Edgar Deu: Publications

  • Deu, E (2017)
    Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation.
    FEBS Journal 284, 2604-2628 PubMed abstract
  • Thomas, JA; Collins, CR; Das, S; Hackett, F; Graindorge, A; Bell, D; Deu, E and Blackman, MJ (2016)
    Development and application of a simple plaque assay for the human malaria parasite Plasmodium falciparum.
    PLOS ONE 11, e0157873 PubMed abstract
  • Deu, E; Chen, IT; Lauterwasser, EMW; Valderramos, J; Li, H; Edgington, LE; Renslo, AR and Bogyo, M (2013)
    Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo.
    Proceedings of the National Academy of Sciences of the United States of America 110, 18244-18249 PubMed abstract
  • Morell, M; Nguyen Duc, T; Willis, AL; Syed, S; Lee, J; Deu, E; Deng, Y; Xiao, J; Turk, BE; Jessen, JR; Weiss, SJ and Bogyo, M (2013)
    Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity.
    Journal of the American Chemical Society 135, 9139-9148 PubMed abstract
  • Tanaka, TQ; Deu, E; Molina-Cruz, A; Ashburne, MJ; Ali, O; Suri, A; Kortagere, S; Bogyo, M and Williamson, KC (2013)
    Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets.
    Antimicrobial Agents and Chemotherapy 57, 4645-4652 PubMed abstract
  • Xiao, J; Broz, P; Puri, AW; Deu, E; Morell, M; Monack, DM and Bogyo, M (2013)
    A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases.
    Journal of the American Chemical Society 135, 9130-9138 PubMed abstract
  • Deu, E; Verdoes, M and Bogyo, M (2012)
    New approaches for dissecting protease functions to improve probe development and drug discovery.
    Nature Structural & Molecular Biology 19, 9-16 PubMed abstract
  • Li, H; Ponder, EL; Verdoes, M; Asbjornsdottir, KH; Deu, E; Edgington, LE; Lee, JT; Kirk, CJ; Demo, SD; Williamson, KC and Bogyo, M (2012)
    Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity.
    Chemistry & Biology 19, 1535-1545 PubMed abstract
  • Stolze, SC; Deu, E; Kaschani, F; Li, N; Florea, BI; Richau, KH; Colby, T; van der Hoorn, RAL; Overkleeft, HS; Bogyo, M and Kaiser, M (2012)
    The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.
    Chemistry & Biology 19, 1546-1555 PubMed abstract
  • Albrow, VE; Ponder, EL; Fasci, D; Békés, M; Deu, E; Salvesen, GS and Bogyo, M (2011)
    Development of small molecule inhibitors and probes of human SUMO deconjugating proteases.
    Chemistry & Biology 18, 722-732 PubMed abstract
  • Deu, E and Kirsch, JF (2011)
    Engineering homooligomeric proteins to detect weak intersite allosteric communication: aminotransferases, a case study.
    Protein Science 20, 1991-2003 PubMed abstract
  • Hall, CI; Reese, ML; Weerapana, E; Child, MA; Bowyer, PW; Albrow, VE; Haraldsen, JD; Phillips, MR; Deu Sandoval, E; Ward, GE; Cravatt, BF; Boothroyd, JC and Bogyo, M (2011)
    Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.
    Proceedings of the National Academy of Sciences of the United States of America 108, 10568-10573 PubMed abstract
  • Mahajan, SS; Deu, E; Lauterwasser, EMW; Leyva, MJ; Ellman, JA; Bogyo, M and Renslo, AR (2011)
    A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite.
    ChemMedChem 6, 415-419 PubMed abstract
  • Ponder, EL; Albrow, VE; Leader, BA; Békés, M; Mikolajczyk, J; Fonović, UP; Shen, A; Drag, M; Xiao, J; Deu, E; Campbell, AJ; Powers, JC; Salvesen, GS and Bogyo, M (2011)
    Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors.
    Chemistry & Biology 18, 711-721 PubMed abstract
  • Suzuki, E; Demo, S; Deu, E; Keats, J; Arastu-Kapur, S; Bergsagel, PL; Bennett, MK and Kirk, CJ (2011)
    Molecular mechanisms of bortezomib resistant adenocarcinoma cells.
    PLOS ONE 6, e27996 PubMed abstract
  • Wang, F; Krai, P; Deu, E; Bibb, B; Lauritzen, C; Pedersen, J; Bogyo, M and Klemba, M (2011)
    Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase 1.
    Molecular and Biochemical Parasitology 175, 10-20 PubMed abstract
  • Deu, E; Leyva, MJ; Albrow, VE; Rice, MJ; Ellman, JA and Bogyo, M (2010)
    Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes.
    Chemistry & Biology 17, 808-819 PubMed abstract
  • Deu, E; Yang, Z; Wang, F; Klemba, M and Bogyo, M (2010)
    Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.
    PLOS ONE 5, e11985 PubMed abstract
  • Puri, AW; Lupardus, PJ; Deu, E; Albrow, VE; Garcia, KC; Bogyo, M and Shen, A (2010)
    Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB.
    Chemistry & Biology 17, 1201-1211 PubMed abstract

[Page last updated 1 Nov 2017]