Tony Holder: Publications

  • Benavente, ED; de Sessions, PF; Moon, RW; Grainger, M; Holder, AA; Blackman, MJ; Roper, C; Drakeley, CJ; Pain, A; Sutherland, CJ; Hibberd, ML; Campino, S and Clark, TG (2018)
    A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line.
    International Journal for Parasitology 48, 191-196 PubMed abstract
  • Schlott, AC; Holder, AA and Tate, EW (2018)
    N-myristoylation as a drug target in malaria: exploring the role of N-myristoyltransferase substrates in inhibitor mode of action.
    ACS Infectious Diseases 4, 449-457 PubMed abstract
  • Wall, RJ; Ferguson, DJP; Freville, A; Franke-Fayard, B; Brady, D; Zeeshan, M; Bottrill, AR; Wheatley, S; Fry, AM; Janse, CJ; Yamano, H; Holder, AA; Guttery, DS and Tewari, R (2018)
    Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.
    Scientific Reports 8, 5610 PubMed abstract
  • Diez Benavente, E; Florez de Sessions, P; Moon, RW; Holder, AA; Blackman, MJ; Roper, C; Drakeley, CJ; Pain, A; Sutherland, CJ; Hibberd, ML; Campino, S and Clark, TG (2017)
    Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations.
    PLOS Genetics 13, e1007008 PubMed abstract
  • Green, JL; Wall, RJ; Vahokoski, J; Yusuf, NA; Ridzuan, MAM; Stanway, RR; Stock, J; Knuepfer, E; Brady, D; Martin, SR; Howell, SA; Pires, IP; Moon, RW; Molloy, JE; Kursula, I; Tewari, R and Holder, AA (2017)
    Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.
    Journal of Biological Chemistry 292, 17857-17875 PubMed abstract
  • Knuepfer, E; Napiorkowska, M; van Ooij, C and Holder, AA (2017)
    Generating conditional gene knockouts in Plasmodium - a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR/Cas9.
    Scientific Reports 7, 3881 PubMed abstract
  • Rea, E; Holder, AA and Tewari, R (2017)
    Plasmodium peekaboo: PK4 mediates parasite latency.
    Cell Host & Microbe 22, 724-725 PubMed abstract
  • Saini, E; Zeeshan, M; Brady, D; Pandey, R; Kaiser, G; Koreny, L; Kumar, P; Thakur, V; Tatiya, S; Katris, NJ; Limenitakis, RS; Kaur, I; Green, JL; Bottrill, AR; Guttery, DS; Waller, RF; Heussler, V; Holder, AA; Mohmmed, A; Malhotra, P and Tewari, R (2017)
    Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development.
    Scientific Reports 7, 15577 PubMed abstract
  • Sherling, ES; Knuepfer, E; Brzostowski, JA; Miller, LH; Blackman, MJ and van Ooij, C (2017)
    The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake.
    eLife 6, 23239 PubMed abstract
  • Crosnier, C; Iqbal, Z; Knuepfer, E; Maciuca, S; Perrin, AJ; Kamuyu, G; Goulding, D; Bustamante, LY; Miles, A; Moore, SC; Dougan, G; Holder, AA; Kwiatkowski, DP; Rayner, JC; Pleass, RJ and Wright, GJ (2016)
    Binding of Plasmodium falciparum merozoite surface proteins DBLMSP and DBLMSP2 to human immunoglobulin M is conserved amongst broadly diverged sequence variants.
    Journal of Biological Chemistry 291, 14285-14299 PubMed abstract
  • Diaz, SA; Martin, SR; Howell, SA; Grainger, M; Moon, RW; Green, JL and Holder, AA (2016)
    The binding of Plasmodium falciparum adhesins and erythrocyte invasion proteins to aldolase is enhanced by phosphorylation.
    PLOS ONE 11, e0161850 PubMed abstract
  • Green, JL; Moon, RW; Whalley, D; Bowyer, PW; Wallace, C; Rochani, A; Nageshan, RK; Howell, SA; Grainger, M; Jones, HM; Ansell, KH; Chapman, TM; Taylor, DL; Osborne, SA; Baker, DA; Tatu, U and Holder, AA (2016)
    Imidazopyridazine inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 also target cyclic GMP-dependent protein kinase and heat shock protein 90 to kill the parasite at different stages of intracellular development.
