Luiz Pedro Carvalho: Publications

  • Craggs, PD; Mouilleron, S; Rejzek, M; de Chiara, C; Young, RJ; Field, RA; Argyrou, A and de Carvalho, LPS (2018)
    On the catalytic mechanism of acetyl transfer catalysed by Mycobacterium tuberculosis GlmU.
    Biochemistry [Epub ahead of print] PubMed abstract
  • Batson, S; de Chiara, C; Majce, V; Lloyd, AJ; Gobec, S; Rea, D; Fülöp, V; Thoroughgood, CW; Simmons, KJ; Dowson, CG; Fishwick, CWG; de Carvalho, LPS and Roper, DI (2017)
    Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.
    Nature Communications 8, 1939 PubMed abstract
  • dos Santos Fernandes, GF; de Souza, PC; Moreno-Viguri, E; Santivañez-Veliz, M; Paucar, R; Pérez-Silanes, S; Chegaev, K; Guglielmo, S; Lazzarato, L; Fruttero, R; Man Chin, C; da Silva, PB; Chorilli, M; Solcia, MC; Ribeiro, CM; Silva, CSP; Marino, LB; Bosquesi, PL; Hunt, DM; de Carvalho, LPS; de Souza Costa, CA; Cho, SH; Wang, Y; Franzblau, SG; Pavan, FR and dos Santos, JL (2017)
    Design, synthesis and characterization of N-oxide-containing heterocycles with in vivo sterilizing antitubercular activity.
    Journal of Medicinal Chemistry 60, 8647-8660 PubMed abstract
  • Ley, SC and de Carvalho, LPS (2017)
    Protein CoAlation: a redox-linked post-translational modification.
    Biochemical Journal 474, 2897-2899 PubMed abstract
  • Pacholarz, KJ; Burnley, RJ; Jowitt, TA; Ordsmith, V; Pisco, JP; Porrini, M; Larrouy-Maumus, G; Garlish, RA; Taylor, RJ; de Carvalho, LPS and Barran, PE (2017)
    Hybrid mass spectrometry approaches to determine how L-histidine feedback regulates the enzyzme MtATP-phosphoribosyltransferase.
    Structure 25, 730-738 PubMed abstract
  • Pisco, JP; de Chiara, C; Pacholarz, KJ; Garza-Garcia, A; Ogrodowicz, RW; Walker, PA; Barran, PE; Smerdon, SJ and de Carvalho, LPS (2017)
    Uncoupling conformational states from activity in an allosteric enzyme.
    Nature Communications 8, 203 PubMed abstract
  • Taban, IM; Elshihawy, HEAE; Torun, B; Zucchini, B; Williamson, CJ; Altuwairigi, D; Ngu, AST; McLean, KJ; Levy, CW; Sood, S; Marino, LB; Munro, AW; de Carvalho, LPS and Simons, C (2017)
    Novel aryl substituted pyrazoles as small molecule inhibitors of cytochrome P450 CYP121A1: Synthesis and antimycobacterial evaluation.
    Journal of Medicinal Chemistry 60, 10257-10267 PubMed abstract
  • Kannan, Y; Perez-Lloret, J; Li, Y; Entwistle, LJ; Khoury, H; Papoutsopoulou, S; Mahmood, R; Mansour, NR; Ching-Cheng Huang, S; Pearce, EJ; de Carvalho, LPS; Ley, SC and Wilson, MS (2016)
    TPL-2 regulates macrophage lipid metabolism and M2 differentiation to control TH2-mediated immunopathology.
    PLOS Pathogens 12, e1005783 PubMed abstract
  • Kavanagh, ME; Coyne, AG; McLean, KJ; James, GG; Levy, CW; Marino, LB; de Carvalho, LPS; Chan, DSH; Hudson, SA; Surade, S; Leys, D; Munro, AW and Abell, C (2016)
    Fragment-based approaches to the development of Mycobacterium tuberculosis CYP121 inhibitors.
    Journal of Medicinal Chemistry 59, 3272-3302 PubMed abstract
  • Larrouy-Maumus, G; Marino, LB; Madduri, AVR; Ragan, TJ; Hunt, DM; Bassano, L; Gutierrez, MG; Moody, DB; Pavan, FR and de Carvalho, LPS (2016)
    Cell-envelope remodeling as a determinant of phenotypic antibacterial tolerance in Mycobacterium tuberculosis.
    ACS Infectious Diseases 2, 352-360 PubMed abstract
  • Prosser, GA; Rodenburg, A; Khoury, H; de Chiara, C; Howell, S; Snijders, AP and de Carvalho, LPS (2016)
    Glutamate racemase is the primary target of β-chloro-ᴅ-alanine in Mycobacterium tuberculosis.
    Antimicrobial Agents and Chemotherapy 60, 6091-6099 PubMed abstract
  • Ganapathy, U; Marrero, J; Calhoun, S; Eoh, H; de Carvalho, LPS; Rhee, K and Ehrt, S (2015)
    Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
    Nature Communications 6, 7912 PubMed abstract
  • Mori, G; Chiarelli, LR; Esposito, M; Makarov, V; Bellinzoni, M; Hartkoorn, RC; Degiacomi, G; Boldrin, F; Ekins, S; de Jesus Lopes Ribeiro, AL; Marino, LB; Centárová, I; Svetlíková, Z; Blaško, J; Kazakova, E; Lepioshkin, A; Barilone, N; Zanoni, G; Porta, A; Fondi, M; Fani, R; Baulard, AR; Mikušová, K; Alzari, PM; Manganelli, R; de Carvalho, LPS; Riccardi, G; Cole, ST and Pasca, MR (2015)
    Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG.
    Chemistry & Biology 22, 917-927 PubMed abstract
  • Nandakumar, M; Prosser, GA; de Carvalho, LPS and Rhee, K (2015)
    Metabolomics of Mycobacterium tuberculosis.
    Methods in Molecular Biology 1285, 105-115 PubMed abstract
  • Young, DB; Comas, I and de Carvalho, LPS (2015)
    Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis.
    Frontiers in Molecular Biosciences 2, 6 PubMed abstract
  • Belardinelli, JM; Larrouy-Maumus, G; Jones, V; de Carvalho, LPS; McNeil, MR and Jackson, M (2014)
    Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis.
    Journal of Biological Chemistry 289, 27952-27965 PubMed abstract
  • Gouzy, A; Larrouy-Maumus, G; Bottai, D; Levillain, F; Dumas, A; Wallach, JB; Caire-Brandli, I; de Chastellier, C; Wu, T-D; Poincloux, R; Brosch, R; Guerquin-Kern, J-L; Schnappinger, D; de Carvalho, LPS; Poquet, Y and Neyrolles, O (2014)
    Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection.
    PLOS Pathogens 10, e1003928 PubMed abstract
  • Larrouy-Maumus, G; Kelly, G and de Carvalho, LPS (2014)
    Chemical mechanism of glycerol 3-phosphate phosphatase: pH-dependent changes in the rate-limiting step.
    Biochemistry 53, 143-151 PubMed abstract
  • Prosser, GA; Larrouy-Maumus, G and de Carvalho, LPS (2014)
    Metabolomic strategies for the identification of new enzyme functions and metabolic pathways.
    EMBO Reports 15, 657-669 PubMed abstract
  • Gouzy, A; Larrouy-Maumus, G; Wu, T-D; Peixoto, A; Levillain, F; Lugo-Villarino, G; Guerquin-Kern, J-L; de Carvalho, LPS; Poquet, Y and Neyrolles, O (2013)
    Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate.
    Nature Chemical Biology 9, 674-676 PubMed abstract
  • Larrouy-Maumus, G; Biswas, T; Hunt, DM; Kelly, G; Tsodikov, OV and de Carvalho, LPS (2013)
    Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis.
    Proceedings of the National Academy of Sciences of the United States of America 110, 11320-11325 PubMed abstract
  • Mao, C; Shukla, M; Larrouy-Maumus, G; Dix, FL; Kelley, LA; Sternberg, MJ; Sobral, BW and de Carvalho, LPS (2013)
    Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition.
    Tuberculosis 93, 40-46 PubMed abstract
  • Prosser, GA and de Carvalho, LPS (2013)
    Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine.
    FEBS Journal 280, 1150-1166 PubMed abstract
  • Prosser, GA and de Carvalho, LPS (2013)
    Metabolomics reveal D-Alanine:D-Alanine ligase as the target of D-Cycloserine in Mycobacterium tuberculosis.
    ACS Medicinal Chemistry Letters 4, 1233-1237 PubMed abstract
  • Prosser, GA and de Carvalho, LPS (2013)
    Reinterpreting the mechanism of inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by D-cycloserine.
    Biochemistry 52, 7145-7149 PubMed abstract
  • Pedreño, S; Pisco, JP; Larrouy-Maumus, G; Kelly, G and de Carvalho, LPS (2012)
    Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase.
    Biochemistry 51, 8027-8038 PubMed abstract
  • Goldstone, DC; Ennis-Adeniran, V; Hedden, JJ; Groom, HCT; Rice, GI; Christodoulou, E; Walker, PA; Kelly, G; Haire, LF; Yap, MW; de Carvalho, LP; Stoye, JP; Crow, YJ; Taylor, IA and Webb, M (2011)
    HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.
    Nature 480, 379-382 PubMed abstract
  • de Carvalho, LPS; Fischer, SM; Marrero, J; Nathan, C; Ehrt, S and Rhee, KY (2010)
    Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.
    Chemistry & Biology 17, 1122-1131 PubMed abstract
  • de Carvalho, LPS; Zhao, H; Dickinson, CE; Arango, NM; Lima, CD; Fischer, SM; Ouerfelli, O; Nathan, C and Rhee, KY (2010)
    Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase.
    Chemistry & Biology 17, 323-332 PubMed abstract
  • Zhao, H; de Carvalho, LPS; Nathan, C and Ouerfelli, O (2010)
    A protecting group-free synthesis of deazathiamine: a step toward inhibitor design.
    Bioorganic & Medicinal Chemistry Letters 20, 6472-6474 PubMed abstract

[Page last updated 1 Jun 2018]

Luiz Pedro Carvalho

Luiz Pedro Carvalho
+44 (0)20 379 62300

  • Qualifications and history
  • 2000-1 MSc Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
  • 2001-6 PhD Albert Einstein College of Medicine, New York, USA
  • 2006-11 Post doctoral fellow Cornell University, New York, USA
  • 2011-2015 Group Leader at Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK