Adrian Hayday: Publications

  • Rahim, A; Meskas, J; Drissler, S; Yue, A; Lorenc, A; Laing, A; Saran, N; White, J; Abeler-Dörner, L; Hayday, A and Brinkman, RR (2018)
    High throughput automated analysis of big flow cytometry data.
    Methods 134-135, 164-176 PubMed abstract
  • Rodrigues, NV; Correia, DV; Mensurado, S; Nóbrega-Pereira, S; deBarros, A; Kyle-Cezar, F; Tutt, A; Hayday, AC; Norell, H; Silva-Santos, B and Dias, S (2018)
    Low-density lipoprotein uptake inhibits the activation and antitumor functions of human Vγ9Vδ2 T cells.
    Cancer immunology research 6, 448-457 PubMed abstract
  • Vantourout, P; Laing, A; Woodward, MJ; Zlatareva, I; Apolonia, L; Jones, AW; Snijders, AP; Malim, MH and Hayday, AC (2018)
    Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.
    Proceedings of the National Academy of Sciences of the United States of America 115, 1039-1044 PubMed abstract
  • Dart, RJ; Samaan, MA; Powell, N and Irving, PM (2017)
    Vedolizumab: toward a personalized therapy paradigm for people with ulcerative colitis.
    Clinical and Experimental Gastroenterology 10, 57-66 PubMed abstract
  • Das, A; Rouault-Pierre, K; Kamdar, S; Gomez-Tourino, I; Wood, K; Donaldson, I; Mein, CA; Bonnet, D; Hayday, AC and Gibbons, DL (2017)
    Adaptive from innate: Human IFN-γ+CD4+ T cells can arise directly from CXCL8-producing recent thymic emigrants in babies and adults.
    Journal of Immunology 199, 1696-1705 PubMed abstract
  • Fishman, D; Kisand, K; Hertel, C; Rothe, M; Remm, A; Pihlap, M; Adler, P; Vilo, J; Peet, A; Meloni, A; Podkrajsek, KT; Battelino, T; Bruserud, Ø; Wolff, ASB; Husebye, ES; Kluger, N; Krohn, K; Ranki, A; Peterson, H; Hayday, A and Peterson, P (2017)
    Autoantibody repertoire in APECED patients targets two distinct subgroups of proteins.
    Frontiers in Immunology 8, 976 PubMed abstract
  • Frémond, M-L; Uggenti, C; Van Eyck, L; Melki, I; Bondet, V; Kitabayashi, N; Hertel, C; Hayday, A; Neven, B; Rose, Y; Duffy, D; Crow, YJ and Rodero, MP (2017)
    Blockade of TANK-binding kinase 1/IKKε inhibits mutant stimulator of interferon genes (STING)-mediated inflammatory responses in human peripheral blood mononuclear cells.
    Arthritis & Rheumatology 69, 1495-1501 PubMed abstract
  • Lamb, CA; Mansfield, JC; Tew, GW; Gibbons, D; Long, AK; Irving, P; Diehl, L; Eastham-Anderson, J; Price, MB; O'Boyle, G; Jones, DEJ; O'Byrne, S; Hayday, A; Keir, ME; Egen, JG and Kirby, JA (2017)
    αEβ7 integrin identifies subsets of pro-inflammatory colonic CD4+ T lymphocytes in ulcerative colitis.
    Journal of Crohns & Colitis 11, 610-620 PubMed abstract
  • Rodero, MP; Decalf, J; Bondet, V; Hunt, D; Rice, GI; Werneke, S; McGlasson, SL; Alyanakian, M-A; Bader-Meunier, B; Barnerias, C; Bellon, N; Belot, A; Bodemer, C; Briggs, TA; Desguerre, I; Frémond, M-L; Hully, M; van den Maagdenberg, AMJM; Melki, I; Meyts, I; Musset, L; Pelzer, N; Quartier, P; Terwindt, GM; Wardlaw, J; Wiseman, S; Rieux-Laucat, F; Rose, Y; Neven, B; Hertel, C; Hayday, A; Albert, ML; Rozenberg, F; Crow, YJ and Duffy, D (2017)
    Detection of interferon alpha protein reveals differential levels and cellular sources in disease.
    Journal of Experimental Medicine 214, 1547-1555 PubMed abstract
  • Salim, M; Knowles, TJ; Baker, AT; Davey, MS; Jeeves, M; Sridhar, P; Wilkie, J; Willcox, CR; Kadri, H; Taher, TE; Vantourout, P; Hayday, A; Mehellou, Y; Mohammed, F and Willcox, BE (2017)
    BTN3A1 discriminates γδ T cell phosphoantigens from non-antigenic small molecules via a conformational sensor in its B30.2 domain.
    ACS Chemical Biology 12, 2631-2643 PubMed abstract
  • Woolf, R; Nussbaumer, O and Hayday, A (2017)
    Human skin-resident innate-like T cells in health and disease.
    Journal of Investigative Dermatology 137, S247, Abstract no.321
  • Dart, RJ; Woolf, R; Irving, PM and Hayday, AC (2016)
    Characterisation of the lymphoid stress surveillance response performed by human colon resident γδ T-cells.
    Journal of Crohns & Colitis 10, S134-S135, Abstract no.P092
  • Di Marco Barros, R; Roberts, NA; Dart, RJ; Vantourout, P; Jandke, A; Nussbaumer, O; Deban, L; Cipolat, S; Hart, R; Iannitto, ML; Laing, A; Spencer-Dene, B; East, P; Gibbons, D; Irving, PM; Pereira, P; Steinhoff, U and Hayday, A (2016)
    Epithelia use butyrophilin-like molecules to shape organ-specific γδ T cell compartments.
    Cell 167, 203-218 e217 PubMed abstract
  • Iannitto, ML; Nussbaumer, O; Woolf, R and Hayday, A (2016)
    New pathways regulating immunosurveillance by tissue-resident gd T cells.
    European Journal of Immunology 46, 254-255
  • Meyer, S; Woodward, M; Hertel, C; Vlaicu, P; Haque, Y; Kärner, J; Macagno, A; Onuoha, SC; Fishman, D; Peterson, H; Metsküla, K; Uibo, R; Jäntti, K; Hokynar, K; Wolff, ASB; APECED patient collaborative; Krohn, K; Ranki, A; Peterson, P; Kisand, K and Hayday, A (2016)
    AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies.
    Cell 166, 582-595 PubMed abstract
  • Salim, M; Knowles, TJ; Hart, R; Mohammed, F; Woodward, MJ; Willcox, CR; Overduin, M; Hayday, AC and Willcox, BE (2016)
    Characterisation of a putative receptor binding surface on Skint-1, a critical determinant of dendritic epidermal T cell selection.
    Journal of Biological Chemistry 291, 9310-9321 PubMed abstract
  • Salim, M; Willcox, CR; Mohammed, F; Hayday, AC; Overduin, M; Willcox, BE and Knowles, TJ (2016)
    Secondary structure and 1H, 13C and 15N resonance assignments of Skint-1: a selecting ligand for a murine γδ T cell subset implicated in tumour suppression.
    Biomolecular NMR Assignments 10, 357-360 PubMed abstract
  • Sobolev, O; Binda, E; O'Farrell, S; Lorenc, A; Pradines, J; Huang, Y; Duffner, J; Schulz, R; Cason, J; Zambon, M; Malim, MH; Peakman, M; Cope, A; Capila, I; Kaundinya, GV and Hayday, AC (2016)
    Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.
    Nature Immunology 17, 204-213 PubMed abstract
  • Woolf, R; Nussbaumer, O and Hayday, A (2016)
    Healthy human skin harbours a resident T cell subset with rapid, innate-like responsiveness: A new perspective on tissue immune-surveillance.
    Journal of Investigative Dermatology 136, S82
  • Prochazkova, J; Sakaguchi, S; Owusu, M; Mazouzi, A; Wiedner, M; Velimezi, G; Moder, M; Turchinovich, G; Hladik, A; Gurnhofer, E; Hayday, A; Behrens, A; Knapp, S; Kenner, L; Ellmeier, W and Loizou, JI (2015)
    DNA repair cofactors ATMIN and NBS1 are required to suppress T cell activation.
    PLOS Genetics 11, e1005645 PubMed abstract
  • Schmolka, N; Wencker, M; Hayday, AC and Silva-Santos, B (2015)
    Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space.
    Seminars in Immunology 27, 19-25 PubMed abstract
  • Swamy, M; Abeler-Dörner, L; Chettle, J; Mahlakõiv, T; Goubau, D; Chakravarty, P; Ramsay, G; Reis e Sousa, C; Staeheli, P; Blacklaws, BA; Heeney, JL and Hayday, AC (2015)
    Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance.
    Nature Communications 6, 7090 PubMed abstract
  • Durazzo, TS; Tigelaar, RE; Filler, R; Hayday, A; Girardi, M and Edelson, RL (2014)
    Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: initiation via direct platelet signaling.
    Transfusion and Apheresis Science 50, 370-378 PubMed abstract
  • Gibbons, D; Fleming, P; Virasami, A; Michel, M-L; Sebire, NJ; Costeloe, K; Carr, R; Klein, N and Hayday, A (2014)
    Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants.
    Nature Medicine 20, 1206-1210 PubMed abstract
  • Marra, P; Mathew, S; Grigoriadis, A; Wu, Y; Kyle-Cezar, F; Watkins, J; Rashid, M; De Rinaldis, E; Hessey, S; Gazinska, P; Hayday, A and Tutt, A (2014)
    IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.
    Cancer Research 74, 4908-4921 PubMed abstract
  • Vantourout, P and Hayday, A (2014)
    Régulation de la visibilité immunlogique par le récepteur de l'EGF [Regulation of immunological visibility by the EGF receptor].
    Médecine Sciences : M/S 30, 742-744 PubMed abstract
  • Vantourout, P; Willcox, C; Turner, A; Swanson, CM; Haque, Y; Sobolev, O; Grigoriadis, A; Tutt, A and Hayday, A (2014)
    Immunological visibility: posttranscriptional regulation of human NKG2D ligands by the EGF receptor pathway.
    Science Translational Medicine 6, 231ra249 PubMed abstract
  • Wencker, M; Turchinovich, G; Di Marco Barros, R; Deban, L; Jandke, A; Cope, A and Hayday, AC (2014)
    Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness.
    Nature Immunology 15, 80-87 PubMed abstract
  • Clop, A; Bertoni, A; Spain, SL; Simpson, MA; Pullabhatla, V; Tonda, R; Hundhausen, C; Di Meglio, P; De Jong, P; Hayday, AC; Nestle, FO; Barker, JN; Bell, RJA; Capon, F and Trembath, RC (2013)
    An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.
    PLOS ONE 8, e71690 PubMed abstract
  • Fineschi, S; De Cunto, G; Facchinetti, F; Civelli, M; Imbimbo, BP; Carnini, C; Villetti, G; Lunghi, B; Stochino, S; Gibbons, DL; Hayday, A; Lungarella, G and Cavarra, E (2013)
    Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice.
    American Journal of Respiratory Cell and Molecular Biology 48, 164-171 PubMed abstract
  • Hayday, A and Vantourout, P (2013)
    A long-playing CD about the γδ TCR repertoire.
    Immunity 39, 994-996 PubMed abstract
  • Markle, JGM; Mortin-Toth, S; Wong, ASL; Geng, L; Hayday, A and Danska, JS (2013)
    γδ T cells are essential effectors of type 1 diabetes in the nonobese diabetic mouse model.
    Journal of Immunology 190, 5392-5401 PubMed abstract
  • Vantourout, P and Hayday, A (2013)
    Six-of-the-best: unique contributions of γδ T cells to immunology.
    Nature Reviews Immunology 13, 88-100 PubMed abstract
  • Abeler-Dörner, L; Swamy, M; Williams, G; Hayday, AC and Bas, A (2012)
    Butyrophilins: an emerging family of immune regulators.
    Trends in Immunology 33, 34-41 PubMed abstract
  • Hayday, A and Tigelaar, R (2012)
    Casting new light on the TCR.
    Nature Immunology 13, 209-211 PubMed abstract
  • Hundhausen, C; Bertoni, A; Mak, RK; Botti, E; Di Meglio, P; Clop, A; Laggner, U; Chimenti, S; Hayday, AC; Barker, JN; Trembath, RC; Capon, F and Nestle, FO (2012)
    Allele-specific cytokine responses at the HLA-C locus: implications for psoriasis.
    Journal of Investigative Dermatology 132, 635-641 PubMed abstract
  • Knight, J; Spain, SL; Capon, F; Hayday, A; Nestle, FO; Clop, A; Wellcome Trust Case Control Consortium; Genetic Analysis of Psoriasis Consortium; I-chip for Psoriasis Consortium; Barker, JN; Weale, ME and Trembath, RC (2012)
    Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis.
    Human Molecular Genetics 21, 5185-5192 PubMed abstract
  • Michel, M-L; Pang, DJ; Haque, SFY; Potocnik, AJ; Pennington, DJ and Hayday, AC (2012)
    Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells.
    Proceedings of the National Academy of Sciences of the United States of America 109, 17549-17554 PubMed abstract
  • Modi, BG; Neustadter, J; Binda, E; Lewis, J; Filler, RB; Roberts, SJ; Kwong, BY; Reddy, S; Overton, JD; Galan, A; Tigelaar, R; Cai, L; Fu, P; Shlomchik, M; Kaplan, DH; Hayday, A and Girardi, M (2012)
    Langerhans cells facilitate epithelial DNA damage and squamous cell carcinoma.
    Science 335, 104-108 PubMed abstract
  • Roberts, NA; White, AJ; Jenkinson, WE; Turchinovich, G; Nakamura, K; Withers, DR; McConnell, FM; Desanti, GE; Benezech, C; Parnell, SM; Cunningham, AF; Paolino, M; Penninger, JM; Simon, AK; Nitta, T; Ohigashi, I; Takahama, Y; Caamano, JH; Hayday, AC; Lane, PJL; Jenkinson, EJ and Anderson, G (2012)
    Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium.
    Immunity 36, 427-437 PubMed abstract
  • Tsoi, LC; Spain, SL; Knight, J; Ellinghaus, E; Stuart, PE; Capon, F; Ding, J; Li, Y; Tejasvi, T; Gudjonsson, JE; Kang, HM; Allen, MH; McManus, R; Novelli, G; Samuelsson, L; Schalkwijk, J; Ståhle, M; Burden, AD; Smith, CH; Cork, MJ; Estivill, X; Bowcock, AM; Krueger, GG; Weger, W; Worthington, J; Tazi-Ahnini, R; Nestle, FO; Hayday, A; Hoffmann, P; Winkelmann, J; Wijmenga, C; Langford, C; Edkins, S; Andrews, R; Blackburn, H; Strange, A; Band, G; Pearson, RD; Vukcevic, D; Spencer, CCA; Deloukas, P; Mrowietz, U; Schreiber, S; Weidinger, S; Koks, S; Kingo, K; Esko, T; Metspalu, A; Lim, HW; Voorhees, JJ; Weichenthal, M; Wichmann, HE; Chandran, V; Rosen, CF; Rahman, P; Gladman, DD; Griffiths, CEM; Reis, A; Kere, J; Collaborative Association Study of Psoriasis; Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetoics Extension; Wellcome Trust Case Control Consortium 2; Nair, RP; Franke, A; Barker, JNWN; Abecasis, GR; Elder, JT and Trembath, RC (2012)
    Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
    Nature Genetics 44, 1341-1348 PubMed abstract
  • Willcox, CR; Pitard, V; Netzer, S; Couzi, L; Salim, M; Silberzahn, T; Moreau, J-F; Hayday, AC; Willcox, BE and Déchanet-Merville, J (2012)
    Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor.
    Nature Immunology 13, 872-879 PubMed abstract
  • Zhang, X; Volpe, EA; Gandhi, NB; Schaumburg, CS; Siemasko, KF; Pangelinan, SB; Kelly, SD; Hayday, AC; Li, D-Q; Stern, ME; Niederkorn, JY; Pflugfelder, SC and De Paiva, CS (2012)
    NK cells promote Th-17 mediated corneal barrier disruption in dry eye.
    PLOS ONE 7, e36822 PubMed abstract
  • Barbee, SD; Woodward, MJ; Turchinovich, G; Mention, J-J; Lewis, JM; Boyden, LM; Lifton, RP; Tigelaar, R and Hayday, AC (2011)
    Skint-1 is a highly specific, unique selecting component for epidermal T cells.
    Proceedings of the National Academy of Sciences of the United States of America 108, 3330-3335 PubMed abstract
  • Bas, A; Swamy, M; Abeler-Dörner, L; Williams, G; Pang, DJ; Barbee, SD and Hayday, AC (2011)
    Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes.
    Proceedings of the National Academy of Sciences of the United States of America 108, 4376-4381 PubMed abstract
  • Gibbons, DL; Abeler-Dörner, L; Raine, T; Hwang, I-Y; Jandke, A; Wencker, M; Deban, L; Rudd, CE; Irving, PM; Kehrl, JH and Hayday, AC (2011)
    Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.
    Journal of Immunology 187, 2067-2071 PubMed abstract
  • Kozlakidis, Z; Mant, C; Abdinur, F; Cope, A; Steiner, S; Peakman, M; Hayday, A and Cason, J (2011)
    Variation of peripheral blood mononuclear cell RNA quality in archived samples.
    Biopreservation and Biobanking 9, 259-263 PubMed abstract
  • Laggner, U; Di Meglio, P; Perera, GK; Hundhausen, C; Lacy, KE; Ali, N; Smith, CH; Hayday, AC; Nickoloff, BJ and Nestle, FO (2011)
    Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis.
    Journal of Immunology 187, 2783-2793 PubMed abstract
  • Shafi, S; Vantourout, P; Wallace, G; Antoun, A; Vaughan, R; Stanford, M and Hayday, A (2011)
    An NKG2D-mediated human lymphoid stress surveillance response with high interindividual variation.
    Science Translational Medicine 3, 113ra124 PubMed abstract
  • Strid, J; Sobolev, O; Zafirova, B; Polic, B and Hayday, A (2011)
    The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy.
    Science 334, 1293-1297 PubMed abstract
  • Swamy, M and Hayday, A (2011)
    Provocative exhibits at the Seventeen Gallery.
    Nature Immunology 12, 1131-1133 PubMed abstract
  • Turchinovich, G and Hayday, AC (2011)
    Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells.
    Immunity 35, 59-68 PubMed abstract
  • Van Hemelrijck, M; Jungner, I; Walldius, G; Garmo, H; Binda, E; Hayday, A; Lambe, M; Holmberg, L and Hammar, N (2011)
    Risk of prostate cancer is not associated with levels of C-reactive protein and other commonly used markers of inflammation.
    International Journal of Cancer 129, 1485-1492 PubMed abstract
  • Van Hemelrijck, M; Walldius, G; Jungner, I; Hammar, N; Garmo, H; Binda, E; Hayday, A; Lambe, M and Holmberg, L (2011)
    Low levels of apolipoprotein A-I and HDL are associated with risk of prostate cancer in the Swedish AMORIS study.
    Cancer Causes & Control 22, 1011-1019 PubMed abstract
  • Cardone, J; Le Friec, G; Vantourout, P; Roberts, A; Fuchs, A; Jackson, I; Suddason, T; Lord, G; Atkinson, JP; Cope, A; Hayday, A and Kemper, C (2010)
    Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.
    Nature Immunology 11, 862-871 PubMed abstract
  • Genetic Analysis of Psoriasis Consortium and Wellcome Trust Case Control Consortium 2 (2010)
    A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
    Nature Genetics 42, 985-990 PubMed abstract
  • Kwong, BY; Roberts, SJ; Silberzahn, T; Filler, RB; Neustadter, JH; Galan, A; Reddy, S; Lin, WM; Ellis, PD; Langford, CF; Hayday, AC and Girardi, M (2010)
    Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis.
    Journal of Investigative Dermatology 130, 1726-1736 PubMed abstract
  • Meraviglia, S; Eberl, M; Vermijlen, D; Todaro, M; Buccheri, S; Cicero, G; La Mendola, C; Guggino, G; D'Asaro, M; Orlando, V; Scarpa, F; Roberts, A; Caccamo, N; Stassi, G; Dieli, F and Hayday, AC (2010)
    In vivo manipulation of Vγ9Vδ2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.
    Clinical and Experimental Immunology 161, 290-297 PubMed abstract
  • Ribot, JC; Chaves-Ferreira, M; d'Orey, F; Wencker, M; Gonçalves-Sousa, N; Decalf, J; Simas, JP; Hayday, AC and Silva-Santos, B (2010)
    Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-γ- or IL-17-producing γδ T cells upon infection.
    Journal of Immunology 185, 6421-6425 PubMed abstract
  • Swamy, M; Jamora, C; Havran, W and Hayday, A (2010)
    Epithelial decision makers: in search of the 'epimmunome'.
    Nature Immunology 11, 656-665 PubMed abstract
  • Van Hemelrijck, M; Garmo, H; Binda, E; Hayday, A; Karagiannis, SN; Hammar, N; Walldius, G; Lambe, M; Jungner, I and Holmberg, L (2010)
    Immunoglobulin E and cancer: a meta-analysis and a large Swedish cohort study.
    Cancer Causes & Control 21, 1657-1667 PubMed abstract

[Page last updated 1 Jun 2018]

Adrian Hayday
+44 (0)20 379 61884

  • Qualifications and history
  • 1979 PhD, Imperial College London, UK
  • 1982 Postdoctoral, MIT, USA
  • 1985 Faculty, Yale University, USA
  • 1998 King's College London School of Medicine, UK
  • 2009 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK