Jean Langhorne: Publications

  • Brugat, T; Reid, AJ; Lin, J-w; Cunningham, D; Tumwine, I; Kushinga, G; McLaughlin, S; Spence, P; Böhme, U; Sanders, M; Conteh, S; Bushell, E; Metcalf, T; Billker, O; Duffy, PE; Newbold, C; Berriman, M and Langhorne, J (2017)
    Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection.
    Nature Microbiology 2, 16276 PubMed abstract
  • Cunningham, DA; Lin, J-w; Brugat, T; Jarra, W; Tumwine, I; Kushinga, G; Ramesar, J; Franke-Fayard, B and Langhorne, J (2017)
    ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model.
    Malaria Journal 16, 185 PubMed abstract
  • Hobbs, CV; Anderson, C; Neal, J; Sahu, T; Conteh, S; Voza, T; Langhorne, J; Borkowsky, W and Duffy, PE (2017)
    Trimethoprim-sulfamethoxazole prophylaxis during live malaria sporozoite immunization induces long-lived, homologous, and heterologous protective immunity against sporozoite challenge.
    Journal of Infectious Diseases 215, 122-130 PubMed abstract
  • Lin, J-W; Sodenkamp, J; Cunningham, D; Deroost, K; Tshitenge, TC; McLaughlin, S; Lamb, TJ; Spencer-Dene, B; Hosking, C; Ramesar, J; Janse, CJ; Graham, C; O'Garra, A and Langhorne, J (2017)
    Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria.
    Scientific Reports 7, 41722 PubMed abstract
  • Moreira-Teixeira, L; Redford, PS; Stavropoulos, E; Ghilardi, N; Maynard, CL; Weaver, CT; Freitas do Rosário, AP; Wu, X; Langhorne, J and O'Garra, A (2017)
    T cell-derived IL-10 impairs host resistance to Mycobacterium tuberculosis infection.
    Journal of Immunology 199, 613-623 PubMed abstract
  • Pérez-Mazliah, D; Nguyen, MP; Hosking, C; McLaughlin, S; Lewis, MD; Tumwine, I; Levy, P and Langhorne, J (2017)
    Follicular helper T cells are essential for the elimination of Plasmodium infection.
    EBioMedicine [Epub ahead of print] PubMed abstract
  • Brugat, T (2016)
    CD36: Russian roulette of host and parasites during malaria infection.
    Journal of Leukocyte Biology 99, 643-645 PubMed abstract
  • Capuccini, B; Lin, J; Talavera-López, C; Khan, SM; Sodenkamp, J; Spaccapelo, R and Langhorne, J (2016)
    Transcriptomic profiling of microglia reveals signatures of cell activation and immune response, during experimental cerebral malaria.
    Scientific Reports 6, 39258 PubMed abstract
  • Langhorne, J and Duffy, P (2016)
    Malaria is down; vaccines might knock it out.
    Cell 167, 597
  • Langhorne, J and Duffy, PE (2016)
    Expanding the antimalarial toolkit: Targeting host-parasite interactions.
    Journal of Experimental Medicine 213, 143-153 PubMed abstract
  • Sharma, A; Conteh, S; Langhorne, J and Duffy, PE (2016)
    Heterologous infection of pregnant mice induces low birth weight and modifies offspring susceptibility to malaria.
    PLOS ONE 11, e0160120 PubMed abstract
  • Yam, XY; Brugat, T; Siau, A; Lawton, J; Wong, DS; Farah, A; Twang, JS; Gao, X; Langhorne, J and Preiser, PR (2016)
    Characterization of the Plasmodium Interspersed Repeats (PIR) proteins of Plasmodium chabaudi indicates functional diversity.
    Scientific Reports 6, 23449 PubMed abstract
  • Borges da Silva, H; Fonseca, R; Cassado, ADA; Machado de Salles, É; de Menezes, MN; Langhorne, J; Perez, KR; Cuccovia, IM; Ryffel, B; Barreto, VM; Marinho, CRF; Boscardin, SB; Álvarez, JM; D'Império-Lima, MR and Tadokoro, CE (2015)
    In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria.
    PLOS Pathogens 11, e1004598 PubMed abstract
  • Coomes, SM; Pelly, VS; Kannan, Y; Okoye, IS; Czieso, S; Entwistle, LJ; Perez-Lloret, J; Nikolov, N; Potocnik, AJ; Biró, J; Langhorne, J and Wilson, MS (2015)
    IFNγ and IL-12 restrict Th2 responses during helminth/Plasmodium co-infection and promote IFNγ from Th2 cells.
    PLOS Pathogens 11, e1004994 PubMed abstract
  • Lin, J-w; Spaccapelo, R; Schwarzer, E; Sajid, M; Annoura, T; Deroost, K; Ravelli, RBG; Aime, E; Capuccini, B; Mommaas-Kienhuis, AM; O'Toole, T; Prins, F; Franke-Fayard, BMD; Ramesar, J; Chevalley-Maurel, S; Kroeze, H; Koster, AJ; Tanke, HJ; Crisanti, A; Langhorne, J; Arese, P; Van den Steen, PE; Janse, CJ and Khan, SM (2015)
    Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance.
    Journal of Experimental Medicine 212, 893-903 PubMed abstract
  • Nahrendorf, W; Scholzen, A; Sauerwein, RW and Langhorne, J (2015)
    Cross-stage immunity for malaria vaccine development.
    Vaccine 33, 7513-7517 PubMed abstract
  • Nahrendorf, W; Spence, PJ; Tumwine, I; Lévy, P; Jarra, W; Sauerwein, RW and Langhorne, J (2015)
    Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization.
    eLife 4, e05165 PubMed abstract
  • Pérez-Mazliah, D; Ng, DHL; Freitas do Rosário, AP; McLaughlin, S; Mastelic-Gavillet, B; Sodenkamp, J; Kushinga, G and Langhorne, J (2015)
    Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria.
    PLOS Pathogens 11, e1004715 PubMed abstract
  • Spence, PJ; Brugat, T and Langhorne, J (2015)
    Mosquitoes reset malaria parasites.
    PLOS Pathogens 11, e1004987 PubMed abstract
  • Brugat, T; Cunningham, D; Sodenkamp, J; Coomes, S; Wilson, M; Spence, PJ; Jarra, W; Thompson, J; Scudamore, C and Langhorne, J (2014)
    Sequestration and histopathology in Plasmodium chabaudi malaria are influenced by the immune response in an organ-specific manner.
    Cellular Microbiology 16, 687-700 PubMed abstract
  • Nahrendorf, W; Scholzen, A; Bijker, EM; Teirlinck, AC; Bastiaens, GJH; Schats, R; Hermsen, CC; Visser, LG; Langhorne, J and Sauerwein, RW (2014)
    Memory B-cell and antibody responses induced by Plasmodium falciparum sporozoite immunization.
    Journal of Infectious Diseases 210, 1981-1990 PubMed abstract
  • Ng, DHL; Skehel, JJ; Kassiotis, G and Langhorne, J (2014)
    Recovery of an antiviral antibody response following attrition caused by unrelated infection.
    PLOS Pathogens 10, e1003843 PubMed abstract
  • Okoye, IS; Czieso, S; Ktistaki, E; Roderick, K; Coomes, SM; Pelly, VS; Kannan, Y; Perez-Lloret, J; Zhao, JL; Baltimore, D; Langhorne, J and Wilson, MS (2014)
    Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.
    Proceedings of the National Academy of Sciences of the United States of America 111, E3081-E3090 PubMed abstract
  • Otto, TD; Böhme, U; Jackson, AP; Hunt, M; Franke-Fayard, B; Hoeijmakers, WAM; Religa, AA; Robertson, L; Sanders, M; Ogun, SA; Cunningham, D; Erhart, A; Billker, O; Khan, SM; Stunnenberg, HG; Langhorne, J; Holder, AA; Waters, AP; Newbold, CI; Pain, A; Berriman, M and Janse, CJ (2014)
    A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
    BMC Biology 12, 86 PubMed abstract
  • Perez-Mazliah, D and Langhorne, J (2014)
    CD4 T-cell subsets in malaria: TH1/TH2 revisited.
    Frontiers in Immunology 5, 671 PubMed abstract
  • Scholzen, A; Nahrendorf, W; Langhorne, J and Sauerwein, RW (2014)
    Expansion of IgG+ B-cells during mitogen stimulation for memory B-cell ELISpot analysis is influenced by size and composition of the B-cell pool.
