Eva Frickel: Publications

  • Encheva, V; Foltz, C; Snijders, AP and Frickel, E-M (2018)
    Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection.
    BMC Research Notes 11, 166 PubMed abstract
  • Clough, B and Frickel, E-M (2017)
    The Toxoplasma parasitophorous vacuole: an evolving host-parasite frontier.
    Trends in Parasitology 33, 473-488 PubMed abstract
  • Foltz, C; Napolitano, A; Khan, R; Clough, B; Hirst, EM and Frickel, E-M (2017)
    TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles.
    Scientific Reports 7, 5209 PubMed abstract
  • Piro, AS; Hernandez, D; Luoma, S; Feeley, EM; Finethy, R; Yirga, A; Frickel, EM; Lesser, CF and Coers, J (2017)
    Detection of cytosolic Shigella flexneri via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility.
    mBio 8, e01979-01917 PubMed abstract
  • Saeij, JP and Frickel, EM (2017)
    Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death.
    Current Opinion in Microbiology 40, 72-80 PubMed abstract
  • Yoshida, N; Frickel, EM and Mostowy, S (2017)
    Macrophage-microbe interactions: Lessons from the Zebrafish model.
    Frontiers in Immunology 8, 1703 PubMed abstract
  • Clough, B; Wright, JD; Pereira, PM; Hirst, EM; Johnston, AC; Henriques, R and Frickel, E-M (2016)
    K63-linked ubiquitination targets Toxoplasma gondii for endo-lysosomal destruction in IFNγ-stimulated human cells.
    PLOS Pathogens 12, e1006027 PubMed abstract
  • Haldar, AK; Piro, AS; Finethy, R; Espenschied, ST; Brown, HE; Giebel, AM; Frickel, E-M; Nelson, DE and Coers, J (2016)
    Chlamydia trachomatis is resistant to inclusion ubiquitination and associated host defense in gamma interferon-primed human epithelial cells.
    mBio 7, e01417 PubMed abstract
  • Johnston, AC; Piro, A; Clough, B; Siew, M; Virreira Winter, S; Coers, J and Frickel, E-M (2016)
    Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii.
    Cellular Microbiology 18, 1056-1064 PubMed abstract
  • Sanecka, A; Yoshida, N; Dougan, SK; Jackson, J; Shastri, N; Ploegh, H; Blanchard, N and Frickel, E-M (2016)
    Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden.
    Immunology 149, 270-279 PubMed abstract
  • Swee, LK; Tan, ZW; Sanecka, A; Yoshida, N; Patel, H; Grotenbreg, G; Frickel, E-M and Ploegh, HL (2016)
    Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.
    Open Biology 6, 160293 PubMed abstract
  • Haldar, AK; Foltz, C; Finethy, R; Piro, AS; Feeley, EM; Pilla-Moffett, DM; Komatsu, M; Frickel, E-M and Coers, J (2015)
    Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins.
    Proceedings of the National Academy of Sciences of the United States of America 112, E5628-E5637 PubMed abstract
  • Jensen, KDC; Camejo, A; Melo, MB; Cordeiro, C; Julien, L; Grotenbreg, GM; Frickel, E-M; Ploegh, HL; Young, L and Saeij, JPJ (2015)
    Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.
    mBio 6, e02280-02214 PubMed abstract
  • Ohshima, J; Sasai, M; Liu, J; Yamashita, K; Ma, JS; Lee, Y; Bando, H; Howard, JC; Ebisu, S; Hayashi, M; Takeda, K; Standley, DM; Frickel, E-M and Yamamoto, M (2015)
    RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.
    Proceedings of the National Academy of Sciences of the United States of America 112, E4581-E4590 PubMed abstract
  • Haldar, AK; Saka, HA; Piro, AS; Dunn, JD; Henry, SC; Taylor, GA; Frickel, EM; Valdivia, RH and Coers, J (2013)
    IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.
    PLOS Pathogens 9, e1003414 PubMed abstract
  • Niedelman, W; Sprokholt, JK; Clough, B; Frickel, E-M and Saeij, JPJ (2013)
    Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication.
    Infection and Immunity 81, 4341-4349 PubMed abstract
  • Sanecka, A and Frickel, E-M (2012)
    Use and abuse of dendritic cells by Toxoplasma gondii.
    Virulence 3, 678-689 PubMed abstract
  • Winter, SV; Niedelman, W; Jensen, KD; Rosowski, EE; Julien, L; Spooner, E; Caradonna, K; Burleigh, BA; Saeij, JPJ; Ploegh, HL and Frickel, E-M (2011)
    Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it.
    PLOS ONE 6, e24434 PubMed abstract
  • Kirak, O; Frickel, E-M; Grotenbreg, GM; Suh, H; Jaenisch, R and Ploegh, HL (2010)
    Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.
    Science 328, 243-248 PubMed abstract
  • Kirak, O; Frickel, E-M; Grotenbreg, GM; Suh, H; Jaenisch, R and Ploegh, HL (2010)
    Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.
    Journal of Visualized Experiments 43, e2168 PubMed abstract
  • Wilson, DC; Grotenbreg, GM; Liu, K; Zhao, Y; Frickel, E-M; Gubbels, M-J; Ploegh, HL and Yap, GS (2010)
    Differential regulation of effector- and central-memory responses to Toxoplasma gondii infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.
    PLOS Pathogens 6, e1000815 PubMed abstract

[Page last updated 1 Jun 2018]

Eva Frickel

+44 (0)20 379 61438

  • Qualifications and History
  • 2004 PhD Biochemistry, ETH Zurich, Switzerland
  • 2005-2010 Post-doctoral fellow at the Whitehead Institute/MIT, Cambridge, MA, USA
  • 2011 Group Leader, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK