Steve Gamblin: Publications

  • Peacock, TP; Benton, DJ; James, J; Sadeyen, J-R; Chang, P; Sealy, JE; Bryant, JE; Martin, SR; Shelton, H; Barclay, WS and Iqbal, M (2017)
    Immune escape variants of H9N2 influenza viruses containing deletions at the hemagglutinin receptor binding site retain fitness in vivo and display enhanced zoonotic characteristics.
    Journal of Virology 91, e00218-00217 PubMed abstract
  • Peacock, TP; Benton, DJ; Sadeyen, J-R; Chang, P; Sealy, JE; Bryant, JE; Martin, SR; Shelton, H; McCauley, JW; Barclay, WS and Iqbal, M (2017)
    Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion.
    Emerging Microbes & Infections 6, e11 PubMed abstract
  • Willows, R; Sanders, MJ; Xiao, B; Patel, BR; Martin, SR; Read, J; Wilson, JR; Hubbard, J; Gamblin, SJ and Carling, D (2017)
    Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells.
    Biochemical Journal 474, 3059-3073 PubMed abstract
  • Justin, N; Zhang, Y; Tarricone, C; Martin, SR; Chen, S; Underwood, E; De Marco, V; Haire, LF; Walker, PA; Reinberg, D; Wilson, JR and Gamblin, SJ (2016)
    Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
    Nature Communications 7, 11316 PubMed abstract
  • Kallewaard, NL; Corti, D; Collins, PJ; Neu, U; McAuliffe, JM; Benjamin, E; Wachter-Rosati, L; Palmer-Hill, FJ; Yuan, AQ; Walker, PA; Vorlaender, MK; Bianchi, S; Guarino, B; De Marco, A; Vanzetta, F; Agatic, G; Foglierini, M; Pinna, D; Fernandez-Rodriguez, B; Fruehwirth, A; Silacci, C; Ogrodowicz, RW; Martin, SR; Sallusto, F; Suzich, JA; Lanzavecchia, A; Zhu, Q; Gamblin, SJ and Skehel, JJ (2016)
    Structure and function analysis of an antibody recognizing all influenza A subtypes.
    Cell 166, 596-608 PubMed abstract
  • Turnbull, ML; Wise, HM; Nicol, MQ; Smith, N; Dunfee, RL; Beard, PM; Jagger, BW; Ligertwood, Y; Hardisty, GR; Xiao, H; Benton, DJ; Coburn, AM; Paulo, JA; Gygi, SP; McCauley, JW; Taubenberger, JK; Lycett, SJ; Weekes, MP; Dutia, BM and Digard, P (2016)
    The role of the B-allele of the influenza A virus segment 8 in setting mammalian host range and pathogenicity.
    Journal of Virology 90, 9263-9284 PubMed abstract
  • Vaswani, RG; Gehling, VS; Dakin, LA; Cook, AS; Nasveschuk, CG; Duplessis, M; Iyer, P; Balasubramanian, S; Zhao, F; Good, AC; Campbell, R; Lee, C; Cantone, N; Cummings, RT; Normant, E; Bellon, SF; Albrecht, BK; Harmange, J-C; Trojer, P; Audia, JE; Zhang, Y; Justin, N; Chen, S; Wilson, JR and Gamblin, SJ (2016)
    Identification of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a potent and selective inhibitor of histone methyltransferase EZH2, suitable for phase I clinical trials for B-cell lymphomas.
    Journal of Medicinal Chemistry 59, 9928-9941 PubMed abstract
  • Zhang, Y; Justin, N; Wilson, JR and Gamblin, SJ (2016)
    Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
    Science 354, 1543 PubMed abstract
  • Sanulli, S; Justin, N; Teissandier, A; Ancelin, K; Portoso, M; Caron, M; Michaud, A; Lombard, B; da Rocha, ST; Offer, J; Loew, D; Servant, N; Wassef, M; Burlina, F; Gamblin, SJ; Heard, E and Margueron, R (2015)
    Jarid2 methylation via the PRC2 complex regulates H3K27me3 deposition during cell differentiation.