    PLOS ONE 9, e102885 PubMed abstract
  • Belyaev, NN; Biró, J; Langhorne, J and Potocnik, AJ (2013)
    Extramedullary myelopoiesis in malaria depends on mobilization of myeloid-restricted progenitors by IFN-γ induced chemokines.
    PLOS Pathogens 9, e1003406 PubMed abstract
  • Bijker, EM; Bastiaens, GJH; Teirlinck, AC; van Gemert, G-J; Graumans, W; van de Vegte-Bolmer, M; Siebelink-Stoter, R; Arens, T; Teelen, K; Nahrendorf, W; Remarque, EJ; Roeffen, W; Jansens, A; Zimmerman, D; Vos, M; van Schaijk, BCL; Wiersma, J; van der Ven, AJAM; de Mast, Q; van Lieshout, L; Verweij, JJ; Hermsen, CC; Scholzen, A and Sauerwein, RW (2013)
    Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.
    Proceedings of the National Academy of Sciences of the United States of America 110, 7862-7867 PubMed abstract
  • Illingworth, J; Butler, NS; Roetynck, S; Mwacharo, J; Pierce, SK; Bejon, P; Crompton, PD; Marsh, K and Ndungu, FM (2013)
    Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion.
    Journal of Immunology 190, 1038-1047 PubMed abstract
  • Roetynck, S; Olotu, A; Simam, J; Marsh, K; Stockinger, B; Urban, B and Langhorne, J (2013)
    Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure.
    PLOS ONE 8, e55195 PubMed abstract
  • Spence, PJ; Jarra, W; Levy, P; Reid, AJ; Chappell, L; Brugat, T; Sanders, M; Berriman, M and Langhorne, J (2013)
    Vector transmission regulates immune control of Plasmodium virulence.
    Nature 498, 228-231 PubMed abstract
  • Craig, AG; Grau, GE; Janse, C; Kazura, JW; Milner, D; Barnwell, JW; Turner, G and Langhorne, J (2012)
    The role of animal models for research on severe malaria.
    PLOS Pathogens 8, e1002401 PubMed abstract
  • Freitas do Rosário, AP; Lamb, T; Spence, P; Stephens, R; Lang, A; Roers, A; Muller, W; O'Garra, A and Langhorne, J (2012)
    IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.
    Journal of Immunology 188, 1178-1190 PubMed abstract
  • Freitas do Rosario, AP and Langhorne, J (2012)
    T cell-derived IL-10 and its impact on the regulation of host responses during malaria.
    International Journal for Parasitology 42, 549-555 PubMed abstract
  • Lawton, J; Brugat, T; Yam, XY; Reid, A; Boehme, U; Otto, T; Pain, A; Jackson, A; Berriman, M; Cunningham, D; Preiser, P and Langhorne, J (2012)
    Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS).
    BMC Genomics 13, 125 PubMed abstract
  • Mastelic, B; Freitas do Rosario, AP; Veldhoen, M; Renauld, J-C; Jarra, W; Sponaas, A-M; Roetynck, S; Stockinger, B and Langhorne, J (2012)
    IL-22 protects against liver pathology and lethality of an experimental blood-stage malaria infection.
    Frontiers in Immunology 3, 00085 PubMed abstract
  • Spence, PJ; Jarra, W; Levy, P; Nahrendorf, W and Langhorne, J (2012)
    Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi.
    Malaria Journal 11, 407 PubMed abstract
  • Spence, PJ and Langhorne, J (2012)
    T cell control of malaria pathogenesis.
    Current Opinion in Immunology 24, 444-448 PubMed abstract
  • Sponaas, A-M; Belyaev, N; Falck-Hansen, M; Potocnik, A and Langhorne, J (2012)
    Transient deficiency of dendritic cells results in lack of a Merozoite Surface Protein 1-specific CD4 T cell response during peak Plasmodium chabaudi blood-stage infection.
    Infection and Immunity 80, 4248-4256 PubMed abstract
  • Adler, G; Steeg, C; Pfeffer, K; Murphy, TL; Murphy, KM; Langhorne, J and Jacobs, T (2011)
    B and T lymphocyte attenuator restricts the protective immune response against experimental malaria.
    Journal of Immunology 187, 5310-5319 PubMed abstract
  • del Portillo, HA; Ferrer, M; Brugat, T; Martin-Jaular, L; Langhorne, J and Lacerda, MVG (2011)
    The role of the spleen in malaria.
