James Briscoe: Publications

  • Blassberg, R and Briscoe, J (2018)
    Smoothened sensor places sodium and sterols center stage.
    Developmental Cell 44, 3-4 PubMed abstract
  • Gabryšová, L; Alvarez-Martinez, M; Luisier, R; Cox, LS; Sodenkamp, J; Hosking, C; Pérez-Mazliah, D; Whicher, C; Kannan, Y; Potempa, K; Wu, X; Bhaw, L; Wende, H; Sieweke, MH; Elgar, G; Wilson, M; Briscoe, J; Metzis, V; Langhorne, J; Luscombe, NM and O'Garra, A (2018)
    c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.
    Nature Immunology 19, 497-507 PubMed abstract
  • Herrera-Delgado, E; Perez-Carrasco, R; Briscoe, J and Sollich, P (2018)
    Memory functions reveal structural properties of gene regulatory networks.
    PLOS Computational Biology 14, e1006003 PubMed abstract
  • Perez-Carrasco, R; Barnes, CP; Schaerli, Y; Isalan, M; Briscoe, J and Page, KM (2018)
    Combining a toggle switch and a repressilator within the AC-DC circuit generates distinct dynamical behaviors.
    Cell Systems 6, 521-530 e523 PubMed abstract
  • Placzek, M and Briscoe, J (2018)
    Sonic hedgehog in vertebrate neural tube development.
    International Journal of Developmental Biology 62, 225-234 PubMed abstract
  • Pusapati, GV; Kong, JH; Patel, BB; Gouti, M; Sagner, A; Sircar, R; Luchetti, G; Ingham, PW; Briscoe, J and Rohatgi, R (2018)
    G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.
    Science Signaling 11, eaao5749 PubMed abstract
  • Pusapati, GV; Kong, JH; Patel, BB; Krishnan, A; Sagner, A; Kinnebrew, M; Briscoe, J; Aravind, L and Rohatgi, R (2018)
    CRISPR screens uncover genes that regulate target cell sensitivity to the morphogen Sonic Hedgehog.
    Developmental Cell 44, 113-129 PubMed abstract
  • Sagner, A; Gaber, ZB; Delile, J; Kong, JH; Rousso, DL; Pearson, CA; Weicksel, SE; Melchionda, M; Mousavy Gharavy, SN; Briscoe, J and Novitch, BG (2018)
    Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.
    PLOS Biology 16, e2003127 PubMed abstract
  • Aigouy, B; Collinet, C; Merkel, M and Sagner, A (2017)
    Quantitative methods to study epithelial morphogenesis and polarity.
    Methods in Cell Biology 139, 121-152 PubMed abstract
  • Blassberg, R and Jacob, J (2017)
    Lipid metabolism fattens up hedgehog signaling.
    BMC Biology 15, 95 PubMed abstract
  • Briscoe, J and Kicheva, A (2017)
    The physics of development 100 years after D'Arcy Thompson's "On Growth and Form".
    Mechanisms of Development 145, 26-31 PubMed abstract
  • Desplan, C; Plachta, N; Monteiro, A; Guillemin, K and Briscoe, J (2017)
    What is the future of developmental biology?
    Cell 170, 6-7
  • Gouti, M; Delile, J; Stamataki, D; Wymeersch, FJ; Huang, Y; Kleinjung, J; Wilson, V and Briscoe, J (2017)
    A gene regulatory network balances neural and mesoderm specification during vertebrate trunk development.
    Developmental Cell 41, 243-261.e247 PubMed abstract
  • Sagner, A and Briscoe, J (2017)
    Morphogen interpretation: concentration, time, competence, and signaling dynamics.
    Wiley Interdisciplinary Reviews. Developmental Biology 6, e271 PubMed abstract
  • Zagorski, M; Tabata, Y; Brandenberg, N; Lutolf, MP; Tkačik, G; Bollenbach, T; Briscoe, J and Kicheva, A (2017)
    Decoding of position in the developing neural tube from antiparallel morphogen gradients.
    Science 356, 1379-1383 PubMed abstract
  • Blassberg, R; MacRae, JI; Briscoe, J and Jacob, J (2016)
    Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz Syndrome.
    Human Molecular Genetics 25, 693-705 PubMed abstract
  • Cohen, M; Page, KM; Perez-Carrasco, R; Barnes, CP and Briscoe, J (2016)
    Mathematical models help explain experimental data. Response to 'Transcriptional interpretation of Shh morphogen signaling: computational modeling validates empirically established models'.
