Publications

An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development

Authors (5)

Scott Wilcockson
Luca Guglielmi
Pablo Araguas Rodriguez
Marc Amoyel
Caroline Hill

Developmental Cell

Published 4 December 2023

Crick labs/ facilities

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Context-dependent TGFβ family signalling in cell fate regulation

Authors (4)

Nature Reviews Molecular Cell Biology

Published 1 December 2023

Crick labs

Caroline Hill

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Nodal signaling establishes a competency window for stochastic cell fate switching

Authors (4)

Developmental Cell

Published 5 December 2022

Crick labs/ facilities

Full details

A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses

Authors (7)

Davide Coda
Harshil Patel
Ilaria Gori
Tessa E Gaarenstroom
Ok-Ryul Song
Michael Howell
Caroline Hill

Journal of Cell Science

Published 15 April 2022

Crick labs/ facilities

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Establishment and interpretation of NODAL and BMP signaling gradients in early vertebrate development

Authors (1)

Caroline Hill

Current Topics in Developmental Biology

Published 20 May 2022

Crick labs

Caroline Hill

Full details

Transforming growth factor‐β family biology: From basic mechanisms to roles in development and disease

Authors (2)

Jan L Christian
Caroline Hill

Developmental Dynamics

Published 1 January 2022

Crick labs

Caroline Hill

Full details

Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Authors (12)

Luca Guglielmi
Claire Heliot
Sunil Kumar
Yuriy Alexandrov
Ilaria Gori
Foteini Papaleonidopoulou
[...]
Phil East
Andrew Economou
Paul MW French
James McGinty
Caroline Hill

Nature Communications

Published 4 November 2021

Crick labs/ facilities

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Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation

Authors (12)

Anassuya Ramachandran
Merima Mehic
Laabiah Wasim
Dessi Malinova
Ilaria Gori
Beata K Blaszczyk
[...]
Eileen M Shore
Chris Jones
Marko Hyvönen
Pavel Tolar
Caroline Hill

The EMBO Journal

Published 15 July 2021

Crick labs/ facilities

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Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

Authors (11)

Ilaria Gori
Roger George
Andrew G Purkiss
Stephanie Strohbuecker
Rebecca A Randall
Roksana Ogrodowicz
Virginie Carmignac
Laurence Faivre
Dhira Joshi
Svend Kjaer
Caroline Hill

eLife

Published 8 January 2021

Crick labs/ facilities

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Id1 and Id3 are regulated through matrix‐assisted autocrine BMP signaling and represent therapeutic targets in melanoma

Authors (21)

Georg Sedlmeier
Vanessa Al‐Rawi
Justyna Buchert
Klaus Yserentant
Melanie Rothley
Anastasia Steshina
[...]
Caroline Hill
Boyan K Garvalov
Nicole Jung
Stefan Bräse
Jonathan P Sleeman

Advanced Therapeutics

Published 1 February 2021

Crick labs

Caroline Hill

Full details

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

Authors (8)

Luke D Hutchinson
Nicola J Darling
Stephanos Nicolaou
Ilaria Gori
Daniel R Squair
Philip Cohen
Caroline Hill
Gopal P Sapkota

Cell Death and Disease

Published 22 January 2020

Crick labs

Caroline Hill

Full details

Temporal dynamics in the formation and interpretation of Nodal and BMP morphogen gradients

Authors (2)

Current Topics in Developmental Biology

Published 1 January 2020

Crick labs

Caroline Hill

Full details

TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation

Authors (3)

Daniel Miller
Bernhard Schmierer
Caroline Hill

Journal of Cell Science

Published 15 July 2019

Crick labs/ facilities

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The dynamics of TGF-β signaling are dictated by receptor trafficking via the ESCRT machinery

Authors (9)

Cell Reports

Published 13 November 2018

Crick labs/ facilities

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Spatial and temporal control of NODAL signaling

Authors (1)

Caroline Hill

Current Opinion in Cell Biology

Published 1 April 2018

Crick labs

Caroline Hill

Full details

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

Authors (10)

Anassuya Ramachandran
Pedro Vizán
Debipriya Das
Probir Chakravarty
Janis Vogt
Katherine W Rogers
Patrick Müller
Andrew P Hinck
Gopal P Sapkota
Caroline Hill

eLife

Published 29 January 2018

Crick labs/ facilities

Full details

Long-range signaling activation and local inhibition separate the mesoderm and endoderm lineages

Authors (4)

Antonius L Van Boxtel
Andrew Economou
Claire Heliot
Caroline Hill

Developmental Cell

Published 22 January 2018

Crick labs/ facilities

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Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

Authors (9)

Davide Coda
Tessa Gaarenstroom
Phil East
Harshil Patel
Daniel Miller
Anna Lobley
Nik Matthews
Aengus Stewart
Caroline Hill

eLife

Published 13 February 2017

Crick labs/ facilities

Full details

Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction

Authors (6)

Irene De Almeida
Nidia MM Oliveira
Rebecca A Randall
Caroline Hill
John M McCoy
Claudio D Stern

Developmental Biology

Published 15 January 2017

Crick labs

Caroline Hill

Full details

Transcriptional control by the SMADs

Authors (1)

Caroline Hill

Cold Spring Harbor Perspectives in Biology

Published 22 July 2016

Crick labs

Caroline Hill

Full details

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Publications

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An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development

Context-dependent TGFβ family signalling in cell fate regulation

Nodal signaling establishes a competency window for stochastic cell fate switching

A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses

Establishment and interpretation of NODAL and BMP signaling gradients in early vertebrate development

Transforming growth factor‐β family biology: From basic mechanisms to roles in development and disease

Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

Id1 and Id3 are regulated through matrix‐assisted autocrine BMP signaling and represent therapeutic targets in melanoma

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

Temporal dynamics in the formation and interpretation of Nodal and BMP morphogen gradients

TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation

The dynamics of TGF-β signaling are dictated by receptor trafficking via the ESCRT machinery

Spatial and temporal control of NODAL signaling

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

Long-range signaling activation and local inhibition separate the mesoderm and endoderm lineages

Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction

Transcriptional control by the SMADs

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