    Molecular Cell 57, 769-783 PubMed abstract
  • Xiong, X; Corti, D; Liu, J; Pinna, D; Foglierini, M; Calder, LJ; Martin, SR; Lin, YP; Walker, PA; Collins, PJ; Monne, I; Suguitan, AL, Jr.; Santos, C; Temperton, NJ; Subbarao, K; Lanzavecchia, A; Gamblin, SJ and Skehel, JJ (2015)
    Structures of complexes formed by H5 influenza hemagglutinin with a potent broadly neutralizing human monoclonal antibody.
    Proceedings of the National Academy of Sciences of the United States of America 112, 9430-9435 PubMed abstract
  • Zhang, Y; Mittal, A; Reid, J; Reich, S; Gamblin, SJ and Wilson, JR (2015)
    Evolving catalytic properties of the MLL family SET domain.
    Structure 23, 1921-1933 PubMed abstract
  • Collins, PJ; Vachieri, SG; Haire, LF; Ogrodowicz, RW; Martin, SR; Walker, PA; Xiong, X; Gamblin, SJ and Skehel, JJ (2014)
    Recent evolution of equine influenza and the origin of canine influenza.
    Proceedings of the National Academy of Sciences of the United States of America 111, 11175-11180 PubMed abstract
  • Cooper, S; Dienstbier, M; Hassan, R; Schermelleh, L; Sharif, J; Blackledge, NP; De Marco, V; Elderkin, S; Koseki, H; Klose, R; Heger, A and Brockdorff, N (2014)
    Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.
    Cell Reports 7, 1456-1470 PubMed abstract
  • Escuret, V; Collins, PJ; Casalegno, J-S; Vachieri, SG; Cattle, N; Ferraris, O; Sabatier, M; Frobert, E; Caro, V; Skehel, JJ; Gamblin, S; Valla, F; Valette, M; Ottmann, M; McCauley, JW; Daniels, RS and Lina, B (2014)
    A novel I221L substitution in neuraminidase confers high-level resistance to oseltamivir in influenza B viruses.
    Journal of Infectious Diseases 210, 1260-1269 PubMed abstract
  • Vachieri, SG; Xiong, X; Collins, PJ; Walker, PA; Martin, SR; Haire, LF; Zhang, Y; McCauley, JW; Gamblin, SJ and Skehel, JJ (2014)
    Receptor binding by H10 influenza viruses.
    Nature 511, 475-477 PubMed abstract
  • Xiong, X; Xiao, H; Martin, SR; Coombs, PJ; Liu, J; Collins, PJ; Vachieri, SG; Walker, PA; Lin, YP; McCauley, JW; Gamblin, SJ and Skehel, JJ (2014)
    Enhanced human receptor binding by H5 haemagglutinins.
    Virology 456-457, 179-187 PubMed abstract
  • Crusat, M; Liu, J; Palma, AS; Childs, RA; Liu, Y; Wharton, SA; Lin, YP; Coombs, PJ; Martin, SR; Matrosovich, M; Chen, Z; Stevens, DJ; Hien, VM; Thanh, TT; Nhu, LNT; Nguyet, LA; Ha, DQ; van Doorn, HR; Hien, TT; Conradt, HS; Kiso, M; Gamblin, SJ; Chai, W; Skehel, JJ; Hay, AJ; Farrar, J; de Jong, MD and Feizi, T (2013)
    Changes in the hemagglutinin of H5N1 viruses during human infection - influence on receptor binding.
    Virology 447, 326-337 PubMed abstract
  • Xiao, B; Sanders, MJ; Carmena, D; Bright, NJ; Haire, LF; Underwood, E; Patel, BR; Heath, RB; Walker, PA; Hallen, S; Giordanetto, F; Martin, SR; Carling, D and Gamblin, SJ (2013)
    Structural basis of AMPK regulation by small molecule activators.
    Nature Communications 4, 3017 PubMed abstract
  • Xiong, X; Coombs, PJ; Martin, SR; Liu, J; Xiao, H; McCauley, JW; Locher, K; Walker, PA; Collins, PJ; Kawaoka, Y; Skehel, JJ and Gamblin, SJ (2013)
    Receptor binding by a ferret-transmissible H5 avian influenza virus.
    Nature 497, 392-396 PubMed abstract
  • Xiong, X; Martin, SR; Haire, LF; Wharton, SA; Daniels, RS; Bennett, MS; McCauley, JW; Collins, PJ; Walker, PA; Skehel, JJ and Gamblin, SJ (2013)
    Receptor binding by an H7N9 influenza virus from humans.
    Nature 499, 496-499 PubMed abstract
  • Xiong, X; Tuzikov, A; Coombs, PJ; Martin, S; Walker, PA; Gamblin, SJ; Bovin, N and Skehel, JJ (2013)
    Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus.
    Virus Research 178, 12-14 PubMed abstract
  • Carling, D; Thornton, C; Woods, A and Sanders, MJ (2012)
    AMP-activated protein kinase: new regulation, new roles?
    Biochemical Journal 445, 11-27 PubMed abstract
  • Hu, H; Voss, J; Zhang, G; Buchy, P; Zuo, T; Wang, L; Wang, F; Zhou, F; Wang, G; Tsai, C; Calder, L; Gamblin, SJ; Zhang, L; Deubel, V; Zhou, B; Skehel, JJ and Zhou, P (2012)
    A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses.
    Journal of Virology 86, 2978-2989 PubMed abstract
  • Lin, YP; Xiong, X; Wharton, SA; Martin, SR; Coombs, PJ; Vachieri, SG; Christodoulou, E; Walker, PA; Liu, J; Skehel, JJ; Gamblin, SJ; Hay, AJ; Daniels, RS and McCauley, JW (2012)
    Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin.
    Proceedings of the National Academy of Sciences of the United States of America 109, 21474-21479 PubMed abstract
  • van der Vries, E; Collins, PJ; Vachieri, SG; Xiong, X; Liu, J; Walker, PA; Haire, LF; Hay, AJ; Schutten, M; Osterhaus, ADME; Martin, SR; Boucher, CAB; Skehel, JJ and Gamblin, SJ (2012)
    H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis.
    PLOS Pathogens 8, e1002914 PubMed abstract
  • Carling, D; Mayer, FV; Sanders, MJ and Gamblin, SJ (2011)
    AMP-activated protein kinase: nature's energy sensor.
    Nature Chemical Biology 7, 512-518 PubMed abstract
  • Corti, D; Voss, J; Gamblin, SJ; Codoni, G; Macagno, A; Jarrossay, D; Vachieri, SG; Pinna, D; Minola, A; Vanzetta, F; Silacci, C; Fernandez-Rodriguez, BM; Agatic, G; Bianchi, S; Giacchetto-Sasselli, I; Calder, L; Sallusto, F; Collins, P; Haire, LF; Temperton, N; Langedijk, JPM; Skehel, JJ and Lanzavecchia, A (2011)
    A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins.
    Science 333, 850-856 PubMed abstract
  • Hardie, DG; Carling, D and Gamblin, SJ (2011)
    AMP-activated protein kinase: also regulated by ADP?
    Trends in Biochemical Sciences 36, 470-477 PubMed abstract
  • Mayer, FV; Heath, R; Underwood, E; Sanders, MJ; Carmena, D; McCartney, RR; Leiper, FC; Xiao, B; Jing, C; Walker, PA; Haire, LF; Ogrodowicz, R; Martin, SR; Schmidt, MC; Gamblin, SJ and Carling, D (2011)
    ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.
    Cell Metabolism 14, 707-714 PubMed abstract
  • Xiao, B; Sanders, MJ; Underwood, E; Heath, R; Mayer, FV; Carmena, D; Jing, C; Walker, PA; Eccleston, JF; Haire, LF; Saiu, P; Howell, SA; Aasland, R; Martin, SR; Carling, D and Gamblin, SJ (2011)
    Structure of mammalian AMPK and its regulation by ADP.
    Nature 472, 230-233 PubMed abstract
  • Gamblin, SJ and Skehel, JJ (2010)
    Influenza haemagglutinin and neuraminidase membrane glycoproteins.
    Journal of Biological Chemistry 285, 28403-28409 PubMed abstract
  • Justin, N; De Marco, V; Aasland, R and Gamblin, SJ (2010)
    Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies.
    Current Opinion in Structural Biology 20, 730-738 PubMed abstract
  • Spencer, J; Murphy, LM; Conners, R; Sessions, RB and Gamblin, SJ (2010)
    Crystal structure of the LasA virulence factor from Pseudomonas aeruginosa: Substrate specificity and mechanism of M23 metallopeptidases.
    Journal of Molecular Biology 396, 908-923 PubMed abstract

[Page last updated 1 Nov 2017]