    Development 143, 1640-1643 PubMed abstract
  • Demers, CJ; Cox, G; Collins, SD and Smith, RL (2016)
    Directing the spatial patterning of motor neuron differentiation in engineered microenvironments.
    Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2016, 477-480 PubMed abstract
  • Demers, CJ; Soundararajan, P; Chennampally, P; Cox, GA; Briscoe, J; Collins, SD and Smith, RL (2016)
    Development-on-chip: in vitro neural tube patterning with a microfluidic device.
    Development 143, 1884-1892 PubMed abstract
  • Kutejova, E; Sasai, N; Shah, A; Gouti, M and Briscoe, J (2016)
    Neural progenitors adopt specific identities by directly repressing all alternative progenitor transcriptional programs.
    Developmental Cell 36, 639-653 PubMed abstract
  • Luchetti, G; Sircar, R; Kong, JH; Nachtergaele, S; Sagner, A; Byrne, EFX; Covey, DF; Siebold, C and Rohatgi, R (2016)
    Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.
    eLife 5, e20304 PubMed abstract
  • Perez-Carrasco, R; Guerrero, P; Briscoe, J and Page, KM (2016)
    Intrinsic noise profoundly alters the dynamics and steady state of morphogen-controlled bistable genetic switches.
    PLOS Computational Biology 12, e1005154 PubMed abstract
  • Uygur, A; Young, J; Huycke, TR; Koska, M; Briscoe, J and Tabin, CJ (2016)
    Scaling pattern to variations in size during development of the vertebrate neural tube.
    Developmental Cell 37, 127-135 PubMed abstract
  • Briscoe, J (2015)
    Morphogens, modeling and patterning the neural tube: an interview with James Briscoe.
    BMC Biology 13, 5 PubMed abstract
  • Briscoe, J and Small, S (2015)
    Morphogen rules: design principles of gradient-mediated embryo patterning.
    Development 142, 3996-4009 PubMed abstract
  • Cohen, M; Kicheva, A; Ribeiro, A; Blassberg, R; Page, KM; Barnes, CP and Briscoe, J (2015)
    Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.
    Nature Communications 6, 6709 PubMed abstract
  • Gouti, M; Metzis, V and Briscoe, J (2015)
    The route to spinal cord cell types: a tale of signals and switches.
    Trends in Genetics 31, 282-289 PubMed abstract
  • Kicheva, A and Briscoe, J (2015)
    Developmental pattern formation in phases.
    Trends in Cell Biology 25, 579-591 PubMed abstract
  • Kong, JH; Yang, L; Dessaud, E; Chuang, K; Moore, DM; Rohatgi, R; Briscoe, J and Novitch, BG (2015)
    Notch activity modulates the responsiveness of neural progenitors to Sonic hedgehog signaling.
    Developmental Cell 33, 373-387 PubMed abstract
  • Cohen, M; Page, KM; Perez-Carrasco, R; Barnes, CP and Briscoe, J (2014)
    A theoretical framework for the regulation of Shh morphogen-controlled gene expression.
    Development 141, 3868-3878 PubMed abstract
  • Goggolidou, P; Stevens, JL; Agueci, F; Keynton, J; Wheway, G; Grimes, DT; Patel, SH; Hilton, H; Morthorst, SK; DiPaolo, A; Williams, DJ; Sanderson, J; Khoronenkova, SV; Powles-Glover, N; Ermakov, A; Esapa, CT; Romero, R; Dianov, GL; Briscoe, J; Johnson, CA; Pedersen, LB and Norris, DP (2014)
    ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.
    Development 141, 3966-3977 PubMed abstract
  • Gouti, M; Tsakiridis, A; Wymeersch, FJ; Huang, Y; Kleinjung, J; Wilson, V and Briscoe, J (2014)
    In vitro generation of neuromesodermal progenitors reveals distinct roles for Wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
    PLOS Biology 12, e1001937 PubMed abstract
  • Jacob, J; Ribes, V; Moore, S; Constable, SC; Sasai, N; Gerety, SS; Martin, DJ; Sergeant, CP; Wilkinson, DG and Briscoe, J (2014)
    Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome.
    Disease Models & Mechanisms 7, 107-117 PubMed abstract
  • Kicheva, A; Bollenbach, T; Ribeiro, A; Valle, HP; Lovell-Badge, R; Episkopou, V and Briscoe, J (2014)
    Coordination of progenitor specification and growth in mouse and chick spinal cord.
    Science 345, 1254927 PubMed abstract
  • Sasai, N; Kutejova, E and Briscoe, J (2014)
    Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity.
    PLOS Biology 12, e1001907 PubMed abstract
  • Briscoe, J and Thérond, PP (2013)
    The mechanisms of Hedgehog signalling and its roles in development and disease.
    Nature Reviews Molecular Cell Biology 14, 416-429 PubMed abstract
  • Briscoe, J and Vincent, J-P (2013)
    Hedgehog threads to spread.
    Nature Cell Biology 15, 1265-1267 PubMed abstract
  • Cohen, M; Briscoe, J and Blassberg, R (2013)
    Morphogen interpretation: the transcriptional logic of neural tube patterning.
    Current Opinion in Genetics & Development 23, 423-428 PubMed abstract
  • Gerety, SS; Breau, MA; Sasai, N; Xu, Q; Briscoe, J and Wilkinson, DG (2013)
    An inducible transgene expression system for zebrafish and chick.
    Development 140, 2235-2243 PubMed abstract
  • Jacob, J; Kong, J; Moore, S; Milton, C; Sasai, N; Gonzalez-Quevedo, R; Terriente, J; Imayoshi, I; Kageyama, R; Wilkinson, DG; Novitch, Bennett G and Briscoe, J (2013)
    Retinoid acid specifies neuronal identity through graded expression of Ascl1.
    Current Biology 23, 412-418 PubMed abstract
  • Kahane, N; Ribes, V; Kicheva, A; Briscoe, J and Kalcheim, C (2013)
    The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling.
    Development 140, 1740-1750 PubMed abstract
  • Liu, JAJ; Wu, M-H; Yan, CH; Chau, BKH; So, H; Ng, A; Chan, A; Cheah, KSE; Briscoe, J and Cheung, M (2013)
    Phosphorylation of Sox9 is required for neural crest delamination and is regulated downstream of BMP and canonical Wnt signaling.
    Proceedings of the National Academy of Sciences of the United States of America 110, 2882-2887 PubMed abstract
  • Moore, S; Ribes, V; Terriente, J; Wilkinson, D; Relaix, F and Briscoe, J (2013)
    Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube.
    PLOS Genetics 9, e1003811 PubMed abstract
  • Panovska-Griffiths, J; Page, KM and Briscoe, J (2013)
    A gene regulatory motif that generates oscillatory or multiway switch outputs.
    Journal of the Royal Society Interface 10, 20120826
  • Tozer, S; Le Dréau, G; Marti, E and Briscoe, J (2013)
    Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube.
    Development 140, 1467-1474 PubMed abstract
  • Balaskas, N; Ribeiro, A; Panovska, J; Dessaud, E; Sasai, N; Page, Karen M; Briscoe, J and Ribes, V (2012)
    Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube.
    Cell 148, 273-284 PubMed abstract
  • Briscoe, J and Rohatgi, R (2012)
    Singapore signalling: the 2012 hedgehog pathway cocktail.
    EMBO Reports 13, 580-583 PubMed abstract
  • Briscoe, J and Sharpe, J (2012)
    Genetics of system biology.
    Current Opinion in Genetics & Development 22, 523-526 PubMed abstract
  • Bushati, N and Briscoe, J (2012)
    Regulation of Neuronal Subtype Identity in the Vertebrate Neural Tube (Neuronal Subtype Identity Regulation).
    In: eLS.
    John Wiley & Sons, Ltd, 2012.
  • Kicheva, A; Bollenbach, T; Wartlick, O; Julicher, F and Gonzalez-Gaitan, M (2012)
    Investigating the principles of morphogen gradient formation: from tissues to cells.
    Current Opinion in Genetics & Development 22, 527-532 PubMed abstract
  • Kicheva, A; Cohen, M and Briscoe, J (2012)
    Developmental pattern formation: insights from physics and biology.
    Science 338, 210-212 PubMed abstract
  • Le Dréau, G; Garcia-Campmany, L; Rabadán, MA; Ferronha, T; Tozer, S; Briscoe, J and Marti, E (2012)
    Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord.
    Development 139, 259-268 PubMed abstract
  • Matheu, A; Collado, M; Wise, C; Manterola, L; Cekaite, L; Tye, AJ; Canamero, M; Bujanda, L; Schedl, A; Cheah, KSE; Skotheim, RI; Lothe, RA; López de Munain, A; Briscoe, J; Serrano, M and Lovell-Badge, R (2012)
    Oncogenicity of the developmental transcription factor Sox9.
    Cancer Research 72, 1301-1315 PubMed abstract
  • Rabadán, MA; Cayuso, J; Le Dréau, G; Cruz, C; Barzi, M; Pons, S; Briscoe, J and Martí, E (2012)
    Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord.
    Cell Death and Differentiation 19, 209-219 PubMed abstract
  • Sasai, N and Briscoe, J (2012)
    Primary cilia and graded Sonic Hedgehog signaling.
    Wiley Interdisciplinary Reviews: Developmental Biology 1, 753-772 PubMed abstract
  • Bangs, F; Antonio, N; Thongnuek, P; Welten, M; Davey, MG; Briscoe, J and Tickle, C (2011)
    Generation of mice with functional inactivation of talpid3, a gene first identified in chicken.
    Development 138, 3261-3272 PubMed abstract
  • Bushati, N; Smith, J; Briscoe, J and Watkins, C (2011)
    An intuitive graphical visualization technique for the interrogation of transcriptome data.
    Nucleic Acids Research 39, 7380-7389
  • Chen, Y; Sasai, N; Ma, G; Yue, T; Jia, J; Briscoe, J and Jiang, J (2011)
    Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
    PLOS Biology 9, e20977 PubMed abstract
  • Escudero, LM; da, FC, L.; Kicheva, A; Briscoe, J; Freeman, M and Babu, MM (2011)
    Epithelial organisation revealed by a network of cellular contacts.
    Nature Communications 2, 526 PubMed abstract
  • Gouti, M; Briscoe, J and Gavalas, A (2011)
    Anterior hox genes interact with components of the neural crest specification network to induce neural crest fates.
    Stem Cells 29, 858-870 PubMed abstract
  • Stamataki, D; Holder, M; Hodgetts, C; Jeffery, R; Nye, E; Spencer-Dene, B; Winton, DJ and Lewis, J (2011)
    Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.
    PLOS ONE 6, e24484
  • Briscoe, J; Lawrence, PA and Vincent, JP (editors).
    Generation and Interpretation of Morphogen Gradients.
    New York, Cold Spring Harbor Laboratory Press, 2010.
  • Cox, B; Briscoe, J and Ulloa, F (2010)
    SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.
    PLOS ONE 5, e11996 PubMed abstract
  • Cruz, C; Ribes, V; Kutejova, E; Cayuso, J; Lawson, V; Norris, D; Stevens, J; Davey, M; Blight, K; Bangs, F; Mynett, A; Hirst, E; Chung, R; Balaskas, N; Brody, SL; Marti, E and Briscoe, J (2010)
    Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling.
    Development 137, 4271-4282 PubMed abstract
  • Dessaud, E; Ribes, V; Balaskas, N; Yang, LL; Pierani, A; Kicheva, A; Novitch, BG; Briscoe, J and Sasai, N (2010)
    Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen Sonic hedgehog.
    PLOS Biology 8, e1000382 PubMed abstract
  • Kicheva, A and Briscoe, J (2010)
    Limbs made to measure.
    PLOS Biology 8, e1000421 PubMed abstract
  • Ribes, V; Balaskas, N; Sasai, N; Cruz, C; Dessaud, E; Cayuso, J; Tozer, S; Yang, LL; Novitch, B; Marti, E and Briscoe, J (2010)
    Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube.
    Genes & Development 24, 1186-1200 PubMed abstract
  • Scott, CE; Wynn, SL; Sesay, A; Cruz, C; Cheung, M; Gaviro, M-VG; Booth, S; Gao, B; Cheah, KSE; Lovell-Badge, R and Briscoe, J (2010)
    SOX9 induces and maintains neural stem cells.
    Nature Neuroscience 13, 1181-1189 PubMed abstract
  • Zhu, D; Jarmin, S; Ribeiro, A; Prin, F; Xie, SQ; Sullivan, K; Briscoe, J; Gould, AP; Marelli-Berg, FM and Gu, Y (2010)
    Applying an adaptive watershed to the tissue cell quantification during T-cell migration and embryonic development.
    Methods in Molecular Biology 616, 207-228 PubMed abstract

[Page last updated 1 Jun 2018]

James Briscoe

James Briscoe

+44 (0)20 379 61388

  • Qualifications and history
  • 1996 PhD Imperial Cancer Research Fund/Kings College, London, UK
  • 1996 Post doctoral fellow Columbia University, New York, USA
  • 2000 Group Leader, Medical Research Council National Institute for Medical Research, London, UK
  • 2015 Group Leader, the Francis Crick Institute, London, UK