Simon Boulton: Publications

  • León-Ortiz, AM; Panier, S; Sarek, G; Vannier, J-B; Patel, H; Campbell, PJ and Boulton, SJ (2018)
    A distinct class of genome rearrangements driven by heterologous recombination.
    Molecular Cell 69, 292-305 e296 PubMed abstract
  • Arnoult, N; Correia, A; Ma, J; Merlo, A; Garcia-Gomez, S; Maric, M; Tognetti, M; Benner, CW; Boulton, SJ; Saghatelian, A and Karlseder, J (2017)
    Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.
    Nature 549, 548-552 PubMed abstract
  • Hewitt, G and Korolchuk, VI (2017)
    Repair, reuse, recycle: The expanding role of autophagy in genome maintenance.
    Trends in Cell Biology 27, 340-351 PubMed abstract
  • Hiraga, S-i; Ly, T; Garzón, J; Hořejší, Z; Ohkubo, Y-n; Endo, A; Obuse, C; Boulton, SJ; Lamond, AI and Donaldson, AD (2017)
    Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.
    EMBO Reports 18, 403-419 PubMed abstract
  • Lehmann, LC; Hewitt, G; Aibara, S; Leitner, A; Marklund, E; Maslen, SL; Maturi, V; Chen, Y; van der Spoel, D; Skehel, JM; Moustakas, A; Boulton, SJ and Deindl, S (2017)
    Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1.
    Molecular Cell 68, 847-859 e847 PubMed abstract
  • Margalef, P; Kotsantis, P; Borel, V; Bellelli, R; Panier, S and Boulton, SJ (2017)
    Stabilization of reversed replication forks by telomerase drives telomere catastrophe.
    Cell 172, [Epub ahead of print] PubMed abstract
  • Speckmann, C; Sahoo, SS; Rizzi, M; Hirabayashi, S; Karow, A; Serwas, NK; Hoemberg, M; Damatova, N; Schindler, D; Vannier, J-B; Boulton, SJ; Pannicke, U; Göhring, G; Thomay, K; Verdu-Amoros, JJ; Hauch, H; Woessmann, W; Escherich, G; Laack, E; Rindle, L; Seidl, M; Rensing-Ehl, A; Lausch, E; Jandrasits, C; Strahm, B; Schwarz, K; Ehl, SR; Niemeyer, C; Boztug, K and Wlodarski, MW (2017)
    Clinical and molecular heterogeneity of RTEL1 deficiency.
    Frontiers in Immunology 8, 449 PubMed abstract
  • Stingele, J; Bellelli, R and Boulton, SJ (2017)
    Mechanisms of DNA-protein crosslink repair.
    Nature Reviews Molecular Cell Biology 18, 563-573 PubMed abstract
  • Takaki, T; Montagner, M; Serres, MP; Le Berre, M; Russell, M; Collinson, L; Szuhai, K; Howell, M; Boulton, SJ; Sahai, E and Petronczki, M (2017)
    Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability.
    Nature Communications 8, 16013 PubMed abstract
  • von Morgen, P; Burdova, K; Flower, TG; O'Reilly, NJ; Boulton, SJ; Smerdon, SJ; Macurek, L and Hořejší, Z (2017)
    MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.
    Oncogene 36, 4943-4950 PubMed abstract
  • Matsuzaki, K and Boulton, S (2016)
    The Role of Fancj in the maintenance of microsatellites and lymphomagenesis.
    Genes & Genetic Systems 91, 341, Abstract no. 341A-304
  • Stingele, J; Bellelli, R; Alte, F; Hewitt, G; Sarek, G; Maslen, SL; Tsutakawa, SE; Borg, A; Kjær, S; Tainer, JA; Skehel, JM; Groll, M and Boulton, SJ (2016)
    Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN.
    Molecular Cell 64, 688-703 PubMed abstract
  • Taylor, MRG; Špírek, M; Ma, CJ; Carzaniga, R; Takaki, T; Collinson, LM; Greene, EC; Krejci, L and Boulton, SJ (2016)
    A polar and nucleotide-dependent mechanism of action for RAD51 paralogs in RAD51 filament remodeling.
    Molecular Cell 64, 926-939 PubMed abstract
  • Ceccaldi, R; Liu, JC; Amunugama, R; Hajdu, I; Primack, B; Petalcorin, MIR; O'Connor, KW; Konstantinopoulos, PA; Elledge, SJ; Boulton, SJ; Yusufzai, T and D'Andrea, AD (2015)
    Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
    Nature 518, 258-262 PubMed abstract
  • Chung, G; Rose, AM; Petalcorin, MIR; Martin, JS; Kessler, Z; Sanchez-Pulido, L; Ponting, CP; Yanowitz, JL and Boulton, SJ (2015)
    REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation in Caenorhabditis elegans.
    Genes & Development 29, 1969-1979 PubMed abstract
  • Higgs, MR; Reynolds, JJ; Winczura, A; Blackford, AN; Borel, V; Miller, ES; Zlatanou, A; Nieminuszczy, J; Ryan, EL; Davies, NJ; Stankovic, T; Boulton, SJ; Niedzwiedz, W and Stewart, GS (2015)
    BOD1L is required to suppress deleterious resection of stressed replication forks.
    Molecular Cell 59, 462-477 PubMed abstract
  • Matsuzaki, K; Borel, V; Adelman, CA; Schindler, D and Boulton, SJ (2015)
    FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
    Genes & Development 29, 2532-2546 PubMed abstract
  • Sarek, G; Marzec, P; Margalef, P and Boulton, SJ (2015)
    Molecular basis of telomere dysfunction in human genetic diseases.
    Nature Structural & Molecular Biology 22, 867-874 PubMed abstract
  • Sarek, G; Vannier, J-B; Panier, S; Petrini, JH and Boulton, SJ (2015)
    TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding.
    Molecular Cell 57, 622-635 PubMed abstract
  • Taylor, MRG; Špírek, M; Chaurasiya, KR; Ward, JD; Carzaniga, R; Yu, X; Egelman, EH; Collinson, LM; Rueda, D; Krejci, L and Boulton, SJ (2015)
    Rad51 paralogs remodel pre-synaptic Rad51 filaments to stimulate homologous recombination.
    Cell 162, 271-286 PubMed abstract
  • Xu, G; Chapman, JR; Brandsma, I; Yuan, J; Mistrik, M; Bouwman, P; Bartkova, J; Gogola, E; Warmerdam, D; Barazas, M; Jaspers, JE; Watanabe, K; Pieterse, M; Kersbergen, A; Sol, W; Celie, PHN; Schouten, PC; van den Broek, B; Salman, A; Nieuwland, M; de Rink, I; de Ronde, J; Jalink, K; Boulton, SJ; Chen, J; van Gent, DC; Bartek, J; Jonkers, J; Borst, P and Rottenberg, S (2015)
    REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
    Nature 521, 541-544 PubMed abstract
  • Beveridge, RD; Staples, CJ; Patil, AA; Myers, KN; Maslen, S; Skehel, JM; Boulton, SJ and Collis, SJ (2014)
    The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling.
    Cell Cycle 13, 3450-3459 PubMed abstract
  • Frizzell, A; Nguyen, JHG; Petalcorin, MIR; Turner, KD; Boulton, SJ; Freudenreich, CH and Lahue, RS (2014)
    RTEL1 inhibits trinucleotide repeat expansions and fragility.
    Cell Reports 6, 827-835 PubMed abstract
  • Hořejší, Z; Stach, L; Flower, TG; Joshi, D; Flynn, H; Skehel, JM; O'Reilly, NJ; Ogrodowicz, RW; Smerdon, SJ and Boulton, SJ (2014)
    Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.
    Cell Reports 7, 19-26 PubMed abstract
  • León-Ortiz, AM; Svendsen, J and Boulton, SJ (2014)
    Metabolism of DNA secondary structures at the eukaryotic replication fork.
    DNA Repair 19, 152-162 PubMed abstract
  • Panier, S and Boulton, SJ (2014)
    Double-strand break repair: 53BP1 comes into focus.
    Nature Reviews Molecular Cell Biology 15, 7-18 PubMed abstract
  • Staples, CJ; Myers, KN; Beveridge, RDD; Patil, AA; Howard, AE; Barone, G; Lee, AJX; Swanton, C; Howell, M; Maslen, S; Skehel, JM; Boulton, SJ and Collis, SJ (2014)
    Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.
    Journal of Cell Science 127, 2910-2919 PubMed abstract
  • Vannier, J-B; Sarek, G and Boulton, SJ (2014)
    RTEL1: functions of a disease-associated helicase.
    Trends in Cell Biology 24, 416-425 PubMed abstract
  • Adelman, CA; Lolo, RL; Birkbak, NJ; Murina, O; Matsuzaki, K; Horejsi, Z; Parmar, K; Borel, V; Skehel, JM; Stamp, G; D'Andrea, A; Sartori, AA; Swanton, C and Boulton, SJ (2013)
    HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
    Nature 502, 381-384 PubMed abstract
  • Ballew, BJ; Joseph, V; De, S; Sarek, G; Vannier, J-B; Stracker, T; Schrader, KA; Small, TN; O'Reilly, R; Manschreck, C; Harlan Fleischut, MM; Zhang, L; Sullivan, J; Stratton, K; Yeager, M; Jacobs, K; Giri, N; Alter, BP; Boland, J; Burdett, L; Offit, K; Boulton, SJ; Savage, SA and Petrini, JHJ (2013)
    A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome.
    PLOS Genetics 9, e1003695 PubMed abstract
  • Chapman, JR; Barral, P; Vannier, J-B; Borel, V; Steger, M; Tomas-Loba, A; Sartori, AA; Adams, IR; Batista, FD and Boulton, SJ (2013)
    RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.
    Molecular Cell 49, 858-871 PubMed abstract
  • Choi, HJC; Lin, J-R; Vannier, J-B; Slaats, GG; Kile, AC; Paulsen, RD; Manning, DK; Beier, DR; Giles, RH; Boulton, SJ and Cimprich, KA (2013)
    NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.
    Molecular Cell 51, 423-439 PubMed abstract
  • Kulkarni, A; Oza, J; Yao, M; Sohail, H; Ginjala, V; Tomas-Loba, A; Horejsi, Z; Tan, AR; Boulton, SJ and Ganesan, S (2013)
    Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.
    Journal of Biological Chemistry 288, 32357-32369 PubMed abstract
  • O'Neil, NJ; Martin, JS; Youds, JL; Ward, JD; Petalcorin, MIR; Rose, AM and Boulton, SJ (2013)
    Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis.
    PLOS Genetics 9, e1003582 PubMed abstract
  • Vannier, J-B; Sandhu, S; Petalcorin, MIR; Wu, X; Nabi, Z; Ding, H and Boulton, SJ (2013)
    RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication.
    Science 342, 239-242 PubMed abstract
  • Chapman, JR; Sossick, AJ; Boulton, SJ and Jackson, SP (2012)
    BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair.
    Journal of Cell Science 125, 3529-3534 PubMed abstract
  • Chapman, JR; Taylor, MRG and Boulton, SJ (2012)
    Playing the end game: DNA double-strand break repair pathway choice.
    Molecular Cell 47, 497-510 PubMed abstract
  • Gari, K; León Ortiz, AM; Borel, V; Flynn, H; Skehel, JM and Boulton, SJ (2012)
    MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
    Science 337, 243-245 PubMed abstract
  • Moldovan, G-L; Dejsuphong, D; Petalcorin, MIR; Hofmann, K; Takeda, S; Boulton, SJ and D'Andrea, AD (2012)
    Inhibition of homologous recombination by the PCNA-interacting protein PARI.
    Molecular Cell 45, 75-86 PubMed abstract
  • Staples, CJ; Myers, KN; Beveridge, RDD; Patil, AA; Lee, AJX; Swanton, C; Howell, M; Boulton, SJ and Collis, SJ (2012)
    The centriolar satellite protein Cep131 is important for genome stability.
    Journal of Cell Science 125, 4770-4779 PubMed abstract
  • Vannier, J-B; Pavicic-Kaltenbrunner, V; Petalcorin, MIR; Ding, H and Boulton, SJ (2012)
    RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity.
    Cell 149, 795-806 PubMed abstract
  • Uringa, E-J; Youds, JL; Lisaingo, K; Lansdorp, PM and Boulton, SJ (2011)
    RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination.
    Nucleic Acids Research 39, 1647-1655 PubMed abstract
  • Youds, JL and Boulton, SJ (2011)
    The choice in meiosis - defining the factors that influence crossover or non-crossover formation.
    Journal of Cell Science 124, 501-513 PubMed abstract
  • Adamo, A; Collis, SJ; Adelman, CA; Silva, N; Horejsi, Z; Ward, JD; Martinez-Perez, E; Boulton, SJ and La Volpe, A (2010)
    Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.
    Molecular Cell 39, 25-35 PubMed abstract
  • Adelman, CA and Boulton, SJ (2010)
    Metabolism of postsynaptic recombination intermediates.
    FEBS Letters 584, 3709-3716 PubMed abstract
  • Boulton, SJ (2010)
    DNA repair: Decision at the break point.
    Nature 465, 301-302 PubMed abstract
  • Boulton, SJ (2010)
    Helicase and translocases required for the maintenance of genome stability.
    DNA Repair 9, 201 PubMed abstract
  • Collis, SJ and Boulton, SJ (2010)
    FANCM: fork pause, rewind and play.
    EMBO Journal 29, 703-705 PubMed abstract
  • Hořejší, Z; Takai, H; Adelman, CA; Collis, SJ; Flynn, H; Maslen, S; Skehel, JM; de Lange, T and Boulton, SJ (2010)
    CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
    Molecular Cell 39, 839-850 PubMed abstract
  • Ward, JD; Muzzini, DM; Petalcorin, MIR; Martinez-Perez, E; Martin, JS; Plevani, P; Cassata, G; Marini, F and Boulton, SJ (2010)
    Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair.
    Molecular Cell 37, 259-272 PubMed abstract
  • Youds, JL; Mets, DG; McIlwraith, MJ; Martin, JS; Ward, JD; ONeil, NJ; Rose, AM; West, SC; Meyer, BJ and Boulton, SJ (2010)
    RTEL-1 enforces meiotic crossover interference and homeostasis.
    Science 327, 1254-1258 PubMed abstract

[Page last updated 1 Feb 2018]

Simon Boulton
+44 (0)20 379 61774

  • Qualifications and history
  • 1998 PhD, University of Cambridge, UK
  • 1998 HFSP and EMBO Postdoctoral Fellow, Harvard Medical School, USA
  • 2002 Established lab at the London Research Institute, Cancer Research UK
  • 2015 Group Leader, The Francis Crick Institute, London, UK