.
    Trends in Endocrinology and Metabolism 23, 261-269 PubMed abstract
  • Zhao, L; Zevallos, SE; Rizzoti, K; Jeong, Y; Lovell-Badge, R and Epstein, DJ (2012)
    Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia.
    Developmental Cell 22, 585-596 PubMed abstract
  • Acloque, H; Ocana, OH; Matheu, A; Rizzoti, K; Wise, C; Lovell-Badge, R and Nieto, MA (2011)
    Reciprocal repression between Sox3 and Snail transcription factors defines embryonic territories at gastrulation.
    Developmental Cell 21, 546-558 PubMed abstract
  • Jakob, S and Lovell-Badge, R (2011)
    Sex determination and the control of Sox9 expression in mammals.
    FEBS Journal 278, 1002-1009 PubMed abstract
  • Knower, KC; Kelly, S; Ludbrook, LM; Bagheri-Fam, S; Sim, H; Bernard, P; Sekido, R; Lovell-Badge, R and Harley, VR (2011)
    Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations.
    PLOS ONE 6, e17751 PubMed abstract
  • Remboutsika, E; Elkouris, M; Iulianella, A; Andoniadou, CL; Poulou, M; Mitsiadis, TA; Trainor, PA and Lovell-Badge, R (2011)
    Flexibility of neural stem cells.
    Frontiers in Physiology 2, Article 16 PubMed abstract
  • Rizzoti, K and Lovell-Badge, R (2011)
    Regenerative medicine: organ recital in a dish.
    Nature 480, 44-46 PubMed abstract
  • Sutton, E; Hughes, J; White, S; Sekido, R; Tan, J; Arboleda, V; Rogers, N; Knower, K; Rowley, L; Eyre, H; Rizzoti, K; McAninch, D; Goncalves, J; Slee, J; Turbitt, E; Bruno, D; Bengtsson, H; Harley, V; Vilain, E; Sinclair, A; Lovell-Badge, R and Thomas, P (2011)
    Identification of SOX3 as an XX male sex reversal gene in mice and humans.
    Journal of Clinical Investigation 121, 328-341 PubMed abstract
  • Takemoto, T; Uchikawa, M; Yoshida, M; Bell, DM; Lovell-Badge, R; Papaioannou, VE and Kondoh, H (2011)
    Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells.
    Nature 470, 394-396 PubMed abstract
  • Caulfield, T; Scott, C; Hyun, I; Lovell-Badge, R; Kato, K and Zarzeczny, A (2010)
    Stem cell research policy and iPS cells.
    Nature Methods 7, 28-33 PubMed abstract
  • Galichet, C; Lovell-Badge, R and Rizzoti, K (2010)
    Nestin-Cre mice are affected by hypopituitarism, which is not due to significant activity of the transgene in the pituitary gland.
    PLOS ONE 5, e11443 PubMed abstract
  • Lovell-Badge, R (2010)
    The early history of the Sox genes.
    International Journal of Biochemistry and Cell Biology 42, 378-380 PubMed abstract
  • Poulou, M; Bell, D; Bozonelos, K; Alexiou, M; Gavalas, A; Lovell-Badge, R and Remboutsika, E (2010)
    Development of a chromosomally integrated metabolite-inducible Leu3p-α-IPM "Off-_n" gene switch.
    PLOS ONE 5, e12488 PubMed abstract
  • Rizzoti, K (2010)
    Adult pituitary progenitors/stem cells: from in vitro characterization to in vivo function.
    European Journal of Neuroscience 32, 2053-2062 PubMed abstract
  • Scott, CE; Wynn, SL; Sesay, A; Cruz, C; Cheung, M; Gaviro, M-VG; Booth, S; Gao, B; Cheah, KSE; Lovell-Badge, R and Briscoe, J (2010)
    SOX9 induces and maintains neural stem cells.
    Nature Neuroscience 13, 1181-1189 PubMed abstract
  • Sekido, R (2010)
    SRY: A transcriptional activator of mammalian testis determination.
    International Journal of Biochemistry and Cell Biology 42, 417-420 PubMed abstract

[Page last updated 1 Jun 2018]

Robin Lovell-Badge
+44 (0)20 379 61509

  • Qualifications and history
  • 1978: PhD in Embryology, University College, London, UK.
  • 1978: Postdoctoral fellow, Genetics Department, University of Cambridge, UK
  • 1981: EMBO Long Term Fellowship, Institute Jacques Monod, Paris, France.
  • 1982: Group leader, MRC Mammalian Development Unit, University College, London, UK.
  • 1988: Group leader (and Head of Division since 1993), Medical Research Council National Institute for Medical Research, London, UK.
  • 2015 Group Leader, the Francis Crick Institute, London, UK