    Antimicrobial Agents and Chemotherapy 60, 1464-1475 PubMed abstract
  • Hill, RJ; Ringel, A; Knuepfer, E; Moon, RW; Blackman, MJ and van Ooij, C (2016)
    Regulation and essentiality of the StAR-related lipid transfer (START) domain-containing phospholipid transfer protein PFA0210c in malaria parasites.
    Journal of Biological Chemistry 291, 24280-24292 PubMed abstract
  • Krishnamurty, AT; Thouvenel, CD; Portugal, S; Keitany, GJ; Kim, KS; Holder, A; Crompton, PD; Rawlings, DJ and Pepper, M (2016)
    Somatically hypermutated Plasmodium-specific IgM+ memory B cells are rapid, plastic, early responders upon malaria rechallenge.
    Immunity 45, 402-414 PubMed abstract
  • Marquet, S; Conte, I; Poudiougou, B; Argiro, L; Cabantous, S; Dessein, H; Burté, F; Oumar, AA; Brown, BJ; Traore, A; Afolabi, NK; Barry, A; Omokhodion, S; Ndoumbe, UE; Shokunbi, WA; Sodeinde, O; Doumbo, O; Fernandez-Reyes, D and Dessein, AJ (2016)
    The IL17F and IL17RA genetic variants increase risk of cerebral malaria in two african populations.
    Infection and Immunity 84, 590-597 PubMed abstract
  • Moon, RW; Sharaf, H; Hastings, CH; Ho, YS; Nair, MB; Rchiad, Z; Knuepfer, E; Ramaprasad, A; Mohring, F; Amir, A; Yusuf, NA; Hall, J; Almond, N; Lau, YL; Pain, A; Blackman, MJ and Holder, AA (2016)
    Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi.
    Proceedings of the National Academy of Sciences of the United States of America 113, 7231-7236 PubMed abstract
  • Alam, MM; Solyakov, L; Bottrill, AR; Flueck, C; Siddiqui, FA; Singh, S; Mistry, S; Viskaduraki, M; Lee, K; Hopp, CS; Chitnis, CE; Doerig, C; Moon, RW; Green, JL; Holder, AA; Baker, DA and Tobin, AB (2015)
    Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion.
    Nature Communications 6, 7285 PubMed abstract
  • Guttery, DS; Roques, M; Holder, AA and Tewari, R (2015)
    Commit and transmit: molecular players in Plasmodium sexual development and zygote differentiation.
    Trends in Parasitology 31, 676-685 PubMed abstract
  • Lasonder, E; Green, JL; Grainger, M; Langsley, G and Holder, AA (2015)
    Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparum schizonts develop into extracellular invasive merozoites.
    Proteomics 15, 2716-2729 PubMed abstract
  • Roques, M; Wall, RJ; Douglass, AP; Ramaprasad, A; Ferguson, DJP; Kaindama, ML; Brusini, L; Joshi, N; Rchiad, Z; Brady, D; Guttery, DS; Wheatley, SP; Yamano, H; Holder, AA; Pain, A; Wickstead, B and Tewari, R (2015)
    Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes.
    PLOS Pathogens 11, e1005273 PubMed abstract
  • Safeukui, I; Gomez, ND; Adelani, AA; Burte, F; Afolabi, NK; Akondy, R; Velazquez, P; Holder, A; Tewari, R; Buffet, P; Brown, BJ; Shokunbi, WA; Olaleye, D; Sodeinde, O; Kazura, J; Ahmed, R; Mohandas, N; Fernandez-Reyes, D and Haldar, K (2015)
    Malaria induces anemia through CD8+ T cell-dependent parasite clearance and erythrocyte removal in the spleen.
    mBio 6, e02493-02414 PubMed abstract
  • Stallmach, R; Kavishwar, M; Withers-Martinez, C; Hackett, F; Collins, CR; Howell, SA; Yeoh, S; Knuepfer, E; Atid, AJ; Holder, AA and Blackman, MJ (2015)
    Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.
    Molecular Microbiology 96, 368-387 PubMed abstract
  • Thavayogarajah, T; Gangopadhyay, P; Rahlfs, S; Becker, K; Lingelbach, K; Przyborski, JM and Holder, AA (2015)
    Alternative protein secretion in the malaria parasite Plasmodium falciparum.
    PLOS ONE 10, e0125191 PubMed abstract
  • Yu, ZY; Brannigan, JA; Rangachari, K; Heal, WP; Wilkinson, AJ; Holder, AA; Leatherbarrow, RJ and Tate, EW (2015)
    Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.
    MedChemComm 6, 1767-1772 PubMed abstract
  • Yusuf, NA; Green, JL; Wall, RJ; Knuepfer, E; Moon, RW; Schulte-Huxel, C; Stanway, RR; Martin, SR; Howell, SA; Douse, CH; Cota, E; Tate, EW; Tewari, R and Holder, AA (2015)
    The Plasmodium class XIV myosin, MyoB has a distinct subcellular location in invasive and motile stages of the malaria parasite, and an unusual light chain.
    Journal of Biological Chemistry 290, 12147-12164 PubMed abstract
  • Ansell, KH; Jones, HM; Whalley, D; Hearn, A; Taylor, DL; Patin, EC; Chapman, TM; Osborne, SA; Wallace, C; Birchall, K; Large, J; Bouloc, N; Smiljanic-Hurley, E; Clough, B; Moon, RW; Green, JL and Holder, AA (2014)
    Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1.
    Antimicrobial Agents and Chemotherapy 58, 6032-6043 PubMed abstract
  • Chapman, TM; Osborne, SA; Wallace, C; Birchall, K; Bouloc, N; Jones, HM; Ansell, KH; Taylor, DL; Clough, B; Green, JL and Holder, AA (2014)
    Optimisation of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
    Journal of Medicinal Chemistry 57, 3570-3587 PubMed abstract
  • Curd, RD; Birdsall, B; Kadekoppala, M; Ogun, SA; Kelly, G and Holder, AA (2014)
    The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design.
    Open Biology 4, 130091 PubMed abstract
  • Diaz, SA; Martin, SR; Grainger, M; Howell, SA; Green, JL and Holder, AA (2014)
    Plasmodium falciparum aldolase and the C-terminal cytoplasmic domain of certain apical organellar proteins promote actin polymerization.
    Molecular and Biochemical Parasitology 197, 9-14 PubMed abstract
  • Douglas, AD; Williams, AR; Knuepfer, E; Illingworth, JJ; Furze, JM; Crosnier, C; Choudhary, P; Bustamante, LY; Zakutansky, SE; Awuah, DK; Alanine, DGW; Theron, M; Worth, A; Shimkets, R; Rayner, JC; Holder, AA; Wright, GJ and Draper, SJ (2014)
    Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.
    Journal of Immunology 192, 245-258 PubMed abstract
  • Ezougou, CN; Ben-Rached, F; Moss, DK; Lin, J-W; Black, S; Knuepfer, E; Green, JL; Khan, SM; Mukhopadhyay, A; Janse, CJ; Coppens, I; Yera, H; Holder, AA and Langsley, G (2014)
    Plasmodium falciparum Rab5B is an N-terminally myristoylated Rab GTPase that is targeted to the parasite's plasma and food vacuole membranes.
    PLOS ONE 9, e87695 PubMed abstract
  • Grüring, C; Moon, RW; Lim, C; Holder, AA; Blackman, MJ and Duraisingh, MT (2014)
    Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research.
    Cellular Microbiology 16, 612-620 PubMed abstract
  • Guttery, DS; Poulin, B; Ramaprasad, A; Wall, RJ; Ferguson, DJP; Brady, D; Patzewitz, E-M; Whipple, S; Straschil, U; Wright, MH; Mohamed, AMAH; Radhakrishnan, A; Arold, ST; Tate, EW; Holder, AA; Wickstead, B; Pain, A and Tewari, R (2014)
    Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.
    Cell Host & Microbe 16, 128-140 PubMed abstract
  • Imura, T; Sato, S; Sato, Y; Sakamoto, D; Isobe, T; Murata, K; Holder, AA and Yukawa, M (2014)
    The apicoplast genome of Leucocytozoon caulleryi, a pathogenic apicomplexan parasite of the chicken.
    Parasitology Research 113, 823-828 PubMed abstract
  • Otto, TD; Böhme, U; Jackson, AP; Hunt, M; Franke-Fayard, B; Hoeijmakers, WAM; Religa, AA; Robertson, L; Sanders, M; Ogun, SA; Cunningham, D; Erhart, A; Billker, O; Khan, SM; Stunnenberg, HG; Langhorne, J; Holder, AA; Waters, AP; Newbold, CI; Pain, A; Berriman, M and Janse, CJ (2014)
    A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
    BMC Biology 12, 86 PubMed abstract
  • Rackham, MD; Brannigan, JA; Rangachari, K; Meister, S; Wilkinson, AJ; Holder, AA; Leatherbarrow, RJ and Tate, EW (2014)
    Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).
