Caroline Hill: Publications

  • Hill, CS (2018)
    Spatial and temporal control of NODAL signaling.
    Current Opinion in Cell Biology 51, 50-57 PubMed abstract
  • Ramachandran, A; Vizán, P; Das, D; Chakravarty, P; Vogt, J; Rogers, KW; Müller, P; Hinck, AP; Sapkota, GP and Hill, CS (2018)
    TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.
    eLife 7, e31756 PubMed abstract
  • van Boxtel, AL; Economou, AD; Heliot, C and Hill, CS (2018)
    Long-range signaling activation and local inhibition separate the mesoderm and endoderm lineages.
    Developmental Cell 44, 179-191 e175 PubMed abstract
  • Bakoyiannis, I; Cherdyntseva, V; Aivalioti, M; Barton, M; Coda, D; Douka, I; Evangelou, A; Evangelou, C; Ioannou, P; Kanta, V; Kapanidis, K; Karagiannidis, I; Kokkinidis, D; Kouni, S; Lehnen, J; Patsalos, A; Pei, J; Petropoulou, PI; Rodemer, W; Scerbo, D; Stefa, A; Tsvetkov, E; Vasilikos, L; Vasilopoulos, T; Vukojicic, A and Zafeiropoulou, E (2017)
    Great need for changes in higher education in Greece.
    Clinical Chemistry and Laboratory Medicine 55, E238-E239 PubMed abstract
  • De Almeida, I; Oliveira, NMM; Randall, RA; Hill, CS; McCoy, JM and Stern, CD (2017)
    Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction.
    Developmental Biology 421, 161-170 PubMed abstract
  • Hill, CS (2016)
    Transcriptional control by the SMADs.
    Cold Spring Harbor Perspectives in Biology 8, a022079 PubMed abstract
  • del Pozo Martin, Y; Park, D; Ramachandran, A; Ombrato, L; Calvo, F; Chakravarty, P; Spencer-Dene, B; Derzsi, S; Hill, CS; Sahai, E and Malanchi, I (2015)
    Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization.
    Cell Reports 13, 2456-2469 PubMed abstract
  • Houseley, J; Hill, CS and Rugg-Gunn, PJ (2015)
    Annual meeting of the EpiGeneSys Network of Excellence - Advancing epigenetics towards systems biology.
    Bioessays 37, 592-595 PubMed abstract
  • van Boxtel, AL; Chesebro, JE; Heliot, C; Ramel, M-C; Stone, RK and Hill, CS (2015)
    A temporal window for signal activation dictates the dimensions of a nodal signaling domain.
    Developmental Cell 35, 175-185 PubMed abstract
  • Gaarenstroom, T and Hill, CS (2014)
    TGF-β signaling to chromatin: how Smads regulate transcription during self-renewal and differentiation.
    Seminars in Cell & Developmental Biology 32, 107-118 PubMed abstract
  • Harding, JL; Horswell, S; Heliot, C; Armisen, J; Zimmerman, LB; Luscombe, NM; Miska, EA and Hill, CS (2014)
    Small RNA profiling of Xenopus embryos reveals novel miRNAs and a new class of small RNAs derived from intronic transposable elements.
    Genome Research 24, 96-106 PubMed abstract
  • Vizán, P; Miller, DSJ; Schmierer, B and Hill, CS (2014)
    Response to comment on "Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway"-Smad2/3 activity does not predict the dynamics of transcription.
    Science Signaling 7, lc2 PubMed abstract
  • Briones-Orta, MA; Levy, L; Madsen, CD; Das, D; Erker, Y; Sahai, E and Hill, CS (2013)
    Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.
    Cancer Research 73, 1800-1810 PubMed abstract
  • Ramel, M-C and Hill, CS (2013)
    The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands.
    Developmental Biology 378, 170-182 PubMed abstract
  • Reichert, S; Randall, RA and Hill, CS (2013)
    A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border.
    Development 140, 4435-4444 PubMed abstract
  • Sanvitale, CE; Kerr, G; Chaikuad, A; Ramel, M-C; Mohedas, AH; Reichert, S; Wang, Y; Triffitt, JT; Cuny, GD; Yu, PB; Hill, CS and Bullock, AN (2013)
    A new class of small molecule inhibitor of BMP signaling.
    PLOS ONE 8, e62721 PubMed abstract
  • Vizán, P; Miller, DSJ; Gori, I; Das, D; Schmierer, B and Hill, CS (2013)
    Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway.
    Science Signaling 6, ra106 PubMed abstract
  • Wakefield, LM and Hill, CS (2013)
    Beyond TGFβ: roles of other TGFβ superfamily members in cancer.
    Nature Reviews Cancer 13, 328-341 PubMed abstract
  • Grönroos, E; Kingston, IJ; Ramachandran, A; Randall, RA; Vizán, P and Hill, CS (2012)
    Transforming growth factor β inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes.
    Molecular and Cellular Biology 32, 2904-2916 PubMed abstract
  • Hill, CS (2012)
    Inhibiting the inhibitor: the role of RNF12 in TGF-β superfamily signaling.
    Molecular Cell 46, 558-559 PubMed abstract
  • Hill, CS and Van Aelst, L (2012)
    Signaling and gradients: what's going down?
    Current Opinion in Cell Biology 24, 155-157 PubMed abstract
  • Ramel, M-C and Hill, CS (2012)
    Spatial regulation of BMP activity.
    FEBS Letters 586, 1929-1941 PubMed abstract
  • Agricola, E; Randall, RA; Gaarenstroom, T; Dupont, S and Hill, CS (2011)
    Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities.
    Molecular Cell 43, 85-96 PubMed abstract
  • González-Pérez, V; Schmierer, B; Hill, CS and Sear, RP (2011)
    Studying Smad2 intranuclear diffusion dynamics by mathematical modelling of FRAP experiments.
    Integrative Biology 3, 197-207 PubMed abstract
  • Wu, MY; Ramel, M-C; Howell, M and Hill, CS (2011)
    SNW1 is a critical regulator of spatial BMP activity, neural plate border formation, and neural crest specification in vertebrate embryos.
    PLOS Biology 9, e1000593 PubMed abstract
  • Daly, AC; Vizán, P and Hill, CS (2010)
    Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-β responses.
    Journal of Biological Chemistry 285, 6489-6497 PubMed abstract
  • Heikkinen, PT; Nummela, M; Leivonen, S-K; Westermarck, J; Hill, CS; Kähäri, V-M and Jaakkola, PM (2010)
    Hypoxia-activated Smad3-specific dephosphorylation by PP2A.
    Journal of Biological Chemistry 285, 3740-3749 PubMed abstract
  • Tsapara, A; Luthert, P; Greenwood, J; Hill, CS; Matter, K and Balda, MS (2010)
    The RhoA activator GEF-H1/Lfc is a transforming growth factor-β target gene and effector that regulates α-smooth muscle actin expression and cell migration.
    Molecular Biology of the Cell 21, 860-870 PubMed abstract

[Page last updated 1 Jun 2018]

Caroline Hill
+44 (0)20 379 61251

  • Qualifications and history
  • 1989 PhD, Cambridge University, UK
  • 1991 Postdoctoral Research Fellow, Imperial Cancer Research Fund, UK
  • 1995 Established lab at Ludwig Institute for Cancer Research, UCL Branch, UK
  • 1998 Moved lab to the Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2015 Group Leader, the Francis Crick Institute, London, UK