Francesca Ciccarelli: Publications

  • Benedetti, L; Cereda, M; Monteverde, L; Desai, N and Ciccarelli, FD (2017)
    Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.
    Oncotarget 8, 37619-37632 PubMed abstract
  • Catapano, M; Ciccarelli, F; Barker, J and Capon, F (2017)
    An investigation of the molecular pathogenesis of Generalized Pustular Psoriasis and its overlap with Psoriasis Vulgaris.
    Journal of Investigative Dermatology 137, S249, Abstract no. 329
  • Gambardella, G; Cereda, M; Benedetti, L and Ciccarelli, FD (2017)
    MEGA-V: detection of variant gene sets in patient cohorts.
    Bioinformatics 33, 1248-1249 PubMed abstract
  • Mahil, SK; Catapano, M; Di Meglio, P; Dand, N; Ahlfors, H; Carr, IM; Smith, CH; Trembath, RC; Peakman, M; Wright, J; Ciccarelli, FD; Barker, JN and Capon, F (2017)
    An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target.
    Science Translational Medicine 9, eaan2514 PubMed abstract
  • An, O; Dall'Olio, GM; Mourikis, TP and Ciccarelli, FD (2016)
    NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings.
    Nucleic Acids Research 44, D992-D999 PubMed abstract
  • Cereda, M; Gambardella, G; Benedetti, L; Iannelli, F; Patel, D; Basso, G; Guerra, RF; Mourikis, TP; Puccio, I; Sinha, S; Laghi, L; Spencer, J; Rodriguez-Justo, M and Ciccarelli, FD (2016)
    Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.
    Nature Communications 7, 12072 PubMed abstract
  • Cereda, M; Mourikis, TP and Ciccarelli, FD (2016)
    Genetic redundancy, functional compensation, and cancer vulnerability.
    Trends in Cancer 2, 160-162 PubMed abstract
  • The Computational Pan-Genomics Consortium (2016)
    Computational pan-genomics: status, promises and challenges.
    Briefings in Bioinformatics [Epub ahead of print] PubMed abstract
  • An, O; Pendino, V; D'Antonio, M; Ratti, E; Gentilini, M and Ciccarelli, FD (2014)
    NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes.
    Database 2014, bau015 PubMed abstract
  • De Grassi, A; Iannelli, F; Cereda, M; Volorio, S; Melocchi, V; Viel, A; Basso, G; Laghi, L; Caselle, M and Ciccarelli, FD (2014)
    Deep sequencing of the X chromosome reveals the proliferation history of colorectal adenomas.
    Genome Biology 15, 437 PubMed abstract
  • Iannelli, F; Collino, A; Sinha, S; Radaelli, E; Nicoli, P; D'Antiga, L; Sonzogni, A; Faivre, J; Buendia, MA; Sturm, E; Thompson, RJ; Knisely, AS; Natoli, G; Ghisletti, S and Ciccarelli, FD (2014)
    Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency.
    Nature Communications 5, 3850 PubMed abstract
  • D'Antonio, M and Ciccarelli, FD (2013)
    Integrated analysis of recurrent properties of cancer genes to identify novel drivers.
    Genome Biology 14, R52 PubMed abstract
  • D'Antonio, M; Guerra, RF; Cereda, M; Marchesi, S; Montani, F; Nicassio, F; Di Fiore, PP and Ciccarelli, FD (2013)
    Recessive cancer genes engage in negative genetic interactions with their functional paralogs.
    Cell Reports 5, 1519-1526 PubMed abstract
  • Shukla, R; Upton, KR; Muñoz-Lopez, M; Gerhardt, DJ; Fisher, ME; Nguyen, T; Brennan, PM; Baillie, JK; Collino, A; Ghisletti, S; Sinha, S; Iannelli, F; Radaelli, E; Dos Santos, A; Rapoud, D; Guettier, C; Samuel, D; Natoli, G; Carninci, P; Ciccarelli, FD; Garcia-Perez, JL; Faivre, J and Faulkner, GJ (2013)
    Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.
    Cell 153, 101-111 PubMed abstract
  • D'Antonio, M; Pendino, V; Sinha, S and Ciccarelli, FD (2012)
    Network of Cancer Genes (NCG 3.0): integration and analysis of genetic and network properties of cancer genes.
    Nucleic Acids Research 40, D978-D983 PubMed abstract
  • D'Antonio, M and Ciccarelli, FD (2011)
    Modification of gene duplicability during the evolution of protein interaction network.
    PLOS Computational Biology 7, e1002029 PubMed abstract
  • Ciccarelli, FD (2010)
    The (r)evolution of cancer genetics.
    BMC Biology 8, 74 PubMed abstract
  • Çivril, F; Wehenkel, A; Giorgi, FM; Santaguida, S; Di Fonzo, A; Grigorean, G; Ciccarelli, FD and Musacchio, A (2010)
    Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.
    Structure 18, 616-626 PubMed abstract
  • De Grassi, A; Segala, C; Iannelli, F; Volorio, S; Bertario, L; Radice, P; Bernard, L and Ciccarelli, FD (2010)
    Ultradeep sequencing of a human ultraconserved region reveals somatic and constitutional genomic instability.
    PLOS Biology 8, e1000275 PubMed abstract
  • Miklos, I and Ciccarelli, FD (2010)
    Preface. The seventh RECOMB-CG Workshop, September 27-29, 2009, Alfred Renyi Institute of Mathematics, Budapest, Hungary.
    Journal of Computational Biology 17, 1095-1096 PubMed abstract
  • Syed, AS; D'Antonio, M and Ciccarelli, FD (2010)
    Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes.
    Nucleic Acids Research 38, D670-D675 PubMed abstract

[Page last updated 1 Nov 2017]

Francesca Ciccarelli

francesca.ciccarelli@kcl.ac.uk or francesca.ciccarelli@crick.ac.uk
+44 (0)20 379 63460

  • 1998 Master's in Pharmaceutical Chemistry at University of Bologna, Italy
  • 2003 PhD in Natural Science at University of Heidelberg, Germany
  • 2005 Established research group at European Institute of Oncology (IEO), Italy
  • 2014 Associate Professor in Cancer Genomics and Bioinformatics at King's College London, UK
  • 2016 Seconded Principal Investigator at the Francis Crick Institute