    Journal of Medicinal Chemistry 57, 2773-2788 PubMed abstract
  • Tarr, SJ; Moon, RW; Hardege, I and Osborne, AR (2014)
    A conserved domain targets exported PHISTb family proteins to the periphery of Plasmodium infected erythrocytes.
    Molecular and Biochemical Parasitology 196, 29-40 PubMed abstract
  • Wright, MH; Clough, B; Rackham, MD; Rangachari, K; Brannigan, JA; Grainger, M; Moss, DK; Bottrill, AR; Heal, WP; Broncel, M; Serwa, RA; Brady, D; Mann, DJ; Leatherbarrow, RJ; Tewari, R; Wilkinson, AJ; Holder, AA and Tate, EW (2014)
    Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.
    Nature Chemistry 6, 112-121 PubMed abstract
  • Biswas, S; Spencer, AJ; Forbes, EK; Gilbert, SC; Holder, AA; Hill, AVS and Draper, SJ (2013)
    Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection.
    Journal of Immunology 188, 5041-5053 PubMed abstract
  • Chapman, TM; Osborne, SA; Bouloc, N; Large, JM; Wallace, C; Birchall, K; Ansell, KH; Jones, HM; Taylor, D; Clough, B; Green, JL and Holder, AA (2013)
    Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
    Bioorganic & Medicinal Chemistry Letters 23, 3064-3069 PubMed abstract
  • Cruz-Gallardo, I; Díaz-Moreno, I; Díaz-Quintana, A; Donaire, A; Velázquez-Campoy, A; Curd, RD; Rangachari, K; Birdsall, B; Ramos, A; Holder, AA and De la Rosa, MA (2013)
    Antimalarial activity of cupredoxins: the interaction of Plasmodium merozoite surface protein 119 (MSP119) and rusticyanin.
    Journal of Biological Chemistry 288, 20896-20907 PubMed abstract
  • Faber, BW; Younis, S; Remarque, EJ; Rodriguez Garcia, R; Riasat, V; Walraven, V; van der Werff, N; van der Eijk, M; Cavanagh, DR; Holder, AA; Thomas, AW and Kocken, CHM (2013)
    Diversity covering AMA1-MSP119 fusion proteins as malaria vaccines.
    Infection and Immunity 81, 1479-1490 PubMed abstract
  • Fernandez-Pol, S; Slouka, Z; Bhattacharjee, S; Fedotova, Y; Freed, S; An, X; Holder, AA; Campanella, E; Low, PS; Mohandas, N and Haldar, K (2013)
    A bacterial phosphatase-like enzyme of the malaria parasite Plasmodium falciparum possesses tyrosine phosphatase activity and is implicated in the regulation of Band 3 dynamics during parasite invasion.
    Eukaryotic Cell 12, 1179-1191 PubMed abstract
  • Heiber, A; Kruse, F; Pick, C; Grüring, C; Flemming, S; Oberli, A; Schoeler, H; Retzlaff, S; Mesén-Ramírez, P; Hiss, JA; Kadekoppala, M; Hecht, L; Holder, AA; Gilberger, T-W and Spielmann, T (2013)
    Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein export.
    PLOS Pathogens 9, e1003546 PubMed abstract
  • Knuepfer, E; Suleyman, O; Dluzewski, AR; Straschil, U; O'Keeffe, AH; Ogun, SA; Green, JL; Grainger, M; Tewari, R and Holder, AA (2013)
    RON12, a novel Plasmodium-specific rhoptry neck protein important for parasite proliferation.
    Cellular Microbiology 16, 657-672 PubMed abstract
  • Komatsuya, K; Hata, M; Balogun, EO; Hikosaka, K; Suzuki, S; Takahashi, K; Tanaka, T; Nakajima, M; Ogura, S-I; Sato, S and Kita, K (2013)
    Synergy of ferrous ion on 5-aminolevulinic acid-mediated growth inhibition of Plasmodium falciparum.
    Journal of Biochemistry 154, 501-504 PubMed abstract
  • Large, JM; Osborne, SA; Smiljanic-Hurley, E; Ansell, KH; Jones, HM; Taylor, DL; Clough, B; Green, JL and Holder, AA (2013)
    Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): preparation and evaluation of pyrazole linked analogues.
    Bioorganic & Medicinal Chemistry Letters 23, 6019-6024 PubMed abstract
  • Lima, WR; Holder, AA and Garcia, CRS (2013)
    Melatonin signaling and Its modulation of PfNF-YB transcription factor expression in Plasmodium falciparum.
    International Journal of Molecular Sciences 14, 13704-13718 PubMed abstract
  • Moon, RW; Hall, J; Rangkuti, F; Ho, YS; Almond, N; Mitchell, GH; Pain, A; Holder, AA and Blackman, MJ (2013)
    Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.
    Proceedings of the National Academy of Sciences of the United States of America 110, 531-536 PubMed abstract
  • Patzewitz, E-M; Guttery, DS; Poulin, B; Ramakrishnan, C; Ferguson, DJP; Wall, RJ; Brady, D; Holder, AA; Szöőr, B and Tewari, R (2013)
    An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission.
    Cell Reports 3, 622-629 PubMed abstract
  • Poulin, B; Patzewitz, E-M; Brady, D; Silvie, O; Wright, MH; Ferguson, DJP; Wall, RJ; Whipple, S; Guttery, DS; Tate, EW; Wickstead, B; Holder, AA and Tewari, R (2013)
    Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite.
    Biology Open 2, 1160-1170 PubMed abstract
  • Prommana, P; Uthaipibull, C; Wongsombat, C; Kamchonwongpaisan, S; Yuthavong, Y; Knuepfer, E; Holder, AA and Shaw, PJ (2013)
    Inducible knockdown of Plasmodium gene expression using the glmS ribozyme.
    PLOS ONE 8, e73783 PubMed abstract
  • Rackham, MD; Brannigan, JA; Moss, DK; Yu, Z; Wilkinson, AJ; Holder, AA; Tate, EW and Leatherbarrow, RJ (2013)
    Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferase.
    Journal of Medicinal Chemistry 546, 371-375 PubMed abstract
  • Sato, S; Sesay, AK and Holder, AA (2013)
    The unique structure of the apicoplast genome of the rodent malaria parasite Plasmodium chabaudi chabaudi.
    PLOS ONE 8, e61778 PubMed abstract
  • Guttery, DS; Holder, AA and Tewari, R (2012 )
    Sexual development in Plasmodium: lessons from functional analyses.
    PLOS Pathogens 8, e1002404 PubMed abstract
  • Amambua-Ngwa, A; Tetteh, KKA; Manske, M; Gomez-Escobar, N; Stewart, LB; Deerhake, ME; Cheeseman, IH; Newbold, CI; Holder, AA; Knuepfer, E; Janha, O; Jallow, M; Campino, S; Macinnis, B; Kwiatkowski, DP and Conway, DJ (2012)
    Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.
    PLOS Genetics 8, e1002992 PubMed abstract
  • Bell, AS; Mills, JE; Williams, GP; Brannigan, JA; Wilkinson, AJ; Parkinson, T; Leatherbarrow, RJ; Tate, EW; Holder, AA and Smith, DF (2012)
    Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.
    PLOS Neglected Tropical Diseases 6, e1625 PubMed abstract
  • da Cruz, LN; Juliano, MA; Budu, A; Juliano, L; Holder, AA; Blackman, MJ and Garcia, CRS (2012)
    Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.
    Malaria Journal 11, 69 PubMed abstract
  • Douse, CH; Green, JL; Salgado, PS; Simpson, PJ; Thomas, JC; Langsley, G; Holder, AA; Tate, EW and Cota, E (2012)
    Regulation of the Plasmodium motor complex: phosphorylation of Myosin A Tail Interacting Protein (MTIP) loosens its grip on MyoA.
    Journal of Biological Chemistry 287, 36968-36977 PubMed abstract
  • Farrow, RE; Green, J; Katismitsoulia, Z; Taylor, WR; Holder, AA and Molloy, JE (2012)
    The mechanism of erythrocyte invasion by the malarial parasite, Plasmodium falciparum.
    Seminars in Cell & Developmental Biology 22, 953-960 PubMed abstract
  • Goncalves, V; Brannigan, JA; Whalley, D; Ansell, KH; Saxty, B; Holder, AA; Wilkinson, AJ; Tate, EW and Leatherbarrow, RJ (2012)
    Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.
