Anne O’Garra: Publications

  • Lin, J-W; Sodenkamp, J; Cunningham, D; Deroost, K; Tshitenge, TC; McLaughlin, S; Lamb, TJ; Spencer-Dene, B; Hosking, C; Ramesar, J; Janse, CJ; Graham, C; O'Garra, A and Langhorne, J (2017)
    Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria.
    Scientific Reports 7, 41722 PubMed abstract
  • Moreira-Teixeira, L; Redford, PS; Stavropoulos, E; Ghilardi, N; Maynard, CL; Weaver, CT; Freitas do Rosário, AP; Wu, X; Langhorne, J and O'Garra, A (2017)
    T cell-derived IL-10 impairs host resistance to Mycobacterium tuberculosis infection.
    Journal of Immunology 199, 613-623 PubMed abstract
  • Blankley, S; Graham, CM; Levin, J; Turner, J; Berry, MPR; Bloom, CI; Xu, Z; Pascual, V; Banchereau, J; Chaussabel, D; Breen, R; Santis, G; Blankenship, DM; Lipman, M and O'Garra, A (2016)
    A 380-gene meta-signature of active tuberculosis compared with healthy controls.
    European Respiratory Journal 47, 1873-1876 PubMed abstract
  • Blankley, S; Graham, CM; Turner, J; Berry, MPR; Bloom, CI; Xu, Z; Pascual, V; Banchereau, J; Chaussabel, D; Breen, R; Santis, G; Blankenship, DM; Lipman, M and O'Garra, A (2016)
    The transcriptional signature of active tuberculosis reflects symptom status in extra-pulmonary and pulmonary tuberculosis.
    PLOS ONE 11, e0162220 PubMed abstract
  • Esmail, H; Lai, RP; Lesosky, M; Wilkinson, KA; Graham, CM; Coussens, AK; Oni, T; Warwick, JM; Said-Hartley, Q; Koegelenberg, CF; Walzl, G; Flynn, JL; Young, DB; Barry III, CE; O'Garra, A and Wilkinson, RJ (2016)
    Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-ᴅ glucose positron emission and computed tomography.
    Nature Medicine 22, 1090-1093 PubMed abstract
  • Howes, A; Taubert, C; Blankley, S; Spink, N; Wu, X; Graham, CM; Zhao, J; Saraiva, M; Ricciardi-Castagnoli, P; Bancroft, GJ and O'Garra, A (2016)
    Differential production of type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages.
    Journal of Immunology 197, 2838-2853 PubMed abstract
  • Marais, S; Lai, RPJ; Wilkinson, KA; Meintjes, G; O'Garra, A and Wilkinson, RJ (2016)
    Inflammasome activation underlies central nervous system deterioration in HIV-associated tuberculosis.
    Journal of Infectious Diseases 215, 677-686 PubMed abstract
  • Moreira-Teixeira, L; Sousa, J; McNab, FW; Torrado, E; Cardoso, F; Machado, H; Castro, F; Cardoso, V; Gaifem, J; Wu, X; Appelberg, R; Castro, AG; O'Garra, A and Saraiva, M (2016)
    Type I IFN inhibits alternative macrophage activation during Mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-γ signaling.
    Journal of Immunology 197, 4714-4726 PubMed abstract
  • O'Garra, A and Gabryšová, L (2016)
    Transcription factors directing Th2 differentiation: Gata-3 plays a dominant role.
    Journal of Immunology 196, 4423-4425 PubMed abstract
  • Pitt, JM; Blankley, S; Potempa, K; Graham, CM; Moreira-Teixeira, L; McNab, FW; Howes, A; Stavropoulos, E; Pascual, V; Banchereau, J; Chaussabel, D and O'Garra, A (2016)
    Analysis of transcriptional signatures in response to Listeria monocytogenes infection reveals temporal changes that result from type I interferon signaling.
    PLOS ONE 11, e0150251 PubMed abstract
  • Cliff, JM; Kaufmann, SHE; McShane, H; van Helden, P and O'Garra, A (2015)
    The human immune response to tuberculosis and its treatment: a view from the blood.
    Immunological Reviews 264, 88-102 PubMed abstract
  • Conejero, L; Potempa, K; Graham, CM; Spink, N; Blankley, S; Salguero, FJ; Pankla-Sranujit, R; Khaenam, P; Banchereau, JF; Pascual, V; Chaussabel, D; Lertmemongkolchai, G; O'Garra, A and Bancroft, GJ (2015)
    The blood transcriptome of experimental melioidosis reflects disease severity and shows considerable similarity with the human disease.
    Journal of Immunology 195, 3248-3261 PubMed abstract
  • Lai, RPJ; Meintjes, G; Wilkinson, KA; Graham, CM; Marais, S; Van der Plas, H; Deffur, A; Schutz, C; Bloom, C; Munagala, I; Anguiano, E; Goliath, R; Maartens, G; Banchereau, J; Chaussabel, D; O'Garra, A and Wilkinson, RJ (2015)
    HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling.
    Nature Communications 6, 8451 PubMed abstract
  • McNab, F; Mayer-Barber, K; Sher, A; Wack, A and O'Garra, A (2015)
    Type I interferons in infectious disease.
    Nature Reviews Immunology 15, 87-103 PubMed abstract
  • Blankley, S; Berry, MPR; Graham, CM; Bloom, CI; Lipman, M and O'Garra, A (2014)
    The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis.
    Philosophical Transactions of the Royal Society B: Biological Sciences 369, 20130427 PubMed abstract
  • Blankley, S; Graham, CM; Howes, A; Bloom, CI; Berry, MPR; Chaussabel, D; Pascual, V; Banchereau, J; Lipman, M and O'Garra, A (2014)
    Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro.
    PLOS ONE 9, e97702 PubMed abstract
  • Dye, C and O'Garra, A (2014)
    The science of infectious diseases.
    Philosophical Transactions of the Royal Society B: Biological Sciences 369, 20140055 PubMed abstract
  • Gabryšová, L; Howes, A; Saraiva, M and O'Garra, A (2014)
    The regulation of IL-10 expression.
    Current Topics in Microbiology and Immunology 380, 157-190 PubMed abstract
  • McNab, FW; Ewbank, J; Howes, A; Moreira-Teixeira, L; Martirosyan, A; Ghilardi, N; Saraiva, M and O'Garra, A (2014)
    Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.
    Journal of Immunology 193, 3600-3612 PubMed abstract
  • Redford, PS; Mayer-Barber, KD; McNab, FW; Stavropoulos, E; Wack, A; Sher, A and O'Garra, A (2014)
    Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway.
    Journal of Infectious Diseases 209, 270-274 PubMed abstract
  • Sriskantharajah, S; Gückel, E; Tsakiri, N; Kierdorf, K; Brender, C; Ben-Addi, A; Veldhoen, M; Tsichlis, PN; Stockinger, B; O'Garra, A; Prinz, M; Kollias, G and Ley, SC (2014)
    Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
    Journal of Immunology 192, 3518-3529 PubMed abstract
  • Teixeira-Coelho, M; Guedes, J; Ferreirinha, P; Howes, A; Pedrosa, J; Rodrigues, F; Lai, WS; Blackshear, PJ; O'Garra, A; Castro, AG and Saraiva, M (2014)
    Differential post- transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages.
    European Journal of Immunology 44, 856-866 PubMed abstract
  • Berry, MPR; Blankley, S; Graham, CM; Bloom, CI and O'Garra, A (2013)
    Systems approaches to studying the immune response in tuberculosis.
    Current Opinion in Immunology 25, 579-587 PubMed abstract
  • Bloom, CI; Graham, CM; Berry, MPR; Rozakeas, F; Redford, PS; Wang, Y; Xu, Z; Wilkinson, KA; Wilkinson, RJ; Kendrick, Y; Devouassoux, G; Ferry, T; Miyara, M; Bouvry, D; Valeyre, D; Gorochov, G; Blankenship, D; Saadatian, M; Vanhems, P; Beynon, H; Vancheeswaran, R; Wickremasinghe, M; Chaussabel, D; Banchereau, J; Pascual, V; Ho, L-P; Lipman, M and O'Garra, A (2013)
    Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers.
    PLOS ONE 8, e70630 PubMed abstract
  • McNab, FW; Ewbank, J; Rajsbaum, R; Stavropoulos, E; Martirosyan, A; Redford, PS; Wu, X; Graham, CM; Saraiva, M; Tsichlis, P; Chaussabel, D; Ley, SC and O'Garra, A (2013)
    TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production.
    Journal of Immunology 191, 1732-1743 PubMed abstract
  • O'Garra, A (2013)
    Brigitte Askonas (1923-2013).
    Nature 494, 37 PubMed abstract
  • O'Garra, A (2013)
    Driving change in tuberculosis research: an interview with Anne O'Garra.
    Disease Models & Mechanisms 6, 6-8 PubMed abstract
  • O'Garra, A (2013)
    Systems approach to understand the immune response in tuberculosis: an iterative process between mouse models and human disease.
    Cold Spring Harbor Symposia on Quantitative Biology 78, 173-177 PubMed abstract
  • O'Garra, A; Redford, PS; McNab, FW; Bloom, CI; Wilkinson, RJ and Berry, MPR (2013)
    The immune response in tuberculosis.
    Annual Review of Immunology 31, 475-527 PubMed abstract
  • Pitt, JM; Blankley, S; McShane, H and O'Garra, A (2013)
    Vaccination against tuberculosis: how can we better BCG?
    Microbial Pathogenesis 58, 2-16 PubMed abstract
  • Banchereau, J; Pascual, V and O'Garra, A (2012)
    From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines.
    Nature Immunology 13, 925-931 PubMed abstract
  • Bloom, CI; Graham, CM; Berry, MPR; Wilkinson, KA; Oni, T; Rozakeas, F; Xu, Z; Rossello-Urgell, J; Chaussabel, D; Banchereau, J; Pascual, V; Lipman, M; Wilkinson, RJ and O'Garra, A (2012)
    Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy.
    PLOS ONE 7, e46191 PubMed abstract
  • Freitas do Rosário, AP; Lamb, T; Spence, P; Stephens, R; Lang, A; Roers, A; Muller, W; O'Garra, A and Langhorne, J (2012)
    IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection.
    Journal of Immunology 188, 1178-1190 PubMed abstract
  • Li, D; Romain, G; Flamar, A-L; Duluc, D; Dullaers, M; Li, X-H; Zurawski, S; Bosquet, N; Palucka, AK; Le Grand, R; O'Garra, A; Zurawski, G; Banchereau, J and Oh, S (2012)
    Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells.
    Journal of Experimental Medicine 209, 109-121
  • Loebbermann, J; Schnoeller, C; Thornton, H; Durant, L; Sweeney, NP; Schuijs, M; O'Garra, A; Johansson, C and Openshaw, PJ (2012)
    IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice.
    PLOS ONE 7, e32371 PubMed abstract
  • Lowe, DM; Redford, PS; Wilkinson, RJ; O'Garra, A and Martineau, AR (2012)
    Neutrophils in tuberculosis: friend or foe?
    Trends in Immunology 33, 14-25 PubMed abstract
  • O'Garra, A (2012)
    Regulation of the immune response to pathogens - Part 1 of 2.
    In: Cytokines: Intercellular mediators regulating host defense. Edited by Oppenheim, JJ.
    The Biomedical & Life Sciences Collection. Henry Stewart Talks Ltd, London.Online talk
  • O'Garra, A (2012)
    Regulation of the immune response to pathogens - Part 2 of 2.
    In: Cytokines: Intercellular mediators regulating host defense. Edited by Oppenheim, JJ.
    The Biomedical & Life Sciences Collection. Henry Stewart Talks Ltd, London.Online talk
  • O'Garra, A and Pamer, E (2012)
    Host pathogens.
    Current Opinion in Immunology 24, 361-363 PubMed abstract
  • Pitt, JM; Stavropoulos, E; Redford, PS; Beebe, AM; Bancroft, GJ; Young, DB and O'Garra, A (2012)
    Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.
    Journal of Immunology 189, 4079-4087 PubMed abstract
  • Tattermusch, S; Skinner, JA; Chaussabel, D; Banchereau, J; Berry, MP; McNab, FW; O'Garra, A; Taylor, GP and Bangham, CRM (2012)
    Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy.
    PLOS Pathogens 8, e1002480 PubMed abstract
  • Urry, Z; Chambers, ES; Xystrakis, E; Dimeloe, S; Richards, DF; Gabryšová, L; Christensen, J; Gupta, A; Saglani, S; Bush, A; O'Garra, A; Brown, Z and Hawrylowicz, CM (2012)
    The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL-10+ CD4+T cells.
    European Journal of Immunology 42, 2697-2708 PubMed abstract
  • Gabryšová, L; Christensen, JR; Wu, X; Kissenpfennig, A; Malissen, B and O'Garra, A (2011)
    Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells.
    European Journal of Immunology 41, 1242-1248 PubMed abstract
  • McNab, FW; Berry, MPR; Graham, CM; Bloch, SAA; Oni, T; Wilkinson, KA; Wilkinson, RJ; Kon, OM; Banchereau, J; Chaussabel, D and O'Garra, A (2011)
    Programmed Death Ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis.
    European Journal of Immunology 41, 1941-1947 PubMed abstract
  • McNab, FW; Rajsbaum, R; Stoye, JP and O'Garra, A (2011)
    Tripartite-motif proteins and innate immune regulation.
    Current Opinion in Immunology 23, 46-56 PubMed abstract
  • Medzhitov, R; Shevach, EM; Trinchieri, G; Mellor, AL; Munn, DH; Gordon, S; Libby, P; Hansson, GK; Shortman, K; Dong, C; Gabrilovich, D; Gabrysova, L; Howes, A and O'Garra, A (2011)
    Highlights of 10 years of immunology in Nature Reviews Immunology.
    Nature Reviews Immunology 11, 693-702 PubMed abstract
  • O'Garra, A; Gabryšová, L and Spits, H (2011)
    Quantitative events determine the differentiation and function of helper T cells.
    Nature Immunology 12, 288-294 PubMed abstract
  • Redford, PS; Murray, PJ and O'Garra, A (2011)
    The role of IL-10 in immune regulation during M. tuberculosis infection.
    Mucosal Immunology 4, 261-270 PubMed abstract
  • Wack, A; Openshaw, P and O' Garra, A (2011)
    Contribution of cytokines to pathology and protection in virus infection.
    Current Opinion in Virology 1, 184-195 PubMed abstract
  • Yang, H-T; Wang, Y; Zhao, X; Demissie, E; Papoutsopoulou, S; Mambole, A; O'Garra, A; Tomczak, MF; Erdman, SE; Fox, JG; Ley, SC and Horwitz, BH (2011)
    NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2—dependent ERK activation.
    Journal of Immunology 186, 1989-1996 PubMed abstract
  • Berry, MPR; Graham, CM; McNab, FW; Xu, Z; Bloch, SAA; Oni, T; Wilkinson, KA; Banchereau, R; Skinner, J; Wilkinson, RJ; Quinn, C; Blankenship, D; Dhawan, R; Cush, JJ; Mejias, A; Ramilo, O; Kon, OM; Pascual, V; Banchereau, J; Chaussabel, D and O'Garra, A (2010)
    An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.
    Nature 466, 973-977 PubMed abstract
  • Redford, PS; Boonstra, A; Read, S; Pitt, J; Graham, C; Stavropoulos, E; Bancroft, GJ and O'Garra, A (2010)
    Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
    European Journal of Immunology 40, 2200-2210 PubMed abstract
  • Saraiva, M and O'Garra, A (2010)
    The regulation of IL-10 production by immune cells.
    Nature Reviews Immunology 10, 170-181 PubMed abstract

[Page last updated 1 Nov 2017]

Anne O’Garra

anne.ogarra@crick.ac.uk
+44 (0)20 379 61547

  • Qualifications and History
  • 1983 PhD Microbiology MRC-NIMR, London, UK
  • 1984-1987 Post Doctoral Fellow Immunology MRC-NIMR, London, UK
  • 1987-1990 Post Doctoral Fellow Immunology DNAX Research Institute (now Merck), Palo Alto, California, USA.
  • 1991-2001 - Group Leader/Principal Scientist, DNAX Research Institute, California, USA.
  • 2001 Group Leader and Head of Division, Immunoregulation, Medical Research Council National Institute for Medical Research, London, UK.
  • 2015  Associate Research Director (Group Leader Development), the Francis Crick Institute.