    Cellular Microbiology 14, 343-355 PubMed abstract
  • Langhorne, J; Buffet, P; Galinski, M; Good, M; Harty, J; Leroy, D; Mota, MM; Pasini, E; Renia, L; Riley, E; Stins, M and Duffy, P (2011)
    The relevance of non-human primate and rodent malaria models for humans.
    Malaria Journal 10, 1-4 PubMed abstract
  • Nduati, E; Gwela, A; Karanja, H; Mugyenyi, C; Langhorne, J; Marsh, K and Urban, BC (2011)
    The plasma concentration of the B cell activating factor is increased in children with acute malaria.
    Journal of Infectious Diseases 204, 962-970
  • Spence, PJ; Cunningham, D; Jarra, W; Lawton, J; Langhorne, J and Thompson, J (2011)
    Transformation of the rodent malaria parasite Plasmodium chabaudi.
    Nature Protocols 6, 553-561 PubMed abstract
  • Stephens, R; Seddon, B and Langhorne, J (2011)
    Homeostatic proliferation and IL-7R alpha expression do not correlate with enhanced T cell proliferation and protection in chronic mouse malaria.
    PLOS ONE 6, e26686 PubMed abstract
  • Tulone, C; Sponaas, AM; Raiber, EA; Tabor, AB; Langhorne, J and Chain, BM (2011)
    Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.
    PLOS ONE 6, e24886 PubMed abstract
  • Belyaev, NN; Brown, DE; Diaz, AIG; Rae, A; Jarra, W; Thompson, J; Langhorne, J and Potocnik, AJ (2010)
    Induction of an IL7-R+c-Kithi myelolymphoid progenitor critically dependent on IFN-γ signaling during acute malaria.
    Nature Immunology 11, 477-485 PubMed abstract
  • Cunningham, D; Lawton, J; Jarra, W; Preiser, P and Langhorne, J (2010)
    The pir multigene family of Plasmodium: Antigenic variation and beyond.
    Molecular and Biochemical Parasitology 170, 65-73 PubMed abstract
  • Fairlie-Clarke, KJ; Lamb, TJ; Langhorne, J; Graham, AL and Allen, JE (2010)
    Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity.
    BMC Immunology 11, 6 PubMed abstract
  • Freitas do Rosario, AP; Langhorne, J; Duffy, PE and Finney, OC (2010)
    Recent advances in malaria research: new tools to understand an old enemy.
    Expert Review of Anti-infective Therapy 8, 863-866 PubMed abstract
  • Nduati, EW; Ng, DHL; Ndungu, FM; Gardner, P; Urban, BC and Langhorne, J (2010)
    Distinct kinetics of memory B-cell and plasma-cell responses in peripheral blood following a blood-stage Plasmodium chabaudi infection in mice.
    PLOS ONE 5, e15007 PubMed abstract
  • Raiber, EA; Tulone, C; Zhang, Y; Martinez-Pomares, L; Steed, E; Sponaas, A; Langhorne, J; Noursadeghi, M; Chain, B and Tabor, AB (2010)
    Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors.
    ACS Chemical Biology 5, 461-476 PubMed abstract
  • Riley, EM; Couper, KN; Helmby, H; Hafalla, JCR; de Souza, JB; Langhorne, J; Jarra, W and Zavala, F (2010)
    Neuropathogenesis of human and murine malaria.
    Trends in Parasitology 26, 277-278 PubMed abstract
  • Stephens, R and Langhorne, J (2010)
    Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria.
    PLOS Pathogens 6, e1001208 PubMed abstract
  • Voisine, C; Mastelic, B; Sponaas, A-M and Langhorne, J (2010)
    Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T cell responses to Plasmodium chabaudi malaria.
    International Journal for Parasitology 40, 711-719 PubMed abstract

[Page last updated 1 Nov 2017]

Jean Langhorne

jean.langhorne@crick.ac.uk
+44 (0)20 379 61498

  • Qualifications and history
  • 1979 PhD, MRC clinical Research Centre and University College, London, UK
  • 1979 Member of Staff, Basel for Immunology, Basel, Switzerland
  • 1981 Fogarty Fellow, NIAID, NIH, USA
  • 1984 Group leader, Max Planck Institute for Immunobiology, Germany
  • 1995 Lecturer/Reader in Immunobiology, Imperial College London, UK
  • 1998 Group Leader Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, The Francis Crick Institute, London, UK