    Journal of Medicinal Chemistry 55, 3578-3582 PubMed abstract
  • Guttery, DS; Ferguson, DJP; Poulin, B; Xu, Z; Straschil, U; Klop, O; Solyakov, L; Sandrini, SM; Brady, D; Nieduszynski, CA; Janse, CJ; Holder, AA; Tobin, AB and Tewari, R (2012)
    A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.
    PLOS Pathogens 8, e1002554 PubMed abstract
  • Guttery, DS; Poulin, B; Ferguson, DJP; Szoor, B; Wickstead, B; Carroll, PL; Ramakrishnan, C; Brady, D; Patzewitz, E-M; Straschil, U; Solyakov, L; Green, JL; Sinden, RE; Tobin, AB; Holder, AA and Tewari, R (2012)
    A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion.
    PLOS Pathogens 8, e1002948 PubMed abstract
  • Holder, AA; Mohd Ridzuan, MA and Green, JL (2012)
    Calcium dependent protein kinase 1 and calcium fluxes in the malaria parasite.
    Microbes and Infection 14, 825-830 PubMed abstract
  • Kitamura, K; Kishi-Itakura, C; Tsuboi, T; Sato, S; Kita, K; Ohta, N and Mizushima, N (2012)
    Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum.
    PLOS ONE 7, e42977 PubMed abstract
  • Lasonder, E; Green, JL; Camarda, G; Talabani, H; Holder, AA; Langsley, G and Alano, P (2012)
    The Plasmodium falciparum schizont phospho-proteome reveals extensive phosphatidylinositol and cAMP-Protein Kinase A signalling.
    Journal of Proteome Research 11, 5323-5337 PubMed abstract
  • Moss, DK; Remarque, EJ; Faber, BW; Cavanagh, DR; Arnot, DE; Thomas, AW and Holder, AA (2012)
    Plasmodium falciparum 19-kilodalton merozoite surface protein 1 (MSP1)-specific antibodies that interfere with parasite growth in vitro can inhibit MSP1 processing, merozoite invasion and intracellular parasite development.
    Infection and Immunity 80, 1280-1287 PubMed abstract
  • Ridzuan, MAM; Moon, RW; Knuepfer, E; Black, S; Holder, AA and Green, JL (2012)
    Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development.
    PLOS ONE 7, e33845 PubMed abstract
  • Yu, Z; Brannigan, JA; Moss, DK; Brzozowski, AM; Wilkinson, AJ; Holder, AA; Tate, EW and Leatherbarrow, RJ (2012)
    Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for anti-malarial drug discovery.
    Journal of Medicinal Chemistry 55, 8879-8890 PubMed abstract
  • Bisseye, C; Yindom, LM; Simpore, J; Morgan, WD; Holder, AA and Ismaili, J (2011)
    An engineered Plasmodium falciparum C-terminal 19-kilodalton merozoite surface protein 1 vaccine candidate induces high levels of interferon-gamma production associated with cellular immune responses to specific peptide sequences in Gambian adults naturally exposed to malaria.
    Clinical and Experimental Immunology 166, 366-373 PubMed abstract
  • Biswas, S; Dicks, MDJ; Long, CA; Remarque, EJ; Siani, L; Colloca, S; Cottingham, MG; Holder, AA; Gilbert, SC; Hill, AVS and Draper, SJ (2011)
    Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1.
    PLOS ONE 6, e20977 PubMed abstract
  • Gómez, ND; Safeukui, I; Adelani, AA; Tewari, R; Reddy, JK; Rao, S; Holder, A; Buffet, P; Mohandas, N and Haldar, K (2011)
    Deletion of a malaria invasion gene reduces death and anemia, in model hosts.
    PLOS ONE 6, e25477 PubMed abstract
  • Ogun, SA; Tewari, R; Otto, TD; Howell, SA; Knuepfer, E; Cunningham, DA; Xu, Z; Pain, A and Holder, AA (2011)
    Targeted disruption of py235ebp-1: Invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein.
    PLOS Pathogens 7, e1001288 PubMed abstract
  • Sato, S (2011)
    The apicomplexan plastid and its evolution.
    Cellular and Molecular Life Sciences 68, 1285-1296 PubMed abstract
  • Shi, J; McIntosh, RS; Adame-Gallegos, J; Dehal, PK; van Egmond, M; van de Winkel, J; Draper, SJ; Forbes, EK; Corran, PH; Holder, AA; Woof, JM and Pleass, RJ (2011)
    The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP119).
    BMC Biotechnology 11, 1-8 PubMed abstract
  • Thøgersen, RL; Holder, AA; Hill, AVS; Arnot, DE; Imoukhuede, EB and Leroy, O (2011)
    Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field?
    Malaria Journal 10, 255 PubMed abstract
  • Cook, WJ; Smith, CD; Senkovich, O; Holder, AA and Chattopadhyay, D (2010)
    Structure of Plasmodium falciparum ADP-ribosylation factor 1.
    Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 66, 1426-1431 PubMed abstract
  • Eslava, I; Payares, G; Pernia, BM; Holder, AA and Spencer, LM (2010)
    Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii.
    Malaria Journal 9, 46 PubMed abstract
  • Goodman, AL; Epp, C; Moss, D; Holder, AA; Wilson, JM; Gao, GP; Long, CA; Remarque, EJ; Thomas, AW; Ammendola, V; Colloca, S; Dicks, MDJ; Biswas, S; Seibel, D; van Duivenvoorde, LM; Gilbert, SC; Hill, AVS and Draper, SJ (2010)
    New candidate vaccines against blood-stage P. falciparum malaria: Prime-boost immunization regimes incorporating human and simian adenoviral vectors and poxviral vectors expressing an optimized antigen based on merozoite surface protein 1.
    Infection and Immunity 78, 4601-4612 PubMed abstract
  • Kadekoppala, M and Holder, AA (2010)
    Merozoite surface proteins of the malaria parasite: the MSP1 complex and the MSP7 family.
    International Journal for Parasitology 40, 1155-1161 PubMed abstract
  • Kadekoppala, M; Ogun, SA; Howell, S; Gunaratne, RS and Holder, AA (2010)
    Systematic genetic analysis of the Plasmodium falciparum MSP7-like family reveals differences in protein expression, location and importance in asexual growth of the blood stage parasite.
    Eukaryotic Cell 9, 1064-1074 PubMed abstract
  • Ngoundou-Landji, J; Nwuba, RI; Anumudu, CI; Odaibo, AB; Matondo Maya, WD; Awobode, HO; Okafor, CM; Morenikeji, OA; Asinobi, A; Nwagwu, M; Holder, AA and Ntoumi, F (2010)
    Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub-microscopic infection.
    Malaria Journal 9, 287 PubMed abstract
  • Omosun, YO; Adoro, S; Anumudu, CI; Odaibo, A; Holder, AA; Nwagwu, M and Nwuba, RI (2010)
    Total immunoglobulin G and IgG1 subclass levels specific for the MSP-119 of Plasmodium falciparum are different in individuals with either processing-inhibitory, blocking or neutral antibodies.
    African Health Sciences 10, 106-110
  • Schmitz, S; Schaap, IAT; Kleinjung, J; Harder, S; Grainger, M; Calder, L; Rosenthal, PB; Holder, AA and Veigel, C (2010)
    Malaria parasite actin polymerisation and filament structure.
    Journal of Biological Chemistry 285, 36577-36585 PubMed abstract
  • Straschil, U; Talman, AM; Ferguson, DJP; Bunting, KA; Xu, Z; Bailes, E; Sinden, RE; Holder, AA; Smith, EF; Coates, JC and Tewari, R (2010)
    The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes.
    PLOS ONE 5, e12901 PubMed abstract
  • Taylor, HM; McRobert, L; Grainger, M; Sicard, A; Dluzewski, AR; Hopp, CS; Holder, AA and Baker, DA (2010)
    The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood stage schizogony.
    Eukaryotic Cell 9, 37-45 PubMed abstract
  • Thomas, JC; Green, JL; Howson, RI; Simpson, P; Moss, DK; Martin, SR; Holder, AA; Cota, E and Tate, EW (2010)
    Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.
    Molecular BioSystems 6, 494-498 PubMed abstract

[Page last updated 1 Jun 2018]

Tony Holder
+44 (0)20 379 62332

  • 1972-1975 PhD Genetics, University of Leeds, UK
  • 1975-1978 Postdoctoral fellow, The Carlsberg Laboratory, Copenhagen, Denmark
  • 1978-1988 Senior Scientist, The Wellcome Research Laboratories, Beckenham, UK
  • 1988-2015 Head, Division of Parasitology, MRC-NIMR, Mill